Retrospective evaluation of COX‐2 expression,histological and clinical factors as prognostic indicators in dogs with renal cell carcinomas undergoing nephrectomy |
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| Authors: | S Carvalho A L Stoll S L Priestnall A Suarez‐Bonnet K Rassnick S Lynch I Schoepper G Romanelli P Buracco M Atherton E M de Merlo A Lara‐Garcia |
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| Affiliation: | 1. Oncology Service, Department of Clinical Sciences and Services, Royal Veterinary College, Hertfordshire, UK;2. Department of Pathology and Pathogen Biology, Royal Veterinary College, Hertfordshire, UK;3. Institute for Animal Health, Veterinary School, Universidad de Las Palmas de Gran Canaria, Arucas, Spain;4. Veterinary Medical Centre of Central New York, New York, USA;5. Davies Veterinary Specialists, Hitchin, UK;6. Tierklinik Hofheim, Hofheim, Germany;7. Clinica Veterinaria Nerviano, Nerviano MI, Italy;8. Department of Veterinary Science, University of Turin, Turin, Italy;9. University of Glasgow School of Veterinary Medicine Glasgow, Glasgow, UK;10. Universidad Complutense de Madrid Facultad de Veterinaria Madrid, Madrid, Spain |
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| Abstract: | Limited veterinary literature is available regarding prognostic markers for canine renal cell carcinoma (CRCC). We retrospectively evaluated COX‐2 expression, histological and clinical features associated with prognosis of CRCC. Sixty‐four cases post‐nephrectomy were included, 54 had histopathological assessment and 30 had COX‐2 immunostaining performed. Eight dogs (13%) had metastatic disease at initial diagnosis. Twenty‐seven dogs (42%) received adjuvant therapy after nephrectomy. On univariate analysis, COX‐2 expression, mitotic index (MI), histologic type, vascular invasion, neoplastic invasiveness and metastasis at diagnosis were significantly associated with overall median survival time (MST). COX‐2 score (COX‐2 score > 3 MST 420 days versus 1176 days if COX‐2 score <3; P = 0.011) and MI (MI > 30 MST 120 days versus 540 days for MI < 30; P = 0.003) were the only variables associated with CRCC outcome on multivariate analysis. The addition of MI and COX‐2 immunostaining to standard histopathological evaluation would help predicting outcome in CRCC patients. |
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| Keywords: | canine renal cell carcinoma chemotherapy COX‐2 expression histologic type metastasis mitotic index poorly differentiated tubular |
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