Albendazole treatment in laying hens: Egg residues and its effects on fertility and hatchability |
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| Authors: | Laura Moreno Mariana Bistoletti Hector Fernández Lucila Cantón Laura Ceballos Candela Cantón Carlos Lanusse Luis I Álvarez |
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| Affiliation: | Laboratorio de Farmacología, Centro de Investigación Veterinaria de Tandil (CIVETAN), Facultad de Ciencias Veterinarias, UNCPBA‐CICPBA‐CONICET, Tandil, Argentina |
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| Abstract: | This work characterized the egg residual concentrations of albendazole (ABZ ) and its sulphoxide (ABZSO ) and sulphone (ABZSO 2) metabolites and evaluated their effect on egg fertility and hatchability after ABZ treatments to laying hens. Seventy hens were allocated in groups: Group‐1 was the control without treatment; Group‐2 received a single ABZ oral dose (10 mg/kg); Group‐3, ‐4 and ‐5 were treated with ABZ in medicated feed over 7 days at 10, 40, or 80 mg kg?1 day?1, respectively. Eggs were analyzed to determine the ABZ /metabolite level by HPLC or subjected to incubation to evaluate the fertility and hatchability. Only ABZSO and ABZSO 2 metabolites were quantified in egg after ABZ single oral administration with maximum concentrations of 0.47 ± 0.08 and 0.30 ± 0.07 μg/ml, respectively. ABZ and its metabolites were found in eggs after 7‐day ABZ treatments. The egg residue exposure estimated as AUC s (areas under the concentration vs . time curve) were 100.5 (ABZ ), 56.3 (ABZSO ) and 141.3 μg hr g?1 (ABZSO 2). ABZ administration did not affect the egg fertility at any dosages. Egg hatchability was not affected by ABZ treatment at 10 mg/kg in medicated feed, but it decreased when the dose was 4–8 times higher. These results should be considered when ABZ is used for deworming laying hens. |
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| Keywords: | albendazole egg fertility egg hatchability egg residues laying hens |
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