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1.
Loretta Rodriguez Elisa J. Livengood Richard D. Miles Frank A. Chapman 《Journal of aquatic animal health》2013,25(2):100-102
Abstract The purpose of this study was to examine the capacity of live brine shrimp Artemia spp. to accumulate metronidazole at different developmental life stages. Metronidazole is used in fish as an antiparasitic medication. An effective drug delivery method is to enrich the Artemia with metronidazole and offer them as live feed to the infected fish, usually ornamental species and other small fishes. Artemia cysts were hatched and then soaked in a metronidazole solution (0.05%) at instars 1–3 of larval development. Our findings indicated that Artemia were able to accumulate metronidazole at levels considered therapeutic to other animals and humans (25–100 mg/kg). However, the levels varied depending on the stage of larval development. Artemia accumulated the highest levels of metronidazole (137–143 mg/kg) when they started filter feeding (instar 2), whereas newly hatched Artemia (instar 1) contained the lowest level (85 mg/kg). Based on this study and a review of the literature, a new protocol recommended for enriching Artemia with metronidazole consists of soaking the Artemia in a 0.05% metronidazole solution for 3 h at room temperature. Because metronidazole is relatively insoluble in water, it must first be dissolved in warm water with continuous stirring. Received December 5, 2010; accepted January 30, 2011 相似文献
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Syakalima O Choongo K Nakazato Y Onuma M Sugimoto C Tsubota T Fukushi H Yoshida M Itagaki T Yasuda J 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2001,63(3):315-318
Exposure and ecological risks to heavy metals (copper, zinc, manganese, iron) at Lochnivar and Blue Lagoon National Parks in wildlife dependent on the Kafue river contaminated with mining waste was evaluated. Samples included water, fish, grasses and Kafue Lechwe (Kobus leche kafuensis) liver. At both parks copper ranged from 0.03-0.04 mg/l; 3.0-6.0 mg/kg; 11.0-44.0 mg/kg; trace -199.0 mg/kg; while zinc was 0.01 mg/l; 32.0-82.0 mg/kg; 15.0-21.0 mg/kg; and 52.0-138.0 mg/kg; in water, fish, grasses and lechwe, respectively. Manganese ranges were 0.15-0.16 mg/l; 7.0-18.0 mg/kg; 51.0-145.0 mg/kg; and 40.0-53.0 mg/kg while iron ranges were 0.13-0.14 mg/l; 26.0-134.0 mg/kg; 1766.0-1797.0 mg/kg; and 131.0-856.0 mg/kg; in water, fish, grasses and lechwe, respectively. Levels in all samples except water were high indicating potential for adverse effects. 相似文献
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军曹鱼幼鱼维生素C需要量的研究 总被引：3，自引：0，他引：3
选用初体均重为25.85 g的军曹鱼幼鱼225尾随机分为5组,每组设3个重复,每个重复15尾.分别投喂添加5种不同剂量维生素C(添加量分别为0、37.5、75、150和300 mg/kg)的试验饲料,试验期为56 d,观察维生素c对军曹鱼幼鱼生长、组织维生素C积累量及非特异性免疫的影响.结果表明,随着饲料中维生素C添加量增加,军曹鱼幼鱼增重率和特定生长率呈现出上升后下降趋势,在75 mg/kg时达到最高值,显著高于0和300 mg/kg组(P<0.05).全鱼粗蛋白质含量随着饲料中维生素C添加量的升高亦呈现先上升后下降趋势,在75 mg/kg时达到最高值,全鱼干物质、粗蛋白质、粗脂肪、灰分含量在各组之间均无显著差异(P>0.05).血清维生素C积累量随着饲料中维生素C添加量的增加呈现先上升后下降趋势,在150 mg/kg时达到最高值且显著高于0 mg/kg组(P<0.05);脑和肝脏中维生素C含量在300 mg/kg时达到最高值.300 mg/kg组脑中维生素C含量显著高于0,37.5和75 mg/kg组(P<0.05),肝脏中维生素C含量显著高于0,37.5和150 mg/kg组(P<0.05).随着饲料中维生素C添加量的增加,溶菌酶活性呈现先上升后下降趋势,在75 mg/kg达到最高,显著高于0,37.5和300 mg/kg组(P<0.05);血清总抗氧化能力呈现上升趋势,75、150和300 mg/kg组显著高于0 mg/kg组(P<0.05);肾抗氧离子自由基在150 mg/kg组达到最高,但各组之间无显著差异(P>0.05).以鱼体增重率和血清溶菌酶含量为指标,经折线模型回归分析求得军曹鱼幼鱼饲料中维生素C的适宜添加量分别为70和80.72 mg/kg. 相似文献
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盐酸沙拉沙星胶囊对家蚕细菌性败血病的防治研究 总被引：2，自引：1，他引：1
盐酸沙拉沙星胶囊是以兽用喹诺酮类药物盐酸沙拉沙星为主要成分制成的蚕用抗菌药剂。盐酸沙拉沙星胶囊对家蚕细菌性败血病的防治效果试验表明,用100mg/L盐酸沙拉沙星药液给感染卒倒芽孢杆菌的4龄起蚕连续添食3d(第1天添食24h,第2、3天每天添食6h),对家蚕败血病的防治效果与用500mg/L盐酸诺氟沙星药液、125mg/L盐酸环丙沙星药液添食的防治效果无明显差异(P0.05);用400mg/L盐酸沙拉沙星药液给感染灵菌的4龄起蚕连续添食3d(添食方法同上),对家蚕败血病的防治效果明显优于用500mg/L盐酸诺氟沙星药液、250mg/L盐酸环丙沙星药液添食的防治效果(P0.05),与用500mg/L盐酸环丙沙星药液添食的防治效果无明显差异(P0.05)。盐酸沙拉沙星对卒倒芽孢杆菌、灵菌的最低抑菌浓度分别为1.25、5μg/mL,最低杀菌浓度分别为5、10μg/mL。分别给4龄、5龄家蚕添食400、800、1200、2000mg/L的盐酸沙拉沙星药液,对家蚕的生长发育、茧质和丝质均未见明显不良影响(t检验,P0.05),且不存在明显的剂量-反应关系。分别给5龄第4天家蚕添食剂量为5、10、20mg/kg的盐酸沙拉沙星后,药物在蚕体内吸收良好,血药浓度-时间曲线符合一级吸收的一室开放式模型。研究结果显示,盐酸沙拉沙星胶囊对卒倒芽孢杆菌或灵菌感染引发的家蚕细菌性败血病具有明显的防治效果,并且对家蚕安全无害。 相似文献
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M. MOMBARG H. CLAESSEN† L. LAMBRECHTS ‡ P. ZWART 《Journal of veterinary pharmacology and therapeutics》1992,15(4):433-436
Spot-on application has proved to be an effective way to reach therapeutic doses of metronidazole and levamisole in fire-bellied toads. The percutaneous absorption of metronidazole and levamisole was quantified, using an aqueous solution of 1.008 mg/ml of metronidazole and an aqueous solution of 3.767 mg/ml of levamisole. High Performance Liquid Chromatography (HPLC) analysis of the percutaneous absorption revealed that of the amount applied, 75% of metronidazole and 90% of levamisole was absorbed. This resulted during 3 days of application in dosages of 23 mg/kg BW of metronidazole and 94 mg/kg BW of levamisole. Of the absorbed substances, 48% of metronidazole and 9% of levamisole were excreted in urine and faeces as unmetabolised substances. 相似文献
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R W Sweeney C R Sweeney L R Soma C B Woodward C A Charlton 《American journal of veterinary research》1986,47(8):1726-1729
Serum and peritoneal fluid concentrations of metronidazole were determined in 6 healthy adult horses given the drug (25 mg/kg) by IV or oral routes. The disposition of metronidazole in horses given the drug by the IV route conformed to a 2-compartment model with a distribution half-life of 0.16 hours, an elimination half-life of 2.9 hours, and a body clearance of 0.40 +/- 0.05 L/kg/hr. The oral absorption half-life was 0.40 hours, and the bioavailability, 85.0 +/- 18.6%. Peritoneal fluid concentrations were approximately equal to serum concentrations at all times, regardless of the route of administration. On the basis of reported minimal inhibitory concentrations for anaerobic bacteria, a dosage of 15 to 25 mg/kg given orally 4 times daily was recommended. 相似文献
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T E Specht M P Brown R R Gronwall W J Rib A E Houston 《American journal of veterinary research》1992,53(10):1807-1812
Serum concentrations of metronidazole were determined in 6 healthy adult mares after a single IV injection of metronidazole (15 mg/kg of body weight). The mean elimination rate (K) was 0.23 h-1, and the mean elimination half-life (t1/2) was 3.1 hours. The apparent volume of distribution at steady state was 0.69 L/kg, and the clearance was 168 ml/h/kg. Each mare was then given a loading dose (15 mg/kg) of metronidazole at time 0, followed by 4 maintenance doses (7.5 mg/kg, q 6 h) by nasogastric tube. Metronidazole concentrations were measured in serial samples of serum, synovia, peritoneal fluid, and urine. Metronidazole concentrations in CSF and endometrial tissues were measured after the fourth maintenance dose. The highest mean concentration in serum was 13.9 +/- 2.18 micrograms/ml at 40 minutes after the loading dose (time 0). The highest mean synovial and peritoneal fluid concentrations were 8.9 +/- 1.31 micrograms/ml and 12.8 +/- 3.21 micrograms/ml, respectively, 2 hours after the loading dose. The lowest mean trough concentration in urine was 32 micrograms/ml. Mean concentration of metronidazole in CSF was 4.3 +/- 2.51 micrograms/ml and the mean concentration in endometrial tissues was 0.9 +/- 0.48 micrograms/g at 3 hours after the fourth maintenance dose. Two mares hospitalized for treatment of bacterial pleuropneumonia were given metronidazole (15.0 mg/kg, PO, initially then 7.5 mg/kg, PO, q 6 h), while concurrently receiving gentamicin, potassium penicillin, and flunixin meglumine IV. Metronidazole pharmacokinetics and serum concentrations in the sick mares were similar to those obtained in the healthy mares. 相似文献
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本研究评估了低水平水溶性、碱提取戊聚糖和木聚糖酶对肉鸡生长性能、器官发育和肠道内容物黏度、pH和微生物数量的影响。试验选择平均体重一致的1日龄肉仔鸡504只,随机分为7组,每组4个重复,每个重复18只。对照组饲喂基础日粮、处理组饲喂基础日粮+40 mg/kg水溶性戊聚糖、基础日粮+80 mg/kg水溶性戊聚糖、基础日粮+40 mg/kg碱提取戊聚糖、基础日粮+80 mg/kg碱提取戊聚糖、基础日粮+2 mg/kg木聚糖酶、基础日粮+4 mg/kg木聚糖酶。结果:从第5~15天,对照组和处理组的体重、法氏囊、肌胃和肠道重量逐渐增加。与对照组相比,40 mg/kg水溶性戊聚糖组体重、法氏囊、前胃和肠道重量的均值显著提高(P<0.05)。4 mg/kg木聚糖酶组法氏囊和肌胃平均重量显著高于对照组(P<0.05)。2 mg/kg木聚糖酶组较40和80 mg/kg碱提取物戊聚糖组显著降低了5~15 d回肠内容物黏度(P<0.05),2 mg/kg木聚糖酶和对照组5和10 d回肠和盲肠内容物pH最低(P<0.05)。40 mg/kg水溶性戊聚糖组及2和4 mg/kg木聚糖酶组直肠乳酸杆菌数量显著高于对照组(P<0.05),同时40 mg/kg水溶性戊聚糖组直肠链球菌和大肠杆菌数量最低(P<0.05)。结论:在玉米-豆粕型日粮中添加水溶性戊聚糖或木聚糖酶可以改善肉鸡体重,其中40 mg/kg水溶性戊聚糖可以促进肉鸡器官发育。 相似文献
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《Journal of aquatic animal health》2013,25(1):24-31
Abstract The effects of dietary zinc and calcium on immunocompetence of channel catfish Ictalurus punctatus (mean initial weight = 3.1 g/fish) were determined after a 10-week feeding trial. Fish were fed daily amounts equal to 3% of their body weight of one of six purified diets that were deficient in zinc (2 mg/kg of diet), calcium (0.02% of diet), or both; replete with zinc (20 mg/kg of diet) and calcium (0.5% of diet); or excessive in zinc (200 mg/kg of diet) or calcium (2.5% of diet). Immunocompetence of immunized and nonimmunized fish fed the various diets was assessed by measuring serum immunoglobulin M levels and mortality after an intraperitoneal injection of live Aeromonas hydrophila. Channel catfish fed diets deficient in zinc, calcium, or both had significantly (P ≤ 0.05) less weight gain and survival as compared with those fed diets replete with or excessive in zinc or calcium. Tissue mineral concentrations of fish indicated that various levels of zinc and calcium nutriture existed when immune functions were tested. Diet affected mortality of only nonimmunized fish in the bacterial-challenge test; zinc deficiency and calcium excess decreased mortality. Whereas growth and survival of fish were reduced by dietary zinc or calcium deficiency, the measured immunological characteristics were not equally impaired by these mineral deficiencies. 相似文献
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We have shown previously that diets in which the nitrogen portion is based on synthetic dipeptides (PP) resulted in weight gain by rainbow trout alevins when free amino acid (FAA) based diets did not. However, the protein‐based diet used as a control in the previous study resulted in a significantly better performance of fish than peptide‐ or FAA based diet fed fish. Therefore, the objectives of our study were (i) to test how stomachless fish respond to peptide‐based diets, (ii) to evaluate PP and protein‐PP mixture diets and (iii) to examine if post‐prandial response to FAA concentrations in the fish body can be used as an indicator of the availability of dietary amino acid sources. The first experiment was conducted with a 4‐day old Koi carp (Cyprinus carpio) larvae and included groups fed a casein–gelatin (CG) based diet, a commercial diet and live Artemia nauplii. In the second experiment, fish fed live Artemia for 3 weeks (69 ± 12 mg) were placed in glass aquaria in triplicate per dietary treatment. Four diets provided equivalent amounts of nitrogen in the form of a CG, a PP, a 50% PP and 50% CG (PP50) mix and as FAA. Fish were fed at 1 and 3 h intervals, and the survival and growth were monitored during the second and third weeks of experiments 1 and 2 respectively. Following the completion of feeding, juvenile carp were sampled prior to feeding and 3 h after a meal. Whole body FAA analyses were carried out. We observed marginal suitability of the CG diet for larval Koi carp, as earlier indicated in common carp. Juvenile Koi carp fed the CG diet achieved 236 ± 19 mg, whereas PP50, PP and FAA diet fed fish grew to 140 ± 37, 70 ± 8 and 73 ± 5 mg respectively. Free amino acids in the fish body, and in particular indispensable amino acids (IDAA), were excellent indicators of dietary availability. The present experiment shows that a dietary 1:1 ratio of protein to synthetic PPs results in better growth, survival and whole body IDAA concentrations in relation to FAA‐ and PP‐based diets confirming earlier reports on the use of synthetic PP‐based diets, although this diet does not match the performance of complete protein, CG‐based diet. 相似文献
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Although species-specific aquaculture production systems typically operate over reduced geographical ranges relative to many other terrestrial animal production systems, it is nonetheless often necessary to transport live fish between facilities by road to permit on-growing or finishing. Road transport is therefore common in Australian salmonid (trout and salmon) production and is a particularly significant feature of Atlantic salmon (Salmo salar) culture in Tasmania, where it is necessary to transport juvenile fish (smolts) from inland freshwater hatchery facilities to coastal marine farms for grow-out to slaughter.The most obvious respect in which road transport of live fish differs from that of terrestrial livestock is the requirement to provide a life-support system for the duration of the process. Aside from an inherent requirement for water, it is essential to provide oxygenation to support basic respiration. Thereafter, water quality must be managed to limit the accumulation of potentially toxic metabolites. Among these, carbon dioxide (CO2) is of particular concern. Without appropriate management, CO2 can rapidly accumulate to levels as high as 80 mg/L-1 and result in hypercapnia, respiratory dysfunction, narcosis, and ultimately death. Current life-support systems typically function to maintain CO2 at acceptable levels of 20-30 mg/L-1. Water temperature changes during and at the end of the transport process may also be an issue but are typically only a relatively minor consideration.In common with other livestock transport systems, the loading process and associated handling can evoke a physiological stress response which, though intended to be adaptive, may interact synergistically with aspects of the life-support system. Increased rates of oxygen consumption and CO2 excretion place additional demands on the life-support system while, from the fish's perspective, the changes in gill perfusion and circulation that facilitate such alterations in gas exchange can also operate to increase solute loss and result in diuresis and ionoregulatory dysfunction. As a consequence, once a suitable life-support system has been provided, the efforts of salmon farmers are focused on the need to minimize handling stress. The majority operate sophisticated pumping and counting systems that are intended to minimize aerial exposure of fish and, in a manner consistent with the natural behavior of the animal, mimic as far as is practicable the process of being washed downstream. 相似文献
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采用液相色谱-串联质谱法(LC-MS/MS)测定了饲料中甲硝唑(MNZ)、地美硝唑(DMZ)、洛硝唑(RNZ)、替硝唑(TNZ)、奥硝唑(ONZ)、异丙硝唑(IPZ)和塞克硝唑(SCZ)等7种硝基咪唑类药物。样品用乙酸乙酯提取,正己烷-磷酸溶液反萃取,MCX柱净化,以0.1%乙酸水溶液和乙腈作流动相进行梯度洗脱,电喷雾电离源正离子(ESI+)多反应监测(MRM)模式下检测。方法的检测限和定量限分别为0.03 mg/kg和0.1 mg/kg。添加浓度为0.1、1 mg/kg和10 mg/kg时的平均回收率为72.9%~98.8%,变异系数为4.9%~12.1%。 相似文献
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Selvaraj RK Koutsos EA Calvert CC Klasing KC 《Journal of animal physiology and animal nutrition》2006,90(1-2):70-80
Two experiments were conducted to study the interaction between dietary lutein and fat levels in broiler chicks hatched from lutein depleted (Experiment I) and repleted (Experiment II) eggs. In both experiments, a 2 x 3 factorial arrangement of treatments resulted in six dietary treatments (fat at 3% and 6% and lutein at 0, 25 and 50 mg/kg feed) that were fed for 23 days to 18 birds per treatment (in three replications). In Experiment I, the anti-dinitrophenyl-keyhole-lympet-hemocyanin (anti-DNP-KLM) serum antibody response at day 22 and macrophage phagocytotic index at day 17 did not differ among treatment groups (p > 0.05). The concavalin A and phytohaemagglutinin-P lymphocyte proliferation index at day 19 was greater in birds fed 50 mg of lutein and 3% fat than in birds fed all other diets (p < 0.05). Independent of the level of dietary fat, dietary lutein increased macrophage (day 23) nitrite production measured 46 h after in vitro stimulation with LPS (p < 0.05). Among the birds fed lutein at 25 or 50 mg/kg feed, birds fed 3% fat had higher LPS-induced nitrite production compared to the birds fed 6% fat after 46 (p = 0.014) or 70 h (p < 0.001). In Experiment II, macrophage nitrite production was measured at 54 h after LPS stimulation on days 11, 15, 19 and 23. An interaction between dietary lutein and fat levels on nitrite production was observed on day 19 (p = 0.012), where macrophages from birds fed 0 mg lutein and 3% fat had the highest nitrite production (p = 0.012). Macrophages from birds fed lutein at 25 and 50 mg/kg diet and 3% fat had higher (p = 0.012) nitrite production than birds fed 6% fat. Thus, in birds hatched from lutein deplete and replete eggs, modulation of macrophage nitrite production by lutein is dependent on the level of dietary fat. 相似文献
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本试验研究饲料不同水平吡啶甲酸铬对其生长、饲料利用,体成分、血液生化指标和非特异性免疫功能的影响。600尾吉富罗非鱼分为5个处理组,每个处理各设4个重复,每重复30尾鱼。每个处理铬添加量分别为0、0.4、0.8、1.2 mg/kg和10.0 mg/kg,在0.38 m3玻璃纤维钢桶中用开放式流水养殖,饲养8周。结果表明,饲料中添加吡啶甲酸铬对吉富罗非鱼的增重率、特异生长率、饲料系数、蛋白效率及蛋白质沉积率均有显著影响(P<0.05)。当铬添加量为0～0.8 mg/kg时,随着添加量增加,可显著提高吉富罗非鱼增重率、特定生长率、蛋白质效率和蛋白质沉积率(P<0.05),显著降低饲料系数(P<0.05),但对成活率和肝体比无显著影响(P>0.05);当饲料中添加为1.2 mg/kg～10.0 mg/kg时并未能进一步提高罗非鱼的生长和饲料利用。同时,铬添加水平为0～0.8 mg/kg,随着添加水平增加,显著提高吉富罗非鱼全鱼的蛋白质和磷含量(P<0.05),显著降低全鱼水分、脂肪和灰分含量(P<0.05),并显著提高吉富罗非鱼血清总蛋白含量以及肝胰脏AKP、ACP和LZM的活性(P<0.05),显著降低血清葡萄糖含量(P<0.05),但对血清胆固醇和甘油三酯含量及肝胰脏T-SOD活性无显著影响(P>0.05)。当饲料中添加铬1.2 mg/kg和10.0 mg/kg,除了显著降低肝胰脏AKP活性外(P<0.05),对血清生化指标和肝胰脏非特异性免疫酶活性无显著影响(P>0.05)。综合生长、饲料利用、体组成成分、血液生化指标和肝胰脏非特异性免疫酶活性的影响结果表明,对于0.91～4.93 g吉富罗非鱼,饲料中以吡啶甲酸铬的形式添加0.8～1.2 mg/kg铬为宜。 相似文献
17.
Pharmacokinetics, tolerance and serum thromboxane inhibition of carprofen in the dog 总被引：1，自引：0，他引：1
Q. A. McKellar T. Pearson J. A. Bogan E. A. Gaibraith P. Lees B. Ludwig M. P. Tiberghien†† 《The Journal of small animal practice》1990,31(9):443-448
The non-steroidal anti-inflammatory drug (NSAID) carprofen was administered to dogs as a mixed-micelle solution at a dose rate of 0–7 mg/kg intravenously, as a palatable paste at a dose rate of 0–7 mg/kg orally, and as an oral tablet formulation at a dose rate of 0–7 mg/kg and 4-0 mg/kg orally for pharmacokinetic studies. It was also administered as an oral tablet formulation at a dose rate of 9-0 mg/kg orally daily for 14 days in a tolerance study. The pharmacokinetics following intravenous administration at a dose rate of 0–7 mg/kg indicate that carprofen has a small volume of distribution (Vd area = 0–09-0-25 litres), a slow systemic clearance (Cls = 1–34-5-57 ml/min) and an elimination half-life of 3–20-11-77 hours. Both oral paste and tablet preparations were highly bioavailable and absorption was proportional to dose rate at 0–7 mg/kg and 4-0 mg/kg bodyweight. Given once daily at dose rates likely to be used clinically it is unlikely to accumulate in the plasma. Carprofen administered as a palatable paste at a dose rate of 0–7 mg/kg did not inhibit serum thromboxane generation and this drug may therefore have a mode of action different from most NSAIDs. Carprofen was well tolerated when administered as an oral tablet formulation at a dose rate of 9.0 mg/kg daily for 14 days in healthy beagle dogs. 相似文献
18.
《Journal of aquatic animal health》2013,25(4):327-330
Abstract The effectiveness of praziquantel (Droncit) against yellow grubs Clinostomum complanatum and unidentified, encysted, larval trematodes was tested in infected sunshine bass Morone chrysops female × M. saxatilis male. Praziquantel treatments significantly reduced the total number of live grubs in the fish in most treatment regimes tested. Treatment at 0.25 mg/L for 24 h was as effective as one at 8 mg/L for 8 h. Mature dead and dying metacercaria may have released toxins that killed host fish in some treatments. 相似文献
19.
中药保肝解毒汤对欧鳗(Anguilla anguilla)实验性肝病保护作用的酶学机理研究 总被引：2，自引：0，他引：2
研究了由茵陈、龙胆、甘草、大黄及栀子组成的中药制剂保肝解毒汤对实验性肝病欧鳗血清转氨酶、肝脏抗氧化酶活性的影响。健康组欧鳗养于清水中，4个处理组先暴露于0．12mg／LCu^2＋溶液4d，其中一组作为阳性空白对照组不治疗，其余3组为中药治疗组，即保肝解毒汤治疗低剂量组（200mg／L）、保肝解毒汤治疗高剂量组（400mg／L）和降酶灵（所含成分为五昧子）治疗对照组（100mg／L），分别在水和相应药液中处理4d。结果显示：阳性空白对照组欧鳗与健康组相比，血清转氨酶AST、ALT活性极显著升高（P〈0．01），肝脏抗氧化酶CAT、GSH-Px活性受抑制（P〈0．01），SOD活性受诱导（P〈0．05）。各治疗组与阳性空白对照组相比，AST、ALT活性回落明显（Pd0．01）；CAT、GSH-Px活性显著升高（P〈0．01），并接近或超过健康组水平；SOD活性则在已有明显升高的基础上，得到进一步增强，其中以治疗低剂量组和治疗对照组最为显著（P〈0．01）。本研究表明该中药制剂具有良好的抗肝损伤及恢复肝功能作用，可用于治疗欧鳗的中毒性肝病。 相似文献