首页 | 本学科首页   官方微博 | 高级检索  
相似文献
 共查询到20条相似文献，搜索用时 58 毫秒
1.
Serum lipid and lipoprotein parameters of Turkman horses   总被引：1，自引：0，他引：1  
BACKGROUND: Lipid transport systems in animals have been evaluated both as experimental models for lipid and lipoprotein metabolism in humans and to gain insight into the lipid metabolism of specific breeds. The Turkman horse is a pure-blooded horse that lives on the margins of the Caspian Basin; information about serum lipids and lipoproteins in this breed is lacking. OBJECTIVE: The purpose of this study was to evaluate serum lipid and lipoprotein concentrations in clinically healthy Turkman horses. METHODS: Concentrations of triglyceride (TG), total cholesterol (TC), high density lipoprotein cholesterol (HDLC), low density lipoprotein cholesterol (LDL-C), and very low density lipoprotein cholesterol (VLDL-C), and lipoprotein electrophoretic patterns were determined in serum samples from 48 Turkman horses of both sexes and 0-12 years of age. Results were analyzed by 1-way ANOVA. RESULTS: In both sexes and all age groups, the relative percentages of LDL-C (44.2-64.3%) were higher than those of HDL-C (29.7-47.1%) and VLDL-C (5.9-9.0%). Serum concentrations of TG and TC were significantly higher in male (0.45 +/- 0.12 mmol/L; 2.70 +/- 0.45 mmol/L) than in female (0.34 +/- 0.1 mmol/L; 2.15 +/- 0.3 mmol/L) horses in most age groups. The relative percentages of alpha- and beta-lipoproteins in electrophoretic tracings were 62.77 +/- 5.05% and 36.67 +/- 4.29%, respectively. CONCLUSION: Serum lipid and lipoprotein values in Turkman horses differ from those of other equine breeds, and may be useful for evaluating metabolic diseases in this species.  相似文献   

2.
Serum lipids and lipoprotein concentrations have been associated with dominance aggression in humans. The aim of this study was to investigate the link between serum lipids, including cholesterol, triglyceride, high-density lipoprotein cholesterol (HDL-C), low-density lipoprotein cholesterol (LDL-C), total cholesterol (TC) to HDL-C ratio and dominance aggression in dogs. Levels of serum TC, triglyceride and HDL-C were significantly lower in dogs with dominance aggression compared with non-aggressive dogs (P < 0.001). These results suggest that a relationship exists between serum lipid profile and dominance aggression in dogs, and hypocholesterolaemia exists in dogs with dominance aggression.  相似文献   

3.
O bjective : To characterise lipid profile in dogs with tail chasing.
M ethods : Fifteen dogs with tail chasing were included in this study. A behavioural diagnosis was made for each dog on the basis of the dog's behavioural history, clinical signs and results of other medical assessments. None of the dogs had concurrent medical disease that would account for compulsive tail chasing. Blood samples were taken from each dog after a fasting period of 12 to 16 hours to measure total cholesterol, triglyceride, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol and very low-density lipoprotein cholesterol levels. Fifteen control dogs were also enrolled on the basis of normal physical examination results, complete blood count and serum biochemistry profiles.
R esults : Dogs with tail chasing had significantly higher total cholesterol (P < 0·01), high-density lipoprotein cholesterol (P<0·05) and low-density lipoprotein cholesterol (P<0·001) compared with control dogs. Very low-density lipoprotein cholesterol and triglyceride levels did not differ significantly between the groups.
C linical S ignificance : Tail chasing may be associated with serum cholesterol elevations in dogs. High serum cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels may be used as biochemical parameters of compulsive tail chasing in clinical settings.  相似文献   

4.
Objective : To investigate the relationship between endocrinopathies and diagnosis of gall bladder mucocele in dogs via a retrospective case‐control study. Methods : Records of 78 dogs with a surgical or ultrasonographic diagnosis of gall bladder mucocele were examined for the presence or absence of hyperadrenocorticism, hypothyroidism and diabetes mellitus. Two age‐ and breed‐matched controls for each gall bladder mucocele dog (156 total control dogs) were examined for the same concurrent diseases. A matched case‐control analysis was performed using conditional logistic regression. Results : The odds of mucocele in dogs with hyperadrenocorticism were 29 times that of dogs without hyperadrenocorticism (P=0·001; 95 per cent CI 3·8, 219·9). No difference was found between dogs with and without diabetes mellitus. Although a significant association was found between gall bladder mucocele and hypothyroidism, potential observation bias was also identifi ed. Clinical Significance : Hyperadrenocorticoid dogs that were presented for acute illness with laboratory evidence of hepatobiliary disease should undergo evaluation for the presence of a biliary mucocele. Dogs diagnosed with a gall bladder mucocele should be screened for concurrent hyperadrenocorticism if clinical suspicion exists.  相似文献   

5.
Two separate studies tested the hypoth-esis that plasma low-density lipoprotein cholesterol (LDL-C) can be decreased by conjugated linoleic acid (CLA) by depressing hepatic acyl-coenzyme A: cholesterol acyltransferase (ACAT) activity. In the first experiment, 3 groups of 6 early-weaned piglets were fed low-fat diets containing either 1.5% CLA, 1.5% corn oil or 1.5% beef tallow;fat provided 8% of the energy intake. In the second experiment, 4 groups of 6 early-weaned piglets were fed high-fat di-ets containing either 15% beef tallow, 12% beef tal-low plus 3% CLA, 15% corn oil, or 12% corn oil plus 3% CLA; fat provided 29% of energy intake. Cholesterol was balanced across diets in both experi-ments. In pigs fed the low-fat diets, all dietary fats in-creased LDL-C and triacylglycerols and decreased high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C). LDL-C was the same in pigs fed low-fat tallow or low-fat CLA diets. However, ACAT activity was near-ly 80% higher in pigs fed the low-fat tallow diet than in pigs fed the low-fat CLA diets. All high-fat diets increased LDL-C, HDL-C and triacylglycerols equally with no effect on VLDL-C. There were no unique fat-ty acid effects of the high-fat diets on ACAT activity.We conclude that supplemental fats had differential effects on hepatic ACAT activity and LDL-C, but on-ly in pigs fed low-fat diets.  相似文献   

6.
Two separate studies tested the hypothesis that plasma low-density lipoprotein cholesterol (LDL-C) can be decreased by conjugated linoleic acid (CLA) by depressing hepatic acyl-coenzyme A:cholesterol acyltransferase (ACAT) activity.  In the first experiment, 3 groups of 6 early-weaned piglets were fed low-fat diets containing either 1.5% CLA, 1.5% corn oil or 1.5% beef tallow; fat provided 8% of the energy intake.  In the second experiment, 4 groups of 6 early-weaned piglets were fed high-fat diets containing either 15% beef tallow, 12% beef tallow plus 3% CLA, 15% corn oil, or 12% corn oil plus 3% CLA; fat provided 29% of energy intake.  Cholesterol was balanced across diets in both experiments.  In pigs fed the low-fat diets, all dietary fats increased LDL-C and triacylglycerols and decreased high-density lipoprotein cholesterol (HDL-C) and very low-density lipoprotein cholesterol (VLDL-C). LDL-C was the same in pigs fed low-fat tallow or low-fat CLA diets.  However, ACAT activity was nearly 80% higher in pigs fed the low-fat tallow diet than in pigs fed the low-fat CLA diets.  All high-fat diets increased LDL-C, HDL-C and triacylglycerols equally with no effect on VLDL-C.  There were no unique fatty acid effects of the high-fat diets on ACAT activity.  We conclude that supplemental fats had differential effects on hepatic ACAT activity and LDL-C, but only in pigs fed low-fat diets.  相似文献   

7.

Background

There are conflicting reports of plasma lipoprotein lipid content in dogs with diabetes mellitus (DM).

Objectives

To determine lipoprotein lipid content of plasma of dogs with DM by spectrophotometry and ultracentrifugation; to compare lipoprotein lipid content in diabetic and healthy dogs; and to quantify apolipoprotein B‐100 (ApoB) in dogs with DM.

Animals

22 dogs with DM and 9 healthy dogs.

Methods

Cross‐sectional study. Triglyceride (TG), total cholesterol (TC), and high‐density lipoprotein cholesterol (HDL‐C) concentrations were measured by spectrophotometry. Very low‐density lipoprotein cholesterol (VLDL‐C) and low‐density lipoprotein cholesterol (LDL‐C) concentrations were calculated after ultracentrifugation. Non‐HDL‐C cholesterol was calculated by subtracting HDL‐C from TC. ApoB was quantified by ELISA. The Mann‐Whitney test was used for comparison of median lipoprotein concentrations, and Spearman's correlation was used to assess associations between ApoB and lipoprotein fractions.

Results

All values are reported in mg/dL. Median TG (122), TC (343.5), HDL‐C, (200), VLDL‐C, (27) LDL‐C (68), non‐HDL‐C (114), and ApoB (320) were significantly higher in dogs with DM, compared to healthy dogs (57, 197, 168, 12, 16, 31, and 258, respectively, P‐values 0.0079, <0.001, 0.029, 0.011, <0.001, <0.001, 0.025, respectively). A significant association was found between ApoB and LDL‐C (Spearman's rho = 0.41, P = 0.022) and between ApoB and non‐HDL‐C (Spearman's rho = 0.40, P = 0.027).

Conclusions and Clinical Importance

Dyslipidemia of dogs with DM is characterized by pronounced increases in LDL‐C and non‐HDL‐C concentrations, although all lipoprotein fractions are significantly increased. Knowledge of specific lipoprotein fraction alterations in dogs with DM can enhance treatment options for diabetic dyslipidemia in dogs.  相似文献   

8.
Objectives : To assess the influence of high‐fibre, moderate‐carbohydrate diets with two levels of dietary fat, compared with a commercial diet with moderate‐fibre, low‐carbohydrate and higher fat, on insulin requirement, glycaemic control and lipid profile of dogs with stabilised diabetes. Methods : Twelve dogs with spontaneous diabetes mellitus were studied. Glycaemic control was evaluated by plasma fructosamine, glycosylated haemoglobin and 48‐hour serial blood glucose measurements. The insulin dosage required to maintain clinical stability was also determined. Lipid profiles comprised serial measurements of plasma cholesterol, triglyceride, free glycerol and free fatty acids. Data were analysed using analysis of variance. Results : There were no significant differences in insulin requirement or glycaemic control among diets. Weight loss occurred when the dogs were fed the high‐fibre, moderate‐carbohydrate, moderate‐fat diet (P<0·002), whereas weight was maintained with the other two diets. The high‐fibre, moderate‐carbohydrate, moderate‐fat diet resulted in lower mean plasma cholesterol compared with either of the higher‐fat diets (P≤0·003), and lower mean plasma triglyceride (P=0·060), free fatty acid (P<0·001) and free glycerol (P=0·015) than the commercial diet. Clinical Significance : For stable diabetic dogs, high‐fibre, moderate‐carbohydrate diets offered no significant advantage compared with a commercial diet with moderate fibre and low carbohydrate. Diets with high fibre, moderate carbohydrate and moderate fat should not be routinely recommended for dogs with thin body condition.  相似文献   

9.
Measurement of serum-free thyroxine (fT4) concentration provides a more accurate assessment of thyroid gland function than serum thyroxine (T4) or 3,5,3'-triiodothyronine (T3). Techniques for measuring serum fT4 concentration include standard equilibrium dialysis (SED), radioimmunoassay (RIA), and a combination of both (modified equilibrium dialysis [MED]). This study compared results of serum fT4 measurements by means of SED, MED, and 5 RIAs in 30 healthy dogs, 10 dogs with hypothyroidism, and 31 euthyroid dogs with concurrent illness for which hypothyroidism was a diagnostic consideration. Serum fT4 concentrations were comparable when determined by the SED and MED techniques, and mean serum fT4 concentrations were significantly (P < .01) lower in dogs with hypothyroidism than in healthy dogs and euthyroid dogs with concurrent illness. Significant (P < .05) differences in fT4 concentrations were identified among the 5 RIAs and among the RIAs and MED and SED. Serum fT4 concentrations were consistently lower when fT4 was determined by the RIAs, compared with either equilibrium dialysis technique. Serum fT4 concentrations were significantly lower (P < .01) in dogs with hypothyroidism than in healthy dogs for all RIAs; were significantly lower (P < .05) in dogs with hypothyroidism than in euthyroid dogs with concurrent illness for 4 RIAs; and were significantly lower (P < .01) in euthyroid dogs with concurrent illness than in healthy dogs for 4 RIAs. RIAs had the highest number of low serum fT4 concentrations in euthyroid dogs with concurrent illness. This study documented differences in test results among fT4 assays, emphasizing the importance of maintaining consistency in the assay used to measure serum fT4 concentrations in the clinical or research setting.  相似文献   

10.
Objective : To determine the effect of signalment on the incidence and presentation of patients suffering from cranial cruciate ligament disease. Methods : Data relating to 426 dogs (44 breeds) that met specific selection criteria were obtained from the hospital archive (2002 to 2008). Cases were followed up for 2 years. Results : The breeds most commonly presented with cranial cruciate ligament disease were Labrador retriever (16%), Rottweiler (15%), golden retriever (12%) and boxer (9%). Rottweilers were significantly more likely (69%; P=0·05) to develop and present with (50%; P=0·03) bilateral cranial cruciate ligament disease. Rottweilers presenting with cranial cruciate ligament disease were significantly younger (median 977 days; P<0·0001) than other breeds; golden retrievers being significantly older at presentation (median 1994 days; P=0·004). Neither sex nor neutered status significantly affected the incidence of developing (P=0·77 and P=0·30, respectively) or presenting with (P=0·62 and P=0·35, respectively) bilateral cranial cruciate ligament disease. Entire dogs were significantly younger than neutered dogs at presentation (P=0·0004). Entire female dogs presented significantly younger than neutered females (P=0·0002), entire males (P=0·01) and neutered males (P=0·0001). Clinical Significance : Breed affects the incidence of developing and presenting with bilateral cranial cruciate ligament disease. Breed and sex both affect the age that patients present with cranial cruciate ligament disease.  相似文献   

11.
Objectives : To compare serum vitamin D metabolites and plasma parathyroid hormone concentrations in dogs with inflammatory bowel disease and normal albumin concentration, dogs with inflammatory bowel disease and hypoalbuminaemia, healthy dogs and hospitalised ill dogs with non‐gastrointestinal illness. Methods : Serum 25 hydroxyvitamin D and 1,25 dihydroxyvitamin D concentrations were measured in 36 healthy dogs, 49 hospitalised ill dogs with non‐gastrointestinal illnesses, 21 dogs with inflammatory bowel disease and normoalbuminaemia and 12 dogs with inflammatory bowel disease and hypoalbuminaemia. Plasma parathyroid hormone and ionised calcium concentrations were measured in a subset of these dogs. Results : Concentrations of serum 25 hydroxyvitamin D were lower in hypoalbuminaemic dogs with inflammatory bowel disease than in the healthy dogs (P<0·001), hospitalised ill dogs (P<0·001) and normoalbuminaemic dogs with inflammatory bowel disease (P<0·001). Dogs with inflammatory bowel disease and hypoalbuminaemia had a higher plasma concentration of parathyroid hormone (P<0·01) and lower plasma concentration of ionised calcium (P<0·001) than hospitalised ill dogs. Dogs with inflammatory bowel disease had a positive correlation between serum 25 hydroxyvitamin D concentrations and serum albumin (P<0·0001), serum calcium (P<0·0001) and plasma ionised calcium (P<0·0005) concentrations. Clinical Significance : Dogs with inflammatory bowel disease and hypoalbuminaemia frequently have ionised hypocalcaemia, high parathyroid hormone and low serum 25 hydroxyvitamin D concentrations. Further studies are indicated to establish the pathogenesis of this disease complication as well as therapeutic strategies to reverse this state.  相似文献   

12.
桑枝皮提取物对急性高血脂症小鼠血脂水平的影响   总被引：1，自引：0，他引：1  
采用单次静脉注射400 mg/kg Triton WR-1339的方法,建立急性高血脂症小鼠模型,灌胃给予桑枝皮提取物(MBBE),18 h后测定小鼠血清中的甘油三酯(TG)、总胆固醇(TC)、高密度脂蛋白胆固醇(HDL-C)和低密度脂蛋白胆固醇(LDL-C)的浓度,并计算动脉粥样硬化指数(AI)和LDL-C/HDL-C的比值,研究MBBE的降血脂作用。试验结果表明,灌胃MBBE的急性高血脂症小鼠血清中的TG浓度水平得到显著抑制(P<0.05),其中高剂量组(600 mg/kg MBBE)小鼠血清中的TG浓度下降36.6%;灌胃MBBE后,小鼠血清中的TC、LDL-C浓度有所下降,而HDL-C浓度略有增加,其中高剂量组小鼠血清中的TC、LDL-C浓度分别下降8.3%、18.3%,HDL-C浓度升高9.3%;灌胃MBBE后,小鼠血清的AI值和LDL-C/HDL-C比值也明显下降,其中高剂量组分别下降45.6%和28.1%。结果显示,给急性高血脂模型小鼠灌胃给予桑枝皮提取物具有明显的降血脂作用以及降低动脉粥样硬化风险的作用,并且呈现剂量效应。  相似文献   

13.
Summary Serum and liver concentrations of selected macro-and trace minerals were determined in Senepol cattle at 8 sites (4 each in a high and low rainfall region) during the dry and wet season on St Croix. At each site an average of 15 mature, lactating cows, grazing native grass/legume pastures without supplementation were blood sampled each season. Liver samples were collected (n=51) at slaughter from mature animals originating from the same sites. A preliminary analysis indicated no differences in serum mineral concentrations between mature lactating cows and growing heifers. There were differences between sites for serum magnesium (Mg) (P<0·001), copper (Cu) (P<0·05) selenium (Se) (P<0·001) and zinc (Zn) (P<0·01) in the dry season, and for Cu (P<0·01), iron (Fe) (P<0·001) and Zn (P<0·01) in the wet season. Higher (P<0·001) serum concentrations of Mg, Cu, Fe and Zn were observed in the dry season, while Se was higher (P<0·001) in the wet season. Liver concentrations of Cu and Fe were lower (P<0·01) and liver molybdenum (Mo) (P<0·001) and Se (P<0·05) higher during the dry season. The seasonal differences in serum Cu, Se and Zn concentrations have not been observed in other studies in the Central American region. More than 50% of serum samples were deficient in phosphorus (P) regardless of season, and in Cu and Zn during the wet season. Mineral supplementation should be considered.
Resumen Se determinó la concentración de minerales (macro y trazas) seleccionados, en ganado Senepol en ocho sitios: cuatro de ellos en una región de alta precipitación y los otros cuatro en regiones de baja precipitación pluvial, durante la estación seca y lluviosa en la isla de Sta Cruz. En cada sitio, un promedio de 15 vacas lactantes, pastoreando pasto nativo y pasturas con leguminosas sin suplementación, se sangraron en cada estación. Se colectó tejido hepático (n=51) en el matadero local, de animales maduros provenientes de los sitios estudiados. Un análisis preliminar, no indicó diferencias en concentraciones séricas de minerales entre animales maduros lactandos y novillas en crecimiento. Hubo diferencias en cuanto a localización respecto al magnesio sérico (Mg) (P<0·001), cobre (Cu) (P<0·05) selenio (Se) (P<0·001) y zinc (Zn) (P<0·01) en la estación seca y para Cu (P<0·01), hierro (Fe) (P<0·001) y Zn (P<0·01) en la estación lluviosa. Se observaron concentracionas séricas màs altas (P<0·001) de Mg, Cu, Fe y Zn en la estación seca, mientras que el Se fue más alto (P<0·001) en la estación lluviosa. Las concentraciones hepáticas de Cu y Fe fueron bajas (P<0·01) y las de molibdeno hepático (Mo) (P<0·001) y Se (P<0·05), fueron altas durante la estación seca. Las diferencias estacionales en concentraciones de Cu, Se, y Zn sérico, no habian sido observadas en otros estudios en la región centroamericana. Mas de 50 por ciento de las muestras de suero fueron deficientes en fósforo (P) sin tener en cuenta la estación y en Cu y Zn durante la estación lluviosa. Se sugiere la necesidas de suplementación mineral.
Résumé Les auteurs ont déterminé les concentrations sériques et hépatiques d'un certain nombre d'oligo éléments et de sels minéraux sur des bovins Senepol éléves sur 8 sites (quatre pour chaque région à forte et faible pluviométrie) pendant la saison humide et la saison sèche sur l'lle Sainte Croix. Sur chaque site, des prélèvements de sang ont été effectués pendant chaque saison sur la base d'une moyenne de 15 vaches adultes en lactation, paturant sur des parcours naturels de graminées/légumineuses, sans complémentation. Les prélèvements de foie (n=51) ont été collectés à l'abattoir sur des animaux adultes originaires de ces mêmes endroits. Une analyse préliminaire n'a indiqué aucune différence dans les concentrations minérales du sérum entre les vaches adultes en lactation et les génisses en cours de croissance. Il y avait des différences entre les sites pour le magnésium sérique (Mg) (P<0,001), le cuivre (Cu) (P<0,05), le sélénium (Se) (P<0,001) et le zinc (Zn) (P<0,01) en saison sèche et pour le cuivre (Cu) (P<0,01), le fer (Fe) (P<0,001) et le zinc (Zn) (P<0,01) en saison humide. En saison sèche, des concentrations plus élevées (P<0,001) on été observées pour Mg, Cu, Fe et Zn alors que le sélénium (Se) était plus abondant en saison humide. Les concentrations hépatiques en Cu et Fe étaient plus basses (P<0,01) mais celles en Molybdène (Mo) (P<0,001) et en sélénium (P<0,05) plus élevées au cours de la saison sèche. Les différences saisonnières entre les concentrations sériques de Cu, Se et Zn n'ont pas été observées en Amérique centrale par d'autres auteurs. Plus de 50 p. 100 des échantillons de sérum étaient carencés en phosphore (P) quelle que soit la saison, et en Cu et Zn pendant la saison humide. Il conviendrait de prendre en considération la complémentation minérale.
  相似文献   

14.
旨在探究苦参苍术颗粒是否通过调节肝组织胆固醇代谢，改善致病性大肠杆菌诱导的肉鸡肝组织胆固醇合成异常。将40只21日龄白羽肉鸡随机分为空白对照组、模型对照组、苦参苍术低剂量组、中剂量组和高剂量组，每组8只。模型对照组和苦参苍术组分别胸部肌肉注射0.7 mL致病性大肠杆菌菌液(8.37×108 CFU·mL-1),苦参苍术组在接种菌液24 h后，在饮水中分别添加不同剂量的苦参苍术颗粒(低剂量组：3.6 g·L-1,中剂量组：5.5 g·L-1,高剂量组：7.3 g·L-1),自由饮水，连用7 d。试验结束，所有试验肉鸡处死，收集血液，采集组织样品，称体重和各器官重；采用石蜡切片技术观察肝组织形态变化；检测血清和肝组织中总胆固醇(total cholesterol, TCH)、甘油三酯(hepatic triglyceride, TG)、高密度脂蛋白胆固醇(high-density lipoprotein-cholesterol, HDL-C)、低密度脂蛋白胆固醇(low-densi...  相似文献   

15.
The objective of this study was to determine whether dogs with atherosclerosis are more likely to have concurrent diabetes mellitus, hypothyroidism, or hyperadrenocorticism than dogs that do not have atherosclerosis. A retrospective mortality prevalence case-control study was performed. The study group included 30 dogs with histopathological evidence of atherosclerosis. The control group included 142 dogs with results of a complete postmortem examination, a final postmortem examination diagnosis of neoplasia, and no histopathological evidence of atherosclerosis. Control dogs were frequency matched for age and year in which the postmortem examination was performed. Proportionate changes in the prevalence of diabetes mellitus, hypothyroidism, and hyperadrenocorticism were calculated by exact prevalence odds ratios (POR), 95% confidence intervals (95% CI), and P values. Multiple logistic regression analysis was used to examine the combined effects of prevalence determinants while controlling for age and year of postmortem examination. Dogs with atherosclerosis were over 53 times more likely to have concurrent diabetes mellitus than dogs without atherosclerosis (POR = 53.6; 95% CI, 4.6-627.5; P = .002) and over 51 times more likely to have concurrent hypothyroidism than dogs without atherosclerosis (POR = 51.1; 95% CI, 14.5-180.1; P < .001). Dogs with atherosclerosis were not found to be more likely to have concurrent hyperadrenocorticism than dogs that did not have atherosclerosis (POR = 1.8; 95% CI, 0.2-17.6; P = .59). Diabetes mellitus and hypothyroidism, but not hyperadrenocorticism, are more prevalent in dogs with atherosclerosis compared to dogs without atherosclerosis on postmortem examination.  相似文献   

16.
Background: Glomerular filtration rate (GFR) is decreased in humans with hypothyroidism, but information about kidney function in dogs with hypothyroidism is lacking.
Hypothesis: Hypothyroidism influences GFR in dogs. The objective of this study was to assess GFR in hypothyroid dogs before implementation of thyroxine supplementation and after re-establishing euthyroidism.
Animals: Fourteen hypothyroid dogs without abnormalities on renal ultrasound examination or urinalysis.
Methods: Blood pressure and GFR (measured by exogenous creatinine clearance) were measured before treatment (T0, n = 14) and at 1 month (T1, n = 14) and at 6 months (T6, n = 11) after beginning levothyroxine supplementation therapy (20 μg/kg/d, PO). The response to therapy was monitored at T1 by measuring serum total thyroxine and thyroid stimulating hormone concentrations. If needed, levothyroxine dosage was adjusted and reassessed after 1 month. Statistical analysis was performed using a general linear model. Results are expressed as mean ± standard deviation.
Results: At T0, the average age of dogs in the study group was 6.3 ± 1.4 years. Their average body weight decreased from 35 ± 18 kg at T0 to 27 ± 14 kg at T6 ( P < .05). All dogs remained normotensive throughout the study. GFR increased significantly with levothyroxine supplementation; the corresponding results were 1.6 ± 0.4 mL/min/kg at T0, 2.1 ± 0.4 at T1, and 2.0 ± 0.4 at T6 ( P < .01).
Conclusion: GFR was <2 mL/min/kg in untreated hypothyroid dogs. Re-establishment of a euthyroid state increased GFR significantly.  相似文献   

17.
Objectives : To investigate risk factors associated with cranial cruciate ligament rupture in dogs. Methods : Retrospective case‐control study: medical records of a first‐opinion veterinary practice were searched for dogs diagnosed with cranial cruciate ligament rupture (1995 to 2007). For each case, six unaffected dogs were randomly selected from all dogs presenting that day for comparison. Multi‐variable binary logistic regression was performed to assess the association of variables on likelihood of cruciate rupture. Results : Frequency of cranial cruciate ligament rupture was 1·19% [95% confidence interval (CI) 1·02 to 1.36%]. West Highland white terriers (n=17), Yorkshire terriers (n=14) and Rottweilers (n=11) were at significantly increased risk of cranial cruciate ligament rupture (P≤0·002). Rottweilers were at five times greater risk compared with other pure breeds (OR 5·12, 95% CI 2·281 to 11·494, P<0·001), obesity quadrupled the risk of cranial cruciate ligament rupture (OR 3·756, 95% CI 1·659 to 8·502, P=0·001) and females were twice as likely to suffer cranial cruciate ligament failure compared to males (OR 2·054, 95% CI 1·467 to 2·877, P<0·001). Dogs less than two years old were statistically less likely to sustain cranial cruciate ligament rupture than dogs older than eight years (OR 0·246, 95% CI 0·127 to 0·477, P<0·001). There was no significant difference in median weights (in kilograms) of neutered dogs, compared to their entire counterparts in either the case group (P=0·994) or in the control group (P=0·630). There was also no significant difference in body condition (‐underweight/normal weight/overweight/obese) of neutered versus entire dogs among the cases (P=0·243), or the controls (P=0·211). Clinical Significance : Cranial cruciate ligament rupture is more likely in Rottweilers and in female dogs, older dogs and obese dogs. Following multi‐variable analysis, it was established that neutering was not associated with increased risk of cranial cruciate ligament rupture.  相似文献   

18.
OBJECTIVE: To characterise the lipid profiles in dogs with parvoviral enteritis. METHODS: Blood was collected before treatment from 30 dogs that fulfilled the criteria for severe sepsis including hypo- or hyperthermia, hypotension, leucopenia, thrombocytopenia and evidences of organ dysfunction. Canine parvovirus was detected by haemagglutination and indirect fluorescence antibody tests in the faeces. Twenty control dogs were also enrolled on the basis of normal physical examination results, complete blood count and serum biochemistry profiles. RESULTS: Tachycardia, tachypnoea, hypotension, leucopenia, thrombocytopenia and increased serum markers of tissue injury (alanine aminotransferase, creatinine kinase myocardial isoenzyme [CK-MB], blood urea nitrogen and creatinine) were observed in dogs with parvoviral enteritis. Serum total cholesterol, high-density lipoprotein cholesterol and low-density lipoprotein cholesterol levels were lower, but serum triglyceride level was higher in dogs with parvoviral enteritis than those in control dogs (P<0.001). Circulating tumour necrosis factor alpha correlated negatively with total cholesterol (r=-0.979; P<0.001) but positively with triglyceride (r=0.953; P<0.001) in dogs with parvoviral enteritis. Serum total cholesterol and high-density lipoprotein cholesterol levels were lower in non-survival (n=9) dogs than in survival dogs (n=21, P<0.001). CLINICAL SIGNIFICANCE: Serum total cholesterol and high-density lipoprotein cholesterol levels decreased, but serum triglyceride level increased in dogs with parvoviral enteritis. Low serum total cholesterol and high-density lipoprotein cholesterol levels may be used as an index of the severity of parvoviral enteritis.  相似文献   

19.
Concentrations of serum cholesterol, triglyceride, and free glycerol were neasured, and serum lipoprotein electrophoresis was performed in normal dogs and in dogs with hypothyroidism, diabetes mellitus, and acute pancreatitis. Twelve privately owned dogs and 20 Basset Hounds from a research colony served as normal subjects. Privately owned had higher serum lipid concentrations than did research dogs. On electrophorisis of normal dog serum, lipoprotein bands were detected at the beta, pre-beta, alpha-2, and alpha-1 positions. Hypercholesterolemia was associated with increased intensity of the alpha-2-lipoprotein band, and hypertriglyceridemia occurred with increased lipoprotein at the origin, or the beta or pre-beta positions. Hypothyroid dogs had normal lipid values and lipoprotein electrophoretic patterns, hypercholesterolemia with increased intensity of the alpha-2-lipoprotein band, or hypercholesterolemia and hypertiglyceridemia with prominent beta-, pre-beta, and alpha-2-lipoprotein electrophoretic patterns were changed to near-normal values after levothyroxine administration. Diabetic dogs had increased serum cholesterol and triglyceride content and a predominance of lower density lipoproteins, as detected by electrophoresis. Insulin therapy caused the lipid concentrations to decrease and the electrophoretic pattern to revert to near normal. Dogs with acute pancreatitis had moderately increased serum lipid content and electrophoretic patterns characterized by increased intensity of the beta-lipoprotein band and by altered migration of alpha-1-lipoproteins.  相似文献   

20.
Objectives : This study aims to investigate lifestyle risk factors for the development of progesterone‐related diabetes mellitus in female elkhounds. Methods : Owners of 48 diabetic elkhounds and 58 healthy elkhounds were interviewed by phone concerning lifetime diet and exercise routines. A logistic model was developed to assess the impact of diet and exercise on diabetes diagnosis. The agreement between lifetime owner‐perceived body condition score (BCS) and veterinary‐perceived BCS at inclusion was estimated in healthy control dogs using the Kappa statistic. Results : The model showed that diabetic dogs had increased odds for having been overweight (before diagnosis) compared with controls (OR=2·8, 95% confidence interval 1·1–7·5, P=0·034). Although feeding other food than commercial dog feed was associated with diabetes case status, the effect was not significant after BCS was entered into the model. The overall agreement between lifetime owner‐ and veterinary‐perceived BCS at inclusion in the study was 75% and had a Kappa statistic of 0·16 (P=0·12). Clinical Significance : This study indicates that a high owner‐perceived lifetime BCS is associated with progesterone‐related diabetes in elkhounds.  相似文献   

设为首页 | 免责声明 | 关于勤云 | 加入收藏

Copyright©北京勤云科技发展有限公司  京ICP备09084417号