共查询到17条相似文献,搜索用时 31 毫秒
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在生产中兽药的滥用可能导致牛奶中的兽药残留并对消费者健康造成风险。由于兽药种类较多,单一检测效率较低,而高通量检测技术可以一次性检测多种兽药残留,省时省力,因此成为当前研究的热点。在样品前处理方面,分散固相萃取技术(如QuEChERS方法)由于其简单、快速、成本低等特点,广泛应用于样品净化过程;另一方面,超高效液相色谱串联质谱由于其分离快、灵敏度与准确度高等特点,展示出比高效液相色谱法更好的分析能力和应用前景。随着新技术的应用和新仪器的使用,兽药残留检测在前处理效率、仪器灵敏度和高通量检测方面发展迅速。作者结合近些年发表的文献,综述了奶及奶制品中兽药残留前处理技术(液液萃取法、固相萃取法、QuEChERS和盐析支持液液萃取)和高通量检测技术(高效液相色谱法、液相色谱-质谱联用、超高效液相色谱串联质谱和液相色谱-飞行时间质谱法),为今后相关检测研究提供参考。 相似文献
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现如今,食品、药品安全隐患问题已经成为全社会关注的焦点,利用先进的检测技术对食品、药品中一些物质的含量进行详细的分析和全面的了解,有利于实现食品药品的安全控制。高效液相色谱是一种分离技术,目前,在食品、医药领域中已得到广泛应用。本文综述了高效液相色谱的主要技术分离原理及其在食品、药品安全及中的应用,以期为今后高效液相色谱技术用于食品与药品安全与检测提供理论参考。 相似文献
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随着食品安全在全世界范围内被日益关注,兽药残留检测技术也不断发展,目前国内兽药残留的检测技术主要有气相色谱、气相-质谱联用、液相色谱和液相-质谱联用和酶免疫技术等,这些检测技术对于“瘦肉精”等常见违禁药物检测精度较高,但是又普遍存在分析成本高、方法复杂、单一等缺点,特别是对于样品中存在的未知药物残留常常会一筹莫展。然而面对瞬息万变的食品安全领域,已有的这些检测技术已经很难满足目前残留检测的需要,必须采用一种快速、广谱系统化的筛选检测技术。本文将已经在人药领域应用成熟的快速广谱药物检测系统(REMIDI HS)〔… 相似文献
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动物源食品中多种兽药残留主要是动物在生长和加工中额外添加。该种残留现象具有水平低、种类多、机制效应复杂的特点。针对该种动物制品在进行兽药残留检测中应综合运用新技术新方。目前在动物源食品中多种兽药残留检测中常用的技术为高效液相色谱质谱联合使用技术,该项技术具有检测灵敏度高,数据获取精准的特点,能对多种兽药残留情况进行定性定量的分析,在动物源食品多种兽药残留检测过程中应用较为广泛。该文主要论述动物源食品中多种兽药残留的种类及兽药残留检测技术。 相似文献
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The abuse of veterinary drugs in production may lead to veterinary drug residues in milk and pose a risk to consumer health.As the kinds of veterinary drugs are too many,the detection method for single target presents low efficiency.Whereas the high-throughput detection technology can detect various veterinary drug residues simultaneously,with time and labor saving,and become a research hot spot.In the aspect of sample pretreatment,dispersed solid phase extraction techniques,such as QuEChERS method,are widely used in sample purification due to its features of simplicity,rapidity and low cost.On the other hand,because of its characteristics of fast separation,high sensitivity and accuracy,ultra-high performance liquid chromatography (UPLC) tandem mass spectrometry (MS) has shown better analytical performance and application prospect than high performance liquid chromatography (HPLC).With the application of new technologies and instruments,veterinary drug residue detection has developed rapidly in terms of pretreatment efficiency,instrument sensitivity and high-throughput detection.In this paper,based on recent literatures and publications,the pretreatment techniques and high-throughput detection technology of veterinary drug residues in milk and dairy products were reviewed,to provide a reference for future research.The pretreatment techniques introduced liquid-liquid extraction (LLE),solid phase extraction (SPE),QuEChERS and salting out support liquid extraction,while the high-throughput detection technology included high-performance liquid chromatography (HPLC),liquid chromatography-mass spectrometry (LC-MS),ultra-high performance liquid chromatography tandem mass spectrometry (UHPLC-MS) and liquid chromatography-time of flight mass spectrometry (LC-TOF-MS). 相似文献
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LC-MS/MS在硝基呋喃类兽药残留检测中的应用 总被引:1,自引:1,他引:0
综述了目前采用高效液相色谱/串联质谱(LC-MS/MS)法同时测定硝基呋喃类兽药代谢物呋喃唑酮、呋喃它酮、呋喃西林、呋喃妥因残留分析的检测现状、最低检测限以及国内外利用同位素内标法使用LC-MS/MS测定硝基呋喃类兽药残留的检测现状及其达到的最低检测限,并阐明了其应用对我国食品安全体系健康发展的重要意义。 相似文献
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免疫亲和色谱及其在兽药残留检测中的应用 总被引:3,自引:0,他引:3
随着对兽药残留检测领域研究的不断深入,免疫亲和色谱技术得到了越来越多的广泛应用。本文详细阐述了免疫亲和色谱的原理和关键技术,介绍了其在动物性食品中兽药及饲料药物添加剂残留检测中的应用与进展。 相似文献
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介绍新的检测技术——拉曼光谱,并分析拉曼光谱仪的特点、综述拉曼光谱在药物分析中的应用以及展望其在兽药打假中的应用前景,特别是执法人员在兽药查处现场快速筛选假劣兽药。相信随着科学技术的发展,拉曼光谱在未来兽药的打假过程中必将发挥重要的作用。 相似文献
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A literature review of reports of the stability and storage of common injectable chemotherapy agents used in veterinary patients 下载免费PDF全文
Many chemotherapy drugs used in human patients are discarded after single use or within 24 h of reconstitution, as per the manufacturer's product label recommendations. This can be wasteful and costly to veterinary clients. This report reviews the published stability and storage data for 19 injectable chemotherapy drugs commonly used in veterinary medicine. Based on these data, storage procedures are presented, assuming aseptic technique and a closed system drug transfer device (CSDTD) are used for drug preparation and handling. Further studies on the risk of microbiological contamination of chemotherapeutics using a CSDTD, and validated high quality drug assays such as stability‐indicating high‐performance liquid chromatography, are required. The authors' intent is not to supersede product label recommendations, but to suggest that longer storage without significant loss of drug efficacy may be possible, thus reducing the costs of chemotherapeutics to some veterinary clients. 相似文献