共查询到19条相似文献，搜索用时 78 毫秒
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目的观察5年生种植人参食用对幼年大鼠心脏血流动力学的影响,探讨人参食用对机体心血管系统功能的调节作用。方法正常幼年Wistar大鼠随机分为10组,即:对照组,5年生种植人参原粉低、中、高剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物低、中、高剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物低、中、高剂量(0.25、0.5、1.0g生药/kg)组,每组14只。各组大鼠连续灌胃给药3个月,观察心功能和血流动力学变化。结果与对照组比较,人参原粉和人参醇提物可使正常幼年大鼠动脉收缩压(SBP)、舒张压(DBP)、平均动脉压(MAP)、左室收缩压(LVSP)、左心室内压最大上升和下降速率(±dp/dtmax)均明显增高(P<0.05或P<0.01),对左心室舒张末压(LVEDP)及心率(HR)均无明显影响(P>0.05)。人参水提物高剂量组可使幼年大鼠±dp/dtmax明显增高(P<0.05),对SBP、DBP、MAP、LVSP、LVEDP及HR均无明显影响(P>0.05)。结论人参原粉和人参醇提物对正常幼年大鼠具有明显的正性肌力(强心)作用,人参水提物对正常幼年大鼠心脏心收缩和舒张功能有一定的增强作用。 相似文献
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目的观察5年生种植人参食用对成年大鼠糖脂代谢及下丘脑-垂体-甲状腺轴功能变化的影响,探讨人参食用对机体内分泌系统功能的调节作用。方法正常成年Wistar大鼠随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只。各组大鼠连续灌胃给药3个月,观察糖脂代谢及下丘脑-垂体-甲状腺轴功能变化。结果与对照组比较,人参醇提物中、大剂量组可使正常成年大鼠血糖明显降低(P0.05或P0.01),人参原粉及人参醇提物中、大剂量组均可使正常成年大鼠TG明显降低(P0.05或P0.01),人参水提物中剂量组可使正常成年大鼠T4明显降低(P0.05),人参原粉、人参水提物及人参醇提物各剂量组对正常成年大鼠甲状腺脏器系数及血清中CHO、TSH、T3含量均无明显影响(P0.05)。结论人参醇提物对正常成年大鼠具有糖脂代谢调节作用;人参原粉及人参水提物对正常成年大鼠的糖脂代谢及下丘脑-垂体-甲状腺轴无明显影响。 相似文献
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刘欣欣冯亚楠赵俐王冰 《人参研究》2023,(2):13-19
目的系统评价血塞通联合营养神经药物治疗糖尿病周围神经病变的有效性和安全性。方法通过计算机检索PubMed、中国知网(CNKI)和中文科技期刊数据库(维普网),搜集有关血塞通与糖尿病周围神经病变的随机对照试验,检索时间均从建库至2022年08月,采用RevMan5.3软件进行meta分析。结果在纳入25个随机对照试验(RCT)中,包括1839例患者,与单纯使用营养神经药物相比,血塞通联合营养神经药物可明显改善糖尿病周围神经病变患者的总有效率(RR=1.33,95%CI:1.26,1.41)、腓总神经运动神经传导速度(MNCV)(MD=5.12m/s,95%CI:4.70,5.55)、腓总神经感觉神经传导速度SNCV(MD=3.99m/s,95%CI:3.60,4.39)、正中神经运动神经传导速度MNCV(MD=4.81 m/s,95%CI:4.29,5.33)、正中神经感觉神经传导速度SNCV(MD=4.38 m/s,95%CI:3.92,4.85)、血浆黏度(MD=0.39mPa·s,95%CI:-0.44,-0.34)、全血黏度高切(MD=-0.55 mPa·s,95%CI:-1.14,0.04)、全血黏度低切(MD=-2.02mPa·s,95%CI:-4.05,0.00)。结论研究表明,血塞通联合营养神经药物治疗糖尿病周围神经病变的有效性优于单纯使用营养神经药物,且相对安全,但受纳入研究的数量、质量等限制,该结论有待更高质量的研究予以验证。 相似文献
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人参皂苷Rg1对人黑素细胞株MV3黑素合成的影响 总被引：1，自引：0，他引：1
目的:观察人参皂苷Rg1对体外培养的人黑素细胞MV3增殖、黑素合成的影响。方法:体外培养黑素细胞,给予不同浓度人参皂苷Rg1(80、40、20、10、5、2.5μg/mL)处理48h后,四甲基偶氮唑蓝法(MTT)观察人参皂苷Rg1对细胞增殖的影响,比色法测定黑素含量变化情况。结果:人参皂苷Rg1 80~10μg/mL剂量能抑制黑素细胞增殖(P<0.01),减少黑素合成(P<0.01或P<0.05),2.5μg/mL剂量则促进黑素细胞增殖,但对黑素合成作用不明显。结论:人参皂苷Rg1可抑制黑素细胞增殖,减少黑素合成,这可能是其具有美白作用的机制之一。 相似文献
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茶多糖和茶多酚的降血糖作用研究 总被引：24，自引：7，他引：17
目的:研究茶多糖、茶多酚对四氧嘧啶致糖尿病SD大鼠的降血糖作用和机制。方法:饲喂SD大鼠茶多糖、茶多酚3周后,观察大鼠血糖、葡萄糖耐量、血胰岛素以及小肠糖降解酶(淀粉酶、蔗糖酶、麦芽糖酶)变化。结果:茶多糖、茶多酚都有显著抑制糖尿病大鼠血糖升高的作用;与对照组比较,茶多糖组大鼠血胰岛素水平有显著提高(P<0.05),蔗糖酶和麦芽糖酶活性显著降低(P<0.05);茶多酚组的血胰岛素水平有升高趋势,小肠各降解酶活力也有下降趋势,但与对照组比较均未达到显著水平。结论:茶多糖对高血糖大鼠有显著的抑制血糖升高的作用,茶多糖的作用机制可能是抑制小肠糖降解酶活性。 相似文献
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目的观察5年生种植人参食用对成年大鼠心功能和血流动力学的影响,探讨人参食用对机体心血管系统功能的调节作用。方法正常成年Wistar大鼠随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只。各组大鼠连续灌胃给药3个月,观察心功能和血流动力学变化。结果与对照组比较,人参原粉和人参醇提物可使正常成年大鼠动脉收缩压(SBP)、左室收缩压(LVSP)、左心室内压最大上升和下降速率(±dp/dtmax)均明显增高(P0.05或P0.01),对舒张压(DBP)、平均动脉压(MAP)、左心室舒张末压(LVEDP)及心率(HR)均无明显影响(P0.05)。人参水提物各剂量组对SBP、DBP、MAP、LVSP、±dp/dtmax、LVEDP及HR均无明显影响(P0.05)。结论人参原粉和人参醇提物对正常成年大鼠具有明显的正性肌力(强心)作用,人参水提物对正常成年大鼠的血压及心脏心收缩和舒张功能均无增强或降低作用。 相似文献
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目的观察人参超微粉对实验性低血压大鼠心脏功能的影响。方法 40只Wistar大鼠随机选取10只作为正常组,其余30只每日2次灌胃(ig)给予复方利血平混悬液10ml/kg制备实验性低血压模型。24只造模成功的大鼠结合血压、体重随机分为3组:模型组、人参超微粉0.5、1.0g/kg组,每组8只。模型组大鼠ig给予0.5%CMC-Na 10ml/kg,其余2组ig给予相应药物,每日1次,连续给药4周。于造模前、造模过程中及给药后每周测量大鼠体重及心率1次,给药结束后每组随机选取2只大鼠测定超声心动图,摘取所有大鼠心脏计算心脏指数,观察人参超微粉对实验性低血压大鼠心脏功能的影响。结果与正常组比较,模型组大鼠体重自造模第1周至给药结束均明显降低(P0.05或P0.01),自造模第7周至实验结束心率均明显升高(P0.001);与模型组比较,人参超微粉0.5、1.0g/kg组大鼠的体重及心率均无明显差异(P0.05)。各组大鼠超声心动图显示,与正常组比较,模型组大鼠出现收缩力降低;与模型组比较,人参超微粉0.5、1.0g/kg组EF、%FS明显上升(P0.05),LVIDd、LVIDs无明显差异(P0.05)。结论人参超微粉对实验性低血压大鼠体重下降及心率升高均无明显改善作用,能改善实验性低血压大鼠心肌收缩功能。 相似文献
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目的观察5年生种植人参食用对成年大鼠下丘脑-垂体-性腺轴的影响,探讨人参食用对机体内分泌系统功能的调节作用。方法正常成年Wistar大鼠随机分为10组,即:对照组,5年生种植人参原粉小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参水提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,5年生种植人参醇提物小、中、大剂量(0.25、0.5、1.0g生药/kg)组,每组14只。各组大鼠连续灌胃给药3个月,观察下丘脑-垂体-性腺轴的变化。结果与对照组比较,人参原粉中、大剂量组,人参水提物大剂量组和人参醇提物中、大剂量组均可使正常成年大鼠血清FSH的含量降低(P0.05或P0.01),人参原粉中剂量组可以使正常大鼠前列腺脏器系数升高(P0.05),人参原粉小、大剂量组可以使正常大鼠睾丸+附睾脏器系数升高(P0.05),人参原粉、人参水提物和人参醇提物各剂量组对正常成年雄性大鼠血清T、Cor.及海绵体组织中NO的含量,雌性大鼠血清E2、Cor.的含量,血清中LH的含量及阴茎、子宫和卵巢脏器系数均无明显影响(P0.05)。结论人参原粉、人参水提物和人参醇提物对正常成年大鼠下丘脑-垂体-性腺轴具有一定的调节作用。 相似文献
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Malek Zarei Masoumeh Sabetkasaei Taraneh Moini Zanjani 《Iranian Biomedical Journal》2014,18(2):94-100
Background: P2X4 receptor (P2X4R), a purinoceptor expressed in activated spinal microglia, plays a key role in the pathogenesis of neuropathic pain. Spinal nerve injury induces up-regulation of P2X4R on activated microglia in the spinal cord, and blockade of this receptor can reduce neuropathic pain. The present study was undertaken to determine whether paroxetine, an inhibitor of P2X4R, could attenuate allodynia and hyperalgesia in chronic constriction injury (CCI) model of neuropathic pain when used preemptively or after the sciatic nerve injury. Methods: Male Wistar rats (150-200 g, n = 6) were divided into 3 different groups: 1- CCI vehicle-treated group, 2- Sham group, and 3- CCI paroxetine-treated group. Paroxetine (10 mg/kg, i.p.) was administered 1 h before surgery and continued daily until day 14. In other part of the study, paroxetine (10 mg/kg, i.p.) was administered at day 7 post injury and continued daily until day 14. von Frey filaments for mechanical allodynia and analgesia meter for thermal hyperalgesia were used to assay pain behavior. Results: In a preventive paradigm, paroxetine significantly attenuated both mechanical allodynia and thermal hyperalgesia (P<0.001). A significant decrease in pain behavior was seen with paroxetine on existing allodynia (P<0.001) and hyperalgesia (P<0.01) when initiated at day 7 post injury. Conclusion: It seems that paroxetine can attenuate pain behavior when administered before and also after sciatic nerve injury in CCI model of neuropathic pain. Key Words: Paroxetine, P2X4 receptor (P2X4R), Allodynia, Hyperalgesia 相似文献
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Currently available local anesthetics have analgesic durations in humans generally less than 12 hours. Prolonged-duration local anesthetics will be useful for postoperative analgesia. Previous studies showed that in rats, combinations of tetrodotoxin (TTX) with bupivacaine had supra-additive effects on sciatic block durations. In those studies, epinephrine combined with TTX prolonged blocks more than 10-fold, while reducing systemic toxicity. TTX, formulated as Tectin, is in phase III clinical trials as an injectable systemic analgesic for chronic cancer pain. Here, we examine dose-duration relationships and sciatic nerve histology following local nerve blocks with combinations of Tectin with bupivacaine 0.25% (2.5 mg/mL) solutions, with or without epinephrine 5 μg/mL (1:200,000) in rats. Percutaneous sciatic blockade was performed in Sprague-Dawley rats, and intensity and duration of sensory blockade was tested blindly with different Tectin-bupivacaine-epinephrine combinations. Between-group comparisons were analyzed using ANOVA and post-hoc Sidak tests. Nerves were examined blindly for signs of injury. Blocks containing bupivacaine 0.25% with Tectin 10 μM and epinephrine 5 μg/mL were prolonged by roughly 3-fold compared to blocks with bupivacaine 0.25% plain (P < 0.001) or bupivacaine 0.25% with epinephrine 5 μg/mL (P < 0.001). Nerve histology was benign for all groups. Combinations of Tectin in bupivacaine 0.25% with epinephrine 5 μg/mL appear promising for prolonged duration of local anesthesia. 相似文献
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Neurotoxicity complicates the use of several commonly administered chemotherapeutic agents (platinum based alkylating agents, taxanes and vinca alkaloids), with chemotherapy-induced peripheral neuropathy being the most common manifestation. Structural damage to the peripheral nervous system results in positive symptoms, e.g., allodynia, hyperalgesia and pain with unpleasant features as burning and shooting. Patients are unable to complete full or optimal treatment schedules. The pathophysiologic basis of nerve injury in chemotherapy-induced peripheral neuropathy is incompletely understood and appears to be unique for each class of the chemotherapeutic agents. Erythropoeitin (EPO), a well-established hematopoietic factor, is a very effective and widely used treatment for anemia in cancer patients undergoing chemotherapy. It also possesses generalized neuroprotective and neurotrophic properties. Co-treatment of chemotherapy and erythropoietin has been proposed for preventing or reversing the disabling peripheral neuropathy induced by the different chemotherapeutic agents. This study first describes the pathophysiological background of the clinically relevant chemotherapeutic agents-inducing peripheral neuropathy. Secondly, the possible mechanisms that might underlie the neuroprotective effect of erythropoietin in chemotherapy-induced neuropathy. Further clinical trials of EPO in cancer patients receiving chemotherapy and suffering from neurological symptoms seem to be warranted in the future. This might improve the quality of life in cancer patients. 相似文献
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Z Akhlaghi JI Mobarakeh M Mokhtari H Behnam AA Rahimi MS Khajeh Hosseini F Samiee 《Iranian Biomedical Journal》2012,16(2):107-112
Background: Initial studies have shown that low-energy ultrasound stimulates living tissue cells to reduce regeneration or speed up their recovery. The purpose of this study was to examine the effects of various ultrasound parameters on the speed of recovery in injured sciatic nerves NMRI.Methods: NMRI mice (n = 200) with injured left paw, caused by crushing their sciatic nerves, were randomly selected. The animals were exposed to ultrasound radiation with various frequencies, intensities, and exposure time. They were allocated into 20 groups (19 treatment and 1 control groups). Sciatic functional index (SFI) test was used to evaluate the difference between the groups with respect to functional efficiency of the sciatic nerve and its recovery. SFI ، (P=0.000).Results: The results of SFI test obtained from the 14th day showed a significant difference among the groups (P<0.05). On the 14th day after treatment, one of the groups (US11) recovered up to 90%..Conclusion: Altered ultrasound exposure parameters had more favorable outcomes compared with our previous work.Key Words: Sciatic nerve, Ultrasonic therapy, Regeneration 相似文献
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Background: Thiamine (VitB1) is a vitamin with various important physiological functions and postulated therapeutic effects. Its use as an analgesic in neuropathic pain has been undergoing in clinical settings. However, there has been little experimental investigation on this effect. In this study, anti-nociceptive and anti-inflammatory effects of thiamine were investigated in mice. Methods: Three doses of thiamine (50, 100 and 125 mg/kg) were used by intraperitoneal injection in this study. Acute and chronic anti-nociceptive effects were examined using hot plate test alone and after sciatic nerve ligation, respectively. Imipramine (40 mg/kg) was used as positive control. Anti-inflammatory effects of thiamine on acute and chronic inflammation were assessed using xylene-induced edema in ears and granuloma caused by compressed cotton implantation, respectively. Sodium diclofenac (15 mg/kg) was used as positive control. Open field test was performed to differentiate the mice responses in the acute anti-nociceptive tests. Results: All three doses of thiamine showed significant analgesic effects in non-ligated mice and also in neuropathic pain in ligated animals. Increasing the dose of thiamine correlated with a more pronounced and sustained effect. Acute anti-inflammatory investigation showed that thiamine injected 30 or 60 minutes before xylene application reduced the weight of edematic ears. However, the effect of thiamine was less pronounced than diclofenac. Furthermore, when injected once daily for 7 days, all doses of thiamine significantly reduced the weight of the cotton disks, showing suppression of granuloma formation. Conclusion: Taken together, it has been shown that thiamine possesses remarkable analgesic activities and also has significant anti-inflammatory effects, confirming its clinical use in controlling pain and less in inflammation. 相似文献
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Md. Mahadhi Hasan Hana Starobova Alexander Mueller Irina Vetter Richard J. Lewis 《Marine drugs》2021,19(2)
The peripheral effects of ω-conotoxins, selective blockers of N-type voltage-gated calcium channels (CaV2.2), have not been characterised across different clinically relevant pain models. This study examines the effects of locally administered ω-conotoxin MVIIA, GVIA, and CVIF on mechanical and thermal paw withdrawal threshold (PWT) in postsurgical pain (PSP), cisplatin-induced neuropathy (CisIPN), and oxaliplatin-induced neuropathy (OIPN) rodent models. Intraplantar injection of 300, 100 and 30 nM MVIIA significantly (p < 0.0001, p < 0.0001, and p < 0.05, respectively) alleviated mechanical allodynia of mice in PSP model compared to vehicle control group. Similarly, intraplantar injection of 300, 100, and 30 nM MVIIA (p < 0.0001, p < 0.01, and p < 0.05, respectively), and 300 nM and 100 nM GVIA (p < 0.0001 and p < 0.05, respectively) significantly increased mechanical thresholds of mice in OIPN model. The ED50 of GVIA and MVIIA in OIPN was found to be 1.8 pmol/paw and 0.8 pmol/paw, respectively. However, none of the ω-conotoxins were effective in a mouse model of CisIPN. The intraplantar administration of 300 nM GVIA, MVIIA, and CVIF did not cause any locomotor side effects. The intraplantar administration of MVIIA can alleviate incision-induced mechanical allodynia, and GVIA and MVIIA effectively reduce OIPN associated mechanical pain, without locomotor side effects, in rodent models. In contrast, CVIF was inactive in these pain models, suggesting it is unable to block a subset of N-type voltage-gated calcium channels associated with nociceptors in the skin. 相似文献
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Background: Diabetes is a major public health problem. The development of new therapies that are able to improve glycemia management and even to cure diabetes is of great interest. In this study, protective effects of sodium tungstate against STZ-induced beta-cell damages were investigated. Methods: Sixty rats were divided into six groups: control, diabetic, sodium tungstate treated diabetic rats from one week before STZ injection (TDB), food-restricted diabetic (FRD), tungstate treated control, sodium tungstate treated diabetic rats from one week after STZ administration (TDA). We evaluated serum insulin, glucose and glucose tolerance; liver glycogen content, glucokinase (GK) activity; blood and pancreas antioxidant power, lipid peroxidation; and fuchsin-aldehyde histochemical staining of beta-cells. Results: Blood glucose levels of TDB group were lower than other diabetic groups (P<0.01). Blood insulin levels of all diabetic groups were lower than controls (P<0.01). Glucose intolerance improved in TDB animals. Blood and pancreas antioxidant power, liver glycogen contents and GK activities and granulated beta cells increased in TDB rats in comparison with other diabetic groups (P<0.01). Likewise, lipid peroxidation decreased significantly in TDB rats (P<0.01). Conclusions: Results suggested that sodium tungstate if administrated before STZ injection improves glycemic state by a direct effect on pancreatic beta-cells and preserves them by reducing the activity of these cells at the time of STZ injection, reducing STZ-induced oxidative stress, reducing insulin secretion, or all of the above mentioned. 相似文献
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Oboh G. Akindahunsi A.A. Oshodi A.A. 《Plant foods for human nutrition (Dordrecht, Netherlands)》2003,58(3):1-7
Parsley is one of the medicinal herbs used by diabetics in Turkey. It has been reported to reduce blood glucose levels. In this study the effects of feeding parsley on diabetes-induced free radical mediated injury in rat aorta and heart tissues were investigated. Swiss albino rats were divided into six groups: Control, diabetic, parsley, diabetic + parsley, glibornurid, and diabetic + glibornurid. Rats were subjected to i.p. streptozotocin (STZ, 65 mg/kg) to induce diabetes. On the fourteenth day of the study, either parsley (2 g/kg) or glibornurid (5 mg/kg) were given for 28 days to the diabetic rats. Aorta and heart tissue lipid peroxidation and glutathione levels as well as blood glucose levels were determined. The results of the present study indicate that lipid peroxidation was increased and glutathione levels were decreased in both aorta and heart tissue of the diabetic rats. However, treatment of the diabetic rats with either parsley or glibornurid reversed the effects of diabetes on blood glucose, and tissue lipid peroxidation and glutathione levels. 相似文献