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牛病毒性腹泻黏膜病的诊断要点及防治措施 总被引：1，自引：0，他引：1
牛病毒性腹泻-黏膜病又称牛病毒性腹泻、牛黏膜病。本病是由牛病毒性腹泻-黏膜病病毒引起的牛的热性传染病。临床特征是厌食,腹泻、脱水、体重减轻,黏膜发炎、糜烂和坏死,以及流产胎儿发育异常等。 相似文献
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牛病毒性腹泻-黏膜病又称牛病毒性腹泻．牛黏膜病。本病是由牛病毒性腹泻-黏膜病病毒引起的牛的热性传染病。临床特征是厌食，腹泻、脱水、体重减轻，黏膜发炎．糜烂和坏死，以及流产胎儿发育异常等。 相似文献
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牛病毒性腹泻-黏膜病（BVD/MD）,又称牛病毒性腹泻（BVD）或牛黏膜病（MD）,是由牛病毒性腹泻病毒引起的一种极为复杂、呈多临床类型表现的疾病。1946年由Olafson等在纽约首次发现。本病在世界各国普遍存在,尤其养牛业发达的地区,这 相似文献
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牛病毒性腹泻-黏膜病是由牛病毒性腹泻病毒(又名黏膜病病毒)引起的,以患牛出现腹泻,口腔、鼻腔黏膜发炎、糜烂、坏死为主要特征的疾病,简称牛病毒性腹泻或牛黏膜病.
1 病原及流行病学
牛病毒性腹泻-黏膜病的病原为牛病毒性腹泻病毒属黄病毒科、瘟病毒属成员,该病毒为单股RNA病毒,呈球形,有囊膜,直径50～80nm,其对高温较为敏感,56℃条件下可很快被灭活,但在低温条件下病毒较稳定,其在-70℃条件下可冻干保存多年,普通消毒药物可很快将其杀死.该病毒可在胎牛的肾、睾丸、肺等牛源性细胞及猪肾细胞上生长,胎牛睾丸细胞和肾细胞最易被感染. 相似文献
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牛病毒性腹泻-黏膜病（BVD-MD）又称牛病毒性腹泻病,由牛病毒性腹泻黏膜病病毒（BVD-MDV）引起。笔者从牛病毒性腹泻病的流行特点、临床症状、发病特点、治疗及预防方法等方面进行介绍。 相似文献
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牛病毒性腹泻-黏膜病（Bovine viral diarrhoea virus-Mucosal disease,BVDV-MD）是由黄病毒科、瘟病毒属的牛病毒性腹泻病毒（Bovine viral diarrhea virus,BVDV）引起的一种传染病。临床上以发热、腹泻、黏膜糜烂、流产或产畸型胎儿为主要特征。病毒引起的急性疾病称为牛病毒性腹泻,引起的慢性持续性感染称为黏膜病,该病呈世界性分布。 相似文献
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正牛病毒性腹泻-黏膜病简称牛病毒性腹泻或黏膜病。1946年Olafson在美国新纽约州发现了一种临床上以腹泻为主的牛接触传染性病毒病,其症状和剖检病变较轻,发病率高而死亡率低,称为病毒性腹泻。1953年Ramsey和Chivers又发现了一种与牛病毒性腹泻十分相似的疾病,但是发病率不高而死亡率高。由于此病的消化道有严重的糜烂和溃疡,故命名为黏膜病。起初这两种病因为在临床症象、病理损害以及 相似文献
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牛病毒性腹泻又名黏膜病。病原为牛病毒性腹泻／黏膜病病毒。各种年龄的牛均有易感性，犊牛、青年牛易感性强，发病中以顽固性腹泻、排灰色或黑色恶臭并混有黏液或血液的糊状粪便．且伴有鼻镜、口腔黏膜糜烂或溃疡等症状为特征，易形成毒血症。死亡率较高。 相似文献
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Thirty-two monoclonal antibodies directed against epitopes on bovine viral diarrhea virus proteins and glycoproteins were tested for immunohistochemical reactivity with bovine viral diarrhea virus in formalin-fixed and paraffin-embedded tissues from 45 cases of bovine viral diarrhea virus-associated mucosal disease. Only one antibody, designated 15C5, which reacts with the 48-kD glycoprotein of bovine viral diarrhea virus, detected an epitope preserved in these specimens. Monoclonal antibody 15C5 and a polyclonal antibody to bovine viral diarrhea virus successfully detected bovine viral diarrhea viral antigens in 44/45 cases of mucosal disease and did not react with formalin-fixed tissues from 30 uninfected cattle. Monoclonal antibody-based immunohistochemical detection of bovine viral diarrhea virus is routinely fixed tissue specimens has advantages over other currently available techniques in terms of the convenience of specimen submission, the relative ease of method standardization, and the rapidity of the test, and by enabling identification of the virus in association with specific tissues, cell types, and histologic lesions. 相似文献
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Goens SD 《The Canadian veterinary journal. La revue veterinaire canadienne》2002,43(12):946-954
The economic importance of bovine viral diarrhea is increasing with the emergence of seemingly more virulent viruses, as evidenced by outbreaks of hemorrhagic syndrome and severe acute bovine viral diarrhea beginning in the 1980s and 1990s. It appears that evolutionary changes in bovine viral diarrhea virus were responsible for these outbreaks. The genetic properties of the classical bovine viral diarrhea virus that contribute to the basis of current diagnostic tests, vaccines, and our understanding of pathogenic mechanisms are now being reevaluated because of these "new" virus strains. This shift in virulence has confounded both nomenclature and the significance of current bovine viral diarrhea virus categorization. The purpose of this review is to summarize our current understanding of bovine viral diarrhea virus with a chronological review of prevailing scientific tenets and practices as described in clinical and scientific North American veterinary journals and textbooks. The first part of this review describes how we have arrived at our current understanding of the viruses, the diseases, and their nomenclature. The second part of the review deals with current concepts in virology and how these concepts may both explain and predict bovine viral diarrhea virus pathogenesis. By reviewing how knowledge of bovine viral diarrhea has evolved and the theories of how the virus itself is able to evolve, the interpretation of diagnostic tests are more effectively utilized in the control and treatment of bovine viral diarrhea virus associated disease. 相似文献
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D Deregt K G Loewen 《The Canadian veterinary journal. La revue veterinaire canadienne》1995,36(6):371-378
Bovine viral diarrhea virus continues to produce significant economic losses for the cattle industry and challenges investigators with the complexity of diseases it produces and the mechanisms by which it causes disease. This paper updates and attempts to clarify information regarding the roles of noncytopathic and cytopathic bovine viral diarrhea viruses in persistent infections and mucosal disease. It also covers, in brief, what is known of the new diseases: thrombocytopenia and hemorrhagic disease, and a disease resembling mucosal disease that is apparently caused solely by noncytopathic virus. Although a good understanding of the roles of the 2 biotypes in the production of persistent infections and the precipitation of mucosal disease has been obtained, there are still unanswered questions regarding the origin of cytopathic viruses and the mechanism by which they cause pathological changes in cells. It is apparent, however, that cytopathic bovine viral diarrhea viruses arise by mutation of noncytopathic viruses, and it is known that p80 is the marker protein for cytopathic viruses. The previous distinction between mild bovine viral diarrhea and fatal mucosal disease has been eroded with the emergence of new virulent bovine viral diarrhea viruses. The new diseases pose a threat to the cattle industry and present a new challenge for investigators. Index Veterinarius (1984-1994) and Medline (1985-1994) databases and personal files updated since 1987 from BIOSIS Previews and Biosciences Information Services were used to search the literature. 相似文献
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牛病毒性腹泻是由病毒性腹泻病毒感染引发的一种传染性疾病,临床上主要表现为急性型、慢性型和隐性感染,其中急性型和慢性型对牛的生长发育会造成巨大影响。为更好地控制该种疾病发生流行,该文主要分析牛病毒性腹泻的诊断和治疗。 相似文献
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Investigation of an outbreak of mucosal disease in a beef cattle herd in southwestern Saskatchewan. 总被引：2，自引：2，他引：0 
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下载免费PDF全文 L F Taylor J Van Donkersgoed O M Radostits C W Booker E J Dubovi J V van den Hurk E D Janzen 《The Canadian veterinary journal. La revue veterinaire canadienne》1994,35(7):425-432
This study describes the epidemiological investigation of an outbreak of mucosal disease that occurred on a ranch in southwestern Saskatchewan. Over a six-month period during the fall and winter of 1991-1992, in a herd of 515 beef cattle and 96 bison, 20 yearling cattle from a group of 105 housed in one feedlot pen died from mucosal disease. A further eight yearlings were slaughtered for salvage because they were at risk of dying from mucosal disease. Mucosal disease mortalities were the first observed evidence of fetal infections with bovine viral diarrhea virus in this herd. Animals that died from mucosal disease exhibited signs of ill thrift prior to death. Deaths from mucosal disease were confined to the progeny of one herd of beef cows. Following an outbreak of fetal infection with bovine viral diarrhea virus during 1989-1990, at least 28 (22%) of the 128 calves born from this herd of cows in the spring of 1990 were persistently infected with bovine viral diarrhea virus. However, only one calf born from this herd in 1991, and five calves born from all herds in 1992 were persistently infected. Of the five persistently infected calves born in 1992, three were born to persistently infected replacement heifers born in 1990. These heifers calved without assistance in 1992, but only one of their calves survived past three days of age, and it was persistently infected. In January 1992, 82% of the total herd had reciprocal antibody titers to bovine viral diarrhea virus of > or = 1024 which suggested a high level of herd immunity to bovine viral diarrhea virus.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
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根据已发表的牛病毒性腹泻病毒株的基因序列,分析合成了一对扩增跨幅为190bp左右的引物,对牛病毒性腹泻病基因I型或基因II型的毒株进行RT-PCR扩增,结果是取得了与预期大小一致的RT-PCR产物,而对照样品的扩增全为阴性;该方法最低可检测到0.10ng的牛病毒性腹泻病毒RNA。 相似文献
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J A Ellis 《Veterinary Clinics of North America: Food Animal Practice》2001,17(3):535-50, vi-vii
The bovine respiratory disease complex continues to be an economically important syndrome in an era when immunologic control is likely to become increasingly important. Recent studies have yielded a better understanding of the interaction, at the molecular level, of various pathogens with the bovine immune system. Improved challenge models for important viral pathogens such as bovine viral diarrhea virus and bovine respiratory syncytial virus have provided evidence of the efficacy of immune responses stimulated by vaccination. This article highlights recent advances in understanding of the role of the immune response in the pathogenesis and prophylaxis of bovine respiratory disease complex. 相似文献