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1.
A 13-year-old neutered female Yorkshire terrier presented with a history of progressive episodic weakness and disorientation of 4 months duration. Physical and neurologic examinations were normal at presentation. Abdominal ultrasound revealed a mass involving the right adrenal gland. Standard planar scintigraphy was performed at 4, 18, and 24 hours after intravenous injection 185 MBq (5mCi) of 123I-labeled metaiodobenzylguanidine (123I-MIBG). An area of focal intense uptake was identified in the area of the right adrenal gland. A pheochromocytoma was confirmed histologically after surgical excision.  相似文献   

2.
Positron emission tomography (PET) with 2-deoxy-2-[18F]fluoro- d -glucose (18FDG) is an important imaging modality for diagnosis and staging of human neoplastic disease. The purpose of this study is to describe the normal 18FDG uptake in adult cats. Six adult healthy female cats were used. Cats were sedated and then injected intravenously with 74.0±13.0 (mean±SD) MBq of 18FDG. General anesthesia was induced and cats were placed in ventral recumbancy on the PET scanner's bed. Static images using multiple bed positions were acquired approximately 60–90 min after injection. A transmission scan was acquired at each bed position utilizing a 57Co point source to perform attenuation and scatter correction. Regions of interest (ROIs) were drawn over the liver, right and left renal cortices, left ventricular wall, and wall of ascending and descending colonic segments. Standardized uptake values (SUV) were calculated using an established formula. Kidneys and intestinal tract had relatively intense uptake of 18FDG; liver activity was intermediate; the spleen was not identified in any of the cats. Cardiac activity was variable but intense activity was noted in the left ventricular myocardium in most cats. No appreciable lung uptake was noted. Mean±SD SUV values were calculated. This study established the normal pattern of uptake of 18FDG in adult cats and provided baseline data for comparison with future studies evaluating a variety of neoplastic and nonneoplastic diseases.  相似文献   

3.
99mTc-pertechnetate is excreted in humans by the thyroid glands, gastric mucosa, salivary glands, choroid plexus, and sweat glands. Uptake attributed to the zygomatic and molar salivary glands is used commonly as a reference to assess thyroid uptake and differentiate euthyroid from hyperthyroid cats. However, the exact location and origin of uptake of 99mTc-pertechnetate in the head during thyroid scintigraphy in cats remains uncertain. The purpose of this study was to localize uptake of 99mTc-pertechnetate in the head of the cat using multimodality image fusion. Computed tomography (CT), magnetic resonance (MR), and single photon emission tomography (SPECT) imaging were performed successively in two cats during the same anesthesia procedure. Transverse, dorsal, and sagittal images were reconstructed for each modality. Images were rescaled and fused manually. The anatomic location of focal 99mTc activity in SPECT images was identified in CT and MR images. Four major and four minor focal areas of uptakes were identified in the head in both cats. A rostral conical-shaped activity was identified in the nasal cavity. Two symmetric focal areas of uptakes seen in the soft tissues in the ventro-caudal retro-bulbar region, and rostro-medial to the vertical ramus of the mandible were attributed to zygomatic salivary glands. A central focal activity located ventral and caudal to the zygomatic uptake was located in the nasopharynx and soft palate. Minor symmetric areas of uptake identified in the retromandibular region were attributed to parotid and mandibular salivary glands. Minor symmetric areas of uptake identified in the region of the mandible were attributed to molar salivary glands. No focal area of uptake was identified in the brain.  相似文献   

4.
Sixty–nine horses having radionuclide bone scans of the foredigit region between 1985 and 1988 were retrospectively analyzed for proximal phalangeal cortical 99mTc–MDP uptake. Patterns of uptake were determined and the factors of age, breed, sex, occupation, and duration of signs prior to imaging were assessed. Twenty–three horses had abnormal proximal phalangeal uptake. Two patterns of uptake were seen, either as linear, diffuse or focal, discrete, fusiform–shaped cortical uptake. The dorsal cortex was always affected in these 23 horses; the palmar cortex was affected in 14 horses, and this uptake was always linear in appearance. There was significant correlation of proximal phalangeal cortical uptake and regular jumping activity, either as a jumping, hunting or three–day event horse ( p < .005). No correlations were determined between uptake and the factors of age, breed, sex or duration of signs prior to imaging. The scintigraphic appearance patterns were similar to those seen in scintigraphic studies of exercise induced traumatic bone injuries in humans.  相似文献   

5.
The scintigraphically measured percentage dose uptake of 99mTc-DTPA by the kidneys and the plasma clearance of 99mTc-DTPA have been reported to correlate well with inulin clearance. These two parameters were evaluated in seven dogs with known or suspected naturally occurring renal disease and compared to simultaneously measured renal inulin clearance. Correlation between inulin clearance and the 99mTc-DTPA plasma clearance was better ( p =.0016) than the correlation between the percentage DTPA uptake by the kidney. It was concluded that measurement of 99mTc-DTPA plasma clearance is a more accurate method to estimate global glomerular filtration rate (GFR) than the percentage kidney uptake.  相似文献   

6.
Technetium-99m methoxy-isobutyl-isonitrile (sestamibi) imaging of malignant canine lymphoma was performed in thirteen dogs 1 hour after intravenous injection of 99mTc-sestamibi at 13 MBq (0.35 mCi) per kilogram body weight. Abnormal tracer uptake was visualized in the liver, spleen, bone marrow, and mesenteric, inguinal, popliteal, sternal, cranial cervical and mandibular lymph nodes. Radiopharmaceutical uptake was also noted in a nasal mass. One large neoplastic renal mass did not have demonstrable sestamibi uptake. Other regions had no significant difference in the target:background ratios when compared with values from normal dogs ( P > 0.05). 99mTc-sestamibi can be used to image malignant lymphoma, and has potential applications in the management of patients to document response to treatment and to stage of extent of disease.  相似文献   

7.
Monoclonal antibodies specific for Dirofilaria immitis were labeled with technetium-99m (99WTc), and their affinity was assessed in vitro. Of six monoclonal antibodies tested, three were IgG and three were IgM. A canine polyclonal IgG was used to establish the labeling technique and later as a control. Diethylenetriaminepentaacetic acid (DTPA) was used as a bifunctional chelator to bind 99mTc covalently to the antibody. Radiochemical purity was measured with the use of gel filtration by a Sephadex G-25 column linked to an absorbance monitor and with instant thin-layer chromatography. The radiochemical purity had no significant influence on percent uptake on the heartworms. The clone designated as Di 130.1 had a significantly higher percent uptake than other clones tested.  相似文献   

8.
Technetium-99m methoxy-isobutyl-isonitrile (sestamibi) is a radiophartnaceutical used for the evaluation of myocardial perfusion. Increased uptake of sestamibi has also been documented in tumors. The objective of this study was to document the extracardiac biodistribution of 99mTc sestamibi in the normal dog. Nine normal beagles were given 0.35 mCi/kg 99mTc sestamibi intravenously, and 60 second images were made of the entire body at 1 hour post injection. A defined distribution pattern was recognized, with good visualization of the heart, liver, gallbladder, small intestine, kidneys, urinary bladder, popliteal lymph nodes, parotid salivary glands and zygomatic salivary glands. Splenic uptake was not seen.
Target to background ratios were calculated for all the regions listed, using background regions-of-interest with the smallest coefficient of variance for the denominator. The mean, range and standard deviation of these ratios are given.  相似文献   

9.
This study was done to investigate the validity of published canine thyroid/salivary (TS) rations of approximately i in normal dogs and to detemine thyroid uptak of 99mTc-pertechnetate (pertechnetate) measured as percent uptake of injected dose. These parameters were evaluated in 13 Beagle dogs over a 4 hour period. Mean ± standard deviation (SD) and median T/S ratios of 1.2 ± 0.3 and 1.1 were essentially the same at twenty minutes and 1 hour. T/S Values ranged from 0.9 to 2.2 at 20minutes and from 0.8 to 2.4 at 1 hour. T/S ratio values progressively declined over the subsequent time intervals with mean ± SD and median values of 0.6 ± 0.2 and 0.6, respectively, measured at 4 hour. The mean with a rang of 0.28% to 0.90%. The mean ± SD time interval from injection of pertechanetate to maximum uptake within the thyroid gland was 160 ± 55 minutes with a range 31–240 minutes. The data derived from this study of normal dogs may be useful in the evaluation of dogs with thyroidal diseases including hypthyroidism  相似文献   

10.
The purpose of this study was to assess the effects of four anesthetic protocols on normal canine brain uptake of 2‐deoxy‐2‐[18F]fluoro‐d ‐glucose (FDG) using positron emission tomography/computed tomography (PET/CT). Five clinically normal beagle dogs were anesthetized with (1) propofol/isoflurane, (2) medetomidine/pentobarbital, (3) xylazine/ketamine, and (4) medetomidine/tiletamine–zolazepam in a randomized cross‐over design. The standard uptake value (SUV) of FDG was obtained in the frontal, parietal, temporal and occipital lobes, cerebellum, brainstem and whole brain, and compared within and between anesthetic protocols using the Friedman test with significance set at P<0.05. Significant differences in SUVs were observed in various part of the brain associated with each anesthetic protocol. The SUV for the frontal and occipital lobes was significantly higher than in the brainstem in all dogs. Dogs receiving medetomidine/tiletamine–zolazepam also had significantly higher whole brain SUVs than the propofol/isoflurane group. We concluded that each anesthetic protocol exerted a different regional brain glucose uptake pattern. As a result, when comparing brain glucose uptake using PET/CT, one should consider the effects of anesthetic protocols on different regions of the glucose uptake in the dog's brain.  相似文献   

11.
Thyroidal 99mTcO4(pertechnetate) uptake percentages were determined in unanesthetized euthyroid (n = 13) and hyperthyroid (n = 18) cats. Maximal uptakes were observed 60 minutes after IV injection of the radionuclide and ranged from 0.3 to 3.9% of the dose in euthyroid cats (median 2.23%) and from 5.2% to 23.9% of the dose in hyperthyroid cats (median 14.8%) ( P < .05). There were no overlaps in pertechnetate uptake percentages during any of the intervals evaluated. It is concluded that the optimal time for visualization of the thyroid by 99mTcO4-scanning is 60 minutes after IV injection of the radionuclide. Calculation of the percentage uptake is of additional diagnostic value.  相似文献   

12.
2‐Deoxy‐2‐[18F]fluoro‐d ‐glucose positron emission tomography/computed tomography (FDG PET/CT) is becoming increasingly available as an imaging modality in veterinary medicine. The purpose of this study was to report semiquantitative standard uptake values (SUV) of malignant and nonmalignant tissues and organs in canine cancer patients. FDG PET/CT was performed in 14 dogs including, nine mesenchymal tumors, four carcinomas, and one incompletely excised mast cell tumor. A generally higher FDG uptake was observed in carcinomas relative to sarcomas. Maximum SUV of carcinomas ranged from 7.6 to 27.0, and for sarcomas from 2.0 to 10.6. The FDG SUV of several organs and tissues, including regional brain uptake is reported, to serve as a reference for future FDG PET studies in canine cancer patients. Several potential pitfalls have been recognized in interpretation of FDG PET images of human patients, a number of these were also observed in this study.  相似文献   

13.
盆栽试验的结果表明,高羊茅、早熟禾、黑麦草和紫花苜蓿在铅锌尾矿土壤或处理的尾矿土壤上都能生长,但在处理土壤上生长的植物长势明显优于对照,其中紫花苜蓿的生物量所受影响比其他几种草本植物更大,说明其重金属抗性低于其他几种植物.单位面积上4种植物体内重金属含量均为Zn>Pb>Cu>Cd,但每种植物对Cd、Pb、Zn和Cu的吸收浓度和分布均不相同,一般为根系浓度大于茎叶.加入改良剂和有机肥(菜枯)使生长在铅锌尾矿污染土壤上的4种草本植物生物量显著增加,植物体中的Cd、Pb和Zn元素浓度下降,但Cu元素浓度反而上升,结果单位面积上4种草本植物吸收各重金属元素的量均有所增加,可见利用改良措施与草本植物相结合的方法来修复重金属污染土壤具有可行性.  相似文献   

14.
Localization of 99mTc-MDP in lymph nodes was apparent on the three-hour bone-scan image in seven dogs. In six dogs injection or leakage of the radiopharmaceutical into the perivascular tissues was associated with subsequent uptake in an ipsilateral lymph node. In the remaining dog, 99mTc-MDP localized in a lymph node infiltrated by metastatic osteosarcoma. This aided staging of the tumor. Possible mechanisms of 99mTc-MDP localization in soft tissues are briefly reviewed.  相似文献   

15.
Positron emission tomography (PET) has found widespread application for staging and monitoring neoplastic diseases in humans. PET is becoming more available in veterinary medicine, therefore biodistribution of 2-deoxy-2-[18F]fluoro- d -glucose (18FDG) in normal dogs is needed for lesion interpretation in disease states. A large field-of-view (FOV) PET scanner with a 70 cm bore diameter and a 53-cm FOV was used in this study to acquire dynamic 18FDG uptake data from parenchymal organs in seven normal dogs. A 2-h, dynamic list-mode acquisition was initiated simultaneously with intravenous 18FDG injection. Regions of interest (ROIs) were manually drawn over liver, spleen, left and right renal cortices, left ventricular free wall, and thymus. Standardized uptake values (SUVs) of these organs were calculated for 24 5-min frames over the 2-h acquisition. This SUV data from parenchymal organs of normal dogs compares favorably with those of normal humans and will be used in ongoing canine studies using PET to evaluate various diseases.  相似文献   

16.
99mTechnetium methylene diphosphonate (99mTc-MDP) scintigraphy was performed in 14 dogs of different breeds after clinical lameness examination, radiography and synovial fluid analysis failed to localise lameness to a specific area of pain. The scintigraphic protocol included an intravenous injection of 17 MBq 99mTc-MDP/kg bodyweight and vascular, soft tissue and bone phase scans in standardised positions with a low-energy all-purpose collimator. Confirmation of diagnosis was achieved in nine dogs by arthroscopy, repeated lesion-orientated radiography, computed tomography and response to treatment. In seven cases, bone phase scans showed single elbow uptakes, in two cases unilateral limb uptake, and in one case each a single shoulder and tibia uptake; in three cases there was no increased uptake. Vascular and soft tissue phase images did not reveal additional information. Diagnosis of humeral condyle fissures, a fragmented medial coronoid process, panosteitis and arthropathy was possible in nine cases. Skeletal pathology was ruled out in three normal scintigrams. In two dogs with unilateral uptake of multiple joints, no diagnostic benefit was gained from scintigraphy. The highly sensitive and relatively specific uptake allowed localisation and characterisation or exclusion of skeletal lesions in most dogs.  相似文献   

17.
Imaging and measurement of proliferation with computed tomography (CT) and positron emission tomography (PET) provide a noninvasive method for improved staging and monitoring of response to cancer treatment. We evaluated prospectively the proliferation marker 3'-deoxy-3'[18F] fluorothymidine (FLT) in the context of FLT-PET/CT for detection of early response, confirmation of posttreatment response, and prediction of relapse in dogs with non-Hodgkin's lymphoma. Nine dogs with non-Hodgkin's lymphoma who were scheduled to receive five cycles of an investigational cytotoxic chemotherapy agent were included. All dogs received baseline FLT-PET/CT imaging immediately before chemotherapy. Intent was to repeat imaging with FLT-PET/CT at various time points: group 1 ( n =4), 5 days after initiation of chemotherapy and 3 weeks following the last chemotherapy administration; group 2 ( n =5), before the fourth cycle of chemotherapy and 3 weeks following the last administration. Two dogs in group 2 did not undergo repeat PET/CT. Body mass standardized uptake values (SUV) for FLT were calculated for each dog. Eight dogs had initially increased FLT uptake (mean SUVmax=9.8 [2.6–22.3]). Mean SUV decreased significantly for the seven dogs that underwent follow-up PET/CT following chemotherapy (mean SUVmax=3.5 [1.1–7.9], P <0.016). Increased uptake preceded clinical and cytological evidence of relapse in two dogs. Ki-67 immunohistochemistry confirmed decreased proliferation corresponding to decreased SUV in three canine lymph node samples. FLT-PET/CT functional and anatomical imaging shows promise for the evaluation of response to cytotoxic chemotherapy in dogs with non-Hodgkin's lymphoma and for predicting relapse before standard clinical and clinicopathologic confirmation.  相似文献   

18.
试验阐明了在景泰的土壤条件下施用氨基酸复合微肥对紫花苜蓿Medicago sativa生长、品质和营养吸收的影响,为苜蓿的合理施肥提供了依据.结果表明:氨基酸复合微肥能够不同程度地增加株高并提高草产量.适当施用氨基酸复合微肥还能提高苜蓿粗蛋白和粗脂肪的含量.且在此试验条件下苜蓿喷施氨基酸复合微肥的最佳用量是1 350 mL/hm2.  相似文献   

19.
Naruepon  Kampa  DVM  Ursula  Wennstrom  DVM  Peter  Lord  BVSc  FRCVS  Robert  Twardock  DVM  PhD  Enn  Maripuu  BSc  Per  Eksell  DVM  PhD  Sten-Olof  Fredriksson  BSc 《Veterinary radiology & ultrasound》2002,43(4):383-391
Determinations of different methods of measurement of uptake of 99mTc-DTPA using scintigraphy of glomerular filtration rate (GFR) were made from 29 studies on 10 healthy beagle dogs. GFR was measured by calculating the percentage dose uptake (integral method) and rate of uptake (slope method) of 99mTc-DTPA using manual kidney regions of interest (ROI) and automatic kidney and background ROIs at different time periods of the uptake phase. These results were compared using linear regression analysis to the GFR obtained from 99mTc-DTPA plasma clearance using multiple blood samples. The best correlation coefficient between percentage DTPA uptake and GFR by DTPA clearance (r = 0.84, P < 0.001) was derived from time intervals between 30s-120s with a perirenal background ROI at 1 or 2 pixels out from the kidney ROI using automatic kidney ROI at 20% threshold. With the slope method, the best correlation coefficient (r = 0.85, P < 0.001) was obtained from time intervals between 30s-peak with the background ROI at 2 pixels out from the kidney ROI using automatic ROI at 35% threshold. The offset was higher, and the correlation varied more with different ROIs and the method was unreliable at time intervals extending beyond the peak radioactivity. Manual kidney ROIs with automatic background ROIs had slightly lower correlations. With DTPA renography both integral and slope uptake method with automatic kidney and background ROIs are accurate methods to estimate the GFR, but that the integral method is much more stable to variations in ROI size and the duration of the uptake phase of the renogram.  相似文献   

20.
1. Absorption, secretion of digestive enzymes and intestinal morphology were determined in poults from hatching to 19 d. 2. Oleic acid was approximately 80% absorbed at hatch and this changed little with age and was not influenced by fasting. In contrast, glucose and methionine were 48 to 56% absorbed at hatch and this increased to 75 to 80% at 4 d; however, this increase in absorption was inhibited by fasting. Percentage absorption of protein did not change between 5 and 19 d, whereas absolute uptake of fat and protein and net secretion of digestive enzymes and fatty acids and N to the duodenum increased with age and body weight (BW). 3. The length and diameter and villus size in the small intestines increased rapidly after hatch whereas the number of villi per cross section did not change with age. Duodenum and ileum surface area reached a plateau after 11 d whereas jejunal surface area continued to increase until 19 d. Duodenal and ileal surface area were not related to BW, but jejunal surface area was significantly correlated. 4. While the major part of the absorption occurred in the duodenum and upper jejunum, uptake of both protein and fat increased in the distal segments of the small intestine with age. Overall absorption of both fat and protein was correlated with BW. 5. It appears that in the posthatch poult intestinal surface area is not a limiting factor in growth, which was correlated with digestive secretions, fat and protein uptake.  相似文献   

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