| 翡翠贻贝糖胺聚糖的制备及其生理活性初探 |
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| 引用本文： | 洪鹏志,杨文鸽,等.翡翠贻贝糖胺聚糖的制备及其生理活性初探[J].上海海洋大学学报,2001(2):158-162. |
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| 作者姓名： | 洪鹏志 杨文鸽 |
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| 作者单位： | [1]湛江海洋大学食品科学与工程系，广东湛江524025 [2]宁波大学生命科学与生物工程学院，浙江宁波315211 |
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| 基金项目： | 国家教委留学回国人员资助项目(1993-360) |
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| 摘 要： | 探讨了翡翠贻贝中提取糖胺聚糖的蛋白酶水解及乙醇沉淀等条件，所制备的翡翠贻贝糖胺聚糖含GAG72.1%，经动物实验，当剂量为80mg/kg体重时，对昆明小鼠移植性肿瘤S-180的抑瘤率可达52.4%，且有增强免疫力的活性。
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| 关 键 词： | 翡翠贻贝 糖胺聚糖 蛋白酶 水解法 提取 抗肿瘤活性 |
| 修稿时间： | 2001/2/14 0:00:00 |
Primary exploration for extractiong technology and physiological activity of Perna viridis glycosaminoglycan |
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| HONG Peng zhi,ZHANG Chao hu,WU Hong mian,YANG Wen ge,HAO Ji ming,ZHANG Jing.Primary exploration for extractiong technology and physiological activity of Perna viridis glycosaminoglycan[J].Journal of Shanghai Ocean University,2001(2):158-162. |
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| Authors: | HONG Peng zhi ZHANG Chao hu WU Hong mian YANG Wen ge HAO Ji ming ZHANG Jing |
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| Abstract: | The extraction of glycosaminoglycan(GAG) from Perna virids was studied.The conditions for proteinase hydrolysis and the deposition with ethanol were proposed.The findings in antitumor test indicated the inhibition rate on Sarcoma 180 was 52.4% when the dosage of P. viridis glycosaminoglycan used was 80 mg/kg,and the weight of spleen (immunity organ) in mice was obviously increased. |
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| Keywords: | Perna viridis glycosaminoglycan proteinase hydrolization method Extration antitumor activity |
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