共查询到20条相似文献，搜索用时 140 毫秒
1.
Basal and phenobarbital-induced rates of hepatic metabolism of coumarin to 7-hydroxycoumarin are markedly higher in DBA/2J mice than they are in the AKR/J, C57BL/6J, and C3H/HeJ strains. Intermediate coumarin hydroxylase activity in F(1) hybrids of mating between DBA/2J and the other three strains indicates an additive mode of inheritance. 相似文献
2.
Male hybrids from a cross between female mice of strain C57BL/6Kh and males of strain DBA/2J lived longer after injection of P815 mastocytoma cells of DBA/2 origin than did their female siblings. Responses to the histocompatibility antigen on the X chromosome of the DBA/2 strain may be involved in resistance to the tumor. When the female parent was replaced with a C57BL/6Kh carrying one of several mutations in the H-2 region, this sex effect disappeared in some of the hybrid combinations. Thus, the H-2 complex appears to be involved in the regulation of the immune response to the X-linked histocompatibility antigen in this tumor model. 相似文献
3.
BRUELL JH 《Science (New York, N.Y.)》1963,142(3600):1664-1666
Serum cholesterol level ( SCL) was measured in 600 mice belonging to five inbred strains of mice ( DBAIIJ, C57BL/ 1OJ, A/ J, C3H/ HeJ, and BALBI cJ) and all 20 F, hybrids resulting from the systematic crossing of the inbreds. Diet was kept constant and its effect on SCL was not evaluated. The data show that in mice, the mode of inheritance of SCL is neither dominant nor recessive, but is intermediate. A simple additive model accounts for the results: the SCL is a linear function of the SCL of the mother, the SCL of the sire, and the sex of the subject; the three factors do not interact. 相似文献
4.
Susceptibility to two strains of Friend leukemia virus in mice 总被引：33，自引：0，他引：33
F Lilly 《Science (New York, N.Y.)》1967,155(761):461-462
A mutant strain of the Friend leukemia virus is described. The parental virus strain, passaged through ICR/Ha mice, shows no or very little activity by the spleen-focus assay in BALB/c mice (by comparison with highly susceptible DBA/2 and ICR/Ha mice) and produces typical Friend disease in these mice only exceptionally; susceptibility to this strain of virus is recessive in the (C57BL/6 x DBA/2) F(1). By contrast, the mutant virus strain is as active in BALB/c mice as in DBA/2 or ICR/Ha mice; susceptibility to the mutant virus strain is dominant in the (C57BL/6 x DBA/2) F(1). 相似文献
5.
Kidneys from BALB/c mice contain a potent metalloendoproteinase, termed meprin, that is active against large proteins as well as small peptides. The enzyme is present in mouse strains C57BR/cdJ, C57BL/6J, BALB/cJ, A/J, DBA/IJ, CD/l, Swiss, and ICR. Three related inbred strains, CBA/J, CBA/CaJ, and C3H/He, are markedly deficient in this enzymatic activity. This is the first report of a heritable deficiency of an intracellular proteinase in mammalian tissues. Meprin deficiency appears to have arisen as an early event in the development of the C stock. Furthermore, meprin is present in the progeny of a cross between a meprin-sufficient female (C57BL/6) and a meprin-deficient male (C3H/HeN), an indication that the trait for the deficiency is recessive. 相似文献
6.
Fetal hemoglobin variants in mice 总被引：8，自引：0，他引：8
Two strains of mice, DBA and C3H, have a fetal globin polypeptide chain which differs in electrophoretic mobility from the corresponding fetal chain of the C57B1 strain. Mice of the DBA and C3H strains also differ from those of the C57B1 in adult hemoglobin type. Results of backcrossing the (DBA x C57B1) hybrid to the C57B1 suggest that the fetal chain locus and the adult beta-chain locus are closely linked. 相似文献
7.
不同品系小鼠精子冷冻及冻融精子体外受精的研究 总被引：6，自引：1，他引：6
采用小鼠精子冷冻、冻融精子体外受精的方法,进行小鼠保种、引种、生物净化及品系标准化的可行性研究,并初步探究小鼠精子冷冻的影响因素。实验选用同一年龄5种不同品系小鼠分别进行精子冷冻、复苏,并比较各品系冷冻效果及冻融精子的体外受精(IVF)率。结果显示,冷冻后各品系小鼠精子复苏存活率约在15%～50%之间;冻融小鼠精子体外受精结果随遗传背景的不同差异显著,受精率分别为:KM小鼠68.4%、ICR小鼠30.3%、DBA/2J小鼠47.2%、C57BL/6J小鼠6.8%、BALB/cA小鼠25%。冻融精子IVF得到的胚胎可以耐受体外培养。 相似文献
8.
采用生物素标记的(GGAT)4寡核苷酸探针对C57BL/6J、BALB/c和DBA/2三种近交系小鼠进行了DNA指纹图分析.结果表明:(GGAT)4寡核苷酸探针对上述3种近交系小鼠产生的DNA指纹图的图带数均为10-12条,具有良好的多态性,品系内平均DNA指纹图的相似系数在0.92~1.00的范围内,具有相同指纹图的概率均在0.40以上,极显著地高于品系间的相似系数(0.21~0.39)和相同指纹图的概率(P<3.10×10-7),说明(GGAT)4寡核苷酸探针可用于制作近交系小鼠的DNA指纹图,以对其进行遗传检测. 相似文献
9.
Pineal melatonin may play an important role in regulation of vertebrate circadian rhythms and in human affective disorders. In some mammals, such as hamsters and sheep, melatonin is involved in photoperiodic time measurement and in control of reproduction. Although wild mice (Mus domesticus) and some wild-derived inbred strains of mice have melatonin in their pineal glands, several inbred strains of laboratory mice (for example, C57BL/6J) were found not to have detectable melatonin in their pineal glands. Genetic analysis suggests that melatonin deficiency in C57BL/6J mice results from mutations in two independently segregating, autosomal recessive genes. Synthesis of melatonin from serotonin in the pineal gland requires the enzymes N-acetyltransferase (NAT) and hydroxyindole-O-methyltransferase (HIOMT). Pineal glands from C57BL/6J mice have neither NAT nor HIOMT activity. These results suggest that the two genes involved in melatonin deficiency are responsible for the absence of normal NAT and HIOMT enzyme activity. 相似文献
10.
Specific inhibition of migration of spleen cells from C57B1/6J mice, which had rejected A/J sarcoma-1 tumors, occurred in the presence of A/J lymph mode antigens. The migration inhibitory effect was transferable to normal C57B1/6J spleen cells by RNA extracted from lymph nodes and spleens of immunized animals. 相似文献
11.
E A Cornelius 《Science (New York, N.Y.)》1972,177(48):524-525
A graft-versus-host reaction induced in (SJL/J x C57BL/1)F(1) hybrid mice by injection of SJL/J spleen cells resulted in 100 percent incidence of tumors at 40 days. Transplantation studies revealed that the tumors were antigenically C57BL/1. Since both SJL/J and C57BL/1 mice carry tumorigenic virus, the evidence suggests a viral etiology. 相似文献
12.
[目的]探讨不同周龄、不同初始注射时间对小鼠超数排卵效果的影响。[方法]用10 IU PMSG+10 IU HCG间隔48 h处理C57BL/6J小鼠,收集并统计合子数。[结果]4周龄超排效果优于于8周龄,可达26.86枚∕只;4周龄C57BL/6J小鼠PMSG和HCG注射时间为12:00—13:00,超排后收集合子数可达30枚∕只以上,而且体外培养的发育状况良好。[结论]4周龄C57BL/6J小鼠适宜超数排卵;PMSG和HCG注射时间为12:00—13:00,超排效果相对理想。 相似文献
13.
14.
目的观察正常小鼠各种器官组织中胸腺间质淋巴细胞生成素（thymicstromal lymphopoietin,TSLP）的表达。方法利用Real-time PCR、免疫荧光法检测正常C57BL/6J小鼠心、肝、脾、肺、肾、肠、胸腺、阴道中TSLP的表达。结果心、肝、脾、肺、肾、肠、胸腺、阴道中均有TSLP表达,其中心、肝、肾、阴道表达较高,肠道表达最低（P〈0.01）。结论 TSLP在正常C57BL/6J小鼠许多器官组织中均有表达,但以心、肝、肾、阴道黏膜中表达较高。 相似文献
15.
Zhang X Beaulieu JM Sotnikova TD Gainetdinov RR Caron MG 《Science (New York, N.Y.)》2004,305(5681):217
Dysregulation of brain serotonin contributes to many psychiatric disorders. Tryptophan hydroxylase-2 (Tph2), rather than Tph1, is preferentially expressed in the brain. We report a functional (C1473G) single-nucleotide polymorphism in mouse Tph2 that results in the substitution of Pro447 with Arg447 and leads to decreased serotonin levels in PC12 cells. Moreover, in BALB/cJ and DBA/2 mice that are homozygous for the 1473G allele, brain serotonin tissue content and synthesis are reduced in comparison to C57Bl/6 and 129X1/SvJ mice that are homozygous for the 1473C allele. Our data provide direct evidence for a fundamental role of Tph2 in brain serotonin synthesis. 相似文献
16.
研究市场上常见的5种饲料对C57BL/6J小鼠及KM小鼠生长和繁殖的影响,为实验小鼠生产中合理使用饲料提供科学依据.实验选取3周龄C57BL/6J小鼠和KM小鼠各250只,每种鼠随机分为5组,每组50只,雌雄各半,饲喂A,B,C,D,E共5种不同厂家的实验动物维持饲料,测定小鼠4～8周龄的体质量和脏器系数.另选取C57BL/6J小鼠及KM小鼠性成熟小鼠各150只,雌雄各半,每种鼠随机分为5组,每组15对,饲喂A,B,C,D,E共5种不同厂家的实验动物繁殖饲料,测定母鼠的产仔数、连胎率.结果表明:①5种维持饲料均能满足小鼠的生长需求, C饲料和E饲料更符合小鼠生长的营养需求.②5种饲料饲喂的小鼠器官指数正常.③5种繁殖饲料饲喂的母鼠第1,2胎的产仔数差异不具有统计学意义(p0.05),说明产仔数更多取决于遗传因素,本次调查的几种饲料对其影响较小.合理选择实验小鼠所需饲料,利于实验数据的稳定. 相似文献
17.
本文对开放式设施内饲养的7个品系中351只实验小鼠的肠道寄生虫作了观察。共检出方种寄生虫;毛滴虫、鼠贾第虫、鼠六鞭虫、隐藏管状线虫、四翼无刺线虫和微小膜壳绦虫;其感染率为:毛滴虫100%、鼠贾第虫49.57%、鼠六鞭虫22.51%、隐藏管状线虫58.40%、四翼无刺线虫21.94%、微小膜壳绦虫21.37%。 相似文献
18.
Diethyldithiocarbamate, a dopamine beta hydroxylase inhibitor, decreases biosynthesis of norepinephrine in the brain. The effects of this inhibitor coincide with alterations in memory as demonstrated in single-trial passive avoidance in C57BL/6J mice. 相似文献
19.
玉竹多糖对高脂膳食小鼠糖脂代谢调节作用的研究 总被引：2，自引：0，他引：2
采用高脂饲料联合玉竹多糖喂养小鼠,连续观察1个月,研究灌胃300 mg/kg的玉竹多糖对高脂膳食小鼠的体重、Lee's指数、肝指数、脂肪指数、血糖水平和血脂代谢等的影响。结果表明:玉竹多糖能明显改善高脂膳食小鼠紊乱的血糖、血脂代谢,显著降低高脂膳食小鼠的体重、Lee's指数、脂肪指数、血糖水平、甘油三酯(TG)、血清总胆固醇(TC)和低密度脂蛋白(LDL-C)(P0.05)。可见,玉竹多糖具有较好的调节糖脂作用,并可抑制小鼠肥胖的形成。 相似文献
20.
为了研究香烟烟雾对雄性小鼠生育能力的影响,将40只C57BL/6J雄性小鼠随机分成烟雾处理组和正常对照组,将2组雄性小鼠分别与未经处理的母鼠一对一交配。统计观察亲本小鼠睾丸组织学改变、精子总数、活动精子比率,以及子代小鼠的平均产仔数、存活率等。结果发现,烟雾处理2周后,子代小鼠的平均产仔数比对照组的低26.03%,仔鼠存活率(吸烟组为87.96%,对照组为93.84%)低6%;精子总数(1.26×105个/mL)和活动精子比率(36%)均分别低于对照组(2.13×105个/mL)和(71%),二者间呈现显著性差异(P<0.001和0.05);组织切片HE染色结果显示:处理组小鼠睾丸组织的正常结构遭到破坏,变得松散,其中的精子数量减少,形态异常。结果表明,香烟烟雾可引起雄性小鼠睾丸组织生精功能障碍,出现精子减少、精子形态异常等病理变化,导致子代出生数和存活率下降。 相似文献