首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献,搜索用时 46 毫秒
1.
Infectious pancreatic necrosis (IPN) is a disease of salmonid fishes. It has been reported in many countries throughout the world (MGonigle 1940, Wood et al. 1955, Besse & Kinkelin 1965, Vestergård Jørgensen & Bregnballe 1969, Sano 1971, Ball et al 1971, Ljungberg & Vestergård Jørgensen 1972, Schlotfeldt et al. 1975). Outbreaks of the disease can cause serious losses in populations of hatchery reared salmonids, the mortality rate varying between 10 and 90 % (Vestergård Jørgensen & Kehlet 1971). There are at least four different serotypes of the virus distinguished by neutralization tests (Wolf et al. 1968). Twenty-five isolates of IPN virus in Denmark proved to represent only two serotypes (Sp and Ab) (Vestergård Jørgensen & Kehlet). The present paper reports the first isolation of IPN virus from the stock at a fish farm in Norway.  相似文献   

2.
Schäffer (1900) and Butkewitch (1903) seem to have been the first to focus attention on the proteolytic activity of micro-fungi. The occurrence and properties of proteolytic enzymes from various fungus species were subsequently studied by several authors. Literature in this field was reviewed by e.g. Ito (1950), Gorbach & Koch (1955), Koch & Dedic (1957), Hagihara (1960), Davies (1963) and Roper & Fennell (1965).In connection with investigation of the proteolytic activity of several fungus species, a gelatin hydrolyzing effect of Aspergillus fumigatus (AF) was reported to be exerted by living organisms in pure culture (Jensen 1931), extracted mycelial material (Maxwell 1950, Dingle & Solomons 1952), and by fluid culture medium in which AF was cultured (Dion 1950a, b, Dingle & Solomons). Ay res & Tobie (1943) demonstrated moderate casein hydrolyzing activity in extracted mycelial material from 4 AF strains, and Amatayakul (1955) observed low fibrinolytic activity in 1 strain.Proteolytic activity measured by breakdown of gelatin and casein was demonstrated by Jonsson & Martin (1964) in culture medium in which AF had been cultured. Three activity optima were observed at pH values around 3, 6.5 and 10. A subsequent study indicated that the activity in neutral and alkaline environment was caused by the same enzyme (Martin & Jönsson 1965).By means of electrophoretic separation combined with reactions for enzyme characterization, Tran Van Ky et al. (1966) demonstrated proteolytic activity in mycelial extracts of 21-day AF cultures. A casein precipitating enzyme (CP enzyme) was demonstrated by Sandvik (1967) in the fluid phase of frozen and thawed skimmilk agar cultures from e.g. AF.In addition to haemolysin and toxin (Rutqvist 1965, 1968, Rutqvist & Persson 1966), mycelial filtrates of AF have proved to contain a proteolytic enzyme. An account is given in the following of a study of this enzyme with respect to (1) casein precipitating ability, (2) casein and gelatin hydrolyzing effect, and (3) relation to toxin and haemolysin.  相似文献   

3.
There is agreement that uterine infection is necessary for the development of the varied picture of clinical pyometra which includes changes in the kidneys and other organs (Børresen 1975). Some important clinical manifestations of the pyometra syndrome have been explained in terms of an endotoxinaemia (Asheim 1964, Schalm 1965).  相似文献   

4.
Eggs from the pig roundworm Ascaris suum are easily obtainable in large numbers from uterus of adult worms. It is therefore natural that eggs isolated from that organ have been used almost exclusively in experimental ascariasis, both in the natural host (Kelley & Nayak 1965, Gaafar & Keittevuti 1972, Andersen et al. 1973, Jørgensen et al. 1975 and others) and in small laboratory animals (Jeska et al. 1969, Berger 1971 and others). In some cases no details are given on the origin and preparation of the infective eggs or the eggs may originate both from uteri of adult worms and from pig faeces (Kelley et al. 1957).  相似文献   

5.
During recent years, Yersinia enterocolitica has been isolated from humans and various animal species in connection with intestinal disorders, such as acute ileitis and appendicitis. Cases of septicaemia, polyarthritis and erythema nodosum have also been described (Mollaret & Destombes 1964, Nilehn 1969, Winblad 1969, Lassen 1972, Langford 1972). Y. enterocolitica has been isolated most frequently from chinchillas and hares, but sporadic isolations from deer, cow, horse, rabbit, goat and dog have been reported (Langford, Krogstad et al. 1972). In Norway, an outbreak of the disease in a goat herd is the only described case of yersiniosis among animal species (Krogstad et al.). A case of chronic enteritis in a dog from which Y. enterocolitica was isolated is presented in the following.  相似文献   

6.
Satisfactory conception rates of deep frozen boar spermatozoa were obtained, with insemination by way of the cervix, after thawing the deep frozen spermatozoa in boar seminal plasma, both in preliminary trials (Crabo & Einarsson 1971, Crabo et al. 1972 b) and in a large field trial (Einarsson et al. 1972). Fertility with pellet frozen boar spermatozoa, thawed without dilution, was reported by Graham et al. (1971 a, b) and Pursel & Johnson (1971).  相似文献   

7.
Sheep is apparently fairly resistant against infections with Listeria monocytogenes (Lm). Grønstøl (unpublished) found that a high proportion of healthy sheep are carriers of Lm. In such animals Lm may cause clinical disease when resistance is lowered. Tick-borne fever (TBF) is known to reduce the resistance against several infections (Øverås 1972). This report describes listeric septicaemia associated with TBF.  相似文献   

8.
Though several agents may be involved in the etiology of enzootic pneumonia of pigs, recent investigations seem to indicate that the great majority of cases are caused by a Mycoplasma species — called M. suipneumoniae in Britain (Goodwin et al 1965) and M. hyopneumoniae in the U.S.A. (Maré & Switzer 1965).  相似文献   

9.
Actinobacillosis in pigs seems to be relatively rare and when it does occur, it usually manifests itself as acute septicaemia during the first weeks of life (Zimmermann 1965). Polyarthritis, pneumonia and heart lesions as well as petechial haemorrhages in skin, viscera and kidneys are also frequently found (MacDonald et al. 1976, Jones & Simmons 1971). Both Actinobacillus suis and Actinobacillus equuli have been isolated from such cases (Pedersen 1977).  相似文献   

10.
A hypochromic microcytic iron deficiency anemia associated with light underfur and increased mortality in mink kits is caused by the feeding of various species of raw marine fish, especially coalfish (Gadus virens) and whiting (Gadus merlangus) as first detected in Norway by Helgebostad (1957). The same disorder caused by fish-feeding was later described from other countries (Stout et al. 1960, Jørgensen & Christensen 1966, Kangas et al. 1967). Nutritional anemia has also been induced in rats by feeding a raw coalfish diet as stated by Gjønnes & Helgebostad (1965).  相似文献   

11.
Ochronosis is a sequela to alcaptonuria — an inherited metabolic disease in man, which to our knowledge has not been described in animals. The background of the disease is as follows (O''Brien et al 1963, Hollander 1966, Wolman 1969, Jaffe 1972).  相似文献   

12.
The clinical and pathological picture of the BVD/MD complex is most protean, and the majority of cases run a subclinical course (Bruner & Gillespie 1966). The disease complex has been recorded in many countries and on all continents (Mills et ah 1965). In Scandinavia a BVD/MD-like disease, the “Umeå disease”, was described by Nystedt in northern Sweden in 1960 and later proved to be a mixed infection of bovine parainfluenza virus type 3 and BVD/MD virus (Dinter & Bakos 1961). In 1961 the Umea syndrome was reported in Denmark by Borgen & Dinter and in Finland by Rislakki. In Norway the picture of the BVD/MD complex has been known for many years although no isolation of the virus has yet been described*. The isolation and identification of the virus from an atypical case of BVD/MD in a heifer is described in the following.  相似文献   

13.
European brown hare syndrome (EBHS) is a viral hepatitis that affects European brown hares (Lepus europaeus) and varying hares (Lepus timidus). The disease occurs today in free-living and farmed hares in most European countries (Gustafsson et al. 1989, Gavier-Widén & Mörner 1991). In Sweden and Denmark the EBHS was first observed at the beginning of the eighties, however, in Finland and Norway the disease has not been reported yet.  相似文献   

14.
Bovine respiratory syncytial virus (BRSV) caused a large epizootic of acute respiratory disease in Japan in 1968—69 (Inaba et al. 1970, Inaba et al. 1972). A much smaller outbreak occurred in Switzerland (Paccaud & Jacquier 1970). In Belgium the virus has been isolated from an outbreak of respiratory disease (Wellemans et al. 1970). BRSV has later been proved an important causal agent of respiratory disorders in the same country (Wellemans & Leiinen 1975). In England and USA the virus has caused and been isolated from outbreaks of acute respiratory disease in calves (Jacobs & Edington 1971, Rosenquist 1974, Smith et al. 1974). In Denmark BRSV has sporadically been isolated from pneumonic calf lungs (Bitsch et al. 1976).  相似文献   

15.
In the last few years special interest has been focused on enteric diseases localized to the lower alimentary tract, especially the ileum of weaned pigs. An increasing frequency of disorders of unknown aetiology described as regional ileitis (Emsbo 1951), necrotic enteritis (Jubb & Kennedy 1970), and intestinal adenomatosis (Rowland et al. 1973) has been reported. The changes include thickening of the ileal mucosa with hypertrophy of the muscular wall. The normal structure of villi is replaced by a proliferation of crypt cells. Necrosis of the mucosa and granulation-tissue proliferation in the submucosa occur in later stages. Regional ileitis in man (Crohn et al. 1932) which is described as a chronic enteric disease with granulomatous inflammatory changes localized to segments of the ileum is also attracting increasing attention in medical research (Liljefors 1972). The lesions are also found in the colon, and the presence of a transmissible agent involved in the aetiology of Crohn''s disease has been discussed on the basis of animal experiments (Cave et al. 1973). The disease in pigs is accompanied by haematological changes, including decreased concentration of total serum protein, albumin, alkaline phosphatase, and zinc (Martinsson et al. 1974, 1976).  相似文献   

16.

Background

There is an unmet clinical need for a cat‐specific formulation of amlodipine to treat hypertensive cats.

Objectives

To assess the efficacy of chewable amlodipine tablets in reducing systolic blood pressure (SBP) in cats diagnosed with systemic arterial hypertension.

Animals

Seventy‐seven client‐owned cats with systemic hypertension were included (median age 14 years).

Methods

The study was randomized, double‐blinded, and placebo‐controlled. Forty‐two cats received 0.125–0.50 mg/kg amlodipine once daily for 28 days; 35 cats received placebo. After 28 days all cats continued with amlodipine for 2–3 months in an open‐label phase. Blood pressure was measured using high definition oscillometry. A responder was defined as a cat showing a decrease of SBP to <150 mmHg at 28 days or a decrease from baseline ≥15%.

Results

Sixty‐one cats completed the study. The responder rate was 63% in amlodipine group and 18% in placebo group. Cats receiving amlodipine were 7.9 (95% CI 2.6–24.1) times more likely to be classified as responders when compared to those receiving placebo (P < .001). From a mean (±SD) baseline value of 181 (±12) mmHg, SBP decreased to 154 (±17) mmHg with amlodipine and to 170 (±21) mmHg with placebo (P < .001). The voluntary acceptance rate of amlodipine formulation was 73%.

Conclusions and Clinical Importance

The chewable amlodipine tablet effectively reduced SBP compared with placebo in hypertensive cats, and was well‐tolerated. It can be used concomitantly with angiotensin‐converting enzyme inhibitors and in cats with chronic kidney disease.  相似文献   

17.
Several successful attempts have been made to induce swine dysentery in pigs using pure cultures of Treponema hyodysen-teriae (Taylor & Alexander 1971, Harris et al. 1972, Akkermans & Pomper 1973, Hughes et al. 1975). In these studies, either conventional or specific-pathogen-free pigs were used. In the present study, 2 approximately 8 weeks old conventional pigs (Nos. 1 and 2) were purchased and fed the same basic ration as used by Teige et al. (1977). In addition, 10 % cod liver oil was incorporated in the diet at each feeding. After a feeding period of 25 days rectal swabs were applied and examined for the presence of spirochaetes. The pigs were then fed a 3 days old primary and pure culture of T. hyodysenteriae on TSA-S400 medium (Songer et al. 1976). The culture originated from the colon of a pig with swine dysentery (Pig No. 4, Teige et al. 1977). Each pig received the agar contents of 5 petri dishes which were mixed with the food.  相似文献   

18.
Considerable evidence for the existence of a direct genetic control of the immune response has been presented during recent years. Experimental work with rodents are the main basis for this evidence. The first study on genetic variations in the antibody response was carried out by Gorer & Schütze (1938). Later Cinader (1960) published detailed considerations about the specificity and inheritance of the antibody response. In mice it has been demonstrated that a few dominant immune response (Ir) genes determine the ability to produce antibodies against certain specific antigens (McDevitt & Tyan 1968). The magnitude of the response is probably under the influence of polygenes, which are not associated with Ir genes. This theory is supported by selection for high and low antibody production in mice (Biozzi et al. 1972).  相似文献   

19.
Cephenemyia ulrichii Brauer 1862, in Swedish moose   总被引:1,自引:0,他引:1  
Larvae of Cephenemyia (Latreille 1818), the moose bot fly (Diptera; Oestridae) are parasites of the nose and pharynx in cervidae. In Europe 4 species of Cephenemyia are reported, C. trompe (Modeer 1786) in reindeer (Rangifer tarandus tarandus L), C. stimulator (Clark 1815) in roe deer (Capreolus capreolus L), C. auribarbis (Meigen 1824) in red deer (Cervus elaphus L) and fallow deer (Dama dama L), and C. ulrichii, Brauer 1862, in moose (Alces alces L) (Zumpt 1965, Grunin 1966). Of these, C. trompe is known from northern Scandinavia (Zumpt 1965, Grunin 1966), C. stimulator is reported from Denmark (Christiansen 1935), and C. ulrichii from Finland (Frey 1914, Brander 1963, Mikkola et al 1982). This is the first report on C. ulrichii larvae found in Sweden.  相似文献   

20.

Background

Acetazolamide is recommended for the reduction of cerebrospinal fluid production in canine internal hydrocephalus. The efficacy of the drug in terms of alleviation of the clinical symptoms and the restoration of normal ventricular volume has not been documented. We hypothesize that acetazolamide inadequately improve clinical signs and has no effect on the ventricular volume. Six dogs with internal hydrocephalus underwent neurological examination and were examined by magnetic resonance imaging, on the day of the diagnosis, after treatment with acetazolamide directly before surgery, and 6 weeks after implantation of a vetriculo-peritoneal shunt due to lack of improvement after medical therapy with 10 mg/kg acetazolamide three times daily (TID). The ventricular volume in relation to the total brain volume was determined on each occasion. The changes in relative ventricular volume and of the neurological status were assessed and compared.

Results

McNemar’s test revealed no significant differences in clinical symptoms before and after medical treatment (P > 0.05). However, clinical symptoms changed significantly after surgical treatment (P = 0.001). The ventricle-brain ratio was not significantly changed after therapy with acetazolamide (P > 0.05); however, after subsequent shunt implantation, it was significantly reduced (P = 0.001).

Conclusion

Acetazolamide (10 mg/kg TID) showed no effects on clinical signs or ventricular volume in dogs with internal hydrocephalus. After subsequent ventriculo-peritoneal shunting, the dogs had a significantly reduced cerebral ventricular volume and five out of six dogs had no abnormal findings in neurological examination.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号