(Röding, 1798) is an important pearl oyster species used to breed seawater pearls in China because it has advantageous characteristics, such as large size, high pearl secretion and growth rates, strong environmental adaptability, and a high survival rate. Previous research on mainly focused on artificial seedlings, oyster culturing, pearl cultivation, morphology, behavioral science, and histology. There have been no reports on the golden-lip and white-lip breeding lines, and there have been few reports on the growth and development of . Our group found that there was a wide diversity of the colors at the edge of the nacre shell of during the breeding phase and that four breeding lines (two geographic populations and two kinds of lip color) had developed. This study compared the differences in growth and survival rates among the Hainan golden-lip breeding line (GLHH), the Hainan white-lip breeding line (WLHH), the Guangxi golden-lip breeding line (GLGG), and the Guangxi white-lip breeding line (WLGG) of pearl oyster , and investigated the growth patterns of the four breeding lines. The survival rate, the shell length, shell height, shell width, hinge length, and body weight of the four F₃ breeding lines, which had been cultured at Xincun Port, Lingshui Li Autonomous County, Hainan Province, were continuously monitored from January 2018 to the end of December 2018, and one-way ANOVA and growth model fitting were used to analyze the data. The one-way ANOVA results showed significant differences in the growth and survival rates of the four shell color breeding lines ( < 0.05). The growth and survival rate of the Hainan golden lip breeding line was the best, and the growth of the Guangxi white lip breeding line was the worst. The results also indicated that the growth and survival of may related to the environment, age, shell color, and geographical population. The SGompertz growth model is a universal growth model for the five growth traits. The study showed that there were differences in the growth patterns of the four breeding lines, and there were differences among the growth patterns for the five growth traits. The growth inflection points of the shell length and hinge length appeared first, at 7.9 (GLHH)-8.5 (WLHH) and 7.9 (GLHH)-9.1 (WLGG) months old months old, followed by shell height and shell width. The growth inflection point appeared at 11.6 (GLHH)-15.9 (WLGG) months old and 11.8 (GLHH)-14.3 (WLGG) months old, and the body weight growth inflection point appeared at 15.8 (GLHH)−18.7 (WLGG) months old. The results of this study indicated that the Hainan golden-lip breeding line had a high survival rate and excellent growth performance during the early growth stage, and that the Guangxi white-lip breeding line may have the greatest growth potential (the growth limit of growth traits was the largest). The results also provide a reference for the breeding of and the production of high-quality pearls.