共查询到19条相似文献，搜索用时 250 毫秒
1.
利用硅胶和凝胶色谱Sephadex LH-20柱层析技术从宽叶短梗南蛇藤中分离得到了9个三萜类化合物,经核磁共振、质谱等检测方法鉴定为β-香树脂醇、齐墩果酸、12-齐墩果烯-3-酮、12-齐墩果烯-3β,11β-二醇、羽扇豆醇,20(29)-羽扇豆烯-3-酮、20(30)-羽扇豆烯-3β,29-二醇、29-羟基-20(30)-羽扇豆烯-3-酮、羽扇豆醇棕榈酸酯. 相似文献
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三花假卫矛三萜类化学成分的研究 总被引：1，自引：1，他引：0
通过核磁共振和质普分析对三花假卫矛藤茎的化学成分进行研究,分离并鉴定了6个三萜类化学成分,分别为β-香树脂醇(Ⅰ)、齐墩果酸(Ⅱ)、β-香树脂醇棕榈酸脂(Ⅲ)、羽扇豆醇(Ⅳ)、20(30)-羽扇豆烯-3-酮(Ⅴ)及20(30)-羽扇豆烯-3β, 29-二醇(Ⅵ)。经检索,所有化合物均为首次从三花假卫矛中分得。 相似文献
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枫香树脂化学成分的研究 总被引：2，自引：0，他引：2
从枫树树脂非挥发固体物分离得到肉桂酸肉桂酯、齐墩果酮醇、齐墩果酮酸、羽扇豆酮酸４种化合物，其中齐墩果酮醇为首次从该植物中得到。枫树脂的挥发油主要成分为α－蒎烯、β－蒎烯、莰烯、异松油烯、石竹烯、乙酸龙脑酯。 相似文献
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对云南潦浒、寻甸及吉林舒兰蒙旦树脂中醇类化学成分进行了GC-MS研究，探索蒙旦树脂醇类作为药用资源的可能性。实验结果表明，树脂醇由正构烷醇、正构酮(甲基酮)、甾醇类、五环三萜醇及五环三萜酮所组成。潦浒、寻甸树脂醇中均存在24-甲基-邓(H)-胆甾烷-筇-醇(C28H50O，分子质量402)、24-乙基胆甾-5，22-二烯-3β-醇(C29H48O，分子质量412)、24-乙基-5α(H)-胆甾烷-3β-醇(C29H52O，分子质量416)、23，24-二甲基胆甾-5-烯-3β-醇(C29H50O，分子质量414)、C29-5β(H)，3β(OH)-甾醇(C29H52O，分子质量416)、24-异丙基胆甾-5，24(28)E-二烯-3β-醇(C30H50O，分子质量426)等甾体类物质。舒兰树脂醇中正构烷醇，正构烷酮含量甚低，甾醇类几乎没有分布，主要是由五环三萜氧化物组成。化学组成表明潦浒、寻甸蒙旦树脂作为药用资源是可能的。 相似文献
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杜英叶挥发油化学成分的GC-MS分析 总被引：2，自引：0，他引：2
采用气-质联用法对杜英叶挥发油的化学成分进行研究,经毛细管色谱分析,共确认出其中的38种成分,所鉴定出化学成分的质量占总量的98.712%。应用色谱峰面积归一法分析各成分的质量分数,含量较高的物质有:α-谷甾醇(15.406%)、沸波醇(14.322%)、α-香树素(13.461%)、3,15,16,21,22,28-六羟基-12-齐墩果烯(11.793%)、3,7,11,15-四甲基-2-十六-烯-1-醇(9.538%)、3-羟基-5,7-雄甾二烯-17-酮(4.519%)等。 相似文献
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青梅叶化学成分研究 总被引：1，自引：0，他引：1
采用正相硅胶柱、反相硅胶柱、凝胶柱等柱色谱及高效液相色谱等方法对青梅叶的化学成分进行分离纯化,并通过理化性质和核磁共振等方法鉴定化合物的结构。从青梅叶75%乙醇提取物中分离了13个化合物,分别鉴定为岩白菜素(1),1,3,4/2,5-环己五醇(2),3-(1-C-β-葡萄糖)-2,6-二羟基-5-甲氧基苯甲酸(3),木栓酮(4),木栓醇(5),羽扇豆醇(6),4-叔丁基苯甲醚(7),对甲氧基苯甲酸(8),邻苯二甲酸二异丁酯(9),邻苯二甲酸二丁酯(10),熊果酸(11),β-谷甾醇(12),β-胡萝卜苷(13)。化合物2～9均为首次从青梅属植物中分离得到,化合物1为青梅中具有保肝护肝的主要活性成分之一。 相似文献
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SONG Xin-ming CHEN Guang-ying SONG Xiao-ping HAN Chang-ri CHEN Sai-qin WENG Shi-chang 《林产化学与工业》2012,32(3)
采用正相硅胶柱、反相硅胶柱、凝胶柱等柱色谱及高效液相色谱等方法对青梅叶的化学成分进行分离纯化,并通过理化性质和核磁共振等方法鉴定化合物的结构.从青梅叶75％乙醇提取物中分离了13个化合物,分别鉴定为岩白菜素(1),1,3,4/2,5-环己五醇(2),3-(1 -C-β-葡萄糖)-2,6-二羟基-5-甲氧基苯甲酸(3),木栓酮(4),木栓醇(5),羽扇豆醇(6),4-叔丁基苯甲醚(7),对甲氧基苯甲酸(8),邻苯二甲酸二异丁酯(9),邻苯二甲酸二丁酯(10),熊果酸(11),β-谷甾醇(12),β-胡萝卜苷(13).化合物2～9均为首次从青梅属植物中分离得到,化合物1为青梅中具有保肝护肝的主要活性成分之一. 相似文献
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分子短程蒸馏和重结晶分离银杏叶甾醇类化合物的研究 总被引：3，自引：2，他引：1
以银杏叶为原料,制备其石油醚提取软膏,通过皂化、萃取和冷冻,除去脂肪酸及其酯、蜡质等杂质,分离甾醇类集分.采用分子蒸馏分离技术和溶剂重结晶纯化甾醇类化合物,银杏叶甾醇收率为0.03%～0.08%.利用GC-MS联用技术鉴定银杏叶甾醇结晶物的化学组成,共分离出17种化合物,其中8种是甾醇类化合物,占所有峰面积的97.633%,依次为β-谷甾醇(67.984%)、8-烯-3β-麦角甾醇(10.624%)、3β-豆甾烷醇(10.065%)、5,24-二烯-3β-豆甾醇(5.255%)、4,22-二烯-3β-豆甾醇(1.926%)、5,8,22 E-三烯-3β-麦角甾醇(0.618%)、岩藻甾醇(0.595%)、α-谷甾醇(0.566%);酮类化合物占1.066%,分别为17,19-二乙酰氧基-4,4-二甲基-3α-雄-5,7-二烯-3-烷酮(0.336%)和17α-乙酰氧基孕烯醇酮(0.730%).除β-谷甾醇外,其它银杏叶甾醇均为首次报道. 相似文献
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对救必应根皮的化学成分进行了系统研究.从其中分离并鉴定了12个化合物,分别为铁冬青酸(Ⅰ)、坡模醇酸(Ⅱ)、具栖冬青苷(Ⅲ)、苦丁冬青苷H(Ⅳ)、3-O-α-L-吡喃阿拉伯糖-3β, 19α-二羟基齐墩果烷-12-烯-28-酸-28-O-β-D-吡喃葡萄糖酯(Ⅴ)、丁香脂素4′-O-β-D-吡喃葡萄糖苷(Ⅵ)、咖啡酸4-O-β-D-吡喃葡萄糖苷(Ⅶ)、香草酸4-O-β-D-吡喃葡萄糖苷(Ⅷ)、丁香苷(Ⅸ)、芥子醛葡萄糖苷(Ⅹ)、β-谷甾醇(Ⅺ)和胡萝卜苷(Ⅻ).其中,化合物Ⅱ、Ⅳ～Ⅷ为首次从该植物中分离得到. 相似文献
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研究雷公藤根心部分的化学成分.采用硅胶柱色谱法进行分离,从其氯仿提取物中分得9个三萜化合物,经波谱分析鉴定为雷公藤素D(1),雷公藤素E(2),直楔草酸(3),雷公藤素H(4),22-β-羟基-3-氧代-12-齐墩果烯-29-羧酸(5),雷公藤三萜酸C(6),雷公藤素G(7),雷公藤酸A(8),雷公藤醇A(9).抗肿瘤生物活性体外筛选实验表明:化合物7和9对P-388小鼠白血病细胞株的生长表现出强的抑制率,化合物1对A-549人肺腺癌表现出强的抑制率. 相似文献
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Reddy KD Rao BV Babu GS Kumar BR Braca A Vassallo A De Tommasi N Rao GV Rao AV 《Fitoterapia》2011,82(7):1039-1043
Phytochemical investigation of Caralluma adscendens var. gracilis and Caralluma pauciflora (Asclepiadaceae) whole plant extracts allowed to isolate one pregnane glycoside and two pregnanes characterized as 12β,20-O-dibenzoyl-5α,6-dihydrosarcostin β-oleandropyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-digitoxypyranosyl-(1→4)-β-cymaropyranosyl-(1→4)-β-cymaropyranoside (1), 12β-O-benzoyl-3β,11α,14β,20R-pentahydroxy-pregn-5-ene (2), and 11α-O-benzoyl-3β,12β,14β,20R-pentahydroxy-pregn-5-ene (3), respectively. Their structural characterization was obtained on the basis of extensive NMR spectral studies. Three known pregnane glycosides along with lupeol and β-sitosterol were also isolated and characterized. 相似文献
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Manase MJ Mitaine-Offer AC Pertuit D Miyamoto T Tanaka C Delemasure S Dutartre P Mirjolet JF Duchamp O Lacaille-Dubois MA 《Fitoterapia》2012,83(6):1115-1119
A new spirostanol saponin (1), along with four known saponins, dioscin (2), protodioscin (3), methyl-protodioscin (4), and indioside D (5), and one known steroid glycoalkaloid solamargine (6) were isolated from the two synonymous species, Solanum incanum and S. heteracanthum. The structure of the new saponin was established as (23S,25R)-spirost-5-en-3β,23-diol 3-O-{β-D-xylopyranosyl-(1→2)-O-α-L-rhamnopyranosyl-(1→4)-[O-α-L-rhamnopyranosyl-(1→2)]-β-D-glucopyranoside}, by using a combination of 1D and 2D NMR techniques including (1)H, (13)C, COSY, TOCSY, NOESY, HSQC and HMBC experiments and by mass spectrometry. The compounds 1, 3, 4 and 5 were evaluated for cytotoxicity against five cancer cell lines and for antioxidant and cytoprotective activity. 相似文献
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Three new steroidal saponins, japonicoside A (1), japonicoside B (2) and japonicoside C (3) were isolated from the dried rhizomes and roots of Smilacina japonica A. Gray. Their structures were elucidated as (25S)-5α-spirostan-9(11)-en-3β-ol 3-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (1), (25S)-5α-spirostan-9(11)-en-3β,17α-diol 3-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (2) and (25S)-5α-spirostan-9(11)-en-3β,17α,24α-triol 3-O-β-D-glucopyranosyl-(1→2)-[β-D-xylopyranosyl-(1→3)]-β-D-glucopyranosyl-(1→4)-β-D-galactopyranoside (3) on the basis of chemical methods and detailed spectroscopic analysis, including 1D, 2D NMR and HR-ESI-MS. The cytotoxicity of isolated compounds was evaluated in vitro for cytotoxic properties against human hepatocellular carcinoma cells (SMMC-7221) and human colorectal adenocarcinoma cells (DLD-1), respectively. 相似文献
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Two compounds were isolated from the leaves of Panax ginseng. Their structures were identified as 3beta,6alpha,12beta-triol-22,23,24,25,26,27-hexanordammaran-20-one, and dammar-20(22),24-diene-3beta,6alpha,12beta-triol by spectral and chemical methods. The complete signal assignments of the two compounds were carried out by means of 2D NMR spectral analysis. 相似文献
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Four new taraxerane triterpenoids, 1β,3β-dihydroxy-11α,12α-oxidotaraxerane (1), 28-hydroxy-11α,12α-oxidotaraxerane-3-one (2), 3β-hydroxy-11α,12α-oxidotaraxerane-28-al (3), and 3-O-acetyl-11α,12α-oxidotaraxerane-28-al (4), together with three known compounds 3β-hydroxy-11α,12α-oxidotaraxerane (5), 3β,28-dihydroxy-11α,12α-oxidotaraxerane (6), and 11α,12α-oxidotaraxerane-3-one (7), were isolated from the 70% EtOH extract of Saussurea graminea. Their structures were elucidated on the basis of extensive 1D and 2D NMR (COSY, HMQC, HMBC and NOESY) analyses. The isolated compounds were evaluated in vitro for cytotoxic properties against eight tumor cell lines (A-549, BGC-823, HCT15, HeLa, HepG2, MCF-7, SGC-7901 and SK-MEL-2). 相似文献
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Three new sesquiterpenoids, 1α-(3″-ethyl-cis-crotonoyloxy)-8-angeloyloxy-3β,4β-epoxy-bisabola-7(14),10-diene (1), 7β-angeloyloxy-14-hydroxy-notonipetranone (2) and 1α-hydroxy-7β-(4-methylsenecioyloxy)-oplopa-3(14)Z,8(10)-dien-2-one (3) were isolated from ethanolic extract of the dried flower buds of Tussilago farfara L., along with nine known sesquiterpenoids (4-12). All of these compounds were evaluated for their effect on the inhibition of nitric oxide (NO) production induced by lipopolysaccharide in macrophage cell line RAW 264.7 and exhibited inhibitory activity on NO production in a dose-dependent manner. 7β-(4-Methylsenecioyloxy)-oplopa-3(14)E,8(10)-dien-2-one (8) was proved to be the best among these tested sesquiterpenoids with an IC(50) value of 10.80 μM. 相似文献