共查询到20条相似文献，搜索用时 46 毫秒
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An inherited functional circadian clock in zebrafish embryos 总被引：1，自引：0，他引：1
Circadian clocks are time-keeping systems found in most organisms. In zebrafish, expression of the clock gene Period3 (Per3) oscillates throughout embryogenesis in the central nervous system and the retina. Per3 rhythmic expression was free-running and was reset by light but not by the developmental delays caused by low temperature. The time of fertilization had no effect on Per3 expression. Per3 messenger RNA accumulates rhythmically in oocytes and persists in embryos. Our results establish that the circadian clock functions during early embryogenesis in zebrafish. Inheritance of maternal clock gene products suggests a mechanism of phase inheritance through ovogenesis. 相似文献
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In contrast to current models, fluorescence resonance energy transfer measurements using a single-cell imaging assay with fluorescent forms of PER and TIM showed that these proteins bind rapidly and persist in the cytoplasm while gradually accumulating in discrete foci. After approximately 6 hours, complexes abruptly dissociated, as PER and TIM independently moved to the nucleus in a narrow time frame. The per(L) mutation delayed nuclear accumulation in vivo and in our cultured cell system, but without affecting rates of PER/TIM assembly or dissociation. This finding points to a previously unrecognized form of temporal regulation that underlies the periodicity of the circadian clock. 相似文献
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哺乳动物昼夜节律生物钟是以24 h为周期的自主维持的振荡器。在分子水平上,生物钟的振荡由自身调控反馈环路的转录和翻译组成,并接受外界环境因素的影响,通过下丘脑视叉上核(Supra Ch iasm atic N u-cleus,SCN)中枢震荡器的同步整和而产生作用。文章对生物钟上下游的分布、反馈环路的转录、翻译后事件、视觉通路、钟的整和等方面进行了综述,并对其今后的研究方向作了展望。 相似文献
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Transcription of class III genes: formation of preinitiation complexes 总被引：125，自引：0，他引：125
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