DNA甲基化与奶牛乳腺泌乳调控的研究进展

›› 2013, Vol. 40 ›› Issue (1): 179-182.

DNA甲基化与奶牛乳腺泌乳调控的研究进展

郑宜文, 王春梅, 高学军, 李庆章

东北农业大学, 乳品科学教育部重点实验室, 黑龙江哈尔滨 150030

收稿日期:2012-09-17 出版日期:2013-01-20 发布日期:2013-01-14
通讯作者: 李庆章,博士生导师,研究方向:泌乳生物学与乳腺功能调控。
作者简介:郑宜文(1987-),男,江西人,硕士生,研究方向:泌乳生物学与乳腺功能调控。
基金资助:
国家重点基础研究发展计划(973)项目(2011CB100804)。

Research Progress on DNA Methylation and Regulation of Mammary Gland Lactation in Dairy Cows

ZHENG Yi-wen, WANG Chun-mei, GAO Xue-jun, LI Qing-zhang

Key Laboratory Dairy Science of Education Ministry, Northeast Agricultural University, Harbin 150030, China

Received:2012-09-17 Online:2013-01-20 Published:2013-01-14

摘要/Abstract

摘要： DNA甲基化是最早发现的表观修饰方式之一,介导基因的表达沉默,在维持细胞功能、遗传印记、个体生长发育中起着重要作用。近年来,DNA甲基化参与调控乳腺生长发育及泌乳相关基因的表达,随着这方面研究的深入,DNA甲基化在奶牛生产、遗传育种方面将会有越来越多的应用。作者主要从DNA甲基化、乳腺泌乳相关基因DNA甲基化及DNA甲基化在奶牛生产中的应用进行综述。

关键词: 奶牛; 泌乳; 表观遗传; DNA甲基化

Abstract: DNA methylation is the earliest epigenetic modified way that results in the silencing of gene expression,and it plays an important role in maintaining the normal cellfunction,genetic imprinting,embryonic development. Recent researches viewed that DNA methylation involvoed in regulation of gene expression associated with mammary gland growth and lactation.With the development of DNA methylation researches,more and more applications would be found on dairy production and genetic breeding.The author reviewed DNA methylatiion,mammary gland lactation related gene DNA methylation and the application of DNA methylation on the dairy cows.

Key words: dairy cows; lactation; epigenetic; DNA methylation

中图分类号:

Q523

郑宜文, 王春梅, 高学军, 李庆章. DNA甲基化与奶牛乳腺泌乳调控的研究进展[J]. , 2013, 40(1): 179-182.

ZHENG Yi-wen, WANG Chun-mei, GAO Xue-jun, LI Qing-zhang. Research Progress on DNA Methylation and Regulation of Mammary Gland Lactation in Dairy Cows[J]. , 2013, 40(1): 179-182.

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