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1.
Clinical signs of dysautonomia, including dilated pupils, dry mucous membranes, and megaesophagus, were observed in a cat. The diagnosis was confirmed by use of autonomic nervous system function testing including 0.1% pilocarpine and physostigmine ocular response tests, plasma catecholamine assays, and cardiovascular responses to various perturbations intended to elicit autonomic responses. The cause of the autonomic dysfunction was not ascertained, and the cat was euthanatized after 5 weeks of unsuccessful treatment with pilocarpine, metoclopramide, prochlorperazine, and parenteral nutrition.  相似文献   

2.
Dysautonomia, or autonomic nervous system dysfunction, was diagnosed in a 1-year-old dog. Clinical signs of disease included diarrhea, vomiting, prolapse of nictitating membranes, and urinary incontinence. Bilateral keratoconjunctivitis sicca, xerostomia, and decreased anal sphincter tone were also observed. On the basis of response to atropine, results of intradermal histamine testing and gastric motility studies, and ocular response to parasympathomimetics and sympathomimetics (direct and indirect acting), autonomic nervous system function was determined to be abnormal. Treatment with metoclopramide hydrochloride and bethanechol chloride resulted in improved attitude, appetite, Schirmer tear test response, and decrease in frequency of vomiting within 24 hours. Bladder function and anal tone improved within 3 weeks.  相似文献   

3.
As far as the authors know this is the first case of Key-Gaskell-syndrome being described in Switzerland. The clinical signs of megaoesophagus, anorexia, constipation, dryness of all mucous membranes, reduced tear production, protrusion of the membrana nictitans, mydriasis, regurgitation and bradycardia are pathognomonic and can't be mistaken by any other disease. The subject of the Key-Gaskell-syndrome is a dysfunction of the autonomic nervous system. Histopathological changes are exclusively related to the autonomic nervous system and to neurons of some nuclei in the cranial nerves. Less severe changes can be found in the neurons of the spinal cord or in the dorsal root ganglia. The etiology remains still unclear. There is a relationship to the grass sickness syndrome in horses and to dysautonomia of man and dog.  相似文献   

4.
Diarrhea associated with myenteric ganglionitis in a dog   总被引：1，自引：0，他引：1  
Diarrhea in a Border Terrier was associated with inflammatory lesions of the myenteric plexus. This lesion has been documented rarely in dogs. It is speculated that the myenteric plexus lesions were responsible for an autonomic nervous system dysfunction, which resulted in extreme intestinal hypermotility and subsequent diarrhea. Suggested tests for dogs suspected to have autonomic dysfunction are given.  相似文献   

5.
OBJECTIVE: To determine characteristics of power spectral analysis of heart rate variability (HRV) during a 24-hour period in dogs and to evaluate the effects of vagal and sympathetic tone on HRV ANIMALS: 16 healthy adult Beagles. PROCEDURE: Power spectral analysis of HRV was conducted, using 24-hour ambulatory ECG recordings. Circadian rhythms were evaluated in terms of absolute units of low-frequency (LF) and high-frequency (HF) powers, their ratio (LF:HF), and their adjusted (normalized) units (LF[norm] and HF[norm]). Three or 4 dogs were used for simultaneous measurement of heart rate and respiratory waveform as well as to evaluate treatment (propranolol, atropine, or both) administered to cause blockade of the autonomic nervous system. RESULTS: Values for LF and HF powers, LF:HF, LF(norm), and HF(norm) had obvious rhythmicity in clinically normal dogs. The HF power of HRV in dogs was extremely high, compared with that of other species, and HF peaks corresponded to peaks obtained from respiratory waveforms. Blockade of the autonomic nervous system documented that HRV in dogs was mostly attributable to vagal activity. CONCLUSION AND CLINICAL RELEVANCE: We determined characteristics of power spectral analysis of HRV in dogs, including circadian rhythm of the autonomic nervous system. Power spectral analysis of HRV may provide a useful noninvasive technique for assessing the effect of drugs on activity of the autonomic nervous system in dogs.  相似文献   

6.
A nine-year-old gelding quarter horse, whose discipline is barrel racing, was experiencing difficulty performing tight turns around the barrels for 8 months prior to treatment. He demonstrated tail swishing as if aggravated when under the saddle, which would escalate to bucking for 3 weeks prior to treatment. This gelding had no previous history of bucking under the saddle. Static and motion palpation findings indicated multiple segmental joint fixations located throughout the spine and extremities. High-velocity low-amplitude adjustments were performed to address the joint fixations found during examination. A comparison of pre and post-treatment thermographic images showed a temperature change indicative of autonomic nervous system improvement caused by joint manipulation. A follow-up at two weeks revealed subjective long term improvements. Subjective, objective, and thermographic evidence indicated that segmental joint dysfunction was causing increased nociception and autonomic dysregulation, most notably over the sacroiliac joints, lateral front left cannon bone and right carpus. Previous research has indicated causative effects of joint manipulation on the autonomic nervous system and nociceptive processes. This case shows the positive thermographic effects post-adjustment on the nervous system, and a two week follow-up indicated that the gelding no longer showed signs or symptoms of pain. This case demonstrates how joint manipulation can affect the autonomic and nociceptive nervous systems in the equine patient.  相似文献   

7.
The aim of this study was to determine whether autonomic nervous activity of a rider with no disability was altered by one practical and applicable horse trekking (HT) exercise. Changes in autonomic nervous activity were analyzed by heart rate variability (HRV). Twenty‐three participants with no disability rode horses along a predetermined HT course at trotting and walking for 60 min. HRV was sampled at 60 min before and immediately, following 60 min, and 120 min after HT. As a control, the same measurements were performed for 22 age‐matched participants during their rest. Only in the HT group, the value of normalized unit in high frequency component (HF nu), an index of parasympathetic nervous activity, was higher at 120 min after treatment than before HT (P < 0.05). The low / high frequency ratio (LF / HF), believed to reflect sympathetic nervous activity, was lower in the HT group than those in the control group at 60 min (P < 0.05) and 120 min after treatment (P < 0.01). These findings suggest that a single HT shifted the autonomic nervous balance of a rider toward parasympathetic dominance. The results obtained by the present study could accelerate the use of horses for human health.  相似文献   

8.
One of the mechanisms by which acupuncture (AP) exerts its purported effects involves modulation of the autonomic nervous system. Heart rate variability (HRV) noninvasively and quantitatively assesses autonomic nervous system activity. We hypothesized that AP treatment would acutely affect HRV by affecting autonomic tone. Eleven horses received three treatments in random order on different days: AP, placement of AP needles at eight AP points; sham AP (SAP), placement of eight AP needles at non-AP points; and control, no needles inserted. A Holter monitor recorded an electrocardiogram for 40 minutes during each treatment session and was analyzed over three periods: 10 minutes of initial “baseline” before AP and/or SAP, the first 10 minutes of a 20-minute AP/SAP/control “treatment”, and the first 10 minutes “post”-AP/SAP/control. RR intervals were measured during each period after the electrocardiograms were inspected and filtered, and mean heart rate (HR), low-frequency (LF) power (0.01–0.07 Hz), high-frequency (HF) power (0.07–0.6 Hz), and LF-to-HF ratio were calculated for each period. Baseline HR decreased with sequential experiments. Within experiments, HF decreased and LF-to-HF ratio increased reciprocally with time. These results suggest that parasympathetic tone decreased over the course of the experiment, perhaps, because of the stress of being restrained. Consequently, HRV indices were either not acutely affected by AP over the intervals studied or autonomic responses to being restrained may have masked any autonomic response to AP.  相似文献   

9.
The aims of this study were to measure the activity of the autonomic nervous system using heart rate variability (HRV) during learning tasks and to clarify the relationship between learning to overcome a difficult situation and the autonomic nervous system in monkeys. Two young male monkeys (Macaca mulatta) were given simple discrimination learning tasks (DL) and delayed matching to samples tasks (DMTS); Holter-type electrocardiography was done, and HRV was measured. We defined the frequency bands of HRV in rhesus macaques; the low frequency (LF) was 0.01-0.15 Hz, and the high frequency (HF) was 0.15-0.50 Hz. Based on these frequency bands, the LF/HF ratios during learning tasks were analyzed, and a significant increase in the ratio was found during the tasks. The variances in the HF differed between the DL and DMTS tasks; during DMTS tasks, HF variances had a tendency to increase. Our results indicate that increased sympathetic activity accompanied learning and suggest that the parasympathetic nervous system plays a key role during learning, particularly when difficult tasks are being learned.  相似文献   

10.
The autonomic nervous system is pivotal in the characteristics of normal and abnormal cardiac rhythms. Some of the unique features (pronounced sinus arrhythmia and wandering pacemaker) of the canine electrocardiogram can be explained by the influence of parasympathetic tone. Perturbations that enhance the sympathetic nervous system can also potentiate arrhythmias, or counteract antiarrhythmic action. Moreover, disorders of the innervation to the heart may actually cause some life-threatening arrhythmias. This article reviews the interactions of the autonomic nervous system and cardiac rhythms as they pertain to the normal dog, as well as to specific arrhythmias in the boxer and German shepherd dog. Emphasis is placed on relating information from electrophysiological investigations to the clinical arena, thus demonstrating the value of linking the basic and clinical sciences as one medicine: knowledge from cell to cageside.  相似文献   

11.
Dysautonomia of domestic animals is pathologically characterized by chromatolytic degeneration of the neurons in the autonomic nervous ganglia that results in clinical signs related to dysfunction or failure of the sympathetic and parasympathetic nervous systems. The exact cause is unknown. It has a poor prognosis among all species reported and no definitive treatment is available currently. To date, most reported feline cases have occurred in the United Kingdom and Scandinavia. The cases reported here highlight the clinical signs, physical examination findings, and results of autonomic nervous system function testing in nine cats with dysautonomia in the US. Feline dysautonomia is uncommon in the US, but may have a regional prevalence, as is seen in dogs with most cases reported in Missouri and Kansas.  相似文献   

12.
Studies of the general histopathology of the fatty liver and kidney syndrome in chickens have shown abnormal accumulations of the lipid in a variety of organs but no degenerative or inflammatory reactions. Lipid was found in some skeletal muscles, alimentary tract, autonomic ganglia, central nervous system and pineal gland as well as in the liver, kidney and heart. Small amounts of lipid were sometimes seen in the exocrine pancreas, adrenal medulla and epithelium of the thyroid follicles. Lipid deposits in the liver were primarily associated with the hepatic structural unit. The glycogen content of the hepatic cell was reduced. The lipid-metabolising gastrocnemius muscle contained abnormal amounts of lipid but this did not apply to the carbohydrate-metabolising pectoralis major muscle. The thymus did not contain excessive lipid but was significantly smaller in affected than in control birds of similar ages. There was loss of tinctorial distinction between the cortex and medulla of the adrenal gland associated with decreased basophilia of the latter region. Many of these morphological changes can be correlated with previously reported biochemical findings and they are discussed in relation to the hyperlipaemia and hypoglycaemia which characterise the disease.  相似文献   

13.
Stress--mechanisms of immunosuppression.   总被引：4，自引：0，他引：4  
Stress, a term commonly used to describe varied phenomena, should be restricted to describe an adaptive response by an animal to threats to homeostasis. The threats to homeostasis are called stressors. Stressors include a variety of physical, psychological, chemical, or infectious causes that are modified by intrinsic and extrinsic factors. Examples of modifiers include stressor severity, duration, novelty, host genetics and immune status. What may be a stressor to an animal in one situation, when modified, may not be a stressor in another situation. Mechanisms of stress once thought to involve a single pathway described by Seyle as the General Adaptation Syndrome, have been rejected. Four pathways, some incompletely defined, have been implicated in modulation of the immune system. They include autonomic nervous system, the hypothalamic adrenal axis, extra-adrenal pathways involving neuropeptides and neurotransmitters and neuroimmunological mediators. The mechanisms of stress-induced immunosuppression resistance are poorly defined in domestic fowl and will require careful experimentation linking defined stressors with altered physiological responses that affect specific immune function and result in increased disease susceptibility.  相似文献   

14.
The autonomic nervous system can be affected as part of a more diffuse peripheral nerve disease such as inflammatory polyneuropathy or diabetes, or as a primary disease, such as dysautonomia. Dysautonomia is being diagnosed with increasing frequency in dogs and other species in the Midwest. Affected animals present with absence of parasympathetic and autonomic ganglia and brainstem nuclei degenerate with minimal inflammation. The cause is unknown and treatment symptomatic.  相似文献   

15.
The ocular surface immunity is a remarkable combination of the innate immune and adaptive immune systems, designed to prevent microbial invasion while minimizing damage to delicate ocular tissue. The innate immune system uses a variety of methods to minimize microorganism invasion, including mechanical tissue barriers and production of antimicrobial peptides. Tolerance of normal ocular flora is achieved by the presence of a minimal number of professional antigen presenting cells, immunosuppressive substances in tears, and the strategic intra- and intercellular location of the Toll-like receptors. Autoimmune diseases are common on the ocular surface, and with contributions of environmental and genetic factors, autoantigens are presented to the adaptive immune response. Toll-like receptors are the link between the innate and adaptive immune response, and are likely key components of the response of ocular tissue to infectious organisms and in the initiation and perpetuation of autoimmune disease.  相似文献   

16.
The aim of the present study was to determine the distribution and density of catecholaminergic nerve fibres and cells in the equine ureter by using immunohistochemical techniques to localise the enzyme tyrosine-hydroxylase (TH). TH-immunoreactive (TH-IR) nerve fibres entered the wall of the ureter as adventitial nerve trunks accompanying the blood vessels. These trunks repeatedly branched as they coursed through the muscular layer towards the epithelium, forming muscular, perivascular and subepithelial nerve plexuses. TH-IR nerve fibres were especially numerous in the pelvic and intravesical ends of the ureter. TH-IR cells have also been identified in the equine ureteral wall, usually grouped as adventitial and intramural nerve ganglia. The results of the present study demonstrated that the equine ureter, like that of other mammals, possesses a rich autonomic supply of catecholaminergic (TH-IR) nerve fibres. These morphological data support a role for the autonomic nervous system in the control of ureteral peristalsis.  相似文献   

17.
Feline dysautonomia is a dysfunction of the autonomic nervous system, the main features of which are dilated pupils, dry mucous membranes, mega-oesophagus and constipation. The clinical and pathological features, treatment and follow-up details of 40 cases seen at the University of Glasgow Veterinary School are described. The pathology was demonstrated to be mainly restricted to the autonomic ganglia and neurons in selected cranial nerve nuclei. Less marked changes were also found in neurons of the spinal cord and dorsal root ganglia. Nine cases recovered but this required up to one year and, in some, mild clinical signs persisted. Viral, toxicological and epidemiological studies were unrewarding and the aetiology is presently unknown. The similarities between this condition, grass sickness of horses and dysautonomia in the dog and man are discussed.  相似文献   

18.
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19.
A number of neurons of the autonomic nervous system are situated in the ganglia and can be systematically divided into pre-vertebrals, paravertebrals, intramural and para-viscerals. The celiac-mesenteric ganglion, an important pre-vertebral ganglion, is located together with the abdominal aorta and links the central nervous system to the peripheral system, participating in the coordination of peripheral reflexes and principally innervating the stomach, intestines, accessory glands (liver and pancreas). In addition, the celiac-mesenteric ganglion also contributes to the innervation of the spleen and has a role in gastrointestinal motility control. This study examined the structural and ultrastructural aspects of 40 celiac-mesenteric ganglia from domestic dogs. For light microscopy ganglia were included in paraplast and stained with haematoxylin-eosin, picrosirius, toluidine blue, Calleja's and Masson's trichrome. For examination by electron microscopy, the ganglia were submitted to cryofracture, enzyme digestion, hydrolysis and fixed in 5% glutaraldehyde in 0.1 M phosphate buffer (pH 7.4). The celiac-mesenteric ganglion was observed as a ganglionic complex composed of various ganglionic units separated by types I and III collagen fibres, predominantly unmyelinated nerve fibres and continuous capillaries. This complex is surrounded by a double-layer capsule (internal and external). The principal ganglion cells had eccentric nuclei with two nucleoli, the nucleolemma was double and presented nuclear pores. In the cytoplasm there were vesicles of the Golgi apparatus, electron-dense vacuoles, mitochondrias, smooth and granulated endoplasmic reticulum and free ribosomes. In conclusion, this ganglionic complex, in contrast to similar structures in the enteric nervous system, presents separate ganglionic units in a systematic arrangement related to the extrinsic and specific innervation of the target organs.  相似文献   

20.
Although there has been a recent surge in using horses to treat mental and emotional human health issues, the consequences of horse-assisted interventions on the stress response of horses have not been well documented. Assessment of the autonomic nervous system and its regulation of cardiovascular function has been used as an indicator of acute and chronic stress in human beings and horses. Heart rate variability (HRV) is a noninvasive measurement that has been used to assess autonomic nervous system regulation of cardiovascular function. There is evidence to suggest that several factors including the genotype, behavior, environment, temperament, and nutritional status of the horse play a key role in the large inter-individual variations in basal HRV. The present study determined whether 24-hour HRV recordings in horses currently working in equine-assisted therapy (EAT) differ from those previously shown in Thoroughbred horses. Findings from the present study found that in contrast to previous studies in Thoroughbred horses, diurnal and nocturnal low frequency and high frequency powers were not significantly different in horses that are currently engaged in EAT. Future studies are needed to determine the short- and long-term consequences of horses participating in EAT programs. Findings from this study will provide the basis for the development of a physiological/behavioral assessment criteria to determine the consequences of EAT on the well-being of horses as well as to help EAT Centers to improve the beneficial effects of EAT in human beings.  相似文献   

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