Plasma matrix metalloproteinase‐9 activity in cats with lymphoma |
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| Authors: | T Tamamoto K Ohno M Takahashi K Fukushima H Kanemoto Y Fujino H Tsujimoto |
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| Affiliation: | Department of Veterinary Internal Medicine, Graduate School of Agricultural and Life Sciences, The University of Tokyo, Tokyo, Japan |
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| Abstract: | In this study, plasma MMP‐9 activity was evaluated in cats with lymphoma. Plasma samples were obtained from 26 cats with lymphoma before treatment. From 13 of the included 26 cats, plasma samples were obtained 4 weeks after the initiation of treatment. Plasma samples were also obtained from 10 healthy cats as a control. Plasma MMP‐9 activity was examined by gelatin zymography and semi‐quantitative value (arbitrary unit; a.u.) for each sample was calculated. Relatively high levels of MMP‐9 were observed in cats with lymphoma compared with those in healthy control cats. MMP‐9 quantification through zymography showed significantly higher activity in cats with lymphoma (median, 0.63 a.u.; range, 0.23–3.24 a.u.) than in healthy controls (0.22 a.u.; 0.12–0.46 a.u.; P < 0.01). MMP‐9 activities were significantly different before (0.73 a.u.; 0.30–3.24 a.u.) and after treatment (0.50 a.u.; 0.14–1.32 a.u.; P = 0.017). Measuring plasma MMP‐9 activity in cats with lymphoma may become an appropriate monitoring tool for feline lymphoma. |
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| Keywords: | cat lymphoma matrix metalloproteinase‐9 (MMP‐9) |
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