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1.
An evaluation of production orders for medicated feedingstuffs for pigs given in 1998 in Schleswig-Holstein showed aminoglycosides, colistin and beta-lactam antibiotics as regularly used antibiotical ingredients. The presented study analyses the production orders which include these antibiotics more in detail particularly with regard to the prescribed dosages. In part, there were deviations to the rules of good clinical practise for the use of anitbiotics. The applied dosage of spectinomycin and apramycin was often lower than suggested in the literature. The low oral bioavailability of amoxicillin was not considered when using amoxicillin in medicated feedingstuffs.  相似文献   

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中兽药是兽医用药的重要组成部分,兽用中药制剂的质量与中药材前处理及中药提取工艺密切相关。文章从车间布局、设施设备和车间环境要求等方面详细分析了《兽药生产质量管理规范》对中药前处理车间和中药提取车间的要求,并结合生产实际提出中药前处理车间和中药提取车间的设计建议,给兽药企业中药前处理车间和提取车间GMP改造提供参考,以期在设计和建造中降低企业成本,满足兽用中药提取物及中药制剂达到安全、有效、稳定、可控的质量要求。  相似文献   

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The oral medication of sick animals is very common and a very preserve therapy. This method of therapy demands a high level of know-how for the veterinarians and also for meet-producers relating to food safety and bacterial resistance. In the new ordinance on veterinary medicine in 2004 many aspects of production and application of medicated feed are regulated in the legislation. This ordinance pretends to control all technical equipments used for production, transport and application of medicated feed by a qualified person (QP) on farms. Important criteria are defined in the ordinance on veterinary medicines.  相似文献   

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The "International Co-operation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH)" is an international programme of co-operation between regulatory authorities and the animal health industries of the European Union, Japan, and the United States of America which aims to harmonise the technical requirements for the registration of veterinary medicinal products. Australia and New Zealand participate as active observers. The objective of the present paper is to present the guidelines established by the working group on Anthelmintic Efficacy Guidelines: (1) efficacy of anthelmintics: general requirements (VICH GL7); (2) efficacy of anthelmintics: specific recommendations for bovines (VICH GL12); (3) efficacy of anthelmintics: specific recommendations for ovines (VICH GL13); (4) efficacy of anthelmintics: specific recommendations for caprines (VICH GL14). These guidelines do not consist of rigid stipulations, but make clear recommendations on the minimal standards needed. To the veterinary profession, livestock producers and animal owners, harmonisation should mean quicker access to safer and more effective veterinary anthelmintics. In general, products should be relatively more affordable because of the reduction in registration costs and efficient use of resources by the regulatory authorities.  相似文献   

6.
The "International Co-operation on Harmonisation of Technical Requirements for Registration of Veterinary Medicinal Products (VICH)" is an international programme of co-operation between regulatory authorities and the animal health industries of the European Union, Japan and the United States of America which aims to harmonise the technical requirements for the registration of veterinary medicinal products. Australia and New Zealand participate as active observers. The objective of this second paper is to present additional guidelines established by the Working Group on anthelmintic guidelines: (1) efficacy of anthelmintics: specific recommendations for equine (VICH GL15), (2) efficacy of anthelmintics: specific recommendations for porcine (VICH GL16), (3) efficacy of anthelmintics: specific recommendations for canine (VICH GL19), (4) efficacy of anthelmintics: specific recommendations for feline (VICH GL20) and (5) efficacy of anthelmintics: specific recommendations for poultry (VICH GL21). These guidelines do not consist of rigid stipulations, but make clear recommendations on the minimal standards needed. To the veterinary profession, livestock producers and animal owners, harmonisation should mean quicker access to safer and more effective veterinary anthelmintics. In general, products should be relatively more affordable because of the reduction in registration costs and efficient use of resources by the regulatory authorities.  相似文献   

7.
通过对兽药GMP实施前后江苏兽药市场质量状况的抽检调查统计,从兽药市场抽检产品类别、抽样环节、动物品种及省内外产品等各方面分析了兽药GMP实施以来全省兽药质量状况和存在的问题,并探析兽药质量问题的内在原因,提出了提高兽药产品质量的对策,为新一轮兽药GMP的复验及兽药监管工作提供参考。  相似文献   

8.
The lack of Federal Drug Administration-approved drug products in the United States for avian and exotic animals creates daily challenges for the practitioner. The day-to-day practice of avian and exotic animal medicine requires us to meet these challenges in many ways, including by: extralabel use of domestic human and animal products; simple compounding or other manipulations in the clinical setting; using a pharmacy compounding service; using medicated feeds; and using imported pharmaceutical products. These may present legal and ethical issues to the practitioner that he or she may not be aware of. This paper will discuss some of practical and legal implications of these methods (based on U.S. laws), with an emphasis on compounding and extralabel use.  相似文献   

9.
Although seemingly rare, adverse reactions to veterinary products do occur. These may arise from inadvertent exposure during use or as a result of occupational accidents. They are often mild in nature and include adverse effects such as minor skin reactions. However, more serious reactions may occur, and they are not restricted to the effects of the veterinary medicines themselves. For example, high-pressure injection injuries may occur as a result of accidents occurring during animal vaccination operations. This paper reviews some of these events, mentions where appropriate the regulatory actions taken, and describes some of the measures used to minimise such effects in the future, and serves to bring the issues discussed here to the attention of pharmacologists, pharmacoepidemiologists and others who train those who use veterinary medicinal products.  相似文献   

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在对山东省畜禽养殖管理情况和用药现状的调研中,一方面看到了近几年在饲养管理和兽药等投入品监管中的进步,另一方面也发现,在畜禽养殖场中不规范用药是影响畜产品质量的重要风险之一.同时,深刻分析了兽药残留和耐药性的产生原因并提出了规范用药、保障畜产品安全的对策,以提升畜产品质量安全监管水平,促进畜牧业科学发展.  相似文献   

13.
A study was conducted in the Madikwe District of the North West Province to investigate the supply of veterinary medicinal products to small-scale, subsistence and emerging farmers. A combination of individual interviews, focus groups and direct observation was used to collect data. Stock remedies were made available to farmers within the district at Field Service Units that were managed by administrative staff of the Directorate of Field Services. The state veterinarian and animal health technicians were not directly involved with the sale of products. Most farmers still travelled to farmers' cooperatives in the larger centres outside the district to purchase the veterinary medicinal products they needed. Factors such as the quality of service provided, affordability and availability of required products as well as inaccessibility of outlets to all farmers contributed to the poor support of these outlets by the farmers of the district.  相似文献   

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The animal-health industry continues to offer many different opportunities for veterinarians interested in business applications for products and ideas vested in animal health and animal husbandry. These opportunities are expanding rapidly and becoming more diverse every day. Successful animal-health companies are increasing the recruiting and retention of business-savvy veterinary professionals. Employment earnings and broad offerings of employment extras in the animal health industries are in the top strata of the many veterinary professional options.  相似文献   

16.
Dental, oral, and maxillofacial diseases are some of the most common problems in small animal veterinary practice. These conditions create significant pain as well as localized and potentially systemic infection. As such, the World Small Animal Veterinary Association (WSAVA) believes that un- and under treated oral and dental diseases pose a significant animal welfare concern. Dentistry is an area of veterinary medicine which is still widely ignored and is subject to many myths and misconceptions. Effective teaching of veterinary dentistry in the veterinary school is the key to progression in this field of veterinary medicine, and to the improvement of welfare for all our patients globally. These guidelines were developed to provide veterinarians with the information required to understand best practices for dental therapy and create realistic minimum standards of care. Using the three-tiered continuing education system of WSAVA, the guidelines make global equipment and therapeutic recommendations and highlight the anaesthetic and welfare requirements for small animal patients. This document contains information on common oral and dental pathologies, diagnostic procedures (an easily implementable and repeatable scoring system for dental health, dental radiography and radiology) and treatments (periodontal therapy, extractions). Further, there are sections on anaesthesia and pain management for dental procedures, home dental care, nutritional information, and recommendations on the role of the universities in improving veterinary dentistry. A discussion of the deleterious effects of anaesthesia free dentistry (AFD) is included, as this procedure is ineffective at best and damaging at worst. Throughout the document the negative effects of undiagnosed and/or treated dental disease on the health and well-being of our patients, and how this equates to an animal welfare issue, is discussed.  相似文献   

17.
Diethylstilboestrol is currently only available in Australia for oral use in dogs and cats. As an orally and systemically active non-steroidal oestrogen, DES has been widely used in small animal veterinary medicine for a variety of indications. A review of the literature reveals that many of the recommendations for use are founded on anecdotal or unreported clinical observations. While many of the uses may be valid, accurate determinations of optimum dosing regimens have not been defined. This is especially unfortunate in view of the potential toxicity of DES to small animals. Nevertheless, particularly in cases of low-dose intermittent administration, oral DES appears indicated at least until data on alternative safe and effective interventions become available.  相似文献   

18.
Claw diseases pose a major problem for dairy and sheep farms. As well as systemic treatments of these illnesses by means of drug injection, veterinarians discuss the application of footbaths for the local treatment of dermatitis digitalis or foot rot. On farms footbaths are used with different substances and for various purposes. The author presents the requirements for veterinary medicinal products (marketing authorization and manufacturing authorization) and demonstrates the operation of the "cascade in case of a treatment crisis". In addition, the distinction between veterinary hygiene biocidal products and veterinary medicinal products and substances to care for claws is explained.  相似文献   

19.
An evaluation of production orders for medicated feedingstuffs for pigs given in 1998 in Schleswig-Holstein showed macrolides, lincomycin and tiamulin as frequently used antibiotical ingredients. The presented study analyses the production orders which include macrolides, lincomycin or tiamulin in more detail. There were large deviations to the rules of good clinical practise for the use of antibiotics (2000). The applied dosage was often lower than suggested in the literature.  相似文献   

20.
An evaluation of production orders for medicated feedingstuffs for pigs given in 1998 in Schleswig-Holstein showed sulphonamides and combinations of sulphonamides and trimethoprim as frequently used antibiotical ingredients. The presented study analyses the production orders which include sulphonamides and combinations of sulphonamides and trimethoprim in more detail. There were large deviations to the rules of good clinical practise for the use of antibiotics. The applied dosage was often lower than suggested in the literature.  相似文献   

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