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1.
A 17-year-old female crossbred cat developed a mass on the left ovary. The mass was solid, firm, 5.5 x 3.5 x 4.5 cm. The mass contained ectodermal components (skin and appendages), mesodermal components (osseous, cartilaginous and adipose structures), and endodermal components (glandular structures lined by columnar epithelium). The tumor was diagnosed as a solid, mature teratoma of the ovary.  相似文献   

2.
A definitively diagnosed case of left ventricular noncompaction (LVNC) has not been previously reported in a non‐human species. We describe a Maine Coon cross cat with echocardiographically and pathologically documented LVNC. The cat was from a research colony and was heterozygous for the cardiac myosin binding protein C mutation associated with hypertrophic cardiomyopathy (HCM) in Maine Coon cats (A31P). The cat had had echocardiographic examinations performed every 6 months until 6 years of age at which time the cat died of an unrelated cause. Echocardiographic findings consistent with LVNC (moth‐eaten appearance to the inner wall of the mid‐ to apical region of the left ventricle (LV) in cross section and trabeculations of the inner LV wall that communicated with the LV chamber) first were identified at 2 years of age. At necropsy, pathologic findings of LVNC were verified and included the presence of noncompacted myocardium that consisted of endothelial‐lined trabeculations and sinusoids that constituted more than half of the inner part of the LV wall. The right ventricular (RV) wall also was affected. Histopathology identified myofiber disarray, which is characteristic of HCM, although heart weight was normal and LV wall thickness was not increased.  相似文献   

3.
Described are pathological studies of eight dogs which died in congestive heart failure, with a clinical diagnosis of congestive cardiomyopathy. Examination revealed marked dilatation and enlargement of all four chambers of the heart. The ventricular walls were thin with small atrophic papillary muscles. Histological studies on the myocardium revealed scattered areas of myocardial necrosis, especially around the papillary muscles of the left ventricle and random scattered areas of fibrosis. Electron microscopic studies revealed fewer and disoriented myofibrils, myocytolysis, increased numbers of mitochondria with swelling and inclusions, increased glycogen granules and increased numbers of lysosomes, lipofuscin granules and lipid droplets. Mild Z-band abnormalities were found throughout the myofibers.  相似文献   

4.
A winter outbreak of ascites in cultured Japanese amberjack Seriola quinqueradiata was examined. Affected fish displayed bloody ascitic fluid in the peritoneal cavity, their hearts were covered with a white membrane, their livers were congested and their kidneys were swollen. Renal tubular epithelia displayed extensive necrosis and often contained hyaline droplets, while some glomeruli showed atrophy and necrosis. Hematopoietic tissue in the kidney contained some swollen reticular cells. In the heart, an inflammatory reaction accompanied by edema, hemorrhage and fibrin deposition occurred in the epicardium of the atrium and ventricle and in the pericardial cavity. The epicardium and pericardium were partially adhered to each other. Hepatic lesions included dilatation of sinusoids accompanied by severe edema and congestion. Edema and fibrin deposition were often observed in the hepatic serosa and perivascular tissue. Splenic tissues with atrophied pulp showed definite increases in trabecula thickness. These findings suggest that the examined fish might have a systemic circulatory disturbance due to cardiac lesions associated with renal failure.  相似文献   

5.
Peliosis hepatis (PH) is a rare condition characterized by dilatation of hepatic sinusoids and the presence of blood-filled spaces within the liver. The disease occurs mainly in subjects exposed to toxic substances or estrogens, and is often asymptomatic. A 9 year-old pekingese female dog was sent to Division of Pathology for autopsy because of sudden death of unclear cause. Autopsy revealed severe hydroperitoneum (1500 ml of transsudate), dilatation of heart ventricles, passive hyperemia of lungs, spleen and kidneys. The liver was enlarged, with slightly wrinkled surface, with many red spots, of different size and shape. Microscopic examination of the liver revealed the presence of areas with severe dilatation of hepatic sinusoids, and multiple cystic spaces filled with blood. Some of these spaces were lined with endothelium and other were not. Spaces were different in shape and size and were localized in the areas between dilated sinusoids. Based on the macroscopic and microscopic examination, the liver lesions were identified as severe hepatic sinusoidal dilatation with formation of peliosis hepatis-like structures.  相似文献   

6.
The cecal surface epithelium of cattle was lined entirely by columnar cells except near the openings of the glands where a few partially depleted goblet cells were encountered. Surface columnar cells with pale cytoplasm, indented (sometimes dome-shaped) apical border and irregular microvilli, were also found near the gland orifices. Surface columnar cells -near the openings of the glands contained large cytoplasmic vacuoles and lysosomal-like bodies. Near the extrusion zone, however, the columnar cells contained highly indented and apically displaced nuclei. The glands were usually long and straight and lined by an epithelium concisting mainly of undifferentiated and goblet cells. There were few entero-endocrine and non-epithelial cells (intra-epithelial lymphocytes and globule leukocytes). Paneth cells were absent. The undifferentiated cells contained many free ribosomes and apical secretory granules. Some of these cells were undergoing mitotic division. Goblet cells exhibited a typical brandy-glass appearance and showed dark and light mucigenous granules. Endocrine cells with polymorphic secretory granules and cells with more uniform secretory granules were identified in the basal part of the epithelium. Globule leukocytes and intra-epithelial lymphocytes were usually encountered near the basal part of the epithelium. The lamina propria was highly cellular. It contained many plasma cells, mast cells and small lymphocytes, and few eosinophils, neutrophils and globule leukocytes. Some of the plasma cells contained large, dense Russell bodies within the cisternae of the rough-surfaced endoplasmic reticulum. The neutrophils displayed distinct populations of small and large cytoplasmic granules. Some of the eosinophilic granules showed narrow crystalline cores. Large lymphocytes were found in the lamina propria, but occurred less frequently than small lymphocytes.  相似文献   

7.
Primary cardiac granular cell tumor in a dog   总被引：1，自引：0，他引：1  
The histological, histochemical, and ultrastructural features of a granular cell tumor in the wall of the right atrium of the heart in a nine-year-old dog are described. The histologic appearance of the mass varied from areas of spindle-shaped cells to sheets of globoid cells with foamy granular cytoplasm. The globoid neoplastic cells contained numerous cytoplasmic granules which were variably positive to periodic acid-Schiff staining, with and without disastase digestion. Ultrastructurally, the globoid cells had numerous various-sized, heterogeneous lysosomes with pleomorphic content. A granular cell tumor originating in the heart has not been reported previously in animals. The support for a neural origin of these tumors by the recent identification of several nervous tissue specific proteins in their granular cells is discussed.  相似文献   

8.
Ten cecal tumors were identified during the postmortem examination of seven horse carcasses at slaughter (one horse had three tumors). The multinodular and hemorrhagic tumors ranged from 1 to 10 cm in diameter and consisted of spindle cells arranged in thin, interconnected trabeculae that were often separated by sinuses filled with mucinous fluid, erythrocytes, and siderophages. Spindle cells of all tumors were immunopositive for vimentin, neuron-specific enolase, and c-kit protein but lacked reactivity with antibodies to glial fibrillary acidic protein, S100 protein, and desmin. In one tumor, spindle cells diffusely bound antibodies to synaptophysin. Most tumors contained focal reactivity to smooth muscle actin antibodies; one tumor reacted diffusely. Ultrastructurally, tumor cells were connected by desmosome-like structures and exhibited extended cell processes; some contained dense core neurosecretory granules. These equine stromal tumors appeared to share some characteristics with human gastrointestinal stromal tumors.  相似文献   

9.
A free-living mouflon (Ovis musimon) was presented with a mass on the left shoulder. At necropsy, multifocal, slightly protruding whitish spots were noted on the kidneys, and several lymph nodes were abnormal. Histologically, the mass was composed of epithelial cells arranged in tubular and tubulopapillary structures. The cytoplasm of the epithelial cells had numerous periodic acid-Schiff-positive and diastase-resistant granules. Ultrastructurally, the cytoplasm of the neoplastic cells contained numerous pleomorphic secretory granules and microvilli, which partially covered the luminal surface of the tumor cells. Metastatic foci were present in prescapular and mediastinal lymph nodes and kidneys. On the basis of histological and ultrastructural findings, this tumor was diagnosed as a tubulopapillary adenocarcinoma, arising from apocrine sweat glands of the skin.  相似文献   

10.
We report a case of multiple glomus tumors associated with bovine papillomavirus type 2 (BPV-2) infection in the urinary bladder of a 13-year-old cow suffering from severe chronic enzootic hematuria. Macroscopically, multiple submucosal reddish nodules were seen swelling the vesical mucosa. Histologically, neoplastic proliferation was characterized by the presence of numerous blood vessels. These were lined by normal endothelial cells surrounded by round epithelioid cells with central nuclei, prominent nucleoli, acidophilic cytoplasm, and well-defined cytoplasmic borders. Tumor cells were distributed around open vascular lumina and in perivascular spaces. They were immunohistochemically positive for actin and vimentin and negative for cytokeratins, desmin, and factor VIII-related antigen. On the basis of these findings, this tumor was diagnosed as glomus tumor, a neoplasm not previously reported in cattle and exceedingly rare in animals. BPV-2 DNA was amplified from the formalin-fixed, paraffin-processed tissue specimens obtained by laser capture microdissection. This report widens the spectrum of mesenchymal tumors of the bovine urinary bladder. Finally, the microscopic pattern of tumor described here shares striking morphologic and immunohistochemical similarities with the angiomatous form of glomus tumor known to occur in man.  相似文献   

11.
将人工感染弓形虫兔于濒死期(3～46d不等)扑杀,取其心、肝、脾、肺和肾五种脏器组织,作了病理形态学观察。主要结果如下:肝、心、脾组织中有周边无炎性反应的凝固性坏死;肝组织中还有网状细胞增生形成的结节;肺脏表现为肺泡隔炎等,这些特征性病变与其他动物弓形虫病变基本相同。同时观察到在肝窦状隙、小叶间动、静脉、肺泡壁毛细血管、肺支气管动脉、心肌纤维间毛细血管和脾静脉窦内均有血栓形成,同时伴?坏死性血栓性血管炎;各脏器的动脉管壁呈现不同程度的玻璃样变,以及由血栓形成所致其周围组织的病变。另外,应用PAS、PTAH、Weigert-Gram等染色方法显示组织切片中的弓形虫,比H.E染色更易于观察。  相似文献   

12.
A case of malignant melanoma, originating at the base of the left horn, was diagnosed in a white 11-year-old Pygora doe. At necropsy, the goat had an ulcerated, black-pigmented, 2.5-cm mass at the base of the left horn. Firm masses diffusely black on the cut surface were present at the left horn base, subcutaneously over the frontal bones, and infiltrating into the frontal sinuses, the submandibular lymph node, and left parotid salivary gland. The left maxillary premolars and molars were loosened from the periodontia. Multiple black foci of metastasis were observed in the liver. Histologically, the masses consisted predominantly of moderately pleomorphic, polyhedral to spindle cells that contained variable amounts of dark brown intracytoplasmic pigment granules. The tumor cells were positive for Melan A by immunohistochemical staining.  相似文献   

13.
Five canine cutaneous histiocytomas were studied by electron microscopy and esterase cytochemistry. The tumor cells contained irregular nuclei, characteristic lysosomal granules, and perinuclear microfilaments. The cells showed activity with alpha-naphthyl acetate esterase stains. These characteristics are evidence that this tumor originates from the mononuclear phagocyte system.  相似文献   

14.
An approximately 3-year-old adult male zebra finch (Taeniopygia guttata) was diagnosed with malignant melanoma. The large darkly pigmented tumor was located in the coelom, extended from the apex of the heart to the cloaca, and was adherent to the intestines and the ventriculus. Dark small masses (likely metastases) were observed in the lungs. Cytologically, the neoplasm consisted mainly of round to oval cells with brown or pale blue to blue-brown pigment. Lesser numbers of cells were stellate to dendritic with abundant amounts of brown pigment granules or were markedly pleomorphic with variable amounts of pigment. Histologically, the tumor consisted of dense sheets and aggregates of infiltrative melanocytes that were negative for S-100 and Melan A. A few cells were consistent with "signet-ring" melanocytes. Melanocytes examined by electron microscopy contained typical structures, mainly premelanosomes and melanosomes, of this cell type. However, melanocytes with marked pleomorphism also contained intracytoplasmic aggregates of filaments, consistent with previously reported ultrastructural findings in signet-ring or rhabdoid melanoma of nonavian species.  相似文献   

15.
A cutaneous mass at the base of the retroauricular region of a 4-year-old, female Golden Retriever was examined pathologically. Histologically, the mass formed multiple nodules consisting of a proliferation of large clear cells with abundant cytoplasm. Mitotic figures among the neoplastic cells were very sparse. The large clear cells were intensely positive for cytokeratins (AE1/AE4, cytokeratin 8 and 18) and moderately positive for lysozyme and contained periodic acid-Schiff-positive granules in the cytoplasm. In addition, small flat cells lined the islands of neoplastic large clear cells, and these were strongly positive for alpha-smooth muscle actin and vimentin, and some were positive for cytokeratin (AE1/AE4), suggesting they were myoepithelial cells. No local recurrence or metastasis has been recognized during the 18 months since surgical excision. On the basis of these findings, the present tumor was diagnosed as apocrine sweat gland adenoma, clear cell variant. There have been few previous reports of canine apocrine adenomas showing a clear cell morphology.  相似文献   

16.
A melanotic neurofibroma in a steer was investigated histologically, immunohistochemically and ultrastructurally. A very large tumor mass was located in the region of the head and right cheek. The tumor tissue consisted of an admixture of cells resembling Schwann cells and spindle-shaped cells, and they frequently contained melanin granules. Neoplastic Schwann cells were positive for S100 protein, with variation in intensity of staining, but most spindled cells were S100 negative. The tumor cells displayed ultrastructural features similar to those of Schwann cells or perineurial cells. The presence of melanosomes in varying stages of melanization in both cell types suggests that they have a common origin. This is a tumor of neural crest origin showing schwannian and perineurial differentiation, with ectopic production of melanin granules.  相似文献   

17.
The outer medullary (juxtacortical) zone of a normal equine adrenal gland had columnar chromaffin-positive cells arranged with their long axes perpendicular to fine vascular channels. The deeper medullary regions were composed of smaller irregularly round to polygonal chromaffin positive cells in small packets. Both cell types contained two types of membrane-bound cytoplasmic secretory granules. Osmiophilic granules with a homogeneous core, crenated membrane and narrow submembranous halo predominated in the columnar juxtacortical cells. The rounder, central medullary cells contained predominantly electron dense granules with a wide irregular electron lucent space between an eccentric core and the granule membrane. In contrast, irrespective of cell type or zone, cells from a pheochromocytoma contained only one type of granule similar to that described for the juxtacortical region of the normal equine adrenal medulla. The tumor cells could be classified into three subtypes based on density of granule packing but the granules were morphologically similar in all tumor cells.  相似文献   

18.
A cerebral vascular hamartoma was identified in the frontal lobe, striatum and thalamus of the right side of the brain of a male, 7-year-old Shih Tzu. Histologically, the lesion consisted of thin-walled vessels, which showed various sizes and occasionally contained fibrin thrombi. These vascular walls were composed of a single layer of fibromuscular tissue lined by flat endothelium with various amount of collagen, but devoid of large coat of smooth muscles and elastic tissue. Immunohistochemically, the lining endothelial cells were positive for von Willebrand Factor antibody. Neuropil between the vessels was stained with Klüver-Barrera stain, and positive for synaptophysin and GFAP antibodies. Based on these findings, the lesion was diagnosed as vascular hamartoma, which might resemble venous malformation in humans.  相似文献   

19.
Juvenile bovine angiomatosis: a syndrome of young cattle   总被引：3，自引：0，他引：3  
This report describes the clinical and pathological features associated with angiomatous lesions in two calves. In the first case, a single mass located in the atrioventricular ring of the heart was responsible for congestive cardiac failure. The mass was composed of numerous vascular cavities filled with blood and lined by a single layer of well differentiated endothelial cells. The second case had multiple blood-filled cutaneous masses which were confirmed as benign vascular tumours by histological examination of a biopsy specimen. The calf was later euthanased after profuse and uncontrollable haemorrhage from one of the lesions. At necropsy, additional tumours were found in the liver, spleen, kidneys, spinal canal and attached to the pleura, omentum and mesentery. It is proposed that these two cases are representatives of solitary and multiple forms of a syndrome which should be called juvenile bovine angiomatosis.  相似文献   

20.
Gastric pleomorphic leiomyosarcoma in a Shetland sheepdog   总被引：1，自引：0，他引：1  
A solitary mass of 6 x 6 x 5 cm was found in the smooth muscle layer of the pyloric part in the stomach of a Shetland sheepdog. The excised mass was solid, gray-white in color, and had central necrosis with hemorrhages. Microscopically, the neoplasm was composed of irregular bundles of spindle-shaped tumor cells and round tumor cells. A few multinucleated cells and gangliocyte-like cells were observed. The nuclei exhibited a high degree of atypia and many cells contained mitotic figures. Immunohistochemically, tumor cells were positive for vimentin and desmin, but negative for c-kit antibody. Ultrastructurally, tumor cells contained cytoplasmic myofilaments and pinocytotic vesicles. Based on these pathological findings, the tumor was diagnosed as gastric pleomorphic leiomyosarcoma.  相似文献   

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