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In this paper, we analyzed a very large field data set on intramammary infections (IMI) and the associated somatic cell count (SCC) in dairy cows. The objective of the study was to analyze the impact of coagulase-negative staphylococci (CNS) IMI on cow SCC, both mean and variability, and on the potential of these infections to have a major impact on the bulk milk SCC (BMSCC). Data and milk samples for bacterial culture were collected by Quality Milk Production Services (QMPS) between 1992 and March of 2007. The QMPS program services dairy farms in New York State and other states in the Northeastern USA and operates in conjunction with Cornell University. Only records from cows where SCC and milk production data were available, and where only one organism was isolated from bacterial cultures of milk samples (or where culture was negative) were used for this analysis. A total of 352,614 records from 4200 whole herd mastitis screening sampling qualified for this study. Within herds an average of 15% (S.D. 12%) of cows sampled were infected with CNS, ranging between 0 and 100%. Average within herd prevalence of cows with a CNS IMI and an SCC over 200,000 cells/ml was 2% (S.D. 4%) with a minimum of 0% and a maximum of 50%. Results of linear mixed models showed three distinct populations of IMI statuses: negative cultures with the lowest SCC; CNS and Corynebacterium bovis with a moderate increase in SCC, and Streptococcus agalactiae, Streptococcus spp. and Staphylococcus aureus showing an important increase in SCC. Surprisingly, milk production was slightly but significantly higher in CNS infected cows compared to culture-negative cows, whereas it was strongly reduced in cows with a major pathogen IMI. The percentage contribution of CNS infections to the BMSCC was 17.9% in herds with a BMSCC less than 200,000 cells/ml. This value decreased to 11.9 and 7.9% in herds with bulk milk SCC between 200,000 and 400,000 and over 400,000 cells/ml, respectively. We concluded that very few herds with milk quality problems would have an important increase in BMSCC that could be mostly attributed to CNS infections. On the other hand, in herds with low BMSCC, CNS infections may be an important contributor to the total number of somatic cells in the bulk milk.  相似文献   

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There is evidence of a link between animal and human abuse so there may be value in cross-reporting between the authorities responsible for investigating suspected cases. A debate called 'Turning a blind eye to abuse?' at this year's BVA Congress considered vets' ability to recognise non-accidental injury in animals and discussed protocols for reporting it.  相似文献   

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<正>报告人:Dr.Jun Lyv报告时间:2015年4月10日下午16:30报告地点:国际交流中心207会议室报告人简介:吕俊博士是自然子刊《Nature Plants》的助理编辑。曾以第一作者和并列第一作者在Nature communication和Nature Biotechnology杂志上发表植物遗传学方面的文章,并获得了2013年度的华人生物学在读博士的最高奖项"吴瑞奖学金"2014年从中科院昆明动物研究所获得遗传学博士学位后,即被自然集团招募到英国参与创办植物领域尖杂志《Nature Plants》,目前在自然集团驻上海分部工作。这次他  相似文献   

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Antimicrobial resistance is a public health emergency, placing veterinary antimicrobial use under growing scrutiny. Antimicrobial stewardship, through appropriate use of antimicrobials, is a response to this threat. The need for antimicrobial stewardship in Australian veterinary practices has had limited investigation. A 2016 survey undertaken to investigate antimicrobial usage patterns by Australian veterinarians found that antimicrobial dose rates were varied and often inappropriate. Doses of procaine penicillin in horses and cattle were often low, with 68% and 90% of respondents, respectively, reporting doses that were unlikely to result in plasma concentrations above minimum inhibitory concentrations for common equine and bovine pathogens. Frequency of penicillin administration was also often inappropriate. Gentamicin doses in horses were largely appropriate (89% of dose rates appropriate), but 9% of respondents reported twice daily dosing. Amoxycillin and amoxycillin‐clavulanate were administered at the appropriate doses, or above, to dogs and cats by 54% and 70% of respondents, respectively. Here, we explore the potential reasons for inappropriate antimicrobial dose regimens and report that antimicrobial labels often recommend incorrect dose rates and thus may be contributing to poor prescribing practices. Changes to legislation are needed to ensure that antimicrobial drug labels are regularly updated to reflect the dose needed to effectively and safely treat common veterinary pathogens. This will be especially true if changes in legislation restrict antimicrobial use by veterinarians to the uses and doses specified on the label, thus hampering the current momentum towards improved antimicrobial stewardship.  相似文献   

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Nanotechnologies are one of the two most prominent actors of the scientific revolution marking the beginning of the new Millennium. As for biotechnology, nanotechnologies are the outcome of an interdisciplinary, new approach to old technological issues ranging from device manufacturing to energy conversion, from sensing to signal amplification and transmission. The discovery of unexpected physical and chemical behavior of matter at the nanometer scale has paved the way to a number of exploitations (some current, most real but prospective). In this paper I will briefly review the nanotechnologies, showing most promise for Medicine and Veterinary Medicine. In this specific area, I will discuss current techniques and soon-to-come applications in nano-pharmaceuticals (i.e. pharmaceuticals based on the specific chemistry of nanoparticles), in vivo targeted nanodispensers, and nanoactuators. Some closing remarks will be made on how this will affect animal health control and healing in the near future.  相似文献   

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