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1.
A 12-year-old male shih tzu dog was diagnosed as having a calcifying epithelial odontogenic tumour. One and a half years prior to presentation, a mass was noticed on the right mandible by the owners. Radiography revealed irregular, faintly radiopaque material within the tumour. A right hemimandibulectomy was performed, based on the clinical diagnosis of osteosarcoma. Histopathological evaluation of the mandibular mass showed that it was composed of a polyhedral odontogenic epithelial cell nest, fibrous stroma, homogeneous eosinophilic material and rounded calcifying material. The eosinophilic material was visualised by staining with Congo red, and observed under green birefringence by polarisation microscopy. Although the tumour had not recurred 12 months after surgery, the dog was euthanased because of aspiratic pharyngitis. The literature on the clinical behaviour of calcifying epithelial odontogenic tumours in dogs and cats is reviewed.  相似文献   

2.
A 10-year-old, male, Shih-Tzu dog presented with swelling of the right lower jaw caused by a mass arising from the right mandibular gingiva. Radiographic examination revealed bone lysis of the right wing of the mandible. Histopathologically, the growth was characterized by indistinctly lobulated nests, islands, and strands of proliferating odontogenic and squamous epithelial cells, intermingled in close association with large numbers of irregular extracellular deposits of amyloid and amorphous calcified substance. Immunohistochemically, both epithelial components stained strongly positive for cytokeratin (AE1/AE3); the squamous epithelial cells also reacted strongly with neuron-specific enolase (NSE) and S-100 protein, whereas the odontogenic epithelial cells displayed weak immunoreactivity to NSE and partial reactivity to S-100 protein. The amyloid deposits were AE1/AE3-negative. The growth was diagnosed as an amyloid-producing odontogenic tumor.  相似文献   

3.
BackgroundOdontogenic tumors present diverse clinical and histopathological behaviors that range from benign odontoma or hamartoma lesions to malignant tumors. In angelfish Pterophyllum scalare, findings of tumorous masses have been reported in the frontal region of the mouth, encompassing both the maxilla and mandible. Histologically, oral tumors have been characterized as angelfish lip fibroma or ameloblastoma.MethodsIn this report, we describe the occurrence of a compound odontoma/hamartoma in 60 angelfish from a population of 300, all of which were collected from a Mexican ornamental fish farm.ResultsAll fish presented a tumor-like mass on the rostral part of the mouth. Histological analyses revealed the tumor-like mass was covered by a hyperplastic stratified squamous epithelium, with fully differentiated denticles in various states of organization, immersed among normal dental tissues and showing a mild disorganized pattern. Radiograph analysis revealed radiopaque denticles in a radiolucent protuberance. Bacterial and viral isolation procedures and electron microscopy analysis revealed no presence of these microorganisms.Conclusion and clinical relevanceAlthough findings of odontogenic tumors in the mouth of angelfish are reported as sporadic, our study detected odontogenic mouth tumors in 60 angelfish, but the possible cause of alteration is not yet clarified. Further research is needed to clarify pathogenesis and to identify possible genetic abnormalities.  相似文献   

4.
Incisional biopsies from the oral cavity of 2 adult cats were submitted for histological investigation. Cat No. 1 showed a solitary well-circumscribed neoplasm in the left mandible. Cat No. 2 demonstrated a diffusely infiltrating neoplasm in the left maxilla. Both tumors consisted of medium-size epithelial cells embedded in a fibrovascular stroma. The mitotic index was 0 to 1 mitosis per high-power field. The epithelial cells showed an irregular arrangement forming nests or streams in cat No. 1, whereas a palisading growth was noted in cat No. 2. Both tumors, especially that of cat No. 1, showed multifocal accumulations of amyloid as confirmed by Congo red staining and a distinct green birefringence under polarized light, which lacked cytokeratin immunoreactivity as well as and AL and AA amyloid immunoreactivity. In addition, the amyloid in cat No. 2 was positive for the odontogenic ameloblast-associated protein, formerly termed APin. In sum, both cats suffered from an amyloid-producing odontogenic tumor, but their tumors varied with respect to morphology and type of amyloid produced.  相似文献   

5.
Odontogenic cysts, which showed cystic radiolucency in the jaw bone by radiographic examination and computed tomography, were enucleated by operation in 3 dogs. One dog had a odontogenic keratocyst in the incisive bone of the right maxilla and another 2 cases revealed dentigerous cysts in the mandible. These cyst walls were enucleated or transpired by semiconductor laser. Afterwards, osteogenesis was confirmed at the defective part of jaw bone by extirpation of the cyst in all cases, and no recurrence has been noted in any cases. Odontogenic cyst is a disease which should be treated by surgical extirpation or transpiration.  相似文献   

6.
Objective— To describe a surgical technique for excision of minimally invasive mandibular tumors at the level of the premolar and molar teeth, and report outcome in 7 dogs that had mandibular rim excision. Study Design— Case series. Animals— Dogs (n=7) with a mandibular tumor at the level of the premolar and molar teeth. Methods— Using an intraoral approach to the mandible, buccal, and lingual mucosal incisions are made to obtain a 10 mm clean margin beyond neoplastic tissue. After subperiosteal soft tissue elevation, a curvilinear rim mandibulectomy is performed, leaving the mandibular canal and ventral cortex intact, followed by osteoplasty. The remaining attached gingiva and alveolar mucosa are sutured over the bony defect. Results— Seven dogs were treated (1997–2008) for odontogenic and early malignant neoplasms involving the mandible by mandibular rim excision. All dogs had healed, healthy gingival covering over the surgical defect, very good postoperative function, and good quality of life. Conclusion— Mandibular rim excision, with preservation of the ventral cortex and mandibular canal content, can be a good option for treatment of early odontogenic and malignant lesions of the mandible in medium to large breed dogs. Clinical Relevance— In medium to large dogs with minimally invasive mandibular neoplasia, mandibular rim excision should be considered as a viable surgical option.  相似文献   

7.
A 5-year-old female neutered Boxer dog was diagnosed with extensive odontogenic cysts that affected the left and right mandibles. Rostral mandibular swelling was detectable clinically, and bilateral cystic mandibular lesions were identified radiographically. The dog's owners elected for euthanasia. A full postmortem was performed. Cystic cavities were confirmed in the body of each mandible, extending from the incisor teeth to the mid premolar region. Incisor, canine, and premolar tooth roots indented each cavity. Histologic examination of the cystic cavities reflected an inner lining of attenuated stratified squamous epithelium overlying a fibrous layer infiltrated by a mixed, predominantly mononuclear, inflammatory infiltrate.  相似文献   

8.
Odontogenic tumors present as locally invasive, slow growing, firm swellings on the face. They are rare in all species and are characterized histologically by the degree of differentiation and dental tissue of origin. Radiographic appearance is not pathognomonic for these lesions. Computed tomographic (CT) examination allows exact determination of tumor extension and aggressiveness. The objectives of this retrospective, case series study were to describe the clinical presentation, CT characteristics, and outcome in horses with histologically confirmed odontogenic tumors, and to identify imaging features suggestive of individual types of tumors. Four ameloblastomas, two ameloblastic carcinomas, three ameloblastic fibromas, and two complex odontomas were included. All but one complex odontoma presented as a single mass. All tumors were associated with maxillary or mandibular bone expansion, alveolar and cortical bone lysis, and cortical bone thinning. The majority also had cortical bone thickening and periosteal proliferation. All tumors contained some degree of mineral attenuation, although only the complex odontomas contained enamel attenuation allowing differentiation from other types of odontogenic tumors in this study. Ameloblastomas were found to have variable CT characteristics likely due to the sub‐groups of ameloblastomas. Both ameloblastic carcinomas contained a mixture of mineralized and soft tissue attenuating material whereas ameloblastic fibromas were mainly composed of soft tissue attenuating material. Computed tomographic characteristics of odontogenic tumors generally indicate that they are expansile, aggressive tumors and can occur in a wide range of ages. Further investigation is needed to elucidate differences between each type of equine odontogenic tumor.  相似文献   

9.
Primary hepatic neuroendocrine tumors (PHNETs) are rare in dogs, and limited information exists about the treatment of these tumors. A 12-year-old castrated male French bulldog was presented to our clinic with gastrointestinal signs. Diagnostic tests revealed increased hepatic enzyme levels, a mass in the hepatic quadrate lobe, multiple intrahepatic nodules, and enlarged hepatic hilar lymph nodes. The liver mass was diagnosed cytologically as a malignant epithelial tumor suspected to be of neuroendocrine origin. The dog was treated with single-agent toceranib phosphate (TOC) and survived 25.1 months after the initial presentation. On necropsy, a liver mass was found and was subsequently diagnosed as a PHNET on histopathology. To the best of our knowledge, this is the first report of long-term survival in a dog with PHNET treated with TOC.  相似文献   

10.
A case of odontogenic myxoma in an old Doberman bitch involving the periodontal region of the mandible was recorded. Grossly, the tumour mass was soft and slimy, having brownish-black foci on cut surface. Histopathologically, the tumour predominantly consisted of mesenchyme-like cells with prominent nuclei and nucleoli. The tumour had abundant ground substance, rich in acid mucopolysaccharides.  相似文献   

11.
Objective— To report treatment of a complex odontoma of the mandible by partial mandibulectomy and immediate surgical reconstruction using bridging plate fixation with a synthetic graft.
Study Design— Clinical case report.
Animals— A 4-year-old male castrated cocker spaniel.
Methods— Immediate reconstruction of the left mandible (5 cm gap) was performed after complete excision of a complex odontoma. Locking plate fixation was applied immediately before complete excision of the mass. Fixation was removed, then after partial mandibulectomy, including all abnormal tissue, restored to achieve occlusion. The resulting mandibular defect was filled with recombinant human bone morphogenetic protein-2 (rhBMP-2) delivered in an absorbable collagen sponge containing hydroxyapatite/tricalcium phosphate granules (compression resistant matrix [CRM]).
Results— New bone growth was evident radiographically and on palpation at 3 months. Bony remodeling was evident during follow-up examinations up to 26 months. Bone collected by biopsy at the graft site at 7 months had robust new bone formation and evidence of continued remodeling. Only minor complications (repeated intraoral plate exposure) were encountered postoperatively and were easily resolved.
Conclusions— An osteoinductive factor (rhBMP-2/CRM) was successfully used as a graft substitute in immediate reconstruction of a large mandibular defect.
Clinical Relevance— Immediate reconstruction of large mandibular defects with osteoinductive materials as a graft substitute may be a viable alternative to partial mandibular resection or radiation therapy for benign odontogenic tumors in dogs.  相似文献   

12.
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13.
The feline inductive odontogenic tumor (FIOT) is a rare entity among oral tumors in cats, the cytologic features of which are not well characterized but may prove useful. A fine‐needle aspiration biopsy was performed on the right mandible between the permanent canine (404) and permanent fourth premolar (408) of an 8‐month‐old female mongrel cat. Cytologic smears showed epithelial cells and occasional spindle cells with extracellular homogenous acidophilic material in a hematic background. The initial diagnosis of benign tumor was confirmed by histopathologic examination of the biopsy specimen. This report describes the cytologic findings in a case of FIOT.  相似文献   

14.
Odontogenic neoplasms are locally invasive oral tumors in dogs. The purpose of this retrospective study was to describe CT characteristics for varying histopathologic types of canine odontogenic neoplasms. A board‐certified veterinary radiologist who was unaware of histologic findings reviewed and scored imaging studies. A total of 29 dogs were included in the study. Twenty‐three of these dogs had concurrent dental radiographs. The most common CT characteristics for all tumor types were a direct association with or in the region of multiple teeth in 96.4% (27/28), contrast enhancement in 96.3% (26/27), alveolar bone lysis in 93.1% (27/29), and mass‐associated tooth displacement in 85.2% (23/27). Mass‐associated cyst‐like structures were identified in 53.6% (15/28) and were only present in tumors containing odontogenic epithelium. Canine acanthomatous ameloblastomas (n = 15) appeared as extra‐osseous (10/15) or intra‐osseous (5/15) masses. Intra‐osseous canine acanthomatous ameloblastomas were more likely to have mass‐associated cyst‐like structures and were subjectively more aggressive when compared with extra‐osseous canine acanthomatous ameloblastomas. Amyloid‐producing odontogenic tumors (n = 3) had subjectively uniform CT imaging characteristics and consisted of round soft tissue and mineral attenuating masses with multiple associated cyst‐like structures. Fibromatous epulides of periodontal ligament origin (n = 4) were contrast enhancing extra‐osseous masses that were rarely referred for CT examinations and 25% (1/4) were not visible with CT. Other odontogenic tumors were less represented or had more variable CT imaging characteristics. Mass‐associated tooth destruction was appreciated more often with dental radiographs and extra‐oral tumor extension was identified more often with CT.  相似文献   

15.
Nephrotomography and ultrasonography were used in 11 dogs with hyperadrenocroticism to assess the value of these techniques for the localization of biochemically diagnosed hyperfunctioning adrenocortical tumors. Both techniques enabled accurate localization of a unilateral adrenal mass in each of the dogs. Cross-sectional diameters of the masses ranged from 1 to 4 cm. In 1 dog, expansion of tumor into the caudal vena cava was revealed by caudal venacavography and ultrasonography. Mineralization in the tumor mass in 2 dogs was easily recognized by nephrotomography, but not by ultrasonography. Paracostal laparotomy confirmed the presence of an adrenocortical tumor in each dog, and expansion of tumor into the caudal vena cava in 1 dog. Cross-sectional diameters of the tumors ranged from 1.2 to 4.5 cm and corresponded well with cross-sectional measurements by nephrotomography and ultrasonography. It was concluded that nephrotomography and ultrasonography have similar diagnostic accuracies for the detection and localization of hyperfunctioning adrenocortical tumors.  相似文献   

16.
An 8-year-old Siberian husky dog was presented for a mass involving the rostral mandible. Intraoral radiographs demonstrated diffusely irregular bone and displacement of all mandibular incisor teeth. The mass was diagnosed as a grade I multilobular tumor of bone based on incisional biopsy. A bilateral rostral mandibulectomy was performed with tumor negative margins. Oral examination at 14-months following surgery indicated normal healing with minimal side effects and no evidence of tumor recurrence.  相似文献   

17.
Mini titanium plates were used to repair certain fractures of the maxilla and mandible in dogs and cats, under general anaesthesia. The location of the fractures treated were: corpus mandible, one dog; corpus mandible and symphysis, two dogs; caudal mandible, two dogs; rostral mandible, one dog; maxilla, one dog; nasal bone, one dog; corpus mandible and symphysis, one cat; caudal mandible, one cat; and maxilla, one cat. The healing periods varied from 6 to 9 weeks. In seven cases, implants were removed after a period of 3.5 to 18 months. In four cases the implants were left in place. The follow up period was between 8 and 36 months. In ten cases the procedure was successful, however in one case the outcome was not satisfactory due to a broken plate. There were no instances of dental malocclusion, nonunion, malunion, osteomyelitis or soft tissue infection. Eating, playing with toys, a fast transition to solid food and a quick return to normal jaw movements were observed. In our hands, the mini titanium plate fixation system was a safe and effective method for repairing certain maxillary and mandibular fractures in dogs and cats.  相似文献   

18.
The clinical, laboratory, radiographic, and histologic features and the response to therapy in three dogs with actinomycosis are reported. One dog (dog 1) had a 12-cm nonresectable mass extending from the ventrolateral chest wall into the left ventricular myocardium. Another dog (dog 2) had a diffuse peritonitis with "sulfur granules" and two large masses. One of these masses was nonresectable involving adjacent abdominal structures. A third dog (dog 3) had a subvertebral mass at T1-3 producing quadraplegia. Two dogs had periosteal reactions involving adjacent sternebrae (dog 1) or ribs and vertebral bodies (dog 3) that are characteristic of Actinomyces spp infections. In dogs 1 and 2 the diagnosis was based on the morphologic and tinctorial properties of free sulfur granules and/or tissue granules. Culture results were variable. Tissue from dog 1 yielded no growth, while polymicrobial infections, which included Actinomyces spp, were identified in dogs 2 and 3. Actinomyces odontolyticus was isolated from dog 3. Although the actinomycotic granulomas were either not excised or only partially excised from dogs 1 and 2, both animals were cured by the oral administration of high doses of penicillin G for 19 and 6 months, respectively. Dog 3 responded dramatically to the same antibiotic therapy given for 5 months. However, within 4 months of discontinuing treatment an abscess and draining fistulous tracts developed in the left axillary region. Two surgical fistulectomies and additional penicillin therapy were required to cure this animal. These cases and the current veterinary and human literature on actinomycosis are used to propose a rational approach to the treatment of actinomycosis in the dog.  相似文献   

19.
To compare changes in dose distribution in irregularly shaped volumes treated using fields with noncoincident isocenters compared with fields with coincident isocenters. The hypothesis was that use of fields with noncoincident isocenters would result in improved homogeneity of dose distribution. We chose to test the hypothesis in canine nasal tumors because of the increased dorsoventral thickness of the caudal compared with the rostral nasal cavity. Computed tomography images from eight dogs with nasal tumors were selected. A tissue-contouring program was used to outline contours, including the mandible as a normal tissue structure and the planning target volume (PTV), divided into a rostral and caudal volume. A traditional computerized treatment plan consisting of two parallel-opposed fields was constructed for each dog. A second treatment plan using a third caudally located field having a different isocenter was constructed for comparison. Dose-volume histograms were generated and compared for each contoured structure in both plans. In all dogs the use of noncoincident fields resulted in increased dose to the ethmoid region through the caudal field. Minimum dose in the caudal tumor PTV increased as well. At the same time, dose delivered to the mandible, prone to develop significant side effects, was lower in all dogs with the use of noncoincident fields, as it was possible to reduce the dose delivered from the ventral field. Use of photon fields with noncoincident isocenters can improve the dose distribution in irregularly shaped volumes in comparison with fields with coincident isocenters. Improved tumor dose distribution was achieved with the addition of a smaller field having a different isocenter.  相似文献   

20.
This report describes a congenital odontogenic keratocyst in the left mandible of a filly. A definitive diagnosis was only made after histopathological examination. Mandibular cysts of odontogenic and osteogenic origin have been reported in the past but a case of a keratocyst has not been previously reported in the horse.  相似文献   

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