共查询到19条相似文献，搜索用时 250 毫秒
1.
为探讨艾叶挥发油对H2O2诱导的鲤鱼肝脏氧化损伤的保护作用,本试验以H2O2为诱导剂构建鲤鱼肝脏氧化应激损伤模型,分别投喂添加0.1、0.2和0.4 g·kg-1艾叶挥发油的饵料对其进行保护。试验进行30 d后,采集鲤鱼的血清和肝脏,检测谷丙转氨酶(ALT)、谷草转氨酶(AST)、超氧化物歧化酶(SOD)、过氧化氢酶(CAT)、谷胱甘肽过氧化物酶(GPx)活性和总蛋白(TP)、白蛋白(ALB)、丙二醛(MDA) 含量;采用组织学方法对鲤鱼肝组织切片进行显微观察;使用实时荧光定量PCR (qRT-PCR)技术检测Cu/Zn-SOD、Mn-SOD、GPx、CAT和核转录因子(Nrf2) mRNA的相对表达量。结果表明,H2O2暴露30 d后,鲤鱼血清中ALT、AST活性升高,TP、ALB含量下降;血清和肝脏中SOD、CAT、GPx活性降低,MDA含量上升,H2O2导致肝脏组织病理损伤,抗氧化基因表达受到抑制。而艾叶挥发油能够抑制ALT、AST活性的上升和TP、ALB含量的下降,提高机体的抗氧化能力,缓解肝脏组织的病理损伤,激活Nrf2诱导细胞抗氧化基因的表达。综上所述,艾叶挥发油对H2O2诱导的鲤鱼肝脏氧化损伤具有一定的保护作用。本研究可为进一步探究艾叶挥发油作为绿色安全的抗氧化剂提供思路和基础资料。 相似文献
2.
为研究辣木叶黄酮(FMOL)对高脂血症小鼠的体质量、血脂和肝脏的影响,将60只雄性小鼠随机分为6组:正常组、高脂模型组、阳性对照组(辛伐他汀)、FMOL高剂量组、FMOL中剂量组、FMOL低剂量组,对正常组喂养基础饲料,其余各组喂养高脂饲料,连续喂养5周后,测定小鼠相关指标及肝脏组织形态变化。结果表明,FMOL可以显著抑制高脂膳食小鼠的体质量增长,降低肝脏指数;降低血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇(LDL-C)和动脉硬化指数(AI)水平;同时降低谷草转氨酶(AST)、谷丙转氨酶(ALT)和丙二醛(MDA)水平。此外,小鼠的高密度脂蛋白胆固醇(HDLC)水平和超氧化物歧化酶(SOD)活性都有所提升。本研究结果为辣木叶总黄酮的开发利用提供了一定的理论依据。 相似文献
3.
蛋氨酸铜对西门塔尔牛日粮养分消化代谢及血液指标的影响 总被引：1，自引：0，他引：1
选用16头平均体重420 kg、年龄2.5岁的中国西门塔尔牛阉牛,采用随机区组设计分为4组,以混合精料和风干玉米秸秆为基础日粮,以蛋氨酸铜为铜源,在基础日粮中分别添加铜0 mg·kg-1、8 mg·kg-1、16mg·kg-1和24 mg·kg-1,研究蛋氨酸铜对西门塔尔牛营养物质消化代谢和血液指标的影响。结果表明:添加铜处理可显著提高有机物质(OM)、粗蛋白质(CP)、粗脂肪(EE)和无氮浸出物(NFE)消化率(P<0.05)。8 mg·kg-1和16 mg·kg-1处理组显著提高中性洗涤纤维(NDF)和酸性洗涤纤维(ADF)消化率(P<0.05)。蛋氨酸铜补充组显著提高消化氮(DN)、沉积氮(RN)和RN/DN。8～16 mg·kg-1蛋氨酸铜补充组较0 mg·kg-1组显著增加血清甘油三酯(TG)、葡萄糖(GLU)、总胆固醇(TC)、白蛋白(ALB)和总蛋白(TP)含量(P<0.05)。24 mg·kg-1处理组血清尿素氮(SUN)明显低于对照组(P<0.05)。随着蛋氨酸铜添加水平的提高,各组间血清谷草转氨酶(GOT)、谷丙转氨酶(GPT)、碱性磷酸酶(AKP)、酸性磷酸酶(ACP)、乳酸脱氢酶(LDH)差异均不显著(P>0.05),血清铜蓝蛋白(Cp)逐渐增加(P<0.05),超氧化物歧化酶(SOD)和谷胱甘肽过氧化物酶(GSH-px)活性显著提高(P<0.05),丙二醛(MDA)呈下降趋势(P<0.05)。16 mg·kg-1和24mg·kg-1处理组血清铜含量显著高于对照和8 mg·kg-1处理组(P<0.05)。根据试验结果,蛋氨酸铜添加量以8～16 mg·kg-1为宜。 相似文献
4.
血管紧张素转化酶2(ACE2)对大鼠肾氧化应激损伤的保护作用及其机制 总被引：1，自引：0，他引：1
本研究以腹腔注射链脲佐菌素(STZ)制造大鼠(Rattus norregicus)肾脏氧化应激损伤模型,并每天皮下注射3.7×10-5mol/L的胰岛素溶液1mL进行干预,探讨血管紧张素转化酶2(ACE2)在高糖所致的肾脏氧化应激损伤中的保护作用及其可能的机制。30d后,所有大鼠断头处死,采集血清及肾脏组织。测定所用大鼠血清中糖基化终末产物(AGEs)、丙二醛(MDA)、超氧化物歧化酶(SOD)、血管紧张素Ⅱ(AngⅡ)、血管紧张素1-7(Ang1-7)含量和肾脏组织中ACE2及Ang1-7受体MasmRNA水平。结果表明,与对照组相比,高血糖组大鼠血清AGEs、MDA和AngⅡ含量均极显著升高(P<0.01),SOD和Ang1-7含量极显著下降(P<0.01);肾脏组织中ACE2mRNA表达极显著下调(P<0.01),MasmRNA表达极显著上调(P<0.01)。胰岛素治疗后,大鼠血清中AGEs和MDA含量极显著下降(P<0.01),血清SOD含量极显著升高(P<0.01);AngⅡ含量显著下降(P<0.05),Ang1-7含量显著升高(P<0.05);肾脏组织中ACE2及其受体MasmRNA表达均极显著上... 相似文献
5.
为了研究浒苔多酚(Enteromorpha prolifera polyphenols, EPP)对高脂饮食诱导小鼠肥胖的预防作用,将24只C57BL/6J小鼠分为4组,即空白对照组、模型对照组、低剂量浒苔多酚处理组(100 mg·kg-1·d-1)以及高剂量浒苔多酚处理组(300 mg·kg-1·d-1),连续灌胃14周,考察不同剂量浒苔多酚干预对肥胖小鼠生理生化指标以及肠道菌群数量和结构的影响。结果表明,EPP能抑制肥胖小鼠体重增长,降低血清中总胆固醇(TC)、甘油三酯(TG)、低密度脂蛋白胆固醇浓度(LDL-C)、丙二醛(MDA)、谷草转氨酶(AST)和谷丙转氨酶(ALT)浓度,增加高密度脂蛋白胆固醇(HDL-C)浓度,提高超氧化物歧化酶(SOD)、过氧化氢酶(CAT)以及谷胱甘肽过氧化物酶(GSH-Px)活性。此外,EPP干预可提高有益菌如拟杆菌属(Bacteroides)、艾克曼菌属(Akkermansia)及副杆菌属(Parabacteroides)的相对丰度,促进短链脂肪酸(SCFAs)分泌;降低有害菌如瘤胃球菌属(Ruminococcaceae)及颤螺菌属(Oscillospira)的相对丰度。因此,浒苔多酚作为功能性食品成分能够减轻高脂饮食诱导的小鼠肥胖症状。本研究为浒苔多酚作为海洋资源的开发与利用提供了理论依据与数据支撑。 相似文献
6.
朗德鹅肝脏和脂肪组织LXRα基因表达水平的比较 总被引：4，自引：0，他引：4
采用荧光定量PCR技术检测了填饲和未填饲朗德鹅(landes anser)肝脏、腹脂、皮下脂肪组织和肌肉肝X受体α(LXRα)mRNA的表达水平,并与谷丙转氨酶等6种血清生化指标进行了相关性分析.结果发现,填饲组肝脏和腹脂组织LXRαmRNA表达水平显著高于对照组(P<0.05),高肝组皮下脂肪组织LXRα mRNA表达水平显著高于对照组和低肝组(P<0.05);肝脏组织LXRαmRNA表达水平与肝重/体重比呈显著正相关(P<0.05),相关系数为0.58,皮下脂肪组织LXRαmRNA表达水平与肝重/体重比呈极显著正相关(P<0.01),相关系数为0.77;肝脏LXRαmRNA表达水平与血清中甘油三酯和胆碱脂酶含量呈极显著正相关(P<0.01),相关系数分别是0.66和0.70. 相似文献
7.
研究了姜辣素对60Coγ射线损伤小鼠造血和抗氧化功能的治疗作用。18只雌性健康昆明小鼠被随机分为3组,每组6只,分别为对照组、照射组、照射给药组。对照组不照射,连续灌胃5d蒸馏水;照射组和照射给药组分别用3Gy60Coγ射线进行照射,并分别在照射后30min内灌胃蒸馏水和姜辣素,连续5d。末次灌胃后48h内测定所有小鼠血液中白细胞(WBC)和红细胞(RBC)数量、脏器指数、肝脏超氧化物歧化酶(SOD)活性、总抗氧化能力(T-AOC)、丙二醛(MDA)含量及骨髓嗜多染红细胞微核(MN)数目。与对照组相比,照射组脾脏指数、WBC极显著降低(P<0.01),肝脏MDA含量、骨髓MN数目极显著升高(P<0.01);与照射组相比,照射给药组脾脏指数、T-AOC、SOD活性极显著升高(P<0.01),肝脏指数、WBC、RBC含量也有所升高,MDA含量、MN数目极显著降低(P<0.01)。结果表明,姜辣素对60Coγ射线照射造成的小鼠造血、抗氧化功能损伤具有治疗作用。 相似文献
8.
本实验研究的主要目的是探讨安氟醚麻醉剂、速眠新Ⅱ麻醉剂对本地山羊肝、肾功能的影响。以4只广西都安黑山羊(Carpra hircus)为实验动物,以两周时间为间隔期,分别实施安氟醚吸入麻醉和速眠新肌肉注射麻醉。分别于麻醉前、麻醉后30、60、90、120 min以及麻醉苏醒后30 min采集血样,分离血清,并利用MS500e半自动生化分析仪测定血清总蛋白(TP)、总胆红素(TBIL)、直接胆红素(DBIL)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、γ-谷氨酰转肽酶(γ-GT)、尿素氮(BUN)和肌酐(CRE)的含量。结果表明:(1)两种麻醉方法使山羊的ALT、BUN值都呈现上升趋势,但对AST、DBIL和CRE均无明显的影响;(2)仅速眠新麻醉使TP上升;(3)仅安氟醚麻醉使TBIL上升。结论:(1)两种麻醉方法对山羊肝脏和肾脏功能都有不同程度的损害;(2)安氟醚吸入麻醉对肝功能的影响大于速眠新肌肉内麻醉,但是后者对肾功能的影响大于前者。 相似文献
9.
选用21日龄断奶的杜×长×大仔猪60头,随机分为基础日粮组、添加0.2%中药复方日粮组和添加0.02%粘杆菌素日粮组,试验期为28 d,分别于试验开始后第7、14和28天每组随机取5头试猪,前腔静脉采血,分离血清,测定游离氨基酸含量。结果表明,中药复方日粮组的血清总氨基酸含量在第14天和第28天显著高于基础日粮组(P<0.05),必需氨基酸和非必需氨基酸值在第14天和第28天显著高于基础日粮组和粘杆菌素日粮组(P<0.05),赖氨酸、苏氨酸和蛋氨酸含量在第14天和第28天显著高于基础日粮组(P<0.05)。提示在日粮中添加0.2%中药复方能显著提高早期断奶仔猪血清游离氨基酸(尤其是必需氨基酸)的含量,有利于机体蛋白质的快速沉积及生长性能的提高。 相似文献
10.
选用体重约3 0kg的杜×长×大三元杂生长猪9 6头,随机分成4个处理组,每组6个重复,每重复4头,公母比为1∶1。A组为对照组,饲喂基础饲粮,B、C、D组为试验组(分别以2 5 0、5 0 0、750 U植酸酶/kg饲粮取代基础饲粮中的40%、60%、80%磷酸氢钙),以研究玉米豆粕型饲粮中添加植酸酶对生长猪生长性能和血液生化指标的影响。42 d的饲养试验结果表明:与对照组相比,B、C、D组的日增重分别提高了1.05%(P>0.05)、4.09%(P<0.05)、2.64%(P>0.05);饲料/增重比分别较对照组降低了2.18%、2.62%、1.75%;生长增重的饲料成本分别是对照组的97.38%、97.03%和97.73%;血清中钙含量分别提高了4.22%、4.22%、8.12%(P<0.05);血清中磷含量分别提高了1.46%、0.36%、14.23%(P<0.05),其他生化指标组间无明显差异。 相似文献
11.
为研究不同剂量秋葵微粉对小鼠肠道内环境的影响,将小鼠随机分为4组,即对照组、高剂量组(1 800 mg·kg-1·d-1)、中剂量组(900 mg·kg-1d-1)以及低剂量组(450 mg·kg-1d-1),灌胃6周后,检测其粪便、结肠、盲肠相关的肠道指标。结果表明,与对照组相比,各剂量组小鼠粪便含水量均增加,且高剂量组粪便含水量显著高于对照组(P<0.05);各剂量组粪便pH值均极显著降低(P<0.01);各剂量组盲肠内容物 pH 值和结肠内容物pH值均降低。各剂量组盲肠内容物菌群OTU数量均极显著高于对照组(P<0.01),中剂量组Chaol值显著高于对照组(P<0.05);各剂量组结肠内容物菌群的OTU数量较对照组均有增加,中剂量组和低剂量组Chaol值极显著(P<0.01)和显著(P<0.05)高于对照组。各剂量组盲肠、结肠内容物中短链胎肪酸(SCFA)含量均较对照组增加。秋葵微粉可以提高小鼠肠道中的益生菌比例,降低有害菌比例,促进肠道乙酸、丙酸和丁酸等SCFA含量明显升高。本研究结果为秋葵微粉用于改善动物肠道健康提供了理论依据。 相似文献
12.
为探究葡萄籽原花青素(GSP)对营养肥胖模型大鼠肠粘膜通透性的影响,本试验设置了正常、模型、低剂量、中剂量及高剂量5个处理组,其中正常组投喂普通饲料,灌胃3 mL蒸馏水;模型组和低、中、高剂量组选用32只高脂饲料诱导的肥胖大鼠,模型组灌胃蒸馏水,低、中、高剂量组分别灌胃75、162.5、250 mg·kg-1BW·d-1GSP,灌胃处理6周再禁食12 h后处死,经解剖后测定各处理组大鼠的生理生化相关指标。结果表明,高脂饲料造模成功率48.75%;与模型组相比,低、中、高剂量组大鼠D-乳酸、乳果糖/甘露醇排出率显著降低,回肠绒毛高度/隐窝深度、紧密连接蛋白Occludin和 ZO-1 表达量显著升高;高剂量组大鼠的回肠杯状细胞数显著升高。综上,葡萄籽原花青素可以改善肥胖应激导致的大鼠肠道粘膜屏障损伤,这在一定程度上揭示了葡萄籽原花青素减肥降脂的作用机理。 相似文献
13.
仿刺参肠多糖对免疫功能的影响及抗肿瘤研究 总被引：1，自引：0，他引：1
多糖能参与机体的免疫调节,具有抗肿瘤等多种功能。本实验采用灌胃不同剂量仿刺参(Apostichopus japonicus)肠多糖的方法,研究了多糖对小鼠(Mus musculus)免疫功能的影响及其对小鼠的抗肿瘤作用。结果显示,仿刺参肠多糖对接种的H22肿瘤具有剂量依赖性的抑制作用,高剂量组(400mg/kg/d)抑瘤效果最好;胸腺指数高剂量肿瘤组最高(P<0.05),而其他各组差异不明显,脾脏指数在肿瘤组内随着剂量的增大表现为先升高再降低,而空白组呈一直上升的趋势;高剂量多糖可以显著提高荷瘤小鼠和空白小鼠的白介素2(IL-2)含量(P<0.05),对荷瘤小鼠的肿瘤坏死因子(TNF-α)含量也具有显著提升作用(P<0.05),但对空白组小鼠的TNF-α含量影响不显著;荷瘤小鼠的自然杀伤(NK)细胞活力普遍低于空白小鼠,随灌胃剂量的提升空白小鼠NK细胞活力具有上升趋势,荷瘤小鼠的NK细胞活力在中剂量组达到最高后开始下降。实验表明,仿刺参肠多糖可以促进小鼠的免疫功能,并且对小鼠体内肿瘤在一定剂量范围内具有浓度依赖性的抑制作用。 相似文献
14.
为研究手掌参多糖对电离辐射损伤小鼠造血和抗氧化功能的治疗作用,本试验选用48只健康雌性昆明小白鼠,随机分为8组,分别为空白组,辐射组,手掌参多糖低、中、高给药组(150、300、600 mg·kg-1 组)和辐射低、中、高给药组;辐射组和辐射给药组分别用60Co-γ射线进行辐射,辐射剂量5.0 Gy(剂量率0.8 Gy·min-1)。分别在照射后 30 min内灌胃相应剂量的手掌参多糖和生理盐水(空白组、辐射组),连续5 d。末次灌胃后48 h内测定所有小鼠外周血细胞计数、脾脏指数、肝脏超氧化物歧化酶(SOD)活性、总抗氧化能力(T-AOC)、丙二醛(MDA)含量、骨髓DNA含量、骨髓嗜多染红细胞微核 (MN) 数目及脾脏T淋巴细胞亚群。结果表明,与空白组相比,给药组小鼠抗氧化能力和造血系统得到不同程度的改善,辐射组外周血细胞计数、脾脏指数、骨髓DNA含量、肝脏抗氧化能力及T淋巴细胞亚群极显著降低,MDA含量与MN数目显著升高; 与辐射组相比,辐射给药组小鼠脾脏指数和T-AOC、SOD活性极显著升高,DNA含量、外周血细胞计数也有所升高,CD3+、CD4+、CD8+ T淋巴细胞比率升高,MDA含量、MN数目显著降低。上述试验结果表明,手掌参多糖对60Co-γ射线照射造成的小鼠造血、抗氧化功能损伤具有治疗作用。本研究为手掌参多糖对辐射损伤的治疗提供了技术参考。 相似文献
15.
Yang H Pang W Lu H Cheng D Yan X Cheng Y Jiang Y 《Journal of agricultural and food chemistry》2011,59(5):2069-2076
The metabonomics changes of plasma and brain tissue after dietary supplementation with blueberry extracts (BBE) and cyanidin-3-O-galactoside from blueberry (BBM) in aged mice were investigated by (1)H NMR technique. The mice received intragastric administration of BBE (200 mg/kg/day), BBM (50 mg/kg/day), and saline water (0.9%) for 6 weeks, respectively, in the BBE, BBM, and control groups. At the end of the experiment, plasma and brain samples were collected for NMR analysis. The results demonstrated that the level of choline in plasma from BBE and BBM groups were obviously elevated relative to the control group, whereas the levels of lactate and phosphocholine in plasma were remarkably reduced. Compared with those in the control group, the levels of choline and GABA in the brain from the BBE group were obviously increased, whereas glutamate and phosphocholine in the BBE group were significantly decreased. The level of taurine in the brain from the BBM group was particularly higher than that in the control group. These results indicated supplementation with BBE or BBM might induce similar changes of endogenous plasma and brain metabolic profiles in aged mice. 相似文献
16.
To investigate the influence of a high-fat diet on HCB distribution and accumulation, pregnant rats in study 1 were fed a high-fat or control diet containing HCB, and, in study 2, pregnant rats were given a single HCB dose by intragastric gavage and HCB-free high-fat or control diet. In study 1, the high-fat diet group had higher HCB concentrations in fat tissues and liver than did the controls. In study 2, although the total amounts of HCB in the fat tissue and liver were greater in the high-fat diet group than in the controls, no significant differences in HCB concentration were observed between the two groups. The high-fat diet group also showed more fecal excretion of HCB. Therefore, HCB accumulation in rats fed a high-fat diet was enhanced more by continuous exposure to HCB than by administration of a single dose. 相似文献
17.
A statistical mixed effects model was applied to data from a two-phased experiment in which cholinesterase activity (CA) in red blood cells (RBCs) of rats was monitored following single-and double-gavagead ministrations of the carbamate pesticide, Aldicarb. Our goals were to develop and estimate a nonlinear mixed effects model for describing the inhibition and recovery pattern of CA as a continuous function of time and Aldicarb dose, and to use the results to characterize both the typical-animal CA response and its variability across animals. The Phase 1 experiment involved adult male CD® rats randomly assigned to a control and two dose groups. Blood samples were taken via jugular cannula prior to exposure and at 11 post-dose time points (over six hours) for determination of RBC CA. The Phase II experiment was similar, but involved a second administration approximately 4.5 hours after the first. An open, one-compartment model with first-order kinetics appeared to provide an adequate structural basis for the statistical nonlinear mixed effects model, which was fit to the RBC data of the 26 treatment-group rats from both phases. For the “typical” animal, the model predicts that about a 20% (40%) maximal reduction in activity will occur for the low (high) dose group and that recovery to 90% of the baseline level will occur in 105 minutes (179 minutes) for the low (high) dose group. Based on simulated distributions derived from the model’s variance-covariance matrix of random effects, we estimated that about 99% of animals are expected to require less than 143 minutes (267 minutes) to recover to 90% of their baseline level for the low (high) dose group. Because virtually all animals had returned to near pre-exposure, levels by the time of the second administration, the level of the first dosing had little impact on the CA patterns following the second dose. 相似文献
18.
The protective effect of proanthocyanidins from persimmon peel, using both oligomers and polymers, was investigated in a db/db type 2 diabetes model. Male db/db mice were divided into three groups: control (vehicle), polymer-, or oligomer- (10 mg/(kg body weight x day x p.o.)) administered mice. Age-matched nondiabetic m/m mice were used as a normal group. The administration of proanthocyanidins reduced hyperglycemia in db/db mice through a decline in the serum level of glucose and glycosylated protein. In addition, it had a strong effect on hyperlipidemia through lowering levels of triglyceride, total cholesterol, and nonesterified fatty acids. The protective effect against hyperglycemia and hyperlipidemia was greater in the groups administered the oligomeric rather than polymeric form. The increased oxidative stress in db/db mice was attenuated by the administration of oligomers through inhibiting the generation of reactive oxygen species and lipid peroxidation and elevating the reduced glutathione/oxidized glutathione ratio. On the other hand, polymers did not show such an effect. Moreover, expressions in the liver of sterol regulatory element binding protein (SREBP)-1 and SREBP-2 were downregulated by the administration of proanthocyanidins, especially the oligomeric form. Oligomers caused a slight elevation in the expression of peroxisome proliferator-activated receptors alpha. Furthermore, oligomeric proanthocyanidin regulated the expression of nuclear factor kappaB in db/db type 2 diabetes via the activation of inhibitor protein kappaB-alpha. It also attenuated the protein expressions of cyclooxygenase-2 and inducible nitric oxide synthase. This suggests that oligomers would act as a regulator in inflammatory reactions associated with oxidative stress in type 2 diabetes. The present study results suggest that proanthocyanidin administration, especially the oligomeric form, may improve oxidative stress via the regulation of hyperlipidemia than hyperglycemia in type 2 diabetes. 相似文献
19.
Hypoglycemic effects of a phenolic acid fraction of rice bran and ferulic acid in C57BL/KsJ-db/db mice 总被引：2，自引：0，他引：2
Rice bran contains many phenolic acids, the most abundant of which is the antioxidant, ferulic acid (FA). We evaluated the hypoglycemic effects of a phenolic acid fraction (the ethyl acetate fraction, EAE) of rice bran and of FA in C57BL/KsJ db/db mice. Type 2 diabetic mice were allocated to a control group, an EAE group, or an FA group. Animals were fed a modified AIN-76 diet, and EAE or FA was administered orally for 17 days. There was no significant difference in body weight gain between groups. Administration of EAE and FA significantly decreased blood glucose levels and increased plasma insulin levels. EAE or FA groups had significantly elevated hepatic glycogen synthesis and glucokinase activity compared with the control group. Plasma total cholesterol and low density lipoprotein (LDL) cholesterol concentrations were significantly decreased by EAE and FA administration. These findings suggest that EAE and FA may be beneficial for treatment of type 2 diabetes because they regulate blood glucose levels by elevating glucokinase activity and production of glycogen in the liver. 相似文献