共查询到20条相似文献，搜索用时 281 毫秒
1.
Ramezani R Moghimi A Rakhshandeh H Ejtehadi H Kheirabadi M 《Pakistan journal of biological sciences: PJBS》2008,11(5):746-751
We investigated the effect of Rosa damascena Mill, essential oil on the development of induced amygdala kindling seizures. Male Wistar rats were implanted with one tripolar and two monopolar electrodes in right basolateral amygdala and dura surface, respectively. The control group was injected solvent of essential oil and two experimental groups were injected 750 and 1000 mg kg(-1) of essential oil (ip), 30 min before a daily kindling stimulation. The number of stimulations required for the first appearance of seizure stages was significantly larger in two experimental groups than in control group. Mean after discharge duration was significantly different and essential oil reduced the increase of after discharge duration. Mean after discharge amplitude was also shorter in the groups treated with essential oil than in control group. Duration time for 5th stage of seizure at fully-kindled rats was significantly shorter in two experimental groups than control group. These results suggest that Rosa damascena essential oil significantly retarded the development of seizure stages and possesses the ability to counteract kindling acquisition. The flavonoids of Rosa damascena may act via GABAA receptors as previous studies have proposed for flavonoids of other medicinal plants. More detailed studies are recommended to define the effective component(s) of Rosa on different types of epilepsy. 相似文献
2.
Sunitha T. Manorama R. Rukmini C. 《Plant foods for human nutrition (Dordrecht, Netherlands)》1997,51(3):219-230
This study was undertaken to assess the effect of blended oils, i.e., polyunsaturated fatty acid (PUFA) rich vegetable oils like safflower oil (SFO) and sunflower oil (SNO) with the unconventional and hypocholesterolemic rice bran oil (RBO) on the serum lipid profile of rats. Rats fed RBO + SNO/SFO at 70:30 ratio for a period of 28 days showed significantly (p < 0.05) lower levels of total cholesterol (TC), triglycerides (TG) and low density lipoprotein (LDL) cholesterol and increased high density lipoprotein (HDL) cholesterol in animals fed a high cholesterol diet (HCD) and cholesterol free diet (CFD). Liver total cholesterol (TC) and triglycerides (TG) were also reduced. Fecal excretion of neutral sterols and bile acids was increased with use of RBO blends. RBO, which is rich in tocopherols and tocotrienols, may improve the oxidative stability of the blends. Tocotrienols are known to inhibit 3-hydroxy, 3-methyl, glutaryl CoA (HMG-COA) reductase (rate limiting enzyme in cholesterol biosynthesis), resulting in hypocholesterolemia. In addition to improving the lipid profile by lowering TC, TG and LDL-C and increasing HDL-C, blending of RBO with other oils can result in an economic advantage of lower prices. 相似文献
3.
咖啡碱与儿茶素组合对小鼠体重和脂类代谢的影响 总被引：1，自引：0，他引：1
采用不同浓度咖啡碱与儿茶素组合粉末饲料喂养小鼠12周,通过称量小鼠体重、脏器及腹腔脂肪（IPAT）等器官重量,测定血清中的生化指标和肝脏中脂类含量的方法,研究不同浓度咖啡碱与儿茶素组合对小鼠体重、脂类代谢的影响。结果表明,所有实验组的小鼠体重增加与对照组相比有下降趋势,其中Ⅳ组（0.06%咖啡碱+0.6%儿茶素）从第4周开始小鼠体重增加显著减少。咖啡碱与儿茶素组合处理的IPAT重量与对照组相比均明显减少。Ⅰ组（0.03%咖啡碱+0.3%儿茶素）、Ⅱ组（0.03%咖啡碱+0.6%儿茶素）可显著降低血清中游离脂肪酸（NEFA）浓度;Ⅲ组（0.06%咖啡碱+0.3%儿茶素）、Ⅳ组（0.06%咖啡碱+0.6%儿茶素）与对照组相比血清总胆固醇（TC）、甘油三酯（TG）与瘦素浓度明显降低;咖啡碱与儿茶素组合能降低肝脏中TC或TG浓度。以上结果表明,绿茶成分咖啡碱与儿茶素组合通过降低血液与肝脏中的脂类含量,可能引起体内脂肪沉积减少,抑制体重增加。 相似文献
4.
Zhaohui Xue Jie Gao Zhijun Zhang Wancong Yu Hua Wang Xiaohong Kou 《Plant foods for human nutrition (Dordrecht, Netherlands)》2012,67(4):393-400
This study was undertaken to determine the effects of chickpea albumin hydrolysate (CAH) on antihyperlipidemic and antitumor functions. The antihyperlipidemic results showed that CAH exhibited a dose dependent ability to decrease the levels of serum total cholesterol, triglyceride, LDL cholesterol (LDL-C), while increasing HDL cholesterol (HDL-C). Additionally, the appearance of the hyperlipidemic livers was ameliorated significantly. The antitumor results showed that CAH administration significantly increased the tumor inhibition rate and decreased tumor volume. CAH was also able to increase the spleen index and promote spleen lymphocyte proliferation. In addition, CAH treatment led to a remarkable rise in the superoxide dismutase (SOD) activity, while dramatically decreasing malondialdehyde (MDA) in the liver. Most importantly, we found that the physical conditions, such as appetite, activity, and coat luster of the mice in the CAH test group were better than those in the tumor control (TC) and positive control (PC) groups. These results taken together indicate that CAH warrants being further investigated and developed as an adjunctive element for hepatic lipid control, as well as antitumor and hypolipidemic therapies. 相似文献
5.
黑茶对胎牛血清诱导脂肪变性的HepG2细胞的影响 总被引：1，自引：0，他引：1
利用含有50%的胎牛血清的培养液处理HepG2细胞48 h,建立非酒精性脂肪变性细胞模型,分别从噻唑兰染色吸光度法(MTT值)、甘油三酯(TG)、胆固醇(TC)3个方面评价茯砖提取物(FZ)、六堡茶提取物(LB)、青砖茶提取物(QZ)、千两茶提取物(QL)清除肝细胞脂肪堆积的作用。结果表明,与模型组相比,加药处理组细胞的脂质堆积有缓解趋势,茯砖茶、六堡茶、千两茶、青砖茶提取物都可显著降低细胞内TG累积(P<0.01);而茯砖、青砖茶提取物对TC的清除效果较好(P<0.01),千两茶与六堡茶效果不明显。以上结果表明,黑茶提取物通过降低细胞内的脂类堆积,可能起到缓解脂肪变性的作用。 相似文献
6.
Effect of full-fat or defatted rice bran on serum cholesterol 总被引：6，自引：0，他引：6
R. K. Newman A. A. Betschart C. W. Newman P. J. Hofer 《Plant foods for human nutrition (Dordrecht, Netherlands)》1992,42(1):37-43
Rice bran has been shown to lower serum cholesterol in hamsters. Leghorn cockerel chicks were fed 60% full-fat rice bran (FFRB) and corn/soy (CS) diets with 0.5% added cholesterol. Both diets contained 19% protein. All reported parameters are on blood serum. Significant differences (p<0.05) were found in total cholesterol (TC), triglycerides (TG), high-density and low-density lipoprotein cholesterol (HDL and LDL). In a second study, chicks were fed FFRB, defatted rice bran (DFRB), and CS diets balanced for 18% protein, 14.47% total dietary fiber and 10.78% lipid with 0.5% added cholesterol. Both TC and TG were significantly lower (p<0.05) in chicks fed FFRB and CS diets. Significant differences were found in HDL values for all diets with FFRB exhibiting the highest mean value (155 mg/dl) and CS exhibiting the lowest mean value (114 mg/dl). All diets were significantly different (p<0.05) in LDL, with mean values of 249, 318 and 275 mg/dl for FFRB, DFRB and CS, respectively. FFRB appears to increase HDL and to lower LDL in chicks, but does not always affect TC, whereas DFRB may increase all three serum lipid components.Contribution No. 2575, Montana Agricultural Experiment Station in cooperation with Western Regional Research Center, USDA. 相似文献
7.
Wang MY Anderson G Nowicki D Jensen J 《Plant foods for human nutrition (Dordrecht, Netherlands)》2008,63(3):141-145
Morinda citrifolia L. (noni) has been used throughout the Pacific, Southeast Asia, Central America, and the Caribbean for a variety of health conditions, including heart and liver ailments. In this study, we examined the hepatoprotective effects of TAHITIAN NONI Juice (TNJ) against CCl(4)-induced chronic liver damage in female Sprague Dawley (SD) rats. Twelve female SD rats were divided into control, placebo and TNJ (6 mL/rat/day) groups. On day 15, animals in the placebo and TNJ groups received 0.25 mL/kg CCl(4) in corn oil once a week for 12 successive weeks. All animals were sacrificed at week 16. Blood and liver were collected for liver function, lipid panel tests, and histological observation. Histopathological examination revealed that liver sections from the TNJ + CCl(4) appeared similar to controls, whereas typical hepatic steatosis was observed in the placebo + CCl(4) group. Serum alkaline phosphatase (ALP), aspartate aminotransferase (AST), alanine transaminase (ALT), total cholesterol (TC), triglycerides (TG), low-density lipoprotein (LDL), and very low-density lipoprotein (VLDL) levels were increased in the placebo group compared with the TNJ group. In contrast, high-density lipoprotein (HDL) was increased in the TNJ group and decreased in the placebo group. Thus, TNJ juice appears to protect the liver from chronic exogenous CCl(4) exposures. Such protective mechanisms are supportive evidence for the utility of noni in traditional medicine for liver ailments. 相似文献
8.
This study investigated the effects of chitosan oligosaccharide (COS) on glucose metabolism and hepatic steatosis in a high-fat (HF) diet/streptozotocin-induced diabetic rat model. Male Wistar rats were divided into: (1) normal control (NC group), (2) HF diet (HF group), (3) streptozotocin (STZ)-induced diabetes with HF diet (DF group), and DF group supplemented with (4) 0.5% COS (D0.5F group), (5) 1% COS (D1F group), and (6) 5% COS (D5F group) for 4 weeks. COS supplementation significantly decreased the plasma glucose, BUN, creatinine, uric acid, triglyceride (TG), and total cholesterol (TC) levels, and hepatic glucose-6-phosphatase activity, and significantly increased hepatic hexokinase activity and glycogen content in diabetic rats; but the increased hepatic TG and TC levels could not be significantly decreased by COS supplementation. Supplementation of COS increased superoxide dismutase activity and decreased lipid peroxidation products in the diabetic rat livers. COS supplementation significantly increased phosphorylated AMP-activated protein kinase (AMPK) protein expression, and attenuated protein expression of hepatic phosphoenolpyruvate carboxykinase (PEPCK) and phosphorylated p38 and renal sodium-glucose cotransporter-2 (SGLT2) in diabetic rats. These results suggest that COS may possess a potential for alleviating abnormal glucose metabolism in diabetic rats through the inhibition of hepatic gluconeogenesis and lipid peroxidation and renal SGLT2 expression. 相似文献
9.
茶多酚对动物血清血脂和载脂蛋白水平的影响和抗氧化作用 总被引：28，自引：3，他引：25
采用Transansio全自动生化分析仪、自动冲洗旋转式血液流变仪及Chrono -log4 0 0血小板聚集仪分别测定各试验组动物血脂、血粘度、凝血时间、血小板聚集率脂质过氧化物及载脂蛋白水平的作用。结果 2 0 0mg kg-1·d-1茶多酚处理具有明显降低高脂血症小白鼠的血清TC、TG、LDL -C、apoB10 0 ,升高HDL -C (P 相似文献
10.
This study was designed to investigate the effects of long-term feeding of chitosan on plasma glucose and lipids in rats fed a high-fructose (HF) diet (63.1%). Male Sprague-Dawley rats aged seven weeks were used as experimental animals. Rats were divided into three groups: (1) normal group (normal); (2) HF group; (3) chitosan + HF group (HF + C). The rats were fed the experimental diets and drinking water ad libitum for 21 weeks. The results showed that chitosan (average molecular weight was about 3.8 × 105 Dalton and degree of deacetylation was about 89.8%) significantly decreased body weight, paraepididymal fat mass, and retroperitoneal fat mass weight, but elevated the lipolysis rate in retroperitoneal fats of HF diet-fed rats. Supplementation of chitosan causes a decrease in plasma insulin, tumor necrosis factor (TNF)-α, Interleukin (IL)-6, and leptin, and an increase in plasma adiponectin. The HF diet increased hepatic lipids. However, intake of chitosan reduced the accumulation of hepatic lipids, including total cholesterol (TC) and triglyceride (TG) contents. In addition, chitosan elevated the excretion of fecal lipids in HF diet-fed rats. Furthermore, chitosan significantly decreased plasma TC, low-density lipoprotein cholesterol (LDL-C), very-low-density lipoprotein cholesterol (VLDL-C), the TC/high-density lipoprotein cholesterol (HDL-C) ratio, and increased the HDL-C/(LDL-C + VLDL-C) ratio, but elevated the plasma TG and free fatty acids concentrations in HF diet-fed rats. Plasma angiopoietin-like 4 (ANGPTL4) protein expression was not affected by the HF diet, but it was significantly increased in chitosan-supplemented, HF-diet-fed rats. The high-fructose diet induced an increase in plasma glucose and impaired glucose tolerance, but chitosan supplementation decreased plasma glucose and improved impairment of glucose tolerance and insulin tolerance. Taken together, these results indicate that supplementation with chitosan can improve the impairment of glucose and lipid metabolism in a HF-diet-fed rat model. 相似文献
11.
Dongye He Ping Zhang Xuan Sai Xiaoyu Li Lili Wang Yongping Xu 《Plant foods for human nutrition (Dordrecht, Netherlands)》2017,72(4):372-379
Camellia euphlebia (family, Theaceae) has been used for the prevention and treatment of cardiovascular diseases in Southern China. However, there has been no report on the hypolipidemic activity of Camellia euphlebia flower. This study evaluated the hypolipidemic activity of different preparation of Camellia euphlebia flower extracts using in vivo models. Mice intragastrically administered aqueous extract at 400 mg/kg dose or ethanol extract at 100 and 400 mg/kg doses of Camellia euphlebia flower for 28 days exhibited significant decreases in the levels of total cholesterol, triglycerides and low-density lipoprotein cholesterol, while displaying increased level of high-density lipoprotein cholesterol in the serum. The Camellia euphlebia flower extracts also improved the antioxidant ability of hyperlipidemic mice as well as protecting the animals against liver damage by lowering the level of glutamic-pyruvic transaminase activity. Furthermore, 400 mg/kg ethanol extract effectively down-regulated the mRNA levels of fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and glycerol-3-phosphate acyl transferase, suggesting that Camellia euphlebia flower extract may potentially inhibit lipid accumulation in the liver by regulating the expression of fatty acid synthase, 3-hydroxy-3-methylglutaryl CoA reductase and glycerol-3-phosphate acyl transferase. These results provided support for the potential hypolipidemic activity of Camellia euphlebia flower and could partly explain the basis of using Camellia euphlebia for the treatment of hyperlipidemia. 相似文献
12.
Abuelgassim AO 《Pakistan journal of biological sciences: PJBS》2010,13(23):1141-1145
The aim of the present investigation was to examine the effect of Flax Seeds (FS) and Date Palm Leaves (DPL) extracts on the concentration of serum glucose and lipids in alloxan diabetic rats. Rats were divided into six groups, normal control rats (without treatment with either FS or DPL), normal control rats treated with either FS or DPL extract for four weeks, diabetic control rats and diabetic rats treated with either FS or DPL extract for four weeks. The concentration of glucose in diabetic rats treated with FS (D+FS) for four weeks was significantly decreased from 17.20 +/- 2.33 to 8.14 +/- 0.54 mmol L(-1) (p < 0.001). Serum total cholesterol concentration (TC) of diabetic rats treated with either FS or DPL extract showed significant decrease by 40 and 31% respectively in the fourth week. Also, serum low density lipoprotein cholesterol (LDL-C) concentration was significantly decreased after two weeks of treatment (p < 0.001 and p < 0.01, respectively). However, no significant changes were obtained in serum high density lipoprotein cholesterol (HDL-C) concentration. Results of the present study showed that FS extract has a hypoglycaemic effect against alloxan diabetic rats. Present findings also showed that treatment of alloxan diabetic rats with either FS or DPL extract significantly decreased serum concentration of TC and LDL-C. Present findings suggest that both of FS and DPL extracts could have a protective effect against diabetes complications as well as against hyperlipidemia through improvement of lipid profile. 相似文献
13.
Reza NM Fatemeh BR Fahimeh MT Fatemeh ZN Morteza BR 《Pakistan journal of biological sciences: PJBS》2008,11(11):1467-1471
To investigate the effects of dietary proteins on the level of serum total cholesterol (TC), triglyceride (TG) and high density lipoprotein (HDL), 32 male Wistar rats were randomly divided in control and 3 experimental groups (El, E2 and E3). The feeding regimes of rats were as follow: control, standard diet; E1, a cholesterol free diet containing 20% soybean protein; E2, a cholesterol free diet containing 20% casein and E3, a cholesterol free diet containing 10% soybean protein and 10% casein. The experimental period was 11 weeks but at the end of 7th week the diets of E1 and E2 groups were crossed over for the next 4 weeks. Blood samples were collected weekly, via the ophthalmic sinus and the serum levels TC, TG and HDL were measured. In comparison with control group, the results show that at the end of 7th week TC levels in E1 and E2 groups were significantly (p<0.05) increased while HDL level unchanged and the TC value of E2 was bigger (not significant) than E1. However by crossing over the diets, the TC level was significantly (p<0.05) diminished in E2 while TG value remarkably (p<0.05) increased. These results indicate that soybean protein may insert its hypocholesterolemic effect in hypercholestrolemic condition than in normolipidemic condition. 相似文献
14.
Banana Prevents Plasma Oxidative Stress in Healthy Individuals 总被引：1，自引：1，他引：0
There is increasing evidence that lipid peroxidation and oxidative modification of low density lipoprotein (LDL) is important in atherogenesis. The present study was designed to study the effects of a single banana meal on plasma lipids and lipoprotein profile, plasma oxidative stress and susceptibility of LDL to oxidation in 20 healthy volunteers. Lipid and lipid peroxide (LPO) levels were measured before the meal (baseline, fasting) and 2 h after it (post-dose). The susceptibility to copper-induced oxidation of baseline and post-dose LDL was measured as conjugated diene (CD) formation. Results showed that the LPO contents in plasma, very low density lipoprotein (VLDL), LDL and high density lipoprotein (HDL) decreased significantly in the 2 h post-dose phase. Prolongation of lag phase and decrease of CD formation during LDL oxidation indicated that post-dose LDL was less susceptible to oxidative modification than the homologous fasting LDL. In conclusion, the consumption of banana reduces the plasma oxidative stress and enhances the resistance to oxidative modification of LDL. 相似文献
15.
Yunlong Liu Zhangzhao Gao Qingtuo Guo Tao Wang Conger Lu Ying Chen Qing Sheng Jian Chen Zuoming Nie Yaozhou Zhang Wutong Wu Zhengbing Lv Jianhong Shu 《Marine drugs》2014,12(3):1512-1529
To determine whether cholera toxin B subunit and active peptide from shark liver (CTB-APSL) fusion protein plays a role in treatment of type 2 diabetic mice, the CTB-APSL gene was cloned and expressed in silkworm (Bombyx mori) baculovirus expression vector system (BEVS), then the fusion protein was orally administrated at a dose of 100 mg/kg for five weeks in diabetic mice. The results demonstrated that the oral administration of CTB-APSL fusion protein can effectively reduce the levels of both fasting blood glucose (FBG) and glycosylated hemoglobin (GHb), promote insulin secretion and improve insulin resistance, significantly improve lipid metabolism, reduce triglycerides (TG), total cholesterol (TC) and low density lipoprotein (LDL) levels and increase high density lipoprotein (HDL) levels, as well as effectively improve the inflammatory response of type 2 diabetic mice through the reduction of the levels of inflammatory cytokines tumor necrosis factor-α (TNF-α) and interleukin-6 (IL-6). Histopathology shows that the fusion protein can significantly repair damaged pancreatic tissue in type 2 diabetic mice, significantly improve hepatic steatosis and hepatic cell cloudy swelling, reduce the content of lipid droplets in type 2 diabetic mice, effectively inhibit renal interstitial inflammatory cells invasion and improve renal tubular epithelial cell nucleus pyknosis, thus providing an experimental basis for the development of a new type of oral therapy for type 2 diabetes. 相似文献
16.
藤茶总黄酮及二氢杨梅素降血脂作用研究 总被引：16，自引：0，他引：16
本文探讨了藤茶中主要活性成分黄酮及二氢杨梅素对高血脂症小鼠的降血脂效果。结果表明:与高脂模型组比较,二氢杨梅素对高脂血症小鼠体重有明显减轻作用;黄酮及二氢杨梅素都能不同程度降低小鼠血清TC、TG、LDL-C、MDA含量,提高血清HDL-C含量及SOD活性,降低肝系数。肝脏病理学观察表明,喂饲藤茶黄酮及二氢杨梅素组小鼠肝细胞变性、肿胀的程度减轻。说明藤茶黄酮及二氢杨梅素能降低小鼠血脂,增强机体抗氧化能力,减轻高脂对肝细胞的损伤作用。 相似文献
17.
Afshar S Heidari R Farshid AA Ilkhanipour M 《Pakistan journal of biological sciences: PJBS》2008,11(13):1742-1745
The aim of this study was to evaluate the effects of acute exposure to various doses of fenitrothion (FNT) on level of serum glucose, total protein, triglycerides (TG), total cholesterol (TC) and some hematological parameters. The study was conducted on 8-week-old male Wistar rats that divided into four groups (three experimental groups and one control group), were treated orally with different doses (25, 50 and 100 mg kg(-1)) of fenitrothion for 28 consecutive day. After treatment, blood samples were collected for biochemical and hematological studies. Present results demonstrated that exposed groups led to significant dose-dependent increase in serum glucose and cholesterol levels. Significant decrease was observed in some hematological parameters [Red Blood Cell (RBC) counts, Hemoglobin (Hb), Haematocrite (Ht) and Mean Corpuscular Hemoglobin (MCH) values]. Serum total protein and triglycerides were also decreased not significantly in exposed groups when compared with control. Generally, the degrees of observed variations were found to be dose dependent. 相似文献
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为了探究千层金叶片醇提物的抗氧化活性,本文研究了千层金叶片醇提物及其不同极性部位的抗氧化活性和总多酚含量。研究结果表明：千层金叶片醇提物正丁醇相的总多酚含量最高,为(453.75±0.75) mg/g;75%甲醇粗提物及其正丁醇相对ABTS +自由基的清除能力较抗坏血酸（VC）强;各组分还原力强弱顺序为VC>正丁醇相>75%甲醇粗提物>水相>乙酸乙酯相>BHT>石油醚相;正丁醇相和乙酸乙酯相对DPPH自由基的清除能力较醇提物和水相强,石油醚相最弱;千层金叶片醇提物及其不同极性部位清除ABTS +自由基清除能力、DPPH自由基清除能力及还原力均与其总多酚含量呈正相关。除石油醚相外,千层金叶片醇提物及其不同极性部位均有较强的抗氧化活性,可作为一种良好天然抗氧化剂的物质来源。 相似文献
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