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1.
Sato T Ito J Shibuya H Asano K Watari T 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2005,52(10):510-513
A mass that developed in the lung of a 10-year-old mixed-breed dog was pathologically examined. Histopathological examination showed papillary and tubular growth of glandular epithelium-like cells in some areas and growth of squamous cells arranged in nests in other areas, showing coexistence of adenocarcinoma and squamous cell carcinoma in a lung tumour. Immunohistochemical staining with anti-keratin-cytokeratin antibody was strongly positive for cytoplasms in both components. Electron microscopically, the neoplastic cells of the adenocarcinoma component had features of glandular cells, with microvilli, numerous free ribosomes, large round secretory granules and intercellular desmosomes. Non-keratinized squamous cells had tonofilaments and intercellular desmosomes. These findings led to the diagnosis of primary adenosquamous carcinoma, which demonstrates phenotypic profiles characteristic of both epidermal keratinocytes and glandular epithelium. 相似文献
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J. M. Liptak E. Monnet W. S. Dernell S. J. Withrow 《Veterinary and comparative oncology》2004,2(1):1-12
The efficacy and outcome of pulmonary metastatectomy in the management of hypertrophic osteopathy (HO) secondary to metastatic osteosarcoma was retrospectively evaluated in four dogs. Metastatectomy was performed by subpleural enucleation, partial lung lobectomy or complete lung lobectomy through either a median sternotomy or thoracoscopically. Perioperative morbidity was minimal. Clinical signs associated with HO resolved within 24 h of pulmonary metastatectomy in all dogs. Durable remission of symptomatic HO was achieved in all dogs (range, 50–294 days), although recurrence of HO was noted in one dog, 246 days postmetastatectomy due to metastasis to the lungs and chest wall. Pulmonary metastatectomy resulted in a rapid and prolonged resolution of HO, and the clinical benefits of metastatectomy potentially exceed the morbidity associated with the surgical procedure. 相似文献
3.
Salgüero R Langley-Hobbs S Warland J Brearley M 《Journal of Feline Medicine and Surgery》2012,14(6):432-435
A 14-year-old male neutered Burmese cat presented for investigation of right fore limb lameness that was non-responsive to anti-inflammatory drugs and opioids. Thoracic radiography showed multiple pulmonary soft tissue nodules and a larger cavitated mass. Right elbow radiographs revealed marked peri-articular proliferation of new bone and periosteal reaction primarily affecting the ulna. Histopathological examination of an incisional biopsy of the right ulna revealed neoplastic proliferation of epithelial cells; this was confirmed as a poorly differentiated carcinoma with immunohistochemistry. Amputation of the right fore limb was performed at the owner's request. After surgery, radiographs of the limb showed progression of bone proliferation. Repeat pathological analysis confirmed a metastatic carcinoma. The cat deteriorated 3 days after surgery and was euthanased a week later as a result of severe respiratory distress. This case represents an unusual case of metastasis of a suspected primary lung tumour to the ulna in a Burmese cat. 相似文献
4.
Charles W. Brockus DVM John T. Hathcock DVM MS Diplomate ACVR 《Veterinary radiology & ultrasound》1988,29(4):184-188
Hypertrophic osteopathy (HO) associated with pulmonary blastomycosis was diagnosed in a 5–year-old male mixed-breed dog. One year prior to referral, increased pulmonary opacity had been identified on radiographs made during an examination for a chronic cough. Although serologic tests for blastomycosis were negative, the dog was treated with oral ketoconozole on the basis of suspicious lesions seen on radiographs and clinical signs. Ten months after completing the ketoconozole therapy, the dog was presented for a persistent cough and lameness. Intrapulmonary masses and periosteat proliferation were observed radiographically. A biopsy of the pulmonary masses was done, and Blastomyces dermatitidis was identified. Amphotericin B and ketoconozole administration resulted in clinical improvement and partial resolution of the HO lesions five months after initiation of therapy. 相似文献
5.
A case of hypertrophic osteopathy secondary to a pulmonary spindle cell sarcoma is described. The 9‐year‐old male cat presented with a 1‐month history of decreased appetite, decreased activity and progressive lameness with swelling and pain of all four limbs. Thoracic radiographs showed a soft tissue opaque mass in the left caudal lung lobe. Radiographs of all limbs showed extensive periosteal new bone formation of uniform opacity demonstrating a ‘palisading’ pattern. The lung mass was removed at exploratory thoracotomy; histopathological examination diagnosed a low‐grade spindle cell sarcoma. Prior to surgery, the cat had a non‐specific conjunctivitis that resolved spontaneously following lobectomy raising the possibility of a paraneoplastic association. The lameness also resolved; six months after surgery, the periosteal palisading of new bone on the long bones had remodelled, and there was no evidence of pulmonary metastases. 相似文献
6.
Canine bicavitary carcinomatosis with transient needle tract metastasis diagnosed by multiplex immunocytochemistry 
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下载免费PDF全文 A Russell Moore Emily Coffey Sarah E. Leavell Greta Krafsur Colleen Duncan Kristy Dowers Kelly S. Santangelo 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2016,45(3):495-500
A 6‐year‐old, male castrated, mixed‐breed dog was referred to the James L. Voss Veterinary Teaching Hospital at Colorado State University for bicavitary effusion. On examination, the dog was tachycardic and tachypneic with bilaterally decreased lung sounds. Thoracic and abdominal ultrasonic examination revealed pleural and peritoneal effusions, which were aspirated and submitted for fluid analysis and cytology. Both cavity fluids were classified as exudates with a large population of vacuolated mononuclear cells. Multiplex immunocytochemistry (ICC) for cytokeratin and vimentin demonstrated exclusively cytokeratin expression, indicating these cells were of epithelial origin. A full diagnostic evaluation was performed, including CBC, clinical chemistry, a pet‐side test for heartworm disease, ehrlichiosis, Lyme disease, and anaplasmosis, imaging modalities of thorax, abdomen, and heart, urinalysis, and fine‐needle aspirations of spleen, liver, and popliteal lymph nodes. The dog was diagnosed with pleural and peritoneal carcinoma with presumed carcinomatosis. A single dose of intracavitary carboplatin was administered before discharge, and over a period of 2 weeks, 5 thoracocenteses were performed. A subcutaneous mass was noted at a thoracocentesis site one week after initial presentation. Cytology of the mass was consistent with carcinoma, and neoplastic seeding of the tumor cells from the thoracocentesis was suspected. The dog was euthanized 15 days after the first visit, and a necropsy was performed. Findings were consistent with carcinomatosis secondary to anaplastic pulmonary carcinoma with transient subcutaneous seeding of neoplastic cells during routine thoracocentesis. This case demonstrates the utility of multiplex ICC in the clinical setting. 相似文献
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Caroline Fina Massimo Vignoli Rossella Terragni Federica Rossi Erik Wisner Jimmy H. Saunders 《Veterinary radiology & ultrasound》2014,55(1):16-22
Canine pulmonary eosinophilic granulomatosis is a rare inflammatory pulmonary disease characterized by formation of eosinophilic granulomas that tend to obliterate the normal pulmonary architecture. The purpose of this retrospective study was to describe the CT characteristics of confirmed idiopathic pulmonary eosinophilic granulomatosis in a group of dogs. Five dogs met inclusion criteria. All patients were young adult dogs of variable breeds. No dog had concurrent occult heartworm disease. Computed tomographic characteristics most commonly included pulmonary masses and nodules of variable size, and lesions were most commonly located in the caudal lung lobes. Four dogs had large pulmonary masses with or without additional nodules and one dog had nodular lesions disseminated throughout the entire lung parenchyma. All large eosinophilic granulomas were smoothly margined, heterogeneous pulmonary masses displaying heterogeneous contrast enhancement. A honeycomb‐like enhancement pattern was observed in all but one mass and consisted of multiple hyperattenuating rims delineating central hypoattenuating areas, suggestive of bronchiectatic lung with peripheral enhancing airway walls and fluid‐filled, necrotic bronchial lumen. One dog had evidence of tracheobronchial lymphadenopathy. Findings indicated that canine eosinophilic pulmonary granulomatosis should be included as a differential diagnosis for dogs with CT characteristics of multiple pulmonary masses and/or nodules in caudal lung lobes, and a honeycomb‐like enhancement pattern in masses after intravenous administration of iodinated contrast medium. 相似文献
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Karen L. Hamerslag Sydney M. Evans Richard Dubielzig 《Veterinary radiology & ultrasound》1980,21(5):194-196
A 6-year-old male Saint Bernard dog was examined because of a firm nonpainful tail-base mass. Radiographs revealed an expansile heterogeneous bony mass of the sixth coccygeal vertebra. The tail was amputated. The histologic diagnosis was coccygeal vertebral chondrosarcoma. Chondrosarcomas account for ten to eleven percent of all skeletal tumors and occur commonly in the flat bones in large-breed dogs. Radiographically chondrosarcomas appear predominantly osteolytic but may contain mottled mineralized densities. In the dog described here the radiographic signs were typical of a malignant cartilaginous tumor: cortical destruction, mottled mineralized densities, ill-defined margins, and continued but relatively slow growth. However, there was no periosteal reaction and the chondrosarcoma was at an unusual site. 相似文献
11.
Foster WK Armstrong JA 《Journal of the American Veterinary Medical Association》2006,228(9):1366-1369
CASE DESCRIPTION: A 4-year-old English Pointer was examined because of chronic, progressive signs of pulmonary disease and failure to respond to medical treatment. CLINICAL FINDINGS: At examination, radiography of the thorax revealed increased pulmonary opacity and air bronchograms in the right caudal lung lobe, and radiography of the forelimbs revealed periosteal bone production typical of hypertrophic osteopathy. Attempts to isolate a causative organism included bacterial culture of bronchoalveolar lavage fluid and a lung tissue specimen obtained via fine-needle aspiration. Despite a cytologic diagnosis of septic suppurative inflammation in the lavage fluid, those specimens did not yield bacterial growth. However, a biopsy specimen obtained during a lung lobectomy procedure yielded growth of Eikenella corrodens. TREATMENT AND OUTCOME: Despite successful surgical removal of the consolidated lung lobe and initiation of antimicrobial treatment, the dog died 6 days after surgery. CLINICAL RELEVANCE: The authors are not aware of reports of pulmonary infection with E. corrodens in animals. Infection with the organism is rare, but it is possible that infections are underreported given that the organism is difficult to culture and biopsy may be necessary to obtain enough tissue to yield a diagnosis. 相似文献
12.
Diana BINANTI Davide Danilo ZANI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(4):479-482
An 11-year-old cat with a 4-month history of lethargy, inappetence, dysphagia, partial
mandibular paralysis and weight loss, was euthanized due to the rapid deterioration of his
condition. Post-mortem radiographic examination revealed severe bone lysis of the left
zygomatic arch, temporal and parietal bones. Magnetic resonance imaging of the head showed
a large isointense mass of the left side of the skull associated with extensive lysis of
the parietal and temporal bones and destruction of the adjacent tympanic bulla. Gross and
histological examinations revealed a pulmonary adenosquamous carcinoma of the left lung,
with metastases to the spleen, liver, mesenteric lymph nodes, mesentery, diaphragm,
abdominal aorta, left orbit and calvaria. No limb or digit metastases were detected. 相似文献
13.
Anderson TP Walker MC Goring RL 《Journal of the American Veterinary Medical Association》2004,224(9):1464-6, 1453
A 5-year-old castrated male Shetland Sheepdog was examined because of progressive bilateral hind limb thickening. Cyanosis of the preputial mucous membranes was evident, whereas the oral mucous membranes had a normal color. A well-structured, palisade-like periosteal reaction with no underlying bone destruction was evident on radiographs of the hind limbs. The radiographic changes were consistent with hypertrophic osteopathy (HO). Severe right-sided cardiomegaly was seen on thoracic radiographs, and a diagnosis of patent ductus arteriosus with right-to-left shunting was made by means of echocardiography and contrast echoaortography. The cyanotic heart disease was believed to be the cause of the HO. Hypertrophic osteopathy has been associated with a number of diseases in animals and humans. In humans, congenital heart defects that cause cyanosis are among the most common causes of HO. 相似文献
14.
Becker TJ Perry RL Watson GL 《Journal of the American Animal Hospital Association》1999,35(6):499-505
A 12-year-old, spayed, female domestic shorthair cat was diagnosed with severe and extensive hypertrophic osteopathy of the appendicular skeleton. Diagnostic ultrasound detected a mass lesion in the right adrenal gland. A right adrenalectomy was performed, and histopathological examination confirmed an adrenocortical carcinoma. No radiographic evidence of pulmonary metastasis was found on initial presentation or recheck thoracic radiographs taken 15 weeks later. Almost complete regression of periosteal new bone formation occurred 15 weeks following the successful surgical removal of the adrenal tumor. 相似文献
15.
Extraosseous chondrosarcomas are uncommon in the dog, and those originating in the lung are rare. This report presents a 9-year-old Beagle dog with a pulmonary mass which caused depression, fever, tachypnea, cough, and laboratory abnormalities. The mass was composed predominantly of chondroid tissue, and was histologically diagnosed as chondrosarcoma. 相似文献
16.
Sun-Hye Song Noh-Won Park Ki-Dong Eom 《The Canadian veterinary journal. La revue veterinaire canadienne》2014,55(5):466-470
A 9-year-old spayed female cocker spaniel dog was referred for hematuria. A large abdominal mass and multiple pulmonary nodules were identified radiographically. A whole-body 2-deoxy-2-[18F]fluoro-d-glucose positron emission tomography/computed tomography (PET/CT) scan revealed intensely increased uptake in a renal mass and the pulmonary nodules. Renal cell carcinoma was diagnosed on histological examination. 相似文献
17.
Ferreira AJ Peleteiro MC Correia JH Jesus SO Goulão A 《The Journal of small animal practice》2005,46(6):286-290
A small-cell carcinoma of the lung was identified in a six-year-old female German shepherd dog with a history of chronic lameness of the left forelimb, Horner's syndrome and sensory deficits on the caudal portion of the left forelimb below the elbow. A mass, the exact location of which was difficult to ascertain, was identified during radiographic examination of the thorax. It was easily identified, using magnetic resonance imaging, as an apical tumour of the left lung with dorsal extension and involvement of paraspinal structures, such as spinal nerve roots C8 to T1 and the sympathetic trunk. Postmortem examination confirmed a mass in the left apical lobe of the lung, compatible with a diagnosis of small-cell carcinoma by histopathology and immunohistochemistry. This clinical presentation is similar to Pancoast syndrome described in humans. 相似文献
18.
G. C. Macpherson B. J. Chadwick P. D. Robbins 《The Journal of small animal practice》1993,34(5):242-246
A dog was presented with signs of subacute, progressive myelopathy. A tentative diagnosis of a diffuse intramedullary spinal cord mass was made using contrast radiography (myelography). At autopsy a solitary, large bronchoalveolar carcinoma was detected in a lung lobe. Histological examination of the cranial thoracic spinal cord revealed a tumour which was similar, but not identical, to the lung tumour. Immunohistochemistry helped to confirm that the spinal lesion was a metastasis of the lung tumour. 相似文献
19.
Guyot H Sandersen C Rollin F 《The Canadian veterinary journal. La revue veterinaire canadienne》2011,52(12):1308-1311
A 12-year-old cow was presented with chronic respiratory disease and lameness. Chronic pleuritis, pneumonia, and bronchial carcinoma were found as well as periosteal proliferation on limb bones. Ancillary tests and necropsy confirmed a combined pathology of pulmonary inflammation and neoplasm, and hypertrophic pulmonary osteopathy. 相似文献
20.
Yoshifumi ENDO Toshikazu SAKAI Sho FUKUI Ai HORI Ryosuke ECHIGO Satoru MATSUNAGA Tsuyoshi KADOSAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2022,84(2):218
A 10-year-old spayed female Golden Retriever was referred for hindlimb lameness. A firm mass was palpated over the right caudal pelvis. Computed tomography revealed an osteolytic bone region and an associated periosteal reaction in the ischium, including the acetabulum. The histological diagnosis was sarcoma of unknown origin. A mid-to-caudal partial hemipelvectomy was performed to remove the mass. Femoral head and neck osteotomy was performed to allow hindlimb preservation. Following surgery, the dog regained satisfactory hindlimb use over time and was alive for 821 days with no recurrence or metastatic disease. This report indicates that mid-to-caudal partial hemipelvectomy with femoral head and neck osteotomy is technically feasible and allows for tumor control with preservation of the hindlimb and its function. 相似文献