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1.
通过选用四环素、长效土霉素、原虫净、三氮脒对长沙市某规模猪场48头猪附红细胞体病的猪只进行治疗,结果表明:上述四种药物都能抑制和杀灭附红细胞体病原,均具有一定的疗效,但原虫净在红细胞感染率和治疗有效率方面要优于四环素、长效土霉素和三氮脒。 相似文献
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2013年7月23日上杭县溪口镇双华村钟某养猪场两栏共32头40 kg架子猪中有4头发病,表现为食欲不振、体温41.5℃、便秘。3 d后又有3头猪先后发病,症状相似,用青、链霉素、解热药治疗3 d,无明显效果。后经检查诊断为猪附红细胞体病,通过用三氮脒和10%磺胺间甲氧嘧啶钠注射治疗取得了很好的效果。 相似文献
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山羊爆发附红细胞体病的诊治与预防 总被引：1，自引：0，他引：1
附红细胞体病是近年来对养殖业危害较大的一种人畜共患传染病，该病对山羊的感染率很高，荆州市一个养羊场中羊的死亡率达15．1％，用三氮脒治疗山羊附红细胞体病获得良好效果。 相似文献
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《饲料与畜牧》2017,(22)
为研究三氮脒和强力霉素对猪附红细胞体病的治疗效果,为该病防治提供参考依据。本试验共分为2个试验组和1个对照组,仔猪舍之间完全隔开,30头/组,对试验组和对照组红细胞进行镜检,并进行胆红素代谢试验以及三氮脒和强力霉素治疗对比试验。结果发现,发病猪红细胞周围呈刺状或无规则形状,可不规则移动,在血浆中可见到游离活附红细胞体。治疗后,血浆中游离的附红细胞体消失。发病猪血清TBIL和IBIL明显升高,治疗后,与对照组相比,治疗组TBIL和IBIL明显下降(P0.05),三氮脒组和强力霉素组之间TBIL存在显著差异(P0.05),并且强力霉素组IBIL降低至正常范围内(3.51μmol/L)。得出结论,附红细胞体病可引起发病猪只IBIL显著升高,三氮脒或强力霉素均有较好的治疗效果,且强力霉素较三氮脒效果好。 相似文献
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犬附红细胞体病的治疗药物在临床应用与分析 总被引：1，自引：0，他引：1
对治疗犬附红细胞体病的四环素类、阿维菌素类、咪唑苯脲类、有机胂类、喹诺酮类、三氮脒、黄色素和磺胺类等8个种类药物,18个品种制剂的作用、剂量和方法作一介绍和分析,并将临床治疗效果进行比较.文中提示,在治疗附红细胞体病用药的同时,辅助治疗用药和对症治疗用药,是增强动物机体防御能力和提高治疗效果的完善举措. 相似文献
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1用药理论
三氮脒。附红细胞体病的病理变化是导致患病动物低血糖、酸中毒、溶血性贫血及黄疸。奶牛按5毫克/千克体重，猪按7.5-12.5毫克/千克体重用药后，使机体在一段时间内血糖更低，导致附红细胞体营养缺乏，浆泡破裂而死亡。过去三氮脒效果显著，用药4小时即见泡体破裂，后药效明显降低，毒副作用越来越明显。按说明书用药，少数奶牛可出现流涎、肌肉震颤、腹痛、腹泻等情况。 相似文献
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附红细胞体病临床治疗药物的合理应用 总被引：1，自引：0，他引：1
附红细胞体病是附红细胞体寄生于猪、牛、羊等动物红细胞或血浆中引起的一种传染病,主要以发热、贫血、黄疸为主要临床症状。随着畜牧养殖业的不断发展,本病也有不断蔓延的趋势,全国大多数地区基本都有本病发生,给我国畜牧养殖业造成严重的经济损失,成为危害当前畜牧养殖业的主要疾病之一。本病治疗药物较多,归结起来有以下几种:(一)贝尼尔(三氮脒)贝尼尔是治疗附红细胞体病的首选药物,但是随着贝尼尔的频繁及长期应用,附红细胞体对其已产生了耐药性,使得其治疗效果较之以前有所下降。原来猪每千克体重5mg深部肌注2～3次即可取得满意疗效,但… 相似文献
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The therapeutic activity of difluoromethylornithine (DFMO), diminazene aceturate (Berenil) and their combination against chronic trypanosomiasis was investigated in experimental Trypanosoma brucei brucei infections of growing pigs. DFMO (300 mg/kg/day orally for 10 days), diminazene aceturate (7 mg/kg in single intramuscular injection) and a combination of the two agents at the above dosages produced varied periods of aparasitaemia in the treated pigs. Relapse parasitaemia occurred in all treatment groups, with diminazene aceturate providing the longest relief period of 17 days, combination treatment 11 days and DFMO 6 days. The packed cell volume, blood haemoglobin concentration and red cell count values decreased after the pigs were infected with the parasites. The values improved following treatment with the agents and their combination. 相似文献
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Itoh N Higuchi S Kawamura S 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》1988,17(4):94-98
The effect of diminazene aceturate on splenectomized and nonspienectomized dogs with Babesia gibsoni (B. gibsoni) infection was investigated. In splenectomized dogs, the fissional and multiplicational stages of B. gibsoni were observed in peripheral blood films, and hemoglobinuria was frequently observed. These findings were different from previous reports and were not changed by administration of diminazene aceturate. It is clear that the intramuscular administration of diminazene aceturate at the dose of 3 mg/kg body weight for 3 days is not effective against B. gibsoni infection in splenectomized dogs. 相似文献
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F W Jennings 《Research in veterinary science》1987,43(2):173-176
The simultaneous administration, to Trypanosoma brucei infected mice, of rolitetracycline or oxytetracycline and diminazene aceturate appeared to have no effect on the initial trypanocidal action of the diminazene aceturate in that trypanosomes were cleared from the circulation. It also had no effect on the duration of the aparasitaemic period which follows diminazene aceturate treatment and the mice remained free of circulating trypanosomes for some time. However, if used prophylactically, relatively large amounts of tetracyclines (4 x 10 mg kg-1) administered with 40 mg kg-1 diminazene aceturate caused a reduction of the prophylactic period compared with those mice given only diminazene aceturate. This reduction in the prophylactic period is unlikely to have any practical significance in the combination diminazene aceturate/tetracycline treatment of domestic animals as diminazene aceturate is used therapeutically and not prophylactically in the control of trypanosomiasis. 相似文献
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托克逊县是牛环形泰勒虫病的疫区之一,准确诊断以及有效治疗是防控该病的要点。论文采用流行病学调查、实验室方法检测和临床诊断的方法综合确诊45头舍饲患牛作为研究对象。将45头阳性牛随机分为西药治疗组、中药治疗组以及空白组,按1、2、3、4、5d以及1周,分别对每组患牛进行临床症状观察、体温测定、血涂片观察、染虫率统计,评价治疗效果。结果表明,托克逊县夏乡5个镇散养户的194头牛血液涂片中62份有环形泰勒虫虫体;PCR检测有57份DNA样品得到与预期结果相同的534bp条带;临床诊断有45头牛表现为牛环形泰勒虫病症状;西药治疗组治愈率为93.33%(14/15)明显高于中药治疗组治愈率为73.33%(11/15)。西药组对于治疗环形泰勒虫病具有显著的效果,可为新疆有效治疗环形泰勒虫病提供参考。 相似文献
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Rashid HB Chaudhry M Rashid H Pervez K Khan MA Mahmood AK 《Tropical animal health and production》2008,40(6):463-467
The present work was conducted to study the comparative efficacy of two anti-protozoan (babesicidal) drugs on the recovery and health of horses. A total of 80 horses, showing typical clinical symptoms of the disease, were selected for this study; the presence of babesiosis was confirmed through blood smear examination. These animals were divided into two groups i.e. A and B. Horses of Group A, were treated with diminazene diaceturate, while horses of Group B were treated with diminazene aceturate. Efficacy of the drugs was determined by the reversal of clinical signs and a negative blood smear examination. The efficacy of diminazene diaceturate was demonstrated to be 80% while diminazene aceturate was found to have 90% efficacy against babesiosis. 相似文献
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The therapeutic activity of diminazene aceturate, difluoromethylornithine (DFMO) and a combination of the two agents was investigated in experimental Trypanosoma brucei brucei infections in mongrel dogs. The criteria used in the assessment of the trypanocidal effect of these compounds included the examination of the blood for the parasite, as well as clinical and haematological changes at intervals following treatment. Diminazene aceturate (7 mg/kg intramuscularly), DFMO (300 mg/kg/day orally in three divided doses for six days) and the combination of diminazene aceturate (7 mg/kg intramuscularly) and DFMO (300 mg/kg/day orally for six days) produced an intermittent aparasitemia in the dogs. Relapse infection occurred in all the three groups, but the period of aparasitemia produced by the combination of the agents was longest. The packed cell volume, haemoglobin concentration and red cell count values decreased after the dogs were inoculated with the parasite. The values improved slightly following the treatments with the agents or their combination. The total white blood cell counts in the infected dogs indicated leucocytosis, but this improved with drug treatment. 相似文献
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Tuntasuvan D Jarabrum W Viseshakul N Mohkaew K Borisutsuwan S Theeraphan A Kongkanjana N 《Veterinary parasitology》2003,110(3-4):227-233
During June–July 2000, an outbreak of surra occurred on an equine breeding farm in Khonkaen Province, Thailand. Forty-two percent of pregnant mares aborted or gave stillbirth and 40% (19/47) of horses and 10% (1/10) of mules died from surra. In August 2000 Trypanosoma evansi were detected in the remaining animals (28 horses and nine mules) on the farm by blood smear and/or the haematocrit centrifuge technique. All animals were treated with diminazene aceturate at 3.5 mg/kg body weight by intramuscular injection on days 0 and 41 of the study. Blood samples of eight randomly selected horses and mules were collected on days 0, 1 and once a week until day 56 and examined for T. evansi by various parasitological techniques. The sera were tested for antibodies against T. evansi using an indirect enzyme linked immunosorbent assay (ELISA).
The results revealed that diminazene aceturate at 3.5 mg/kg appeared to be effective in the first treatment of horses and mules infected with T. evansi. Parasites were cleared from the peripheral blood of horses on days 1 and 7 and mules on days 1 and 14. Thereafter the number of positive animals increased. After the second treatment, 50% of horses and 25% of mules were still positive to surra 24 h after treatment demonstrating that diminazene had no protective effect. Mild to severe toxicity of diminazene was seen in the horses and mules after injection. 相似文献
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The occurrence of cross-resistance among melarsoprol-resistant Trypanosoma brucei rhodesiense isolates was investigated in this study. The isolates, T. b. rhodesiense KETRI 237, 2538, 1992, 2709, 2694 and 3530, had been obtained from sleeping sickness patients in Kenya and Uganda between 1960 and 1985. Five groups consisting of six mice each were inoculated intraperitoneally with 10(5) parasites of each isolate, and 24 h later treated with either melarsoprol, homidium chloride, diminazene aceturate or isometamidium chloride. The control group comprised infected but untreated mice. The mice were monitored for cure for a period of 60 days post-treatment. The mean prepatent period in the control mice was 5 days while the mean survival period was 22 days. Five of the stabilates, KETRI 237, 2538, 2709, 2694, and 3530, were confirmed to be melarsoprol resistant. Cross-resistance was observed, with the majority of the isolates being resistant to homidium chloride (5/6) and diminazene aceturate (5/6), but all were sensitive to isometamidium chloride (6/6). However T. b. rhodesiense KETRI 1992, which was previously considered as melarsoprol resistant, was sensitive to all the drugs tested. In conclusion, our study has revealed the existence of cross-resistance among the melarsoprol resistant isolates which could only be cured by isometamidium. 相似文献
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Twenty dogs of mixed local East African breeds were used. Five of the dogs were uninfected controls and 15 were infected with T. brucei (ILRAD 273). Five of the infected dogs were untreated controls, five were treated with a high curative dose of diminazene aceturate, (7 mg kg-1 body weight (wt.), and five were given a subcurative dose of isometamidium chloride (1 mg kg-1 body wt.). The drugs, given at 8 days post infection (d.p.i..), led to apparent recovery. The antibody titres, however, remained high in both groups and at 42-49 d.p.i. there was at least one relapse in each treatment group. Parasite populations from relapsed animals were more resistant to the drugs than the original infecting populations. The implications of these findings are discussed. 相似文献
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Response of Trypanosoma congolense in goats to single and double treatment with diminazene aceturate. 总被引：3，自引：0，他引：3
R S Silayo M Mamman S K Moloo Y O Aliu M A Gray A S Peregrine 《Research in veterinary science》1992,53(1):98-105
Diminazene aceturate is one of a limited number of compounds currently marketed for treatment of trypanosomiasis in cattle, sheep and goats. The pharmacokinetics of the compound in goats suggest that double treatment with diminazene aceturate might enhance the compound's therapeutic activity. A study was therefore conducted in goats using two clones of Trypanosoma congolense, IL 3274 and IL 1180, which were previously shown to be resistant and sensitive, respectively, to single treatment with diminazene aceturate. The results indicated that, as compared to single treatment, double treatment with diminazene aceturate at a dose of 7.2 mg kg-1 bodyweight, at either eight or 24 hour intervals, did not greatly enhance the therapeutic activity of the drug. Furthermore, treatment with the same drug dose eliminated infections with T congolense IL 3274 when treatment was administered 24 hours after infected Glossina morsitans centralis had fed, but failed to do so if treatment was delayed until after goats were detected to be parasitaemic. This suggests that failure of T congolense IL 3274 to respond to treatment with diminazene may not be due to drug resistance per se. 相似文献