共查询到20条相似文献，搜索用时 31 毫秒
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术后慢性疼痛病因十分复杂,迄今发生机制尚未明析。本研究旨在通过动物模型解析术后急性疼痛向慢性疼痛转化的相关物质,以期找到引发术后疼痛的关键物质。采用气相色谱-质谱（GC-MS）代谢组学技术,比较分析大鼠术后急性疼痛和慢性坐骨神经紧缩损伤疼痛的相关物质,筛选差异代谢物。结果经分析后得到224种代谢物,其中,35种代谢物具有显著差异（VIP>1,P<0.05,∣log2FC∣≥2）,代谢通路富集分析发现,45条潜在相关代谢通路（P<0.05）。分析表明,N-乙酰天冬氨酸（NAA）、泛酸、天冬氨酸、3-羟基丁酸、β-丙氨酸、葡萄糖等差异代谢物及其相关代谢通路可能与术后急性疼痛向慢性疼痛转变密切相关。解析出术后急性疼痛向慢性疼痛转化的相关物质,这为术后疼痛机制的研究提供了参考,也为术后疼痛的识别和治疗提供了新的方法和思路。 相似文献
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Livia Benato Nicola J. Rooney Jo C. Murrell 《Veterinary anaesthesia and analgesia》2019,46(2):151-162
Objective
To provide an overview of pain and analgesia in rabbits with the aim of developing a more accurate understanding of these topics. To illustrate and discuss the areas that have advanced in recent years and those that still require further research.Databases used
Three key subject resources were used: Web of Science, Medline and CAB Abstracts. Search terms were rabbits, lagomorphs, laboratory animals, pet, pain, surgical procedures, ovariohysterectomy, orchiectomy, castration, analgesia, opioids, and non-steroidal anti-inflammatory drugs. References from books and articles relevant to the topics were also included.Conclusions
Rabbit medicine has improved over the last 20 years, but the literature suggests that pain management in this species is still inadequate and veterinary professionals believe their knowledge of pain and analgesia in this species is limited. Assessment and quantification of pain in rabbits can be challenging in a clinical environment not only because, as a prey species, rabbits tend to hide signs of pain but also because there are no validated methods to assess pain, except the Rabbit Grimace Scale, which is based on only one rabbit breed.Current consensus is that perioperative multimodal analgesia is the best practice. However, it is not widely used in rabbits. In rabbits, analgesia protocols and dosages reported in the literature are often poorly researched and do not result in complete pain amelioration with the return of normal. The present literature on rabbit pain and analgesia presents gaps either due to unexplored areas or insufficient findings. Further research should focus on these areas with the aim of improving the welfare of rabbits within a veterinary clinic. 相似文献5.
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The inability to control pain is the most common reason for cessation of treatment and euthanasia in cases of laminitis, yet pain also serves a unique protective function in these cases, particularly in the acute phase when lamellar integrity is weakened. Successful analgesia requires an understanding of the disease pathophysiology, the sources of pain in laminitis, methods of serial pain evaluation, and methods of analgesia including systemic and regional techniques. This review discusses the approach to analgesia including detail of traditional and novel analgesic medications and techniques with specific reference to the laminitis case. 相似文献
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D.C. Brown R.C. Boston J.T. Farrar 《Journal of veterinary internal medicine / American College of Veterinary Internal Medicine》2013,27(1):22-30
Background
Lameness assessment using force plate gait analysis (FPGA) and owner assessment of chronic pain using the Canine Brief Pain Inventory (CBPI) are valid and reliable methods of evaluating canine osteoarthritis. There are no studies comparing these 2 outcome measures.Objective
Evaluate the relationship between CBPI pain severity (PS) and interference (PI) scores with the vertical forces of FPGA as efficacy measures in canine osteoarthritis.Animals
Sixty‐eight client‐owned dogs with osteoarthritis (50 hind limb and 18 forelimb).Methods
Double‐blind, randomized. Owners completed the CBPI, and dogs underwent FPGA on days 0 and 14. Dogs received carprofen or placebo on days 1 through 14. The change in PS and PI scores from day 0 to 14 were compared to the change in peak vertical force (PVF) and vertical impulse (VI).Results
PS and PI scores significantly decreased in carprofen‐ compared with placebo‐treated dogs (P = .002 and P = .03, respectively). PVF and VI significantly increased in carprofen‐ compared with placebo‐treated dogs (P = .006 and P = .02, respectively). There was no correlation or concordance between the PS or PI score changes and change in PVF or VI.Conclusions and Clinical Importance
In these dogs with hind limb or forelimb osteoarthritis, owner assessment of chronic pain using the CBPI and assessment of lameness using FPGA detected significant improvement in dogs treated with carprofen. The lack of correlation or concordance between the change in owner scores and vertical forces suggests that owners were focused on behaviors other than lameness when making efficacy evaluations in their dogs. 相似文献11.
《Veterinary anaesthesia and analgesia》2021,48(6):861-870
ObjectiveTo develop a scale to diagnose and assess the severity of postamputation pain (PAP) in dogs.Study designSingle-center retrospective study.AnimalsA total of 66 dogs that underwent thoracic or pelvic limb amputation and 139 dogs that underwent tibial plateau leveling osteotomy (TPLO) at a veterinary teaching hospital.MethodsAn online survey regarding postoperative behavioral changes was sent to owners. Categorical, multiple-choice responses were entered into a univariable logistic regression model and tested for association with amputation using the Wald test. If p < 0.2, variables were forwarded to a multivariable logistic regression model for manual build. Model simplicity and predictive ability were optimized using the area under the receiver operating curve (AUROC) characteristic, and model calibration was assessed using the Hosmer–Lemeshow test. The selected model was converted to an integer scale (0–10), the Canine Postamputation Pain (CAMPPAIN) scale. Univariable logistic regression related each dog’s calculated score to the probability of PAP.ResultsMultivariable logistic regression identified four independent predictors of PAP (p < 0.05): 1) restlessness or difficulty sleeping, 2) episodes of panic or anxiety, 3) sudden vocalization, and 4) compulsive grooming of the residual limb. Score AUROC was 0.70 (95% confidence interval = 0.63–0.78) with good calibration (Hosmer–Lemeshow statistic p = 0.82). A score of 2 corresponded to a risk probability of 0.5. Taking a score ≥ 2 to indicate PAP, score specificity and sensitivity were 92.1% and 36.4%, respectively. When this score was used to diagnose PAP, prevalence was 36.4% (24/66) and 7.9% (11/139) in the amputation and TPLO groups, respectively.Conclusions and clinical relevancePostamputation pain is characterized by specific postoperative behaviors and appears to affect approximately one-third of canine amputees. The CAMPPAIN scale generated from these data could facilitate diagnosis, treatment and further study of PAP but requires external validation. 相似文献
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苜蓿蛋白质含量高,消化率高,营养价值好。随着畜牧业的发展和农业结构的调整,我国苜蓿种植面积逐年扩大。由于收获期雨热同季导致割晒苜蓿自然晒干较为困难,所以制作成青贮成为近几年苜蓿高效利用的重要方法之一。苜蓿青贮具有适口性好、易于保存、加工损耗低等优点,国内苜蓿种植户纷纷加入制作苜蓿青贮的队伍,但并未推动该产业快速、良性发展。本文探讨苜蓿青贮销售的痛点和难点,并提出建议,以期为同行提供参考。 相似文献
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Equine chronic back pain (CBP) has been linked to different pathologic processes, which directly or indirectly involve spinal structures. Thus, making diagnosis and management very challenging with most horses with the condition recommended for early retirement from athletic activity. This study described the spinal cord lesions and the development of reactive microgliosis and astrocytosis in the spinal cords of horse with CBP. Thoracolumbar spinal cord segments from three horses euthanized because of unresolved CBP were dissected and grossly and histopathologically examined. The expression of activated microglia and astrocytes were demonstrated immunohistochemically using polyclonal rabbit anti-Iba-1 and anti-glial fibrillary acidic protein antibodies, respectively. All horses had radiological evidence of varying degrees of kissing spine involving six to nine vertebrae with the majority of the lesions graded between 2 and 5. Grossly, there was myelomalacia with intramedullary hemorrhages. The gray matters of the spinal cords were characterized by hemorrhagic malacic lesions with medullary disintegration. Reactive microgliosis and astrocytosis were evident in the spinal dorsal horns. White matter lesions include axonal swollen and/or loss, satellitosis, and varying degrees of dilation of myelin sheaths with some containing macrophages. In conclusion, the presence of reactive microgliosis and astrogliosis in the spinal dorsal horn indicates that they are possible precipitating factors in the development of equine CBP. 相似文献