共查询到20条相似文献，搜索用时 46 毫秒
1.
Harvey JW 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2006,35(2):144-156
Deficiencies of enzymes involved in erythrocyte metabolism can have significant effects on erythrocyte function and survival. Animals with pyruvate kinase (PK) or phosphofructokinase (PFK) deficiencies have shortened erythrocyte life spans and regenerative anemia. PK-deficient dogs (but not PK-deficient cats) develop progressive myelofibrosis and osteosclerosis of bone marrow and hemochromatosis and cirrhosis of the liver. PFK-deficient dogs have sporadic episodes of hyperventilation-induced intravascular hemolysis and hemoglobinuria. Cytochrome b5 reductase (Cb5R) deficiency in dogs and cats results in persistent methemoglobinemia and cyanotic mucous membranes. Severe deficiency of glucose-6-phosphate dehydrogenase, the rate-controlling enzyme in the pentose phosphate pathway, resulted in anemia with eccentrocytosis in an American saddlebred colt. Horses with erythrocyte flavin adenine dinucleotide (FAD) deficiency have both eccentrocytosis (attributable to severe deficiency in glutathione reductase activity) and methemoglobinemia (attributable to Cb5R deficiency); the dual enzyme deficiency occurs because FAD is a required cofactor for both enzymes. Erythrocyte enzyme deficiencies do not usually shorten life expectancy, except for PK-deficient dogs and potentially PFK-deficient dogs during a hemolytic crisis. Although enzyme deficiencies are rare causes of anemia and methemoglobinemia, the ability to diagnose deficient animals allows for the possibility of eliminating these undesirable traits in future breeding. DNA-based assays are available for PK and PFK deficiencies; whereas, biochemical tests of enzyme activity are required for other deficiencies. Continued research is needed to document additional enzyme deficiencies that likely occur and to develop additional DNA-based assays to detect heterozygous animals. 相似文献
2.
van Wuijckhuise L de Boer RK Vandehoek JE Terbijhe RJ 《Tijdschrift voor diergeneeskunde》2002,127(11):366-369
Since 1999 18 cows with 'crampiness' were presented for clinical inspection. Most animals were called upon because of clinically 'suspected BSE' by the local veterinary practitioner. The clinical picture of the disease and the differences with BSE are discussed. 相似文献
3.
Inherited coagulation disorders 总被引：2，自引：0，他引：2
4.
Rössel D 《DTW. Deutsche tier?rztliche Wochenschrift》2003,110(5):218-220
Besides dangerous dogs, there are also other species of dangerous animals. While the legal regulations concerning dangerous dogs are well known and discussed everywhere, the rules concerning exotic dangerous animals are mostly unknown and, besides of this, not well practicable because of their considerable deficiencies. 相似文献
5.
A Idel 《DTW. Deutsche tier?rztliche Wochenschrift》1990,97(4):175-177
It's difficult to value the effects on animals caused by genetic engineering. Nowadays an enormous increase on animal tests is taken place. The detrimental alterations of small number of living born gene altered animals are in literature explained by deficiencies in method and the increased growth is described with deficient mechanisms on regulation. Not only the intention to increase productivity by genetic engineering but also the method to improve by fragments (genes) not facing the animals totality is against prevention of cruelty to animals. 相似文献
6.
硒在草地放牧系统“土壤-植物-动物”间的流动与调控 总被引：1，自引：0，他引：1
硒(Se)作为动物必需而容易缺乏的微量元素,具有多种生物学功能。在草地放牧系统中,硒随着物质在土壤、植物和动物之间的转移而循环流动。本文从硒在放牧草地"土壤-植物-动物"间的含量、分布及功能等方面,对国内外的研究现状进行了综述,分析了硒在放牧系统中的循环流动特点。结果表明,硒在土壤、植物和动物中的含量分别为0.1~2.0、0.05~1.50和0.02~0.05mg·kg-1。受多种因素影响,硒在土壤、植物和动物之间的流动量存在较大差异且不稳定,导致放牧家畜往往容易出现硒元素摄入不足的现象。在合理的放牧制度下,采取适宜的施肥方式,补播对硒积累能力强的牧草品种,可有效增加草地放牧系统中硒的循环流动量,以缓解或解决放牧家畜缺硒的不利局面。 相似文献
7.
Ratsch H 《DTW. Deutsche tier?rztliche Wochenschrift》2008,115(4):143-149
In Berlin, the authorization and inspection of experiments on animals and of facilities for laboratory animal breeding and husbandry are carried out by the same authority. According to Section 16 (1) sentence one no. 3 Tierschutzgesetz (German animal protection act), there are presently 1200 procedures registered and 68 facilities approved to breed and keep vertebrates for experiments (according to Section 11 (1) sentence one no. 1 Tierschutzgesetz). In 2006, the use of 300,903 vertebrates was reported. There are 38 animal welfare officers in the twenty major scientific facilities who are in charge of in-house supervision. The authority visits the facilities where experiments take place at regular intervals to observe and supervise their operations. On request, the facilities must send the records from the experiments to the authority for examination (according to Section 9 a Tierschutzgesetz). With the annual laboratory animal report, the authority can verify the number of authorised laboratory animals. By checking the scientific publications the authority can compare them with the authorised animal experiments. Facilities for laboratory animal breeding and husbandry are continuously supervised. Offences against the animal protection act are prosecuted. When there are deficiencies in animal welfare, the authority sets a deadline to correct the defects. If the deficiency still exists after the expiry of the term, the authority imposes a penalty payment or initiates legal proceedings. The important role of the animal welfare officers (Section 8 a Tierschutzgesetz) is apparent. The majority of supervisions show that there are deficiencies. This indicates that more emphasis must be put on prevention. The facilities must provide better support and resources for the animal welfare officers. Furthermore, the scientists must be more receptive to the animal welfare officers in their role as advisers. Continuous and adequate training is imperative to the goal of maintaining sufficient in-house supervision and to keep the animals from suffering. If in-house supervision works well, the State's role in regulating animal experiments can be reduced. 相似文献
8.
W. M. Allen B. F. Sansom C. F. Drake D. C. Davies 《Veterinary research communications》1978,2(1):73-75
Animals require only a few milligrams per day of many essential elements, including iron, zinc, selenium, copper, manganese, iodine and cobalt. However, deficiencies of such trace elements are common, and they are difficult to prevent, particularly when the animals depend upon herbage for their complete diet. A new method for solving this problem is proposed, using small depots of soluble glasses, (controlled release glasses), containing the required elements.It has been shown that when two types of controlled release glass were implanted subcutaneously behind and beneath the ears of heifers they dissolved steadily for 100 days at rates of approximately 0.36 and 0.57% of their initial weight per day, and caused little tissue reaction. A glass of the higher solubility, and containing 40% by weight of selenium, has been made. A 500mg depot of this glass should provide sufficient selenium to a growing steer for 200 days. 相似文献
9.
Greco DS 《Topics in companion animal medicine》2012,27(1):2-7
Diabetes insipidus, arising from damage to or congenital abnormalities of the neurohypophysis, is the most common pituitary deficiency in animals. Hypopituitarism and isolated growth hormone or thyrotropin deficiency may result in growth abnormalities in puppies and kittens. In addition, treatment of associated hormone deficiencies, such as hypothyroidism and hypoadrenocorticism, in patients with panhypopituitarism is vital to restore adequate growth in dwarfed animals. Secondary hypoadrenocorticism is an uncommon clinical entity; however differentiation of primary versus secondary adrenal insufficiency is of utmost importance in determining optimal therapy. This article will focus on the pathogenesis, diagnosis and treatment of hormone deficiencies of the pituitary gland and neurohypophysis. 相似文献
10.
Reptiles are increasingly kept as pets in the UK and the majority of animals presented for veterinary attention have conditions with a bacterial basis, either as a primary infection or secondary to husbandry deficiencies. Culture and sensitivity tests can provide useful information for selecting treatment protocols, but the lack of published data reviewing the normal reptilian microflora means interpretation of results is subjective. This study publishes the results of culture and sensitivity results from all reptilian samples provided to a commercial pathology laboratory over a 24-month period and compares these data with the published literature to assist clinicians to determine appropriate treatment protocols. Results provided a wide range of cultured organisms, although trends were seen for varying anatomical locations, species and time of year. In addition, antibiotic sensitivity revealed some concerning trends. 相似文献
11.
Ferrets, rabbits, and rodents are increasingly being presented to veterinarians for evaluation and treatment. The owners of these animals expect high-level medical and surgical care. Consequently, veterinarians are more often required to provide intensive anesthetic management of these animals. The variability of anesthetic agents used and patient responses are addressed. The consequences of size for anesthetic management are discussed. Successful small mammal anesthesia requires following general anesthetic principles, awareness of limitations, and maintenance of high standards of care. 相似文献
12.
T L Lightfoot 《Veterinary Clinics of North America: Exotic Animal Practice》1999,2(2):447-69, vii
Veterinarians in small animal practice are being presented with an ever-increasing number of exotic species. It has become critical that veterinarians expand their professional knowledge to include the basic procedures necessary for the proper diagnosis and therapy of these animals. Yet the husbandry, temperaments, physiology, and anatomy of many of these species make extrapolation from our well-developed techniques in dog and cat medicine inadequate. This article discusses some of the major species concerns and clinical findings of chinchillas, hedgehogs, prairie dogs, and sugar gliders presented to the veterinary practitioner. Practical techniques for evaluation of these animals with minimal stress (to the animal, the practitioner, and the client) and maximum efficiency are addressed. 相似文献
13.
Zinc and copper deficiencies have been reported in heifers of various breeds at four different locations in Sudan. These were Kuku (5 km north of Khartoum), Seleit (20 km northwest of Khartoum), Medani (180 km south of Khartoum) and El Obeid (600 km west of Khartoum). Phosphorus deficiency was only observed in the serum of heifers at El Obeid. The heifers at all locations showed delayed puberty, stunted growth and infertility. The heifers of the local breeds at El Obeid only attained puberty by 1530 days of age compared with 840 days for the pure Friesian heifers at Seleit. The crossbred animals at Kuku and Medani attained puberty at 1440 and 1020 days of age, respectively. The marginal or low zinc and copper contents in pasture, soil or animal feed may have been predisposing factors for the observed deficiencies and might have been responsible for the delayed age of puberty. 相似文献
14.
Zucker BA Bonin H Müller W 《Berliner und Münchener tier?rztliche Wochenschrift》2005,118(5-6):224-228
In the study presented here the relationship between the hygienic condition and the concentration of different air contaminants in two pig fattening houses was investigated. Deficiencies in routine cleaning, which were characterized by an increased soiling of animals and stable surfaces with faeces, led to increased concentrations of airborne dust, airborne endotoxins as well as increased numbers of total airborne bacteria and airborne gram-negative bacteria. However these deficiencies were not reflected by the concentration of airborne Clostridium perfringens which were earlier postulated as an indicator of faecal pollution in the air of cattle barns. Furthermore the results of this study were used to discuss advantages and disadvantages of impingement and impaction for the sampling of airborne microorganisms in animal houses. 相似文献
15.
Campylobacter jejuni, which is now recognized as a discrete species, is a gram negative, microaerophilic, thermophilic, nalidixic acid sensitive, hippurate positive pathogen requiring special selective media for propogation. The organism is widely distributed in avian species, experimental and companion animals and in humans. Mammalian campylobacteriosis is characterized by an enterocolitis of variable severity. The prevalence of the condition is relatively high in young individuals, in underdeveloped countries and in subjects with diarrhea. Food animals, especially poultry, are reservoirs of the organism and infection occurs following consumption of untreated surface water, unpasteurized milk, incompletely cooked meat or other contaminated food products. Close contact with infected immature companion animals is a significant cause of campylobacteriosis in children and direct intrafamilial transmission and occupational infection have been documented. Campylobacteriosis attributable to C. jejuni is a condition of emerging significance which arises principally from deficiencies in hygiene inherent in the environment and in the food chain which extends from domestic animals to the consumer. 相似文献
16.
R. J. Evans 《The Journal of small animal practice》1989,30(3):144-150
Lysosomal storage diseases are inborn errors of metabolism which are common in a number of breeds of dog and cat, due to specific, genetically determined, deficiencies of degradative enzymes. They are generally inherited as autosomal recessive traits. The enzyme substrate may be a complex lipid, glycoprotein or polysaccharide. In enzyme deficiency this substrate accumulates in swollen lysosomes in specific organs. Assay of the enzyme can be employed to detect affected individuals and also heterozygotes. It is possible to control these diseases by the identification of heterozygous animals and refraining from using them for breeding. Affected animals are normal at birth but the onset of disease is generally during the first months of life. The diseases are progressive and fatal. Neurological signs, hepato- and splenomegaly and skeletal abnormalities are commonly seen. 相似文献
17.
David Risco Pilar Gonalves María Bravo Waldo García‐Jimnez Rosario Cerrato Javier Hermoso de Mendoza Pedro Fernndez‐Llario 《Journal of animal physiology and animal nutrition》2019,103(2):668-674
Vitamin D (VitD) is involved in important mammalian physiological mechanisms, such as Ca–P metabolism, bone development and immunological response. VitD deficiencies are frequently detected in domestic animals and related to various health problems (e.g., rickets, bone deformation). However, knowledge about the status of VitD in wildlife species, such as the wild boar, is scarce. The aims of this work were to explore VitD status in wild boar populations from mid‐western Spain and to elucidate the influence of daylight exposure and food supplementation in levels of VitD. Serum concentration of VitD (measured as 25‐hydroxivitaminD) was assessed in 276 wild boar from 27 game estates located in mid‐western Spain using a commercial ELISA kit. In 19 out of 27 estates, the staff supplied a specific VitD‐enriched food (2,000 UI/Kg) ad libitum throughout the year, while in the remaining estates (8), no food was supplied. Blood samples were extracted from hunted animals (198) between October and February of hunting seasons 2016/2017 and 2017/2018, and from live wild boar (78) that were captured, sampled and released (March–September of 2017). The percentage of animals with VitD deficiency (<20 ng/ml), VitD insufficiency (20–30 ng/ml) and VitD sufficiency (>30 ng/ml) was estimated, and the relationship of these levels to factors like sex, age and season was assessed using chi‐square tests. Furthermore, associations between daylight exposure and supplemental food with VitD levels were explored using linear models. Of the studied wild boar population, 82.2% showed a VitD deficiency or insufficiency. VitD deficiencies were more frequent in animals sampled in winter and spring. Furthermore, levels of VitD positively correlated with daylight exposure and supplemental food intake. Ad libitum supplementation with VitD‐enriched food was insufficient to prevent VitD deficiencies in wild boar from November to April, probably because food consumption is lower during this period. 相似文献
18.
The study of mutant mice with altered or deficient hematopoietic or hemostatic gene products provides a challenge to the researcher, particularly when genetic alterations lead to lethal phenotypes. The following review provides a framework for understanding murine hematopoiesis, based on work with mutant mice, and details experimental approaches used to evaluate these animals. Mice with deficiencies in hemostatic and fibrinolytic system proteins are discussed, and the investigation of their phenotypes is reviewed. 相似文献
19.
Classically, biologists have considered adaptation of behavioural characteristics in terms of long-term functional benefits to the individual, such as survival or reproductive fitness. In captive species, including the domestic horse, this level of explanation is limited, as for the most part, horses are housed in conditions that differ markedly from those in which they evolved. In addition, an individual horse's reproductive fitness is largely determined by man rather than its own behavioural strategies. Perhaps for reasons of this kind, explanations of behavioural adaptation to environmental challenges by domestic animals, including the capacity to learn new responses to these challenges, tend to concentrate on the proximate causes of behaviour. However, understanding the original function of these adaptive responses can help us explain why animals perform apparently novel or functionless activities in certain housing conditions and may help us to appreciate what the animal welfare implications might be. This paper reviews the behavioural adaptation of the domestic horse to captivity and discusses how apparently abnormal behaviour may not only provide a useful practical indicator of specific environmental deficiencies but may also serve the animal as an adaptive response to these deficiencies in an “abnormal” environment. 相似文献
20.
G H Counotte A T van't Klooster J van der Kuilen R A Prins 《Journal of animal science》1979,49(6):1536-1544
A method is presented for the analysis of buffer systems in the rumen using the first derivation of titration curves. Bicarbonate and volatile fatty acids (VFA) are the main components of the buffering system in the rumen fluid of dairy cattle under widely different feeding conditions. Phosphate from saliva is of little importance as a buffer, but neutralizes acids produced in the rumen. After studying five cows during the peripartal period a spontaneous and transient increase in the concentrations of VFA and a soluble marker (PEG) as well as a drop in pH and in the bicarbonate concentrations not related to feeding was observed in two animals that were sampled several hours before parturition. The potential risk of provoking rumen disturbances upon feeding animals close to the time of parturition, when buffering capacity may be minimal, is stressed. 相似文献