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1.
Purified diets, formulated with and without lecithin and containing either casein or a protein isolated from whole crab, were fed to juvenile lobsters. In order to examine the role of these dietary factors on cholesterol uptake and transport, levels of cholesterol were determined in serum, lipo-protein fractions, tissues, and feces of juvenile lobsters fed the experimental diets. Lobsters fed diets supplemented with lecithin had significantly higher levels of serum and lipoprotein cholesterol than lobsters fed diets without supplemental lecithin regardless of the proteins used. Levels of fecal total cholesterol also were generally greater for lobsters fed lecithin-supplemented diets. Tissue, serum, and fecal levels of intubated radiolabeled cholesterol, however, were not significantly different among diet groups, and apoprotein electrophoretic mobility was not affected by the choice of dietary protein.  相似文献   

2.
An 80‐day feeding trial was conducted to evaluate the effects of dietary ascorbic acid (AA) supplementation at different levels (0, 0.2 and 0.4 g/kg l ‐ascorbate‐2‐polyphosphate; 7.6, 77.2 and 146.7 mg/kg AA, respectively) on cholesterol metabolism in rainbow trout (Oncorhynchus mykiss). Dietary AA supplementation regardless of inclusion level increased the serum total cholesterol and low‐density lipoprotein (LDL) cholesterol levels and LDL cholesterol/high‐density lipoprotein cholesterol ratio. No significant differences were observed in the serum triiodothyronine and thyroxine levels, faecal cholesterol content, hepatic activity and mRNA expression of acyl‐coenzyme A:cholesterol acyltransferase among the dietary treatments. Dietary AA inclusion increased the faecal bile acid content, hepatic activity and mRNA expression of 3‐hydroxy‐3‐methylglutaryl coenzyme A reductase and hepatic cholesterol 7α‐hydroxylase mRNA expression, but decreased the hepatic LDL receptor content. High level of AA supplementation (0.4 g/kg) depressed the serum cortisol levels. These results suggest that dietary supplementation with 0.2?0.4 g/kg l ‐ascorbate‐2‐polyphosphate may increase the serum total cholesterol level in rainbow trout. The cholesterol‐raising effect of AA may be due to the increased hepatic cholesterol production and the depressed cholesterol clearance from serum. In addition, dietary AA inclusion also facilitates the hepatic conversion of cholesterol to bile acids.  相似文献   

3.
In teleosts, cortisol is one of the key factors regulating the adaptation to environmental challenges, such as salinity changes. This paper compares interrenal function between fully adapted freshwater (FW) and sea water (SW) specimens of the euryhaline teleost Oreochromis mossambicus (tilapia), combining morphometric and biosynthetic approaches. Interrenal tissue and two tissues producing interrenal secretagogues (ACTH and ANP; atrial natriuretic peptide) were studied. The results demonstrate that sea water adaptation concurs with a sustained stimulation of the interrenal cells, as evidenced by a marked hyperplasia of the cells and the higher initial ex vivo cortisol release in seawater adapted tilapia. This difference was not reflected in ultrastructural differences in the pituitary corticotropes. Plasma ACTH levels were also similar in FW and SW adapted tilapia. Moreover, in vitro data indicate that the ACTH sensitivity of the interrenal cells of both groups was also similar. A second potential interrenal secretagogue (ANP) has recently been implicated in teleost ionic regulation during salinity changes. However, plasma immunoreactive ANP levels and in vitro production of the hormone were also indistinguishable between FW and SW tilapia. ANP pretreatment of tilapia head kidneys in vitro strongly inhibited the response to ACTH, an effect previously undocumented for teleosts. Whereas the sustained stimulation of the interrenal cells under sea water conditions corroborates results obtained with other teleost species, thereby supporting a hypoosmoregulatory role for cortisol, it also is evident that notable species differences exist regarding the regulation of the interrenal gland under these conditions.  相似文献   

4.
低温胁迫对罗非鱼血液生化、免疫及抗氧化指标的影响   总被引：4，自引：0，他引：4  
彭婷  胡庭俊  林勇  唐章生  曾兰 《水产科学》2012,31(5):259-263
研究4个温度T20(20℃)、T16(16℃)、T12(12℃)和T10(10℃)对90日龄尼罗罗非鱼生化、免疫及抗氧化指标的影响。结果显示,水温降至16℃时,与对照组(T20)比较,罗非鱼血清总蛋白、总胆固醇、白蛋白含量极显著降低(P0.01),血清球蛋白含量和脾脏黄嘌呤氧化酶活性显著降低(P0.05),脾脏过氧化物酶活性显著升高(P0.05)。水温降至12℃时,与对照组(T20)比较,血清总蛋白、白蛋白含量与脾脏总抗氧化力极显著降低(P0.01),血清球蛋白、总胆固醇含量与脾脏黄嘌呤氧化酶活性显著降低(P0.05),血清尿素含量显著上升(P0.05),血糖含量极显著上升(P0.01)。水温降至10℃时,与对照组(T20)比较,罗非鱼血清中白蛋白、总胆固醇含量和脾脏黄嘌呤氧化酶活性极显著降低(P0.01),血清中总蛋白、甘油三酯含量和脾脏过氧化氢酶活性水平显著降低(P0.05),血清中尿素含量极显著上升(P0.01),血糖含量极显著上升(P0.01),脾脏总超氧化物歧化酶活性显著升高(P0.05)。试验结果表明,罗非鱼的生化、免疫及抗氧化指标均随着温度的降低发生改变,与低温胁迫致罗非鱼昏迷及死亡有关。  相似文献   

5.
促肾上腺皮质激素释放激素受体(corticotropin-releasing hormone receptor,CRHR)是鱼类下丘脑–垂体–头肾调控轴上的重要应激调节因子。本研究通过c DNA末端快速扩增(RACE)技术成功克隆出团头鲂(Megalobrama amblycephala)CRHR1 m RNA全长序列,应用生物信息学方法对其序列特征进行解析;同时采用荧光定量PCR技术分析了团头鲂CRHR1的组织分布图谱及外源性皮质醇注射模拟应激处理下团头鲂CRHR1 m RNA的表达变化。研究结果表明,CRHR1 m RNA序列开放阅读框(open reading frame,ORF)为1290 bp,编码429个氨基酸。团头鲂CRHR1氨基酸序列与鲤科鱼类的CRHR1氨基酸序列同源性最高;该受体具有7次横跨膜结构和氨基端激素受体结构域。CRHR1在垂体中表达量最高,其次为下丘脑,在心脏、肝、脾等组织中表达丰度较低。经外源性皮质醇注射后,实验组血糖和血清皮质醇显著高于对照组,在处理2 h后达到峰值;实验组血清ACTH水平与对照组差异总体不显著,但呈现先升高后下降。应激处理后,CRHR1转录水平在4种组织中的表达变化存在差异;垂体中CRHR1在早期出现明显的表达抑制,在下丘脑中则呈现先缓慢升高后缓慢下降的趋势,而心脏和头肾中CRHR1在早期则表现出表达迅速上调而后缓慢下降的趋势。本研究进一步丰富了CRHR在鱼类研究方面的基础资料,为鱼类应激调控提供了理论基础。  相似文献   

6.
The regulation of the interrenal of teleostean fishes is reviewed from the perspective of non-classical control mechanisms and new evidence is presented suggesting gonadotropic control of the interrenal. Cortisol secretion by the interrenal, in addition to regulation by ACTH, appears to be mediated by other hormones. Physiologically relevant, direct control of interrenal function by hydromineral factors is unclear.In vitro experiments with interrenals of coho salmon (Oncorhynchus kisutch) indicate that salmon gonadotropin is extremely corticotropic and both ACTH and gonadotropin stimulate the secretion of large quantities of androstenedione from the interrenal.  相似文献   

7.
This study examined the effects of boat noise pollution on the stress indices of gilthead sea bream (Sparus aurata, Linnaeus 1758). To assess the stress response in these fish, biometric values and plasma parameters such as ACTH, cortisol, glucose, lactate, haematocrit, Hsp70, total protein, cholesterol, triglycerides and osmolarity were analysed. After acclimatization of the animals, the experiment was carried out in a tank fitted with underwater speakers where the fish were exposed to sound treatments (in duplicate) consisting of: 10 days of no sound (control treatment; the animals were only exposed to the experimental tank’s background noise) and 10 days of noise derived from original recordings of motor boats, including recreational boats, hydrofoil, fishing boat and ferry boat (vessel noise treatment). The exposure to noise produced significant variations in almost all the plasma parameters assessed, but no differences were observed in weights and fork lengths. A PERMANOVA analysis highlighted significantly increased values (p < 0.05) of ACTH, cortisol, glucose, lactate, haematocrit, Hsp70, cholesterol, triglycerides and osmolarity in the fish exposed to vessel noise for 10 days. This study clearly highlights that anthropogenic noise negatively affects fish, and they are valuable targets for detailed investigations into the effects of this global pollutant. Finally, these experimental studies could represent part of the science that is able to improve the quality of the policies related to management plans for maritime spaces (Marine Strategy Framework Directive 56/2008 CE) that are aimed at stemming this pollutant phenomenon.  相似文献   

8.
In this study, we showed that feeding rats the organic extract of scallop shells (scallop shell extract) caused a decrease in the weights of white adipose tissues in rats fed a high-fat diet. In addition, the cholesterol concentration in the serum of rats that received a diet containing scallop shell extract was significantly lower than that in the serum of rats on the control diet. Feeding this scallop shell extract to rats increased the fecal weight as well as the fecal excretion of bile acids. The amino acid composition of the feces from rats fed the scallop shell extract was different from that of feces from rats fed the control diet, and treatment of the extract with pepsin and pancreatin identified a protein with a molecular weight of 90 kDa (90-kDa protein) as one of the indigestible proteins. Interestingly the 90-kDa protein was found to be identical to a free radical-scavenging protein we previously identified and showed the ability to bind bile acids. These results suggest that indigestible proteins (resistant proteins) in the scallop shell extract, including the 90-kDa protein, inhibit the absorption of bile acid by binding to it and cause increased excretion of fecal bile acid, which subsequently may decrease the serum cholesterol level.  相似文献   

9.
This study investigates the effect of corticosteroid (cortisol) administration on the stress response of the gilthead sea bream Sparus aurata subjected to a 48 h confinement. The effect of (in-vitro and in-vivo ) cortisol administration on the in-vitro ACTH sensitivity of the interrenal tissue; the plasma levels and tissue concentration of cortisol; and the plasma levels of ACTH, -MSH, -endorphin and glucose were determined. Confinement caused a transient and concomitant increase in plasma cortisol and ACTH levels. However, in cortisol-fed fish the plasma ACTH levels were lower, indicating a suppresion of the ACTH release from the corticotropes by cortisol. In contrast to the activation of the corticotropes, the levels of plasma melanotrope derived peptides were not affected. In spite of the fact that interrenal cells of cortisol-fed gilthead sea bream released less cortisol than controls, the interrenal sensitivity to ACTH was not affected by in-vivo and in-vitro cortisol administration. This suggests that the interrenal sensitivity to ACTH in stressed (confinement) sea bream is probably not regulated by -MSH, N-ac--END, or by cortisol. Thus, in gilthead sea bream the interrenal sensitivity to ACTH could be regulated at the hypothalamus and/or pituitary and communicated via circulating ACTH levels.  相似文献   

10.
The individual polar and neutral lipids of plaice (Pleuronectes platessa L.) ovaries, testes and serum were determined, just before spawning, in February 1984 and March 1985. Serum was also assayed in June and September 1984. Phosphatidylcholine (PC) was found to be the major polar lipid in both male and female plaice serum throughout the year and in the ovaries. The testes, however, contained almost equal amounts of PC and phosphatidylethanolamine. The polar lipid levels in plaice gonads, expressed as a percentage of the total lipid present, were higher in the ovaries than in the testes, but in male plaice serum, the percentage of polar lipid was consistently higher than in the female. In plaice testes, 86% of the total neutral lipid occurred as cholesterol, but this represented only 49% of the total neutral lipid in the ovaries, with triacylglycerol as the other major ovarian neutral lipid.  相似文献   

11.
Multiple malformations were shown in a bovine fetus delivered at slaughter after a gestation period of 469 days. Hypoplasia of the adenohypophysis and a bilateral agenesis of the adrenal cortex suggest that the failure of initiation of parturition resulted from a fetal deficiency of ACTH and glucocorticoid hormones. ACTH, GH (growth hormone) and prolactin could not be demonstrated immunohistochemically within the adenohypophysis. However, TSH immunoreactive pituitary cells were demonstrable. Nevertheless, considering the extremely reduced size of the adenohypophysis a fetal deficiency of TSH is suspected. This view is supported by a bilateral hypoplasia of the thyroid gland. Additionally, the complex fetal endocrine dysfunction had led to a growth retardation of the fetus.  相似文献   

12.
Fish, Clarias Lazera were orally administered onion (Allium cepa) or garlic (Allium sativum) juices. Contents of glucose, free amino acids, total lipids, triglycerides, cholesterol, albumin, total protein, urea, aspartate aminotransferase (AST) and alanine aminotransferase (ALT) in serum as well as glycogen, free amino acids, total lipids, triglycerides and cholesterol contents in liver, white and red muscle were determined 5 h and 24 h after a single dose or after repeated doses (1 dose every 24 h for 5 days). Both onion and garlic treatments caused a temporary hypoglycemia as well as liver glycogen muscle depletion accompanied with a significant elevation in white muscle glycogen suggesting that dietary onion or garlic may enhance the process of glycogenesis in white muscle. Onion feeding caused hypolipidemia accompanied with significant decreases in liver content of total lipids in response to the repeated doses for 5 days and a severe rise in the lipid content of red muscle at all periods. Such results suggest that dietary onion may enhance the process of lipogenesis in red muscle of Clarias lazera. Probably, the main precursor of such lipogenesis in the red muscle was the serum fatty acids. Moreover, dietary onion led to hypocholesterolemia accompanied with a significant rise in cholesterol level of both liver and red muscle. On the other hand, dietary garlic significantly decreased serum free amino acids after 5 h and 5 days. Furthermore, significant elevations of liver free amino acids were dedected in the onion-treated fish group (24 h and 5 days) and in the garlic-treated fish group (5 h), probably due to oxidation of thiol components (sulfur attached to the proteins). This result was accompanied with either a marked increase in white muscle free amino acids at all periods of garlic fish group, or a noticeable drop in the onion group (repeated doses). Also, dietary onion and garlic treatment led to an elevation in hepatic ureagenesis in spite of the unchanged serum urea level. Significant decreases of both serum AST and ALT in garlic groups (all periods) and in onion groups (repeated doses) were observed. In liver, AST and ALT showed temporary rises after onion or garlic supplementation. In general, it could be concluded that both dietary onion and garlic have a transitory hypoglycemic action as well as a promoting effect on the process of glycogenesis in white muscle whereas dietary onion promotes lipogenesis in red muscle of fish. Also, dietary garlic may enhance the white muscle uptake of free amino acids which, in turn, may promote protein synthesis.  相似文献   

13.
A feeding trial was conducted to investigate the effect of partial fish meal (FM) replacement by dietary soybean meal (SBM) on the growth and protein and lipid metabolism of the juvenile Japanese flounder. Four isonitrogenous and isolipidic diets (Diets 1–4) were formulated containing 47% protein and 9% lipid with different SBM inclusion (Diet 1, 11%; Diet 2, 16%; Diet 3, 24%; and Diet 4, 41%). The fish were fed to satiation twice daily for a feeding period of 56 days. The weight gain rate (WGR) and protein efficiency ratio of fish fed Diet 4 were significantly lower than those fed Diets 1, 2, and 3, and feed conversion ratio in the group fed Diet 4 was significantly higher than that in the groups fed Diets 1, 2, and 3. Hepatosomatic indices showed the similar trend as WGR, and the value (1.75%) for Diet 1 was significantly lower than that (1.96–2.2%) for other diets. There were no differences in whole body moisture, crude protein, crude lipid, and ash content among all treatments. With increasing dietary SBM level, serum triglyceride (TG), cholesterol (CHO), and low-density lipoprotein cholesterol (LDL-C) concentrations increased, whereas the serum total protein (TP) and high-density lipoprotein cholesterol (HDL-C) concentrations decreased. Compared with Diet 1, the serum TG, CHO, and LDL-C concentrations of fish fed Diet 4 significantly increased by 78, 37, and 36%, respectively, while the TP and HDL-C concentrations decreased by 14 and 33%, respectively. No significant differences in condition factor, blood urea nitrogen concentration, and alanine and aspartate aminotransferase activities were observed among the dietary treatments. These results indicated that dietary SBM inclusion above 24% could adversely affect the growth and protein and lipid metabolism of Japanese flounder.  相似文献   

14.
猪油对罗非鱼生长及餐后脂质代谢的影响   总被引：1，自引：0，他引：1  
在实用饲料配方的基础上分别添加0%、5%、10%猪油组成试验饲料饲喂罗非鱼(Oreochromis niloticus)(初重43 g)8周,比较研究猪油不同添加水平对罗非鱼生长及餐后脂质代谢的影响。结果表明,罗非鱼的末重(FBW)、特定生长率(SGR)、增重率(WGR)和饲料效率(FE)随着饲料中猪油水平的增加而显著升高。而摄食量(FI)表现出相反的变化趋势,即高水平猪油组显著低于对照组。随猪油添加水平增加,罗非鱼肝胰脏超氧化物歧化酶(SOD)、谷丙转氨酶(ALT)和谷草转氨酶(AST)活力显著降低,而肝脏丙二醛(MDA)含量显著增加。血清中甘油三酯(TG)、胆固醇(CHO)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)和极低密度脂蛋白胆固醇(VLDL-C)含量均随饲料中猪油水平增加而显著升高。各试验组罗非鱼血清中CHO、TG、LDL-C和VLDL-C含量随时间推移均表现出先升高后降低的变化趋势,TG和VLDL-C的峰值出现在餐后6h,而CHO和LDL-C峰值在餐后9 h。但HDL-C表现出相反的变化趋势,即先降低后升高,在餐后6 h达到最低值。总之,饲料中添加不同水平猪油会促进罗非鱼生长,但会影响罗非鱼的肝功能以及餐后脂质代谢,罗非鱼抗氧化能力也相应受到影响。  相似文献   

15.
Baseline serum values of newly captured Malaysian prawns (Macrobrachium rosenbergii) and pink shrimp (Penaeus marginatus) were determined by Sequential Multiple AutoAnalysis. Both of these species have considerable potential for commercial captive culture.Sex differences in serum constituent levels were found within species. Female pink shrimp had higher serum glucose levels than the males. Malaysian prawn males had higher cholesterol levels than females, and the latter had higher levels or activities of urea nitrogen, creatinine and lactic dehydrogenase.Pink shrimp held under laboratory conditions for 10 days had higher levels or activities of serum glucose and alkaline phosphatase and lower levels or activities of serum inorganic phosphorus, total protein, lactic dehydrogenase and glumatic-oxaloacetic transaminase than pink shrimp sampled immediately after capture.  相似文献   

16.
The present study was aimed to establish reference data for nine serum biochemical attributes (glucose, protein, albumin, globulin, albumin/globulin ratio, cholesterol, triglycerides, serum glutamate oxaloacetate transaminase [SGOT] and serum glutamate pyruvate transaminase [SGPT]) of a supreme aquaculture candidate, namely Lutjanus argentimaculatus. Further, the influence of ecotype (cage–wild), condition index and gender on biochemical attributes was evaluated. The results have shown that gender and condition index had no significant effect in the studied age group, whereas ecotype had a significant role, except on serum glucose levels, suggesting the prime importance of estimating ecotype‐specific reference intervals for interpreting fish health. Intra‐ecotype variability of serum biochemical attributes, namely serum protein, globulin, cholesterol and triglycerides, was less, suggesting the possibility of using these parameters as health indices within a specific ecotype. Consistency in terms of the least intra‐ecotype variability coupled with PCA results points serum protein as the best ecotype‐specific health index among the different parameters studied. Altogether, the results of the present study provide thought‐provoking insights on serum biochemistry of L. argentimaculatus as a platform for the health management of this supreme aquaculture candidate.  相似文献   

17.
Sudden fish deaths occurred during summer peaks in India and expected to be more in future. This study was conducted to explain the biochemical responses of Labeo rohita under extreme thermal condition (treated: 37–38°C against controlled: 28–30°C). Exposure of 14 days resulted in 30% of fish mortality. Glucose concentration was maintained in serum for both treated and controlled groups. However, triglycerides, protein, globulin, calcium, cholesterol and haemoglobin were declined and enzymes (glutamate‐pyruvate transaminase, GPT and glutamate‐oxalate transaminase, GOT) were elevated in serum in the treated group. Indicators of overall metabolism (biomolecules: glucose, triglycerides, protein, cholesterol; enzymes: GPT, GOT; and RNA: DNA) were diminished in liver, whereas these were less affected in muscle. Higher GPT, GOT and lower albumin in serum confirmed disturbance in hepatic panel. Simultaneously compromised growth (lower SGR, DNA content in liver) was observed in treated fish due to impaired metabolism. Extreme thermal stress induced by such catastrophic warmer water exposure caused liver problems and anaemia which ultimately caused fish death.  相似文献   

18.
To investigate whether PCB 126 exposure duringembryonic development induces an endocrine stressresponse in larval carp, eggs were exposed,containing 0.01% ethanol (vehicle-control), 10-11,immediately after fertilization, for 48 h to water10-10 or 10-9 mol l-1 PCB in 0.01% ethanol. Eggsincubated in water served as controls. After transferto PCB-free water, mortality, the incidence ofyolk-sac and pe-ricardial oedema, wet and dry weight,rate of skin pigmentation, and whole-body contents ofthe stress hormones ACTH, -MSH and cortisol weredetermined at 48, 96, 144, 168, 192 and 216 hpost-fertilization. Except for the dry weight, allparameters of animals exposed to 10-10 and 10-9 moll-1 PCB increased in a concentration-related manner.However, these changes became evident only at 144 hpost-fertilization, i.e. after resorption of theyolk-sac. Swelling of the yolk sac and pericardiumoccurred, and whole-body ACTH, -MSH and cortisollevels increased. Although animals exposed to 10-10and 10-9 mol l-1 PCB displayed stable but elevatedwhole-body ACTH and -MSH levels until 216 h,whole-body cortisol concentrations gradually decreasedfrom 168 h post-fertilization, and were significantlybelow control values at 216 h post-fertilization.Exposure of the carp embryos to 10-11 mol l-1 PCB only increased whole-body -MSH levels. Increased whole-body ACTH and cortisol levels indicate that PCBinduces a stress response in carp larvae, possiblymediated by a disturbed hydromineral balance (oedema).We further suggest that the PCB-stimulated bodypigmentation is mediated by a stimulation of -MSHsecretion.  相似文献   

19.
为研究饲料中n-3长链多不饱和脂肪酸(n-3LC-PUFA)水平对花鲈幼鱼血清生化指标的影响,以初始体重(29.2±1.34)g的花鲈幼鱼为研究对象,分别投喂n-3LC-PUFA含量分别为0.13、0.30、0.56、1.03、1.45、2.41(%饲料干物质)的饲料,实验周期63d。结果表明,饲料中n-3LC-PUFA水平对花鲈幼鱼血清碱性磷酸酶(ALP)、乳酸脱氢酶(LDH)活性、总甘油三酯(TG)、总胆固醇(TC)含量无显著性影响(P0.05),而血清中肌酐(CREA)水平在饲料中n-3含量为1.45%时显著高于其余各组(P0.05)。结果表明,以血清CREA含量为标准,花鲈幼鱼饲料中n-3LC-PUFA含量应低于1.45%。  相似文献   

20.
为探究柱形病对黄颡鱼(Pelteobagrus fulvidraco)生理机能的影响,随机选取患病和健康黄颡鱼各10尾,采集其血液,静置后离心分离血清以测定血液生化指标如皮质醇、乳酸(LD)含量,乳酸脱氢酶(LDH)、碱性磷酸酶(ALP)活性,葡萄糖、白蛋白(ALB)、总蛋白(TP)、尿素氮(BUN)、总胆固醇(TCHO)、高密度脂蛋白胆固醇(HDLC)、低密度脂蛋白胆固醇(LDLC)含量,谷草转氨酶(AST)、谷丙转氨酶(ALT)活性。结果显示:患病黄颡鱼血清皮质醇浓度和LDH、AST活性均极显著高于健康鱼,LD含量和ALT活性显著高于健康鱼。与健康鱼相比,患病黄颡鱼血清葡萄糖含量极显著降低,而HDLC、LDLC、TCHO、ALB、TP、BUN浓度和ALP活性无显著差异。健康鱼肝细胞呈近圆形,形状较规则,细胞界线清晰,细胞核多位于细胞中央,呈圆形或椭圆形,肝细胞以中央静脉为中心形成放射状排列。患病鱼肝细胞出现局部坏死、空泡化,形成坏死灶,伴有大量中性粒细胞、淋巴细胞浸润。结果表明:柱状黄杆菌感染可引起黄颡鱼鱼体显著的应激反应,并引起鱼体肝脏损伤。  相似文献   

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