Effects of p.o. administered xylitol in cats |
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| Authors: | Á Jerzsele Z Karancsi E Pászti‐Gere Á Sterczer A Bersényi K Fodor D Szabó P Vajdovich |
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| Affiliation: | 1. Department of Pharmacology and Toxicology, University of Veterinary Medicine, Budapest, Hungary;2. Department of Clinic of Internal Medicine, University of Veterinary Medicine, Budapest, Hungary;3. Department of Animal Breeding, Nutrition and Laboratory Animal Science, University of Veterinary Medicine, Budapest, Hungary;4. Department of Veterinary Forensics, Law and Economics, University of Veterinary Medicine, Budapest, Hungary;5. Department of Clinical Pathology and Oncology, University of Veterinary Medicine, Budapest, Hungary |
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| Abstract: | Xylitol is commonly used as sugar substitute in households. While it has numerous beneficial effects on human health, it is highly toxic to dogs. The goal of this study was to examine whether xylitol has similar deleterious effects, such as hypoglycaemia and acute hepatic failure, on cats. Our research included six healthy middle‐aged cats. Xylitol was dissolved in deionized water and administered p.o. at three doses (100, 500 and 1,000 mg/kg body weight). These dosages have been considered toxic and can cause liver failure or even death in dogs. After every xylitol administration, the basic health status and the blood glucose of cats were observed regularly. Additionally, prior to and 6, 24 and 72 hr after xylitol administration, blood samples were taken to check complete blood count, clinical biochemical parameters and enzymes such as ALT, ALKP, GGT, GLDH, bile acids, BUN, creatinine, phosphate, total protein, albumin, sodium and potassium. There were no significant changes (p > .05) in any of the haematological or biochemical parameters. Blood glucose concentrations did not show any significant alterations, except at 1,000 mg/kg dose, where a mild but significant increase was observed, but it was in physiological range. Based on our results, xylitol did not induce toxic effects on cats. |
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| Keywords: | cats complete blood counts glucose concentrations oral xylitol toxicity |
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