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中国人民解放军兽医大学军事兽医研究所寄生虫病研究组 《中国兽医学报》1986,(2)
1984～1985年我们先后研制、提取12批桔皮油,试验用于治疗獭兔、吉林白兔的耳螨病及足螨病。共治疗500余例,全部治愈。经与有机磷、有机氯等作对比治疗试验,用桔皮油治疗兔螨病具有显效快、治疗期短、方法简便、无毒副作用等优点,深受用户欢 相似文献
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四川红桔皮化学成分对家兔耳(足)螨病治疗试验 总被引：2，自引：0，他引：2
用从四川红桔皮中提取的7种化学成分,即川陈皮素(nobiletin)、蜜桔素(tangeratin),5-去甲川陈皮素(5-o-demethyl nobiletin)、4',5,7,8-四甲氧基黄酮(4',5,7,8-tetrahydroxylflavone)、麝香草酚(thymol)、β-谷甾醇(β-sitosterol)、异橙黄酮(isosi-nensetin) (依次用A,B,C,D,E,F,G代表),对兔螨进行了离体杀灭比较试验。结果以C、D、G杀螨力较强,其中又以G最强,1000倍稀释G液15 min能杀死10/10螨虫,C、D液则需4 h才能杀死10/10螨虫,对照组14 h仍有7/10螨虫存活。用G和桔皮油、辛硫磷对比杀螨,G 5～20 min、枯皮油5～30 min均可杀死10/10螨虫,而辛硫磷在6 h还有3/10活螨.以不同稀释倍数G液对5只耳螨兔进行治疗试验,结果250-500倍稀释G液治疗3 d 5/5治愈,1 000-10 000倍稀释者需7～14 d才全部治愈.进而用250-500倍稀释G液对不同养兔单位的208只耳(足)螨兔扩大治疗试验,有效率为100％,其中连续用药2～3次者,97.3％完全治愈,2.7％好转;仅治疗1次者,92％完全治愈,8％好转.用G液治疗兔螨病,无任何毒副作用. 相似文献
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桔皮素乙酰酯对兔耳痒螨药效试验 总被引：7，自引：0，他引：7
将桔皮素乙酰酯制成１％乳浊液,再稀释成一定倍数进行家兔耳痒螨离体药效试验。结果浓度为０．１％～０．０２％的乳浊液在２～１０ｍｉｎ杀死家兔耳痒螨;用１％桔皮素乙酰酯酒精溶液滴耳治疗兔耳痒螨病,结果用药１～２次,７ｄ明显好转,１４ｄ耳道瘕皮脱落完全治愈。 相似文献
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家兔疥癣病的病原体为疥螨、痒螨、足螨。该病以耳、足为多发部位。患部表现红肿、湿润、结痂、脱毛、皮肤增厚。病兔体况消瘦。如由痒螨引起的疥癣病,还表现为剧痒,摇头搔耳,抖动患足,啃咬患部,食欲减退,神情不安。疥癣是兔的一种慢性接触性多发病,常发生在秋冬季,其发病率有时高达85% 相似文献
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桔皮油对螨病的治疗研究 总被引：3，自引：0，他引：3
在对桔皮油进行了分析、纯化、药理、毒理等基础及临床应用系列研究后，用于兔、羊的螨病治疗，有效率为１００％，兔螨治疗２～３次者可１００％治愈；对羊螨病的局部涂擦及药浴治疗均获得满意效果。经毒副试验及治疗观察，本品无毒副作用，不污染环境。 相似文献
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刘学波 《畜牧兽医科技信息》2016,(4):127
正兔痒螨病是由两种病原体所引起,即痒螨科痒螨属的兔痒螨和足螨属的兔足螨寄生于兔的外耳道引起的一种体外寄生虫。它的特征是可引起外耳道炎,也可以引起癫痫症状。1临床症状2015年12月16日,本人接到双塔镇一塔村严某的电话,他家养了50只兔,兔不停的摇头,同时用脚抓搔头部和耳。 相似文献
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桔皮素衍生物对离体兔耳痒螨药效筛选试验 总被引：4，自引：0，他引：4
将桔皮素化学结构改造后获得的７种衍生物制成乳浊液含桔皮素１２．５％,再按要求稀释至所需浓度,对离体兔耳痒螨进行药效筛选试验。结果新衍生物有较好的杀螨作用,效果优于灭螨灵,与双甲脒、螨净相近。试验表明,０．０２％的磺酸取代物在４０ｍｉｎ内将螨虫全部杀灭,０．０５％桔皮素的溴取代物－１、溴取代物－２、碳酸酯、甲基酮－１和甲基酮－２分别在３５、３０、２０、１６和４０ｍｉｎ内将螨虫全部杀灭,０．０５％和０．０２％的桔皮素乙酰酯分别在５和１０ｍｉｎ内将螨虫全部杀灭。对照药品灭螨灵、螨净在０．０２％浓度时分别在１５和１４ｍｉｎ内将螨虫全部杀灭。 相似文献
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痒螨病为家兔党见寄生虫病 ,危害比较严重。痒螨通过接触进行传播 ,可导致整个兔群发病。病兔以皮肤炎症、剧痒 ,消瘦为主要外部特征〔1〕。关于痒螨病兔的血液变化情况未见详细报道。为探讨痒螨对家兔血液的影响 ,笔者对 1 0只健康兔和 6只病兔进行血细胞分析 ,现将结果报告如下 :1 材料与方法1 .1 实验用兔选用新西兰白兔 1 6只 (由本中心提供 ) ,包括1 0只健康兔和 6只轻度感染耳痒螨的病兔 ,体重在2 .2～ 3.1 kg之间。1 .2 抗凝血制备从兔耳缘静脉采血 0 .5m L,加入含有抗凝剂的小离心管内 ,混匀。1 .3 样本分析采用 CELL- DYN… 相似文献
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C. THOMAS M. FINN L. TWIGG P. DEPLAZES RCA THOMPSON 《Australian veterinary journal》1997,75(11):808-810
Objective To determine the prevalence of infection with Encephalitozoon cuniculi i n wild rabbit populations in Western Australia, and to isolate the organism from seropositive rabbits.
Design Serological screening of wild and clinically affected domestic rabbit populations.
Sample population Eighty-one wild rabbits from southwestern Western Australia and 29 laboratory rabbits.
Procedure Indirect immunofluorescence antibody technique and in-vitro amplification of parasite isolates in fibroblast cultures.
Results Of the 81 wild rabbits and 29 laboratory rabbits, 20 and 22 respectively, had antibodies to E cuniculi . E cuniculi from the urine of one seropositive laboratory rabbit and from brain and kidney tissues of eight and five seropositive laboratory and wild rabbits respectively were isolated in fibroblast cultures.
Conclusion E cuniculi infection has been shown for the first time to be prevalent in wild rabbits in Australia. Techniques have been developed for the isolation and culture of the causative agent. Comparative studies can now be undertaken to determine risk factors for clinical disease in domestic rabbits and the relationship among E cuniculi isolates from wild and domestic rabbits. 相似文献
Design Serological screening of wild and clinically affected domestic rabbit populations.
Sample population Eighty-one wild rabbits from southwestern Western Australia and 29 laboratory rabbits.
Procedure Indirect immunofluorescence antibody technique and in-vitro amplification of parasite isolates in fibroblast cultures.
Results Of the 81 wild rabbits and 29 laboratory rabbits, 20 and 22 respectively, had antibodies to E cuniculi . E cuniculi from the urine of one seropositive laboratory rabbit and from brain and kidney tissues of eight and five seropositive laboratory and wild rabbits respectively were isolated in fibroblast cultures.
Conclusion E cuniculi infection has been shown for the first time to be prevalent in wild rabbits in Australia. Techniques have been developed for the isolation and culture of the causative agent. Comparative studies can now be undertaken to determine risk factors for clinical disease in domestic rabbits and the relationship among E cuniculi isolates from wild and domestic rabbits. 相似文献
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Dipineto L Rinaldi L Santaniello A Sensale M Cuomo A Calabria M Menna LF Fioretti A 《Zoonoses and public health》2008,55(3):173-175
Pet rabbits (n = 125) from Southern Italy were submitted to a serological screening for Encephalitozoon cuniculi, using an enzyme-linked immunosorbent assay (ELISA) and a carbon immunoassay (CIA). Seventy-eight examined rabbits showed clinical signs suggestive of encephalitozoonosis (head tilt, ataxia, paralysis, cataracts, uveitis, polyuria and polydipsia), whereas 47 were healthy rabbits. Antibodies anti-E. cuniculi were found in 84/125 (67.2%) sera analysed. The results of the chi-squared test showed that sex and health status had no significant effect (P > 0.05) on E. cuniculi seropositivity; however, rabbits older than 4 months had a seropositivity for E. cuniculi significantly (P < 0.05) higher than that of rabbits aged up to 4 months. The results of the present survey reinforce the assumption that rabbit may be indicated as the main reservoir of E. cuniculi; therefore, routine screening examinations in pet rabbits are strongly advised considering the zoonotic potential of this parasite. 相似文献
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Giordano C Weigt A Vercelli A Rondena M Grilli G Giudice C 《Veterinary ophthalmology》2005,8(4):271-275
PURPOSE: Encephalitozoon cuniculi is a microsporidium with a wide range of mammalian hosts. In rabbits it can be responsible for cataract and lens-induced uveitis (LIU). The aim of this study was to provide specific immunohistochemical demonstration and localization of E. cuniculi within the eye, in rabbits with LIU. MATERIAL AND METHODS: Four rabbits were presented with a white mass in the eye and iris discoloration. Complete ophthalmic examinations were performed and a presumptive diagnosis of LIU was made in all cases. Initial therapy with a topical steroid, atropine and systemic enrofloxacin was instituted while serologic (IFA or ICA tests) and cytologic lab results were pending. The final outcome in all cases was enucleation. Routine histology and immunohistochemistry (ABC method) with an antiserum anti-Encephalitozoon cuniculi were performed. RESULTS: Indirect immunofluorescence performed on one rabbit serum expressed a titer of 1 : 32; carbon immunoassay on the serum of the other three rabbits expressed a titer of 1 : 5120 in one, and a titer of 1 : 2560 in the other two cases. Histologically, an intraocular, locally extensive pyogranulomatous infiltration that partially filled the posterior chamber, encasing a wide anterior lens capsule break, was detected in all cases. Immunohistochemically, spores reacting with anti-Encephalitozoon cuniculi antiserum were present in all specimens, occasionally within macrophages and lens epithelial cells. CONCLUSION: Detection of E. cuniculi in rabbits with phacoclastic uveitis has been investigated in the past with different methods. Based on our results, we suggest that immunohistochemistry should be regarded as a useful tool both for specific demonstration of E. cuniculi and for its localization within tissues. 相似文献
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R. W. Cook 《Australian veterinary journal》1981,57(2):72-75
SUMMARY The recently described species, Raillietia manfredi was recovered from ears of 24/185 (13%) goats and from 17/23 (74%) herds sampled. Psoroptes cuniculi was recovered from ears of 38/185 (21%) goats and from 5/23 (22%) herds. The youngest goat infested with R. manfredi was 14 days old. Common clinical signs attributed to ear mite infestation included twitching and scratching of ears, and head shaking. 相似文献
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Akerstedt J 《Veterinary parasitology》2003,113(3-4):203-210
Encephalitozoon cuniculi causes severe diseases in blue fox puppies. When pregnant vixens are infected, parasites are transmitted over the placenta to the unborn that subsequently develop encephalitozoonosis. Adult foxes themselves do not have signs of disease, but show antibody titres to E. cuniculi. The purpose of the present study was to gain information on the immune response in adult foxes after experimental infection. Sixteen foxes were infected orally with E. cuniculi spores, eight of them twice and 28 days apart. The two groups of animals showed elevated serological values in both the carbon immunoassay and in the ELISA. Elevated serological levels were recorded up to 1 year after the infection took place. The control group (n=8) remained serologically negative throughout the trial. The results of the study showed that blue foxes could be seropositive for at least a year after oral infection with E. cuniculi. 相似文献
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为了有效地治疗兔脑炎原虫病,本研究根据脑炎原虫的生物学特点和对组织损伤的特征选用阿苯达唑进行了治疗试验。将28只3～4月龄隐性感染的獭兔,随机分为对照组和治疗组进行试验。治疗组按30mg／kg剂量（首次给药量为50mg／kg）,每隔12h给药1次,连续用药10d,停药1周为1个治疗期,共治疗3个疗程。对照组按正常饲养。每1疗程之后,均采血和尿液进行ELISA检测和尿沉渣虫体检查。结果,治疗组的病兔用阿苯达唑治疗3个疗程后,ELISA检测的D值均低于标准值（〈0．044）,即抗脑炎原虫血清抗体呈阴性反应,从尿沉渣中也不能检出虫体。而对照组病免的D值则大大高于正常值．从尿沉渣中均易检出虫,并有1只对照兔出现典型的神经症状,剖检后从脑组织中检出脑炎原虫性肉芽肿。经方差分析,2组间差异非常显著（P〈0．01）。试验证明,阿苯达唑对兔脑炎原虫有良好治疗作用,用药的时机以脑炎原虫还未进入脑组织时最合适,用药的剂量一定要保持有效的杀虫浓度。 相似文献
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目的:探讨藏兽药蓝花侧金盏对兔螨的抑杀作用。方法:应用体外培养杀螨实验,比较了蓝花侧金盏水提取物、甲醇提取物、乙酸乙酯提取物及石油醚提取物的杀螨活性,并对活性较强的提取物的毒力和治疗兔螨病效果进行了评价。结果:4种提取物中,乙酸乙酯提取物具有较强的体外杀螨活性,高剂量(500 mg/mL)在体外培养6 h内全部杀死螨虫,4种浓度(500、250、125和62.5 mg/mL)的半数致死时间分别为0.743、2.73、5.919和22.536 h,并且其能有效治疗兔螨病,总有效率为90%。结论:蓝花侧金盏乙酸乙酯提取物具有良好的杀兔螨活性。 相似文献