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1.
以人工诱发鸡毒支原体和大肠杆菌混合感染为模型,以酒石酸泰乐菌素为对照药物,评价了延胡索酸泰妙菌素的疗效.按每1 L水中分别加入312.5、468、625 mg延胡索酸泰妙菌素及500 mg酒石酸泰乐菌素的用量给病鸡饮水给药,连用5 d.试验表明,用药组的成活率、日增重、料肉比、气囊损伤度与感染对照组比较差异极显著(P＜0.01);延胡索酸泰妙菌素大剂量组日增重与小剂量组比较差异显著(P＜0.05),与其他各用药组比较差异极显著(P＜0.01),料肉比与其他各用药组比较差异极显著(P＜0.01);酒石酸泰乐菌素组的料肉比与延胡索酸泰妙菌素小剂量组比较差异不显著(P＞0.05);而与其他各组比较差异极显著(P＜0.01).数据分析表明,延胡索酸泰妙菌素大剂量组能有效地降低气囊损伤度,提高饲料转化率. 相似文献
2.
1 材料与方法1.1 试验药物 (1)“禽速康”颗粒 :中牧股份成都药械厂提供 ,批号 2 0 0 30 10 1,规格 10 0 g/瓶。由板蓝根、大青叶、甘草、冰片、蟾酥、茵陈、连翘、鱼腥草、射干、蒲公英、木香、白头翁 ,共 12味中药浓缩制成。 (2 )罗红霉素可溶性粉 ,山东某兽药厂生产 ,批号2 0 0 30 715 ,规格 10 0 g/瓶 ,主要成分为 10 %罗红霉素。 (3)酒石酸泰乐菌素可溶性粉 ,广东某兽药厂生产 ,批号 2 0 0 2 0 5 19,规格 5 0 g/袋 ,主要成分为 10 %酒石酸泰乐菌素。(4 )甲磺酸达氟沙星可溶性粉 ,浙江某兽药厂生产 ,批号 2 0 0 2 0 90 3,规格 2 0 0… 相似文献
3.
利用酒石酸泰乐菌素在试管中对鸡毒支原体进行了抑菌试验和在鸡体内对人工诱发的鸡毒支原体病进行了治疗试验。结果表明 :酒石酸泰乐菌素能有效地抑制试管中鸡毒支原体的生长繁殖。当饮水中药物浓度达到250mg/L以上时 ,能提高感染鸡的成活率 ;当饮水中药物浓度达到500mg/L以上时能降低气囊损伤 ,对提高鸡体增重也有一定的作用 ;当浓度达到1000mg/L时 ,则部分治疗的感染鸡体内检测不到鸡毒支原体抗体。国产酒石酸泰乐菌素作用与进口酒石酸泰乐菌素相接近 相似文献
4.
利用酒石酸泰乐菌素在试管中对鸡毒支原体进行了抑菌试验和在鸡体内对人工诱发的鸡毒支原体病进行了治疗试验。结果表明,酒石酸泰乐菌素能有效地抑制试管中鸡毒支原体的生长繁殖。当饮水中药物浓达到２５０ｍｇ／Ｌ以上时,能提高感染鸡的成活率,当饮水中药物浓度达到５００ｍｇ／Ｌ以上时能降低气囊损伤,对提高鸡体增重也有一定的作用;当浓度达到１０００ｍｇ／Ｌ时,则部分治疗的感染鸡体内检测不到鸡毒支原体抗休画产酒石酸泰 相似文献
5.
鸡慢性呼吸道病在大多势的鸡场、专业户的鸡群中广泛存在,危害颇大。对于此病的防制,目前主要依靠药物,我们曾应用英国彼得汉饲料添加剂有限公司生产的酒石酸泰乐菌素对患鸡进行治疗试验,获得显著效果。1987～1988年间,我县某专业户所养的本地三黄鸡均患过慢性呼吸道病,头一年中 相似文献
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7.
《畜牧兽医科技信息》2015,(3)
<正>鸡慢性呼吸道病是由鸡毒支原体(MG)引起的以咳嗽、喘气、呼吸罗音、流鼻涕、窦部肿胀为特征的慢性呼吸道病。给养鸡业带来巨大的经济损失。本试验旨在对MG感染进行诊断,以便及时确诊,投药治疗,防止继发感染。1材料与方法1.1试验材料1.1.1试验动物45只病鸡,15只死鸡。1.1.2试验药物泰乐菌素;中药组方(主要成分:洋金花、麻黄素、苦杏仁、甘草酸、蟾酥等)。1.2试验方法 相似文献
8.
替米考星用于鸡毒支原体和大肠杆菌混合感染的临床试验 总被引：2，自引：1，他引：2
试验以人工诱发鸡毒支原体和大肠杆菌混合感染为模型,以酒石酸泰乐菌素为对照药物,评价替米考星溶液的疗效。按每升水加入400m g、200m g、100m g替米考星及500m g酒石酸泰乐菌素的用量给病鸡饮水给药,连用5天。试验表明:替米考星大剂量和中剂量组料肉比与药物对照差异不显著(P>0.05),与其余各组差异极显著(P<0.01)。大剂量组与中剂量组气囊损伤评分与其他各组比较差异极显著(P<0.01),表明大、中剂量均能明显减轻支原体和大肠杆菌混合感染引起的气囊损伤。大剂量和中剂量组的死亡率与药物对照组相比差异均不显著(P>0.05),与其余各组相比差异极显著(P<0.01)。从治愈率来看,大剂量组中剂量组与其他各组相比差异极显著(P<0.01),而小剂量组与药物对照组的治愈率相当(P>0.05)。数据分析表明:替米考星溶液中剂量组能有效地降低气囊损伤度,提高饲料转化率。 相似文献
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10.
双原清对猪支原体病的治疗试验 总被引：1，自引：0，他引：1
以人工诱发猪支原体感染为模型,以酒石酸泰乐菌素为对照药物,评价了进口泰妙菌素与双原清（国产泰妙菌素）的疗效。按照每吨饲料中分别添加进口泰妙菌素65ppm和150ppm金霉素,双原清65ppm和150ppm金霉素,酒石酸泰乐菌素150ppm和150ppm金霉素,150ppm金霉素4组进行连续30d添加。试验结果表明双原清可明显控制猪支原体病,提高育成猪的增重,改善料肉比,同时双原清（国产泰妙菌素）与进口泰妙菌素在使用效果中无明显差异。 相似文献
11.
F. T. W. JORDAN B. K. HORROCKS S. K. JONES A. C. COOPER C. J. GILES 《Journal of veterinary pharmacology and therapeutics》1993,16(1):79-86
Groups of chicks were infected with a virulent strain of Mycoplasma gallisepticum (MG) and treated with either danofloxacin or tylosin while one infected group was left untreated and a further group was uninfected and untreated. Control of
clinical signs and mortality was better with danofloxacin than tylosin and there
was significantly (P <0.05)greater weight gain with danofloxacin at 21 days
after infection. However ht necropsy the prevalence of lesions of the airsac walls
was similar in both groups. MG was recovered from fewer live chicks for the first
week following treatment with danofloxacin, but at 2 weeks and at necropsy, at
the termination of the experiment, it was recovered from a similar proportion of
birds in both treated groups. This was reflected also in the serological results at
the end of the trial. 相似文献
clinical signs and mortality was better with danofloxacin than tylosin and there
was significantly (P <0.05)greater weight gain with danofloxacin at 21 days
after infection. However ht necropsy the prevalence of lesions of the airsac walls
was similar in both groups. MG was recovered from fewer live chicks for the first
week following treatment with danofloxacin, but at 2 weeks and at necropsy, at
the termination of the experiment, it was recovered from a similar proportion of
birds in both treated groups. This was reflected also in the serological results at
the end of the trial. 相似文献
12.
A.C. Cooper J.R. Fuller M.K. Fuller P. Whittlestone D.R. Wise 《Research in veterinary science》1993,54(3):329
The activities of danofloxacin, a novel fluoroquinolone, and two other antimicrobials were determined in vitro against field isolates of seven Mycoplasma species of veterinary importance isolated from cattle, swine and poultry in five European countries. The minimum inhibitory concentrations (MIC) of danofloxacin, tylosin and oxytetracycline were determined against a total of 68 isolates. Danofloxacin showed excellent activity against isolates of all Mycoplasma species (range 0·008 to 0·5 μg ml−1), but in some isolates there was evidence of reduced sensitivity to tylosin (range 0·008 to 2·0 μg ml−1) and oxytetracycline (range 0·008 to over 16·0 μg ml−1). Danofloxacin was more active than other antimicrobials against, M hyopneumoniae, M dispar and M bovigenitalium, and showed activity similar to that of tylosin against M bovis and M gallisepticum. Tylosin was the most active against M synoviae and M hyosynoviae. Generally, oxytetracycline showed the poorest activity, but was superior to tylosin against M bovigenitalium. A second (final) MIC reading was taken for all isolates 14 or 21 days after the initial reading, and MIC values rose during that time. However, the increase seen in danofloxacin values (typically one to two dilutions) was less than that seen for tylosin and oxytetracycline. It is concluded that danofloxacin is highly active in vitro against all of the Mycoplasma species tested, and thus shows great potential for the treatment of respiratory and other infections caused by Mycoplasma species in cattle, pigs and poultry. 相似文献
13.
I Kempf F Gesbert M Guittet G Bennejean A C Cooper 《Research in veterinary science》1992,53(2):257-259
Specific pathogen free day-old chicks were inoculated with a virulent strain of Mycoplasma gallisepticum. Birds received either danofloxacin (50 ppm), tylosin (500 ppm) or no medication in the drinking water from 24 hours after infection for three days. The effects of medication on mortality, weight gain, serology, lesions and reisolation of M gallisepticum 21 days following infection were studied. Treatment with danofloxacin and tylosin significantly decreased mortality and increased weight gain compared with infected unmedicated birds. Twenty-one days after infection, M gallisepticum was isolated from 96 per cent of unmedicated birds compared with only 6 per cent of danofloxacin-treated and 40 per cent of tylosin-treated birds, and the percentage showing positive serological tests was reduced from 100 per cent of unmedicated birds to 0 per cent of danofloxacin-treated and 29 per cent of tylosin-treated birds. In both cases, the proportion of positive birds from the danofloxacin-treated group was significantly lower than that from the tylosin-treated group. The occurrence of air sac lesions was also significantly lower in danofloxacin-treated than in tylosin-treated birds. 相似文献
14.
Effects of danofloxacin or consecutive fluoroquinolone and macrolide treatments on resistance development in Campylobacter have remained uncharacterised. Therefore we analysed the development of resistance in porcine Campylobacter coli before and after danofloxacin and tylosin treatments at a farrowing farm. Danofloxacin-treated (n=12, group A) and control pigs (n=15, group B) were subsequently treated with tylosin and sampled longitudinally. C. coli were isolated and susceptibilities to ciprofloxacin and erythromycin were assessed, isolates were genotyped with PFGE and resistance-related mutations were identified. Isolates from the danofloxacin-treated pigs had more frequently non-wild type MICs (above the epidemiological cut-off value (ECOFF)) for ciprofloxacin (P<0.001) and erythromycin (P<0.05) than those isolated before danofloxacin or those from the controls. Subsequent tylosin treatment increased proportion of isolates with non-wild type MICs for erythromycin in both groups A and B (P<0.01) and, interestingly, proportion of isolates with non-wild type MICs for ciprofloxacin in group B (P<0.001) with high MICs (128 μg/ml). PFGE analysis revealed treatments selecting predominant genotypes with variable resistance patterns and decreasing initial diversity of genotypes. The most common genotype had mainly high MICs for ciprofloxacin among danofloxacin-treated pigs but wild type MICs (below the ECOFF) among the controls housed in the same pens. This suggests that the non-wild type isolate was rarely transmitted or outcompeting wild type genotype in the control pigs without selection pressure. Isolates exhibiting non-wild type MICs for ciprofloxacin harboured the C257T (Thr-86-Ile) mutation in the gyrA gene. In conclusion, a high dose of danofloxacin used at the farm did not prevent emergence of isolates with high MICs for ciprofloxacin. After subsequent tylosin treatment isolates had even higher MICs for ciprofloxacin and erythromycin than before the treatment. Therefore, controlled use of antimicrobials in food animal production is essential. 相似文献
15.
旋光法测定甲磺酸达氟沙星的含量 总被引：1，自引：0，他引：1
采用旋光法测定甲磺酸达氟沙星的含量,结果表明,在6～14 mg/mL浓度范围内,甲磺酸达氟沙星的旋光度与浓度呈良好的线性关系(r=0.999 8).与电位滴定法相比,本法具有简单、快速、易操作等优点. 相似文献
16.
采用荧光分光光度法测定了甲磺酸达氟沙星粉的含量。激发和发射波长分别为350nm和448 nm,平均回收率为102.5%,RSD为1.1%。在0.01~5μg/mL范围内,其荧光强度与浓度线性关系良好。 相似文献
17.
The susceptibilities of 40 recent Belgian field isolates of Mycoplasma bovis to 10 antimicrobial agents were assessed. Tiamulin was the most active antimicrobial agent against M bovis, with an initial inhibitory concentration (IIC50) of 0.06 microg/ml, but it is not licensed for the treatment of cattle. All three fluoroquinolones tested (danofloxacin, enrofloxacin and marbofloxacin) were effective against strains of M bovis, and had a minimum mycoplasmacidal concentration (MMC50) less than or equal to 1 microg/ml. Gentamicin was poorly effective, having an IIC50 of 8 microg/ml. Many strains of M bovis were resistant to tylosin, spectinomycin, lincomycin, tetracycline and oxytetracycline. 相似文献
18.
将260只28日龄试验鸡(体质量215~230 g)随机分成5组:健康对照组20只,甲磺酸达氟沙星溶液静注给药组和内服给药组、甲磺酸达氟沙星脂质体静注给药组和内服给药组,每组60只。以5 mg/kg体质量剂量分别采用静脉注射和内服2种给药途径给予健康蛋雏鸡甲磺酸达氟沙星溶液和脂质体混悬液,于给药后0.167、0.333、0.5、0.75、1、1.5、2、4、6、9、12、24 h各剖杀5只鸡,取血液、肝脏、肾脏、肺脏和肌肉样品。采用反相HPLC色谱内标法测定各组织中达氟沙星浓度。应用MCPKP分析软件处理血浆药物浓度-时间数据,比较2种剂型的组织药动学参数。结果显示,与溶液组相比,甲磺酸达氟沙星脂质体组肝脏、肺脏中的药物分布明显提高,肾脏中的分布降低;通过相对摄取率、靶向效率和峰浓度比3个靶向指标的对比,脂质体组明显提高了肺部靶向性,且在肺部有一定的缓释作用。 相似文献
19.
Efficacy of danofloxacin 18% injectable solution in the treatment of Escherichia coli diarrhoea in young calves in Europe 总被引：1，自引：0，他引：1
Sunderland SJ Sarasola P Rowan TG Giles CJ Smith DG 《Research in veterinary science》2003,74(2):171-178
The efficacy of danofloxacin 18% against naturally occurring Escherichia coli diarrhoea was investigated in calves at seven European sites. Treatment commenced on day 0, with either a single subcutaneous injection of danofloxacin 18% (n=267) at 6 mg/kg repeated on day 2 if required, or reference product containing baquiloprim/sulphadimidine (n=37) or gentamicin (n=98) administered as recommended. E. coli was isolated from 90% to 100% of calves pre-treatment, and the prevalence of serotypes K99 and F41 was 8-46% and 46-92%, respectively. In both treatments, the majority of calves (93.2-93.9%) showed clinical improvement and completed the studies. There were significant reductions for both treatments, in severity of clinical signs on days 4 and 10 compared to day 0 (P<0.0001), and between days 4 and 10 (P<0.05), but no significant differences between treatments (P>0.05). Danofloxacin 18% was clinically safe, and as effective as the reference products in the treatment of E. coli diarrhoea in calves. 相似文献
20.
The efficacy of in-feed medication with tylosin for the treatment of enzootic pneumonia was examined in an experimental Mycoplasma hyopneumoniae infection model. One group of 10 conventional M. hyopneumoniae-free pigs was inoculated intratracheally with a highly virulent field isolate of M. hyopneumoniae; a second group of 10 pigs was inoculated in the same way and after 12 days was given tylosin at 100 mg/kg feed for 21 days; a third group of 10 pigs was inoculated with sterile culture medium, and these pigs were not given tylosin. The pigs were examined daily for clinical signs and each pig was given a respiratory disease score. Thirty-three days after they had been infected the pigs were euthanased, the lung lesions were quantified and samples of lung were processed for immunofluorescence testing for M. hyopneumoniae. The mean (sd) respiratory disease and lung lesion scores were significantly higher (P<0.05) in both the infected groups than in the uninfected group. Between 23 and 33 days after infection the mean respiratory disease score of the pigs treated with tylosin was 0.54 (0.22), significantly (P<0.05) lower than that of the infected pigs which were left untreated, 1.54 (0.46); similarly, their average lung lesion score, 1.72 (1.20), was significantly lower than that of the untreated pigs, 5.27 (3.85). 相似文献