兽用喹噁啉类药物毒理学研究进展

doi:10.11924/j.issn.1000-6850.2014-2345

中国农学通报 ›› 2015, Vol. 31 ›› Issue (17): 16-21.doi: 10.11924/j.issn.1000-6850.2014-2345

兽用喹噁啉类药物毒理学研究进展

王旭,程古月,周秋格,刘嘉婧,郝海红,戴梦红,刘振利,袁宗辉

武汉华中农业大学国家兽药残留基准实验室,华中农业大学国家兽药残留基准实验室,华中农业大学动物医学院,华中农业大学动物医学院,武汉华中农业大学国家兽药残留基准实验室,武汉华中农业大学国家兽药残留基准实验室,武汉华中农业大学国家兽药残留基准实验室,武汉华中农业大学国家兽药残留基准实验室

收稿日期:2014-08-27 修回日期:2015-05-14 接受日期:2014-11-24 出版日期:2015-07-27 发布日期:2015-07-27
通讯作者: 王旭
基金资助:
国家自然科学基金“喹噁啉类化合物肾上腺毒性机制的研究”(31272614)；中央高校基本科研业务费专项基金“大肠杆菌中喹噁啉类化合物关键活化酶的筛选、鉴定及其功能分析”(2013QC002)；华中农业大学大学生科技创新基金“喹赛多引起DNA损伤方式的研究”(2013019)。

Progress of Study on the Toxicity of Quinoxaline 1,4-Dioxides

Received:2014-08-27 Revised:2015-05-14 Accepted:2014-11-24 Online:2015-07-27 Published:2015-07-27

摘要/Abstract

摘要： 喹噁啉-1,4-二-N-氧化物类抗菌促生长化合物广泛用于畜禽生产和疾病防治，主要包括喹乙醇、卡巴氧、喹赛多、喹烯酮和乙酰甲喹。因其毒副作用，卡巴氧和喹乙醇已被禁止或限制使用，中国相继批准了乙酰甲喹和喹烯酮的使用，并正在开发较为安全的喹赛多等同类产品。文章对喹噁啉类抗菌促生长化合物的毒性作用做一综述，主要包括短、长期毒性、遗传毒性和光敏毒性，为评价其安全性，指导其合理使用，避免其危害提供参考。

关键词: 落叶, 落叶

Abstract: Quinoxaline 1,4-di-N-oxide type antibacterial and growth promoting agents, including olaquindox, carbadox, mequindox, quinocetone, cyadox, are widely used in livestock production and disease control. Because of their toxicity, carbadox and olaquindox had been prohibited or restricted in the market. China has successively approved the use of mequindox and quinocetone, and now is developing safer similar products such as cyadox. The toxicity of this kind of agents was reviewed in this article, including short- and long-term toxicity, genotoxicity, and photoallergic toxicity. It will provide references to evaluate safety, guide rational use and avoid the harm of these agents.

王旭,程古月,周秋格,刘嘉婧,郝海红,戴梦红,刘振利,袁宗辉. 兽用喹噁啉类药物毒理学研究进展[J]. 中国农学通报, 2015, 31(17): 16-21.

参考文献

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兽用喹噁啉类药物毒理学研究进展

Progress of Study on the Toxicity of Quinoxaline 1,4-Dioxides

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