共查询到20条相似文献，搜索用时 15 毫秒
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Transcription of class III genes: formation of preinitiation complexes 总被引：125，自引：0，他引：125
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Nicolas P Mäder U Dervyn E Rochat T Leduc A Pigeonneau N Bidnenko E Marchadier E Hoebeke M Aymerich S Becher D Bisicchia P Botella E Delumeau O Doherty G Denham EL Fogg MJ Fromion V Goelzer A Hansen A Härtig E Harwood CR Homuth G Jarmer H Jules M Klipp E Le Chat L Lecointe F Lewis P Liebermeister W March A Mars RA Nannapaneni P Noone D Pohl S Rinn B Rügheimer F Sappa PK Samson F Schaffer M Schwikowski B Steil L Stülke J Wiegert T Devine KM Wilkinson AJ van Dijl JM Hecker M Völker U Bessières P 《Science (New York, N.Y.)》2012,335(6072):1103-1106
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Developmental regulation of two 5S ribosomal RNA genes 总被引：36，自引：0，他引：36
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Aloy P Böttcher B Ceulemans H Leutwein C Mellwig C Fischer S Gavin AC Bork P Superti-Furga G Serrano L Russell RB 《Science (New York, N.Y.)》2004,303(5666):2026-2029
Images of entire cells are preceding atomic structures of the separate molecular machines that they contain. The resulting gap in knowledge can be partly bridged by protein-protein interactions, bioinformatics, and electron microscopy. Here we use interactions of known three-dimensional structure to model a large set of yeast complexes, which we also screen by electron microscopy. For 54 of 102 complexes, we obtain at least partial models of interacting subunits. For 29, including the exosome, the chaperonin containing TCP-1, a 3'-messenger RNA degradation complex, and RNA polymerase II, the process suggests atomic details not easily seen by homology, involving the combination of two or more known structures. We also consider interactions between complexes (cross-talk) and use these to construct a structure-based network of molecular machines in the cell. 相似文献
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