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犬甲状腺机能减退是由于甲状腺功能异常而引起甲状腺激素分泌不足或合成减少导致犬的内分泌紊乱的一类综合性疾病。长期的甲状腺激素分泌不足,可能继发糖尿病的发生。通过对1例患犬临床症状表现为全身被毛稀疏,多饮多尿多食,双眼白内障等,结合实验室检查(血常规、生化、甲状腺功能检查),总甲状腺(T4)<6.5,参考范围15 nmol/L^50nmol/L,血糖(GLU)20.7 mmol/L,参考范围3.9 mmol/L^8.0 mmol/L,确诊为甲状腺机能减退并发糖尿病。经补充左甲状腺素片治疗甲状腺机能减退,同时用胰岛素控制血糖,再结合中药和针灸辅助治疗病情得到缓解,为临床诊疗该类病提供了参考。 相似文献
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2012年-2014年杭州地区宠物犬肿瘤调查 总被引：1，自引：0，他引：1
《动物医学进展》2015,(11)
在浙江大学附属动物医院门诊收集了133例犬肿瘤自然发生病例,通过对其临床症状、发病部位、品种、年龄、性别、饮食等进行调查。发现肿瘤发病早期一般不表现全身症状,恶性肿瘤发生转移时会有恶病质的表现;乳腺和皮肤及软组织是犬肿瘤临床高发的部位,分别占全部患犬的42.11%和24.81%;京巴犬、杂交犬、贵宾犬、西施犬和可卡犬是肿瘤高发品种,分别占患犬的19.55%、14.29%、11.28%、7.52%和6.77%;患病犬年龄1岁~15岁,平均年龄9.39岁,6岁~10岁发病率最高;一些肿瘤类型与性别、是否绝育有关;日常饮食与犬肿瘤的发生有关,肉拌饭类、纯肉加火腿肠类、狗粮加肉类和纯狗粮类,发病比例分别为39.85%、26.32%、21.05%和12.78%,纯狗粮饲养的犬发病率较低。 相似文献
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目的:明确犬甲状腺功能减退症临床诊断与治疗方法。方法:将本中心2018年1月至2019年7月接诊的18例患犬作为研究对象,明确犬甲状腺功能减退症临床诊断与治疗方法。结果:18例患犬经过临床治疗后,有10例患犬治疗效果明显,3例患犬病情好转后转院治疗,5例患犬主人放弃治疗。结论:利用临床诊断与皮肤检查、生化检查、内分泌检测以及血常规检查等手段可以有效的确诊犬甲状腺功能减退症,通过口服左旋甲状腺素钠并结合针对性治疗方法可以有效的控制犬甲状腺功能减退症。 相似文献
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《上海畜牧兽医通讯》2016,(4)
正甲状腺机能减退是犬最常见的内分泌疾病〔1〕,约80%的患犬会出现皮肤症状,这种皮肤病称为甲状腺机能减退性皮肤病。笔者于2014~2015年间接诊了5例该病患犬,现将治疗情况报告如下。 相似文献
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2023年1月22日,1只4岁雌性比熊犬出现呕吐、吐黄水、食欲减退、体质量下降等症状。通过临床观察、血常规检查、生化检测、电解质检测和促肾上腺皮质激素（ACTH）刺激试验进行诊断。血常规检查结果显示,红细胞压积和红细胞数目升高,提示患犬严重脱水;生化检测结果显示,肌酐、尿素氮含量增加,提示患犬肾功能异常;电解质检测结果显示,患犬出现低钠、高钾与低氯血症,为艾迪森特征性血症;ACTH刺激试验结果显示,肾上腺皮质机能减退。综合上述结果,确诊该犬患有艾迪森病。通过止吐,纠正低血压和低血容量,调节电解质平衡,纠正低血糖,增强食欲以及皮下注射地塞米松磷酸钠注射液或口服波尼松龙片等进行治疗,患犬预后良好。本病例为犬艾迪森病的诊断分析与治疗方案制定提供了参考。 相似文献
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《上海畜牧兽医通讯》2016,(3)
在阐述了犬甲状腺机能减退各种诊断方法诊断原理的基础上,从内分泌学诊断、影像学诊断、遗传学诊断和治疗性诊断4个方面,对犬甲状腺机能减退诊断方法研究成果进行了概述,归纳了不同方法的优缺点,并分析了原因。指出:单独使用一种诊断方法对犬甲状腺机能减退进行诊断不够准确,目前内分泌学诊断是主要的诊断方法,根据患犬血清总四碘甲腺原氨酸(TT4)、游离四碘甲腺原氨酸(FT4)和促甲状腺素(TSH)浓度测定结果,结合病史与临床症状,可对绝大多数甲状腺机能减退病例作出诊断。 相似文献
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为了解和分析犬慢性肾脏衰竭发病规律,在内蒙古呼和浩特地区部分宠物医院收集30例犬慢性肾脏衰竭病例,对其品种、年龄、性别、发病时间、饮食习惯、血液相关指标、影像学检查进行调查。结果发现,杂种犬占了总病例数的37%,远远高于其他品种病犬;调查中患犬年龄为2～13岁大小不等,平均年龄7.53岁,以7～9岁病例数最多,占所有患犬的53%,其中17例患犬(57.0%)为公犬,13例(43.0%)为母犬;发病时间以春、夏为主;患犬多以自制食物为主,自制食物多为肉类;患犬均有不同程度的贫血,尿素氮、肌酐、磷增高明显,钠离子、钾离子整体呈下降趋势;影像学检查发现,病犬肾脏体积变大、变小或正常,肾组织回声增强。 相似文献
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OBJECTIVE: To assess thyroid hormone levels in hyperadrenocorticoid dogs before and after therapy with trilostane, a reversible inhibitor of steroidogenesis. METHODS: Serum total thyroxine, free thyroxine and endogenous canine thyroid-stimulating hormone concentrations were measured in 20 dogs with spontaneously occurring hyperadrenocorticism before and six months after successful treatment with trilostane. RESULTS: Fourteen dogs demonstrated an increase in thyroxine following trilostane treatment; however, this was not significant (P=0.108). Fourteen dogs demonstrated an increase in canine thyroid-stimulating hormone concentrations with trilostane therapy (P=0.006). Of the 14 dogs that demonstrated an increase in thyroxine concentrations following therapy, 10 also showed an increase in canine thyroid-stimulating hormone concentrations. Before treatment, free thyroxine values were within, above and below the reference range in 10, six and two dogs, respectively. Sixteen of 18 dogs had free thyroxine values within the reference range after treatment, with 11 dogs showing a decrease in free thyroxine levels following therapy (P=0.029). CLINICAL SIGNIFICANCE: While treatment with trilostane did not induce a significant change of thyroxine concentrations, there was a significant increase in canine thyroid-stimulating hormone concentrations following treatment, a finding that supports thyroid-stimulating hormone suppression as one of the factors that contributes to the effects of glucocorticoids on the hypothalamic-pituitary-thyroid axis. The significant elevation in free thyroxine values following treatment with trilostane was unexpected and did not support the findings of previous studies in this area. 相似文献
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This prospective, cross-sectional, interventional study was designed to determine the association between the hormones of the pituitary-adrenal and pituitary-thyroid axes and other clinical parameters with the blood glucose perturbations in dogs with naturally occurring Babesia canis rossi babesiosis. Thirty-six dogs with canine babesiosis were studied. Blood samples were obtained from the jugular vein in each dog prior to treatment at admission to hospital and serum endogenous adrenocorticotrophic hormone (ACTH), pre-ACTH cortisol, thyroxine, free thyroxine and TSH concentrations were measured. Immediately thereafter each dog was injected intravenously with 5 microg/kg of ACTH (tetracosactrin). A 2nd blood sample was taken 1 hour later for serum post-ACTH cortisol measurement. Three patient groups were recruited: hypoglycaemic dogs (glucose < 3.3 mmol/l, n = 12); normoglycaemic dogs (glucose 3.3-5.5 mmol/l, n = 12); hyperglycaemic dogs (glucose > 5.5 mmol/l, n = 12). Basal and post-ACTH serum cortisol concentrations were significantly higher in hypoglycaemic dogs, whereas body temperature, serum thyroxine and free thyroxine were significantly lower in hypoglycaemic dogs. Haematocrit was significantly lower in both hypo-and hyperglycaemic dogs compared with normoglycaemic dogs. Low blood glucose concentrations were significantly associated with high basal and post-ACTH cortisol concentrations and with low serum thyroxine and free thyroxine concentrations in dogs suffering from B. canis rossi babesiosis. 相似文献
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A cross-sectional study was performed in order to examine the association between canine aggression to familiar people and serum concentrations of total thyroxine (TT4), free thyroxine (fT4), thyroxine autoantibodies (T4AA), total triiodothyronine (TT3), free triiodothyronine (fT3), triiodothyronine autoantibodies (T3AA), thyroid stimulating hormone (TSH), and thyroglobulin autoantibodies (TgAA). The subjects were 31 dogs historically aggressive to familiar people and 31 dogs with no history of aggression. Behavioral evaluation and physical examination were completed for each dog in addition to a complete blood count, serum chemistry panel, TT4, fT4 by equilibrium dialysis, TT3, fT3, TgAA, T3AA, and T4AA. Significant differences were found between the two groups with respect to only T4AA, which was increased in the aggressive group, but the concentrations for both groups were within the normal reference range. There were no differences between the two groups in the thyroid analytes most commonly measured by veterinary practitioners evaluating thyroid function in dogs. The results of this study revealed no significant difference between aggressive and non-aggressive dogs in the thyroid concentrations most commonly used to diagnose canine hypothyroidism. 相似文献
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例犬急性肾衰竭的诊断与治疗 《畜牧与饲料科学》2019,40(7):109-112
通过病史调查、临床特征观察、血液学指标、尿比重检测以及影像学检验等进行确诊,对某宠物医院接诊的3例犬急性肾衰竭诊断分析。结果显示,3例犬急性肾衰竭的临床症状主要为精神沉郁、厌食或食欲下降、呕吐、腹泻、尿量异常等;患犬血液中白细胞总数增多,血肌酐、尿素氮和无机磷指标都高于标准值的上限;患犬的尿比重均较低;影像学检查有2例肾脏体积无变化,1例肿大。 相似文献
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Effects of hemolysis and storage on quantification of hormones in blood samples from dogs, cattle, and horses 总被引：1，自引：0，他引：1
T J Reimers S V Lamb S A Bartlett R A Matamoros R G Cowan J S Engle 《American journal of veterinary research》1991,52(7):1075-1080
Veterinary diagnostic endocrinology laboratories frequently receive hemolyzed plasma, serum, or blood samples for hormone analyses. However, except for the previously reported harm done by hemolysis to canine insulin, effects of hemolysis on quantification of other clinically important hormones are unknown. Therefore, these studies were designed to evaluate effects of hemolysis on radioimmunoassay of thyroxine, 3,5,3'-triiodothyronine, progesterone, testosterone, estradiol, cortisol, and insulin in equine, bovine, and canine plasma. In the first experiment, hormones were measured in plasma obtained from hemolyzed blood that had been stored for 18 hours. Blood samples were drawn from pregnant cows, male and diestrous female dogs, and male and pregnant female horses. Each sample was divided into 2 equal portions. One portion was ejected 4 times with a syringe through a 20-gauge (dogs, horses) or 22-gauge (cows) hypodermic needle to induce variable degrees of hemolysis. Two subsamples of the blood were taken before the first and after the first, second, and fourth ejections. One subsample of each pair was stored at 2 to 4 C and the other was stored at 20 to 22 C for 18 to 22 hours before plasma was recovered and stored at -20 C. The second portion of blood from each animal was centrifuged after collection; plasma was recovered and treated similarly as was blood. Concentrations of thyroxine in equine plasma, of 3,5,3'-triiodothyronine, estradiol, and testosterone in equine and canine plasma, and of cortisol in equine plasma were not affected by hemolysis.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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The aim of this study was to investigate samples from dogs suggestive of active canine borreliosis (group A) by culture and PCR and the detection of antibodies against Borrelia burgdorferi sensu lato in order to confirm a presumptive clinical diagnosis of canine borreliosis by laboratory results. Criteria for such a diagnosis were: history of tick exposure, lameness, neurological signs, nephropathy, lethargy, anorexia, and fever. A total of 302 samples comprising EDTA blood, urine, synovial fluid, cerebrospinal fluid, and tissue (skin, synovial membrane, kidney) from 98 dogs (26 with arthritis, 46 with neurological signs, 21 with nephropathy, 5 with non-specific symptoms) were collected and examined. Moreover, 55 healthy dogs (group B) and 236 dogs with symptoms or injuries unlikely to be associated with borreliosis (group C) were included in this study. Blood serum samples collected from all individuals (n=389) were analysed by ELISA. Twenty-one (21%) out of 98 dogs from group A, 4 (7%) out of 55 from group B and 15 (6%) out of 236 dogs from group C were positive for antibodies against B. burgdorferi sensu lato. The seroprevalences between groups A, B and C differed significantly. None of the corresponding samples investigated by PCR and culture were positive for spirochetal DNA or viable spirochetes. Borrelia afzelii was grown from one EDTA-blood sample but the corresponding blood serum sample remained antibody-negative. Consequently, the etiologic role of B. afzelii in this case is unclear. In approximately 40% of the presumptive canine borreliosis cases, other lesions have been found to be responsible for clinical signs. This study affirms that a definitive diagnosis of canine borreliosis cannot be made by clinical symptoms and serology based on a single consultation. Moreover, this study clearly revealed that the diagnostic sensitivity is enhanced by a thorough consideration and exclusion of other diseases. 相似文献
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本研究旨在分析犬呼吸道冠状病毒(canine respiratory coronavirus, CRCoV)的感染情况和在北京地区的流行病学状况。采用RT-PCR方法,对自2015年12月—2017年3月于中国农业大学动物医院采集的487份犬咽鼻拭子进行了CRCoV检测,同时,对部分样本进行了犬副流感病毒(canine parainfluenza virus, CPIV)、犬腺病毒II型(canine adenovirus type 2,CAV-2)、犬瘟热病毒(canine distemper virus, CDV)等病毒的混合感染情况调查。结果表明：CRCoV的阳性率为21.36%(104/487);CRCoV与CPIV、CAV-2、CDV的混合感染率分别为3.43%(11/321),0%(0/156)和3.85%(6/156)。在所有呼吸道症状记录完整的455例样本中,无呼吸道症状的犬CRCoV携带率为27.19%(31/114);呈轻度呼吸道症状(鼻液、咳嗽)的犬CRCoV感染率为19.73%(59/299);呈中至重度呼吸道症状(肺炎)的犬CRCoV感染率为14.28%(6/... 相似文献
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C. J. Henry A. W. Hahn J. W. Tyler H. S. Steinberg C. W. Caldwell 《Veterinary and comparative oncology》2005,3(1):33-33
Introduction: Surveillance, Epidemiology & End Results (SEER) data indicate that non‐Hodgkin's lymphoma (NHL) is approximately 50% more common among men than women. A similar male predisposition is reported for canine lymphoma, yet the underlying role of gender in lymphoma etiology remains elusive. Because similarities exist between canine lymphoma and NHL, databases including the Veterinary Medical Database (VMDB) and Veterinary Cancer Registry (VCR) may prove useful in understanding lymphoma epidemiology. This study sought to determine the relationship between gender and development of canine lymphoma.
Materials: Data from 1980 to 2000 were retrieved from the VMDB and sorted by gender and reproductive status. Spayed or neutered dogs diagnosed with lymphoma were compared to intact dogs seen each year in each gender category using a two‐tailed Student's t‐test. The VCR was searched for all canine lymphoma cases. The number of cases in each gender group was compared to the number of cancer diagnoses per group using a Chi‐square test (3 degrees of freedom). Differences were deemed significant when P < 0.050.
Results: The VMDB included 15,091 lymphoma cases in a population of 1.34 million dogs. In the VCR database, 394 lymphoma cases were identified amongst 6,070 canine cancer diagnoses. In both analyses, intact females were significantly less likely to develop lymphoma than were other gender groups.
Conclusions: In dogs, as in people, female gender and intact reproductive status appears to be protective against the development of lymphoma. This data suggests that further examination of the role of estrogen in lymphoma prevention is warranted. 相似文献
Materials: Data from 1980 to 2000 were retrieved from the VMDB and sorted by gender and reproductive status. Spayed or neutered dogs diagnosed with lymphoma were compared to intact dogs seen each year in each gender category using a two‐tailed Student's t‐test. The VCR was searched for all canine lymphoma cases. The number of cases in each gender group was compared to the number of cancer diagnoses per group using a Chi‐square test (3 degrees of freedom). Differences were deemed significant when P < 0.050.
Results: The VMDB included 15,091 lymphoma cases in a population of 1.34 million dogs. In the VCR database, 394 lymphoma cases were identified amongst 6,070 canine cancer diagnoses. In both analyses, intact females were significantly less likely to develop lymphoma than were other gender groups.
Conclusions: In dogs, as in people, female gender and intact reproductive status appears to be protective against the development of lymphoma. This data suggests that further examination of the role of estrogen in lymphoma prevention is warranted. 相似文献
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Oxidative stress indices in gastroenteritis in dogs with canine parvoviral infection 总被引：1，自引：0，他引：1
Gastroenteritis of viral origin has emerged as a major cause of morbidity and mortality in dogs during the last two decades. Amongst the viral etiologies responsible for gastroenteritis in dogs, canine parvovirus (CPV) is considered as the most pathogenic. The disease is characterized by hemorrhagic enteritis, bloody diarrhoea and myocarditis in young pups. The present study was carried out to examine alterations in oxidative stress indices in the erythrocytes from dogs suffering from gastroenteritis with or without canine parvoviral infection as confirmed by CPV-DNA amplification from faeces using specific primers for CPV-2 as well as CPV-2a and CPV-2b variants by polymerase chain reaction (PCR). The present investigation utilized clinical cases of dogs with signs of acute diarrhea (n = 56), and 14 more apparently healthy dogs of similar age group. Erythrocytic oxidative stress indices such as lipid peroxides level and antioxidant enzymes like superoxide dismutase and catalase activity, and blood micro-mineral (iron, copper, cobalt and zinc) status were analyzed in each dog (n = 70). The acute cases of gastroenteritis in dogs were associated with altered erythrocytic lipid peroxidation as evident by estimation of malonaldehyde (MDA) concentration. The activities of antioxidant enzymes catalase and superoxide dismutase, the first line of antioxidant defense against damaging effects of free radicals, were also altered. The alterations in oxidative stress indices were more pronounced in cases with involvement of canine parvovirus as compared to parvo-negative cases. Our results also revealed decreased blood zinc level in diarrhoea in dogs irrespective of involvement of canine parvovirus. 相似文献
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探讨同源异体骨髓间充质干细胞(BMMSCs)移植对犬急性肝功能损伤的治疗作用,为犬干细胞治疗相关疾病提供理论基础和技术支持。对患急性肝损伤的10只病犬经超声引导腹腔内肝门附近移植BMMSCs,移植后检测血常规、肝功能和肝脏B超,观察同期的症状体征和不良反应情况。结果显示,干细胞移植7天后可使患犬各项肝功能指标明显改善,10d后B超结果显示肝组织回声均匀,无明显异常,14d后患犬的精神、体力、食欲明显好转,干细胞移植21d后血常规各项指标恢复正常,患犬基本康复,移植干细胞的患犬均未发现有不良反应。说明相对于常规治疗,犬BMMSCs同源异体移植治疗急性肝损伤可明显缩短治疗时间,显著提高患犬生活质量。 相似文献