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1.
OBJECTIVE: To compare analgesic and adverse effects of ketoprofen and carprofen when used to control pain associated with elective orthopedic surgeries in dogs. DESIGN: Prospective randomized clinical trial. ANIMALS: 93 client-owned dogs: 46 undergoing reconstruction of the cranial cruciate ligament, 47 undergoing femoral head and neck excision, and 15 control dogs anesthetized for radiographic procedures. PROCEDURE: Dogs undergoing surgery were randomly given ketoprofen, carprofen, or saline (0.9% NaCl) solution, SC, prior to surgery. Pain score and serum cortisol concentration were recorded for 12 hours after surgery for all dogs. When pain score was > or = 7, oxymorphone was administered i.m. Bleeding time was measured prior to and during surgery. RESULTS: The proportion of dogs that required oxymorphone was significantly higher for the carprofen and placebo groups than for the ketoprofen group. Pain score for the placebo group was significantly higher than for the ketoprofen and carprofen groups, 2, 8, and 9 hours after surgery. Cortisol concentration was significantly higher for the placebo group than for the carprofen group at 4 and 6 hours after surgery. Significant differences were not detected between ketoprofen and carprofen groups with respect to pain score and cortisol concentration. Bleeding time was significantly longer for the ketoprofen group than for the other groups during surgery. One dog treated with ketoprofen developed a hematoma at the surgical site. CONCLUSIONS AND CLINICAL RELEVANCE: Ketoprofen and carprofen given prior to surgery were effective for postoperative pain relief in dogs. However, ketoprofen should not be used when noncompressible bleeding may be a problem.  相似文献   

2.
Castration is an ancient husbandry procedure used to produce docile cattle for draught work, to reduce unwanted breeding, and to modify carcass quality. All the physical methods used to castrate cattle have side-effects and cause pain. The plasma cortisol response to castration using Burdizzo clamps and, by inference, the acute pain experienced, is less than that caused by surgical, rubber-ring or latex-band castration. The cortisol response may be influenced by the age of the animal castrated, but this has not been well defined. Local anaesthesia virtually eliminates the cortisol response, and thus the acute pain, caused by rubber-ring or latex-band castration, but needs to be combined with a systemic analgesic such as the non-steroidal anti-inflammatory drug ketoprofen to eliminate the cortisol response to Burdizzo or surgical castration. When used alone, ketoprofen sometimes reduces the cortisol response to Burdizzo or surgical castration but may need to be accompanied by local anaesthesia to eliminate the pain-induced behaviour seen during the castration process itself. Thus, pharmacological methods are available to virtually eliminate the acute pain experienced by calves during the 12 h following castration. The use of these methods is an additional cost for farmers and may be limited by the availability of drugs for farmers to use and the scarcity of veterinarians in farm animal practice.  相似文献   

3.
Castration is an ancient husbandry procedure used to produce docile cattle for draught work, to reduce unwanted breeding, and to modify carcass quality. All the physical methods used to castrate cattle have side-effects and cause pain. The plasma cortisol response to castration using Burdizzo clamps and, by inference, the acute pain experienced, is less than that caused by surgical, rubber-ring or latex-band castration. The cortisol response may be influenced by the age of the animal castrated, but this has not been well defined. Local anaesthesia virtually eliminates the cortisol response, and thus the acute pain, caused by rubber-ring or latex-band castration, but needs to be combined with a systemic analgesic such as the non-steroidal anti-inflammatory drug ketoprofen to eliminate the cortisol response to Burdizzo or surgical castration. When used alone, ketoprofen sometimes reduces the cortisol response to Burdizzo or surgical castration but may need to be accompanied by local anaesthesia to eliminate the pain-induced behaviour seen during the castration process itself. Thus, pharmacological methods are available to virtually eliminate the acute pain experienced by calves during the 12 h following castration. The use of these methods is an additional cost for farmers and may be limited by the availability of drugs for farmers to use and the scarcity of veterinarians in farm animal practice.  相似文献   

4.
OBJECTIVE: To determine the effects of preoperative administration of ketoprofen on anesthetic requirements and signs of postoperative pain in dogs undergoing elective ovariohysterectomy. DESIGN: Randomized, controlled clinical trial. ANIMALS: 22 clinically normal client-owned dogs. PROCEDURE: 60 minutes before induction of anesthesia, 11 dogs were given ketoprofen (2 mg/kg [0.9 mg/lb], i.m.), and the other 11 were given saline (0.9% NaCl) solution. Dogs were premedicated with glycopyrrolate, acepromazine, and butorphanol and anesthetized with thiopental; anesthesia was maintained with isoflurane. Ovariohysterectomy was performed by an experienced surgeon, and butorphanol was given 15 minutes before completion of the procedure. Objective behavioral scores and numerical pain scores at rest and with movement were recorded every 2 hours for 12 hours after surgery and then every 4 hours for an additional 12 hours. RESULTS: Preoperative administration of ketoprofen did not reduce the dose of thiopental required to induce anesthesia or the end-tidal concentration of isoflurane required to maintain anesthesia. Activity levels and median objective behavioral scores were significantly higher 4 and 6 hours after surgery in dogs given ketoprofen than in dogs given saline solution. However, mean numerical pain scores in dogs given ketoprofen were not significantly different from scores for dogs given saline solution at any time. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that preoperative administration of ketoprofen does not reduce anesthetic requirements in dogs undergoing elective ovariohysterectomy but may reduce signs of pain after surgery. Results also suggest that the objective behavioral score may be a more sensitive measure of acute postoperative pain than traditional numerical pain scores.  相似文献   

5.
OBJECTIVE: To compare the safety and efficacy of preoperative administration of meloxicam with that of ketoprofen and butorphanol in dogs undergoing abdominal surgery. ANIMALS: 36 dogs undergoing laparotomy, splenectomy, or cystotomy. PROCEDURE: Dogs were randomly assigned to 1 of 3 groups. In the first part of the study, dogs were given a single dose of meloxicam, ketoprofen, or a placebo, and buccal mucosal bleeding times were measured. In the second part of the study, dogs were given meloxicam, ketoprofen, or butorphanol prior to surgery. Dogs in the butorphanol group received a second dose immediately after surgery. Pain scores (1 to 10) were assigned hourly for 20 hours after surgery and used to determine an overall efficacy score for each dog. Dogs with a pain score > or =3 were given oxymorphone for pain. Dogs were euthanatized 8 days after surgery, and gross and histologic examinations of the liver, kidneys, and gastrointestinal tract were conducted. RESULTS: Overall efficacy was rated as good or excellent in 9 of the 12 dogs that received meloxicam, compared with 9 of the 12 dogs that received ketoprofen and only 1 of the 12 dogs that received butorphanol. No clinically important hematologic, biochemical, or pathologic abnormalities were detected. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggest that preoperative administration of meloxicam is a safe and effective method of controlling postoperative pain for 20 hours in dogs undergoing abdominal surgery; the analgesic effects of meloxicam were comparable to those of ketoprofen and superior to those of butorphanol.  相似文献   

6.
瘘管手术会引起牛消化功能的紊乱,手术后护理中,饲喂环节应结合限饲和逐步加量的原则,实现牛采食量的逐步恢复。作者通过对11头奶牛瘤胃瘘管和十二指肠瘘管安装手术、术后护理、采食和体重的恢复状况进行记录,为奶牛的瘘管手术和术后护理提供指导。  相似文献   

7.
Recent studies have identified a phenomenon in which ciliated protozoa engulf Salmonella and the intra-protozoal environment hyperactivates virulence gene expression and provides a venue for conjugal transfer of antibiotic resistance plasmids. The former observation is relegated to Salmonella bearing the SGI1 multiresistance integron while the latter phenomenon appears to be a more generalized event for recipient Salmonella. Our previous studies have assessed virulence gene hyperexpression only with protozoa from the bovine rumen while conjugal transfer has been demonstrated in rumen protozoa from cattle and goats. The present study examined virulence gene hyperexpression for Salmonella exposed to rumen protozoa obtained from cattle, sheep, goats, or two African ruminants (giraffe and bongo). Conjugal transfer was also assessed in these protozoa using Salmonella as the recipient. Virulence gene hyperexpression was only observed following exposure to the rumen protozoa from cattle and sheep while elevated virulence was also observed in these animals. Conjugal transfer events were, however, observed in all protozoa evaluated. It therefore appears that the protozoa-based hypervirulence is not universal to all ruminants while conjugal transfer is more ubiquitous.  相似文献   

8.
本试验旨在研究功能性寡糖(甘露寡糖、果寡糖和大豆寡糖)组合对锦江黄牛的瘤胃液细菌多样性的影响.选择3头健康且体重相近的安装有永久性瘤胃瘘管的锦江黄牛,采用自身对照方法,试验分2期进行,第1期:对照期,饲喂基础饲粮,不添加任何寡糖;第2期:添加期,饲喂基础饲粮+功能性寡糖(0.8％甘露寡糖+1.0％果寡糖+0.8％大豆寡糖),每期持续14 d.利用PCR-变性梯度凝胶电泳(DGGE)方法研究分析牛瘤胃液细菌多样性.结果表明:添加功能性寡糖组合后,牛瘤胃液细菌PCR-DGGE图谱条带数明显增加,3头牛增加了5个共同条带.经测序,其中2个是产琥珀酸丝状杆菌属,3个是未鉴定细菌.饲粮中添加功能性寡糖组合可使瘤胃液细菌菌群种类明显增加.结果提示,饲粮添加功能性寡糖组合能够影响瘤胃菌群区系,增强其稳定性.  相似文献   

9.
牛瘤胃积食又被称为瘤胃急性扩张,是牛养殖中最易发生流行的一种胃部疾病,主要是因为大量的纤维饲料或者易产生气体的膨胀饲料堆积在瘤胃中,不能正常向下运转,造成瘤胃容积显著扩大,内容物长期停滞发酵产生酸性物质,影响前胃机能,形成脱水和酸中毒的一种疾病。在牛养殖中,需要对饮食和饲养管理进行严格的要求,确保整个养殖环境清洁卫生,有效防止牛异食癖引发瘤胃积食的发生,保证牛健康生长。该文主要论述牛瘤胃积食的发病原因、临床症状和防治措施。  相似文献   

10.
OBJECTIVE: To evaluate the degree of postoperative pain in dogs undergoing elective castration or ovariohysterectomy (OHE); determine whether an association exists between surgeon experience, incision length, or surgery duration and degree of postoperative pain; and determine whether analgesic treatment decreases expression of postoperative pain behaviors. DESIGN: Randomized controlled clinical trial. ANIMALS: 426 client-owned dogs undergoing OHE or castration. PROCEDURES: Dogs underwent OHE or castration performed by an experienced veterinarian or a fourth-year veterinary student. Dogs were randomly assigned to 1 of 4 treatment groups: no perioperative analgesic treatment (n = 44), preoperative administration of morphine (144), preoperative administration of nalbuphine (119), and postoperative administration of ketoprofen (119). Dogs were evaluated while in the hospital before anesthesia and for 4 hours after surgery and once a day at home for 3 days after surgery. RESULTS: Dogs in all 4 groups had significant increases in overall pain scores after surgery, compared with baseline scores. There were significant differences among groups, with control dogs having significantly higher increases in overall pain scores than dogs in the other groups. Factors that did not influence the frequency or severity of pain-related behaviors included breed, individual hospital, anesthetic induction protocol, surgeon experience, and duration of surgery. CONCLUSIONS AND CLINICAL RELEVANCE: Results suggested that dogs expressed behaviors suggestive of pain following OHE and castration, that analgesic treatment mitigated the expression of pain-related behaviors, and that surgeon experience and surgery duration did not have any effect on expression of pain-related behaviors.  相似文献   

11.
[目的]分析肉牛场不同牛群全混合日粮(TMR)的粒度和饲料消化率。[方法]在固原市瑞科丰农牧科技有限公司选取西门塔尔牛犊牛、母牛、育肥牛各120头作为试验牛群,对照组和试验组各60头,试验组日粮中添加酵母培养物AYC-X6,对照组未添加。[结果]结果表明,断奶犊牛和育肥牛TMR日粮粒度第2层比例最高分别为51.60%,52.9%。母牛第1,2,3层比例基本相同,在20.30%～21.85%之间。犊牛日粮中添加酵母培养物AYC-X6后第1,2层筛上物合计35%,比例下降,说明犊牛消化程度增加,消化率提高。育肥牛日粮第1,2层筛上物合计分别为64%,48%,分别比对照组降低8%,24%。[结论]肉牛TMR日粮粒度越大,粗饲料越长,过瘤胃速度越慢;育肥前期粗饲料长度为2.5 cm,育肥后期粗饲料长度3.5 cm。断奶犊牛和育肥牛日粮中添加酵母培养物AYC-X6提高了饲料消化率。  相似文献   

12.
The reticulum, rumen, omasum and abomasum were assessed via ultrasonography in 10 healthy female calves before, during and 2h after feeding hay and grass silage. The evaluations were made using an ultrasound machine with a 5.0MHz linear transducer. The reticulum could be visualized before feeding in all the calves. Its appearance and pattern of contractions were similar to those in adult cattle, although the amplitude (5.2±1.06cm) and velocity (3.5±1.42cm/s) of the first contraction were markedly less than in adult cattle. The position and size of the entire rumen including the dorsal and ventral sacs and the ruminal contents were assessed. Except for its smaller size, the ultrasonographic appearance of the omasum of calves was similar to that of adult cattle. The abomasum was seen to the left and right of the ventral midline before feeding in all calves; it occupied considerably more space on the left than the right. Compared with its appearance before feeding, the ultrasonographic appearance of the rumen, omasum and abomasum did not change during or after feeding. Ultrasonography is an ideal imaging tool for evaluating the reticulum, rumen, omasum and abomasum before, during and after feeding in calves.  相似文献   

13.
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14.
Ruminal microorganisms in cattle at a Florida agriculture research station did not have the ability to detoxify leucaena by degradation of 3-hydroxy-4(1H)-pyridone (3,4,-DHP), but a DHP isomer (2,3-DHP) was degraded in some cattle. Cattle with microorganisms that degraded 2,3-DHP were mostly Senepol cattle imported from St. Croix, US Virgin Islands, where leucaena is an indigenous species. Hereford cattle at the research station in Florida generally did not degrade 3,4-DHP or 2,3-DHP. An experiment was conducted in which a pure culture of 3,4-DHP-degrading bacteria was inoculated into Hereford cattle (with ruminal fistula) grazing leucaena. The bacteria successfully colonized the rumen of recipient cattle and persisted through the following winter when there was no leucaena in the diet.  相似文献   

15.
常青 《中国饲料》2020,(2):85-88
本试验旨在研究甘蔗青贮饲料的基因型和成熟期对肉牛瘤胃纤维消化率、采食量、瘤胃发酵、瘤胃动力学和瘤胃细菌数量的影响。试验采用2×2因子设计,即两个基因型(高和低中性洗涤纤维消化率)和2个收割期(早熟和晚熟)。试验日粮以40%青贮甘蔗饲料为试验料。结果:饲喂早熟甘蔗青贮饲料时干物质采食量较大,但仅表现在低中性洗涤纤维消化率基因型(P<0.05)。早熟甘蔗日粮较晚熟甘蔗日粮显著提高了中性洗涤纤维摄入量(P<0.05)。饲喂低中性洗涤纤维基因型饲粮时,瘤胃池干物质、中性洗涤纤维和不可消化中性洗涤纤维含量更高(P<0.05)。饲喂高中性洗涤纤维消化率品种的青贮甘蔗时,中性洗涤纤维和不可消化中性洗涤纤维过瘤胃速率更高(P<0.05)。饲喂早熟青贮甘蔗饲料的肉牛瘤胃pH较大,但表现在高中性洗涤纤维消化率品种组(P<0.05)。饲喂早熟青贮甘蔗饲料时,低中性洗涤纤维消化率品种组肉牛瘤胃短链脂肪酸总浓度较高(P<0.05)。晚熟期青贮甘蔗较早熟期显著提高了埃氏巨球型菌相对含量(P<0.05)。综上所述,采用高中性洗涤纤维消化率品种的青贮甘蔗饲喂生长期肉牛,可以通过更快的纤维过瘤胃速率和纤维周转对瘤胃池产生积极影响,这可能有利于提高采食量。  相似文献   

16.
OBJECTIVE: To compare the safety and efficacy of 2 analgesic protocols (preoperative meloxicam or intraoperative ketoprofen administration) during the first 24 hours after orthopedic surgery in dogs. STUDY DESIGN: Double-blind, prospective randomized clinical trial. ANIMALS: Sixty client-owned dogs. METHODS: Dogs with surgical orthopedic disorders were randomly separated into 2 groups: 30 dogs were administered 0.2 mg/kg meloxicam intravenously (IV) immediately before induction and 30 dogs were administered 2 mg/kg ketoprofen IV, 30 minutes before the end of surgery. Pain was assessed with a visual analog scale (VAS) and a cumulative pain score (CPS) preoperatively and at 30 minutes, 1, 2, 3, 4, 6, 8, and 24 hours after extubation. Selected serum biochemical variables were measured before and 24 hours after surgery and, buccal mucosal bleeding time (BMBT) and whole blood clotting time (WBCT) were measured before and 8 hours after surgery. Dogs were anesthetized with propofol and maintained on halothane in oxygen. Any complications were documented for 7 days after surgery. Results were compared between the 2 groups for significant differences in VAS scores (2-sample t-test) and in CPS (Wilcoxon's 2-sample test). Moreover, results were analyzed for significant differences in area under the curve (AUC) for VAS (2-sample t-test) and CPS (Wilcoxon's 2-sample test) among groups. To assess the effects of treatments on biochemical and coagulation functions, pre- and postoperative mean values of BMBT and WBCT were compared within both treatment groups (paired t-tests) and between both groups (2-sample t-test). RESULTS: No significant differences in pain response or coagulation were found between meloxicam- and ketoprofen-treated dogs. In both groups, alkaline phosphatase and alanine aminotransferase concentrations were significantly increased compared with baseline. No serious complications occurred. CONCLUSIONS: Preoperative administration of meloxicam is a safe and effective method of controlling postoperative pain for up to 24 hours in dogs undergoing orthopedic surgery. CLINICAL RELEVANCE: Analgesia after administration of preoperative meloxicam was comparable with administration of ketoprofen at the end of the surgery.  相似文献   

17.
We investigated changes in the predicted functions of the rumen bacterial community in Japanese Black beef cattle during fattening. Nine cattle were fed a high-concentrate diet during the early, middle, and late fattening stages consecutively (10–14, 15–22, and 23–30 months of age, respectively). The rumen fluid and solid samples collected at each stage were subjected to sequencing analyses. The sequencing results were clustered and classified into operational taxonomic units (OTUs). Representative sequences and a raw counting table for each OTU were submitted to the Piphillin website. The predicted functions were revealed by the Kyoto Encyclopedia of Genes and Genomes database as the ratio of the total sequence. In the early stage, “Biosynthesis of secondary metabolites” was significantly higher in the fluid fraction than in the solid fraction. “Two-component system” in the middle stage was significantly lower and “Purine metabolism” in the late stage was significantly higher in the fluid fraction than those in the solid fraction. The fluid fraction was significantly correlated with acetic acid, propionic acid, and bacterial metabolism, such as “Biosynthesis of secondary metabolites” and “Sugar metabolism.” Moreover, the solid fraction was correlated with “Purine metabolism” and “Biosynthesis of secondary metabolism”. These results suggest that the rumen bacterial community in Japanese Black beef cattle adapts to changes in rumen conditions by altering their functions in response to a long-term high-grain diet.  相似文献   

18.
To determine if ketoprofen, in addition to local anaesthesia, reduces pain following dehorning, we experimentally dehorned dairy calves, less than 2 weeks of age, with (20 calves) or without (20 calves) intramuscular injections of ketoprofen. All calves received a local anesthetic (lidocaine) prior to dehorning and were dehorned with heat cauterization. Cortisol concentration was measured via jugular blood samples taken immediately before dehorning and at 3 and 6 hours following dehorning. Calf behavior was recorded between 0 and 2, 3 and 5, and 6 and 8 hours following dehorning. There was no significant (P > 0.10) effect on creep feed consumption, cortisol concentration, or any of the behavioral measures during the time periods studied. However, the difference in cortisol concentrations from the time of dehorning until 3 hours later was significantly lower (P < 0.05) in the ketoprofen-treated group. These results suggest that ketoprofen, in addition to local anesthesia, may alleviate short-term pain following dehorning with a butane dehorning device in dairy calves less than 2 weeks of age.  相似文献   

19.
作为牛的常见病之一,牛瘤胃臌气的临床特点主要在于左侧腹围膨大明显,且叩诊牛瘤胃存在鼓音。根据牛瘤胃臌气的性质具体分为非泡沫性臌气与泡沫性臌气两种。本研究主要分析与探讨牛瘤胃臌气的诊断和治疗方法。  相似文献   

20.
In the period of 1975-1982 6 experiments with young female cattle of various rearing intensities were carried out. The respiration trial technique for the measuring of energy and protein metabolization in connection with the registration of a number of rumen physiologic data were applied together with comparative studies of the digestibility and the rumen fermentation of the rations used with young cattle and with fully grown sheep. The extent of the experiment was characterized by 695 metabolism periods in calves and young cattle as well as by 149 comparative studies of the digestibility and the rumen metabolism of the fully grown sheep. The results ascertained are the basis of the derivation of the energy requirement for the rearing of young female cattle according to factorial criteria. This first out of six papers on these experiments comprises an outline of the experiment arrangement, the material and the methods as well as of the live weight development of the animals. In four of the six experiments there was a continuous monthly registration of the measured values over the complete period of the rearing of the weaned calves up to their calving with four animals each under conditions of extremely high (experiment 1), medium (experiments 5 and 6) and low (experiment 3) rearing intensity. Experiments 2 and 4 provide additional information on rearing periods under special consideration of the gestation period. In experiment 1 the cows were not milked after the first calving, and measuring was continued to the second calving of the animals.  相似文献   

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