共查询到20条相似文献，搜索用时 15 毫秒
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B Lannek 《Acta veterinaria Scandinavica》1974,15(2):219-238
Intoxication due to short-term oxyquinoline therapy was studied in 100 dogs, which had been so treated because of diarrhoea (except in 2 cases). The latter condition was in itself mild and uncomplicated. The main symptoms of intoxication were listlessness or excitation and nervousness, aggressiveness, tremor, convulsions, and salivation. Clinical examination revealed myocarditis and liver injury. Mortality, i.e. the sum of spontaneous deaths and euthanasia, amounted to 30 %. The treatment considered to be most important was sedation and anticonvulsant measures. It was further essential to correct the dehydration, which was often present. A follow-up investigation showed that approx. 1/3 of the dogs which had recovered from the acute intoxication developed recurrent convulsions within the next 3 years. 相似文献
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JW Finnie 《Australian veterinary journal》2012,90(8):301-307
Traumatic brain injury (TBI) is a frequent occurrence in veterinary medicine, but the mechanisms leading to brain damage after a head impact are incompletely understood, particularly in the postnatal immature and still developing nervous system. This paper reviews neurotrauma studies, largely in paediatric humans and experimental animal models, in order to outline the pathophysiological and biomechanical events likely to be operative in head trauma involving domestic animal species in the postnatal period, as there is almost no other information available in the veterinary literature. Predicting the outcome of TBI is particularly difficult at this developmental time, in large part because recovery is influenced by the stage of brain maturation and neuroplasticity. An important part of the clinical management of TBI is the differentiation of primary brain damage, which occurs at the moment of head impact and is largely refractory to treatment, from the cascade of secondary events, which evolve over time and are potentially preventable and amenable to therapeutic intervention. An understanding of the causes and consequences of secondary brain damage such as hypoxia-ischaemia, brain swelling, elevated intracranial pressure, and infection is critical to limiting the resulting brain injury. 相似文献
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Serum myoglobin,creatine kinase,and cell‐free DNA in endurance sled dogs and sled dogs with clinical rhabdomyolysis 
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下载免费PDF全文 Veronica C. Devall DVM Robert Goggs BVSc DACVECC DECVECC PhD Christina Hansen DVM PhD Christopher W. Frye DVM Jo‐Annie Letendre DVM Joseph J. Wakshlag DVM DACVN DACVSMR PhD 《Journal of Veterinary Emergency and Critical Care》2018,28(4):310-316
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Sensitivity and Specificity of Plasma ALT,ALP, and Bile Acids for Hepatitis in Labrador Retrievers 下载免费PDF全文
下载免费PDF全文 K. Dirksen I.A. Burgener J. Rothuizen T.S.G.A.M van den Ingh L.C. Penning B. Spee H. Fieten 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2017,31(4):1017-1027
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We hypothesized that in horses with naturally occurring joint disorders, the neutrophil response, acute phase response (APR), and oxidative stress parameters elevated significantly and are markers of increased inflammatory response in these conditions. Therefore, the first aim of the study was to evaluate neutrophil response, oxidative status, and APR. The neutrophil activity was assessed on the basis of elastase, myeloperoxidase (MPO), and alkaline phosphatase release, whereas free radical generation was assessed on the basis of nitric oxide and superoxide production. Acute phase response was estimated on the basis of fibrinogen or haptoglobin plasma concentration and oxidative stress on the basis of malondialdehyde plasma concentration. Then, these parameters were compared with lameness grade, and correlation coefficients between them were calculated. The study was conducted on 43 horses divided on control group of healthy horses (n = 17), acute lameness (AL) group (11 horses), and chronic lameness (CL) group (15 horses). The neutrophil activity from horses of both groups of joint disorders (AL and CL) was significantly (P < .01) higher in comparison with healthy horses. Elastase release was 67.28 ± 1.89% of maximal activity in AL group in comparison with 51.72 ± 1.75% in healthy horses and 62.61 ± 1.54% in CL group. The highest values of other enzymes were also noted in AL group. Moreover, in AL group release of elastase and MPO positively correlated (P < .01) with grades of lameness. These findings revealed the mutual relation between studied parameters and obtained results may be useful in the development of new therapeutic strategies in the treatment of acute and chronic joint disorders in horses. 相似文献
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Prevalence,location and symmetry of noncatastrophic ligamentous suspensory apparatus lesions in California Thoroughbred racehorses,and association of these lesions with catastrophic injuries 下载免费PDF全文
下载免费PDF全文 A. E. Hill I. A. Gardner T. E. Carpenter C. M. Lee P. L. Hitchens S. M. Stover 《Equine veterinary journal》2016,48(1):27-32
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Hyun-Kyu Park Woori Jo Hyun-Ji Choi Sungwoong Jang Jae-Eun Ryu Hyo-Ju Lee Hyojin Lee Hyejin Kim Eun-Sil Yu Woo-Chan Son 《Journal of veterinary science (Suw?n-si, Korea)》2016,17(1):45-51
Drug-induced liver injury (DILI) is a significant threat to patient health and a major concern during drug development. Recently, multiple circulating microRNAs (miRNAs) have been reported to be potential biomarkers for DILI. To adapt and validate miRNAs for clinical use, we investigated the time-course changes in miR-122 expression levels in an acetaminophen-induced liver injury model in rats. In addition, miR-155 and miR-21 were evaluated as makers of inflammation and regeneration, respectively, to characterize liver status. Our results revealed that miR-122 is an early and sensitive biomarker of hepatocellular injury at a stage when alanine transaminase, aspartate transaminase, and total bilirubin were not detectable. However, no significant differences in the expression levels of other miRNAs (miR-155 and -21) were observed between treatment and vehicle groups. Collectively, these time-course changes in the expression levels of miRNAs may be useful as markers for clinical decision-making, in the diagnosis and treatment of DILI. 相似文献
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Emergency room and hospital discharge data have been used to describe the risk factors and public health impact of dog bites. These data sets are based on financial charges for severe bites and underestimates dog bite burdens within communities. This study expands both the source of information and risk factor data collected to provide demographic analysis of dog bite injury risk factors reported in Bay County, Florida in 2009–2010. Extended data for dog bites reported by various sources from January 1, 2009 to December 31, 2010 were collected by Florida Department of Health in Bay County. Data collected included bite victim's age and gender, primary reported cause of bite, setting, dog's restraint status and relationship between the victim and the dog. A total of 799 bites were reported. Most bites (55%) were reported first by healthcare practitioners, particularly bites involving children <6 years. Bites involving unfamiliar dogs and dogs off the owner's property were more likely to be reported by other sources. Boys aged 6–14 years accounted for 2.24 times more bites than same‐aged females (P < 0.001) and had the highest incidence with 424 bites per 100 000 persons per year. Persons 6 years or older were 3.6 times more likely to be bitten by an unfamiliar dog. Inappropriate behaviour management was the most common cause of bites (26%), followed by protective behaviour (24%). Bites of unknown cause were 2.5 times more likely in children <6 years. Separating dog fights was the most common cause of bites for persons 15 years or older (24%); females were significantly more likely to be bit than males (P = 0.01). Bites by unrestrained dogs off the owner's property (32% of all bites) most commonly involved males. Estimates based solely on healthcare discharge data significantly underestimate dog bite burden within a community. Characterizing these risks by age group or gender provides an opportunity to implement targeted interventions to prevent dog bites. 相似文献
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Biochemical markers of cardiac injury in normal, surviving septic, or nonsurviving septic neonatal foals 总被引：6，自引：0，他引：6
Slack JA McGuirk SM Erb HN Lien L Coombs D Semrad SD Riseberg A Marques F Darien B Fallon L Burns P Murakami MA Apple FS Peek SF 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2005,19(4):577-580
The cardiac biomarkers cardiac troponin T (cTnT) and I (cTnI) and the cardiac isoenzyme of creatine kinase (CKMB) are used extensively in human medicine to diagnose and provide valuable prognostic information in patients with ischemic, traumatic, and septic myocardial injury. We designed a study to establish normal values for these markers in healthy, neonatal foals and to compare them with values obtained from septic neonates in a referral hospital population. The 25th, 50th, 75th, and 95th percentiles for cTnI and CKMB in the healthy-foal population were 0.08, 0.14, 0.25, 0.49 ng/mL and 1.4, 2.3, 4.0, 7.4 ng/mL, respectively. The values obtained for cTnT were frequently (43/52 foals; 83%) below the lower limit of detection of the assay (0.009 ng/mL), but the median and range were 0.009 and 0.009-0.041 ng/mL, respectively. In the septic foal population, the 25th, 50th, 75th, and 95th percentile values for cTnI and CKMB were 0.05, 0.12, 0.22, and 1.10 ng/mL and 2.0, 4.4, 7.8, and 24 ng/mL, respectively. The values obtained for cTnT were less frequently below the lower limit of detection (23/38 foals; 60%) compared with the healthy foal population, and the median and range were 0.009 and 0.009-0.20 ng/mL, respectively. Significantly higher values were observed for cTnT and CKMB in septic foals compared with the healthy neonatal foal population, but there were no differences among septic foals in survivors compared with nonsurvivors. These findings suggest that myocardial injury occurs during septicemia in neonatal foals but that the injury is not associated with survival among septic foals. 相似文献
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A randomized,blinded, prospective clinical trial of postoperative rehabilitation in dogs after surgical decompression of acute thoracolumbar intervertebral disc herniation 下载免费PDF全文
下载免费PDF全文 Joe Fenn Kim Williams Emily Griffith Peter J. Early Chris L. Mariani Karen R. Munana Julien Guevar Natasha J. Olby 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2018,32(3):1133-1144