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1.
《Medicinal Plant》2015,(Z1)
[Objective] To discuss the protection and regulatory effects of Yupingfeng polysaccharides on immunosuppressed mice. [Methods] The immunosuppressive mice model was established by 80 mg / kg cyclophosphamide. The spleen index,spleen lymphocyte proliferation capability,serum hemolysin antibody generation and serum IL-2 level of mice were researched,so as to observe the effects of Yupingfeng polysaccharides at different dosages( 100,200,400 mg / kg). [Results] Yupingfeng polysaccharides enhanced the spleen index of immunosuppressed mice,improved the proliferation capability of spleen lymphocyte,promoted the generation of serum hemolysin antibody in normal mice,and protected against the secretion reduction of serum hemolysin antibody induced by cyclophosphamide. Besides,Yupingfeng polysaccharides enhanced the IL-2 levels in serum of both immunosuppressed and normal mice,especially that the middle-and low-dosage groups had relatively significant effects.[Conclusions] Yupingfeng polysaccharides protected against the immunosuppression of mice induced by cyclophosphamide,enhanced the immune function and protected the spleen function of mice. 相似文献
2.
为探讨玉屏风复合多糖对免疫功能损伤的调节和保护作用,以环磷酰胺80 mg/kg诱导的免疫低下小鼠为实验动物模型,通过检测小鼠的脾脏指数、脾淋巴细胞增殖能力、血清溶血素和血清中IL-2等指标,观察不同剂量玉屏风复合多糖(100,200,400 mg/kg)对小鼠脾脏指数、脾淋巴细胞增殖能力、血清溶血素和血清IL-2的影响。结果发现,玉屏风多糖能使免疫抑制小鼠的脾脏指数升高,促进脾淋巴细胞的增值;玉屏风多糖可促进正常小鼠血清溶血素抗体的生成,对抗环磷酰胺所致的小鼠血清溶血素抗体分泌减少;玉屏风复合多糖能提高正常小鼠和免疫抑制的小鼠血清的IL-2水平,尤其以中、低剂量组效果较好。结果证实,玉屏风多糖能对抗环磷酰胺诱导的小鼠免疫抑制,提高免疫功能,对小鼠的脾脏功能也有保护作用。 相似文献
3.
《Medicinal Plant》2014,(6)
[Objective]To investigate the preventive protective effects and its mechanism of vitamin C and polysaccharide in Dioscrea pposite Thunb. on cadmium-induced liver damage in mice. [Methods]50 Kunming mice were randomly divided into control group,model group,D. pposite polysaccharides protection group,vitamin C protection group,D. pposite polysaccharides and vitamin C protection group. At the 7th day of feeding,the mice were given saline by gavage,and the mice in other groups were intraperitoneally injected with 3. 0 mg /kg CdCl2 solution. 24 hours after injection,blood was collected for ALT and AST test. Then,mice were sacrificed and the livers were removed for the calculation of hepatosomatic index(liver weight / body weight). Also,the liver homogenates were prepared for the determination of SOD and GSHPx activities and the of MDA and NO contents. [Results]Compared with the mice in model group,the liver-somatic index,serum ALT,AST activity,and contents of liver MDA and NO reduced,the activities of SOD and GSH-Px,and the content of GSH improved in D. pposite polysaccharides and vitamin C protection group(*P 0. 05,**P 0. 01). Compared with the model grfoup,the protective effects of D. pposite polysaccharides combined with vitamin C strengthened(**P 0. 01). [Conclusions]The combination of D. pposite polysaccharides and vitamin C has preventive protection effects on cadmium-induced liver injury in mice by antagonizing cadmium and /or oxidative stress. The application of D. pposite polysaccharides combined with vitamin C had a synergistic effect. 相似文献
4.
《Medicinal Plant》2015,(Z2)
[Objective] To discuss the protective effects of Coriolus versciclor polysaccharides on liver injury of mice induced by CCl4.[Methods]40 male Kunming mice at four moths old were randomly divided into four groups,which were control group,model group,C. versciclor polysaccharides protection group and feeds + C. versciclor polysaccharides group. Mice were fed for 8 d. On 2 h after final administration,intraperitoneal injection of blend oil solution was carried out was carried out in control group. And in other groups,intraperitoneal injection of0. 15% CCl4 blend oil solution( 10 mL / kg) was conducted. After 18 h,eyeballs were collected and serum was isolated. Livers were taken out and the hepatosomatic index was calculated. Liver homogenate was prepared and the ALT and AST were detected,as well as the SOD and NOS activities,and MDA,GSH and NO contents.[Results] Compared with model group,C. versciclor polysaccharides in different administration ways reduced the hepatosomatic index( P 0. 05) and MDA content( P 0. 001),lowered the AST activity in serum( P 0. 05),the NOS activity and the NO content( P 0. 01),and enhanced the SOD activity and GSH content( P 0. 01).[Conclusions] C. versciclor polysaccharides in different administration ways protected the liver injury of mice induced by CCl4. 相似文献
5.
玉屏风散颉颃镉致鸡肝脏氧化损伤作用的研究 总被引：1，自引：1，他引：0
为了研究玉屏风散对镉对鸡肝脏氧化损伤的颉颃作用。将150只30日AA公鸡随机分为3组：对照组（A：饲喂基础日粮）、加镉组（B：组饲喂基础日粮+CdCl2 150 mg/kg）和玉屏风散加镉组（C：饲喂基础日粮+ CdCl2 150 mg/kg的基础上每天灌服玉屏风散1 mL）,所有动物自由采食,染毒后15,30,45,60天时分别从以上3组中取10只鸡剖杀,用于肝脏组织相关指标的检测。结果表明：随着镉作用时间的延长,试验组的GSH-Px、SOD的活性降低,MDA生成量增加;试验组与对照组差异显著(P<0.05)或极显著(P <0.01),C组各项指标数据介于A组和B组之间。因此,玉屏风散可减轻镉中毒对机体抗氧化功能的影响,对镉中毒有颉颃作用。 相似文献
6.
《Medicinal Plant》2015,(Z6)
[Objective] To discuss the effects of Yuezhitang decoction on promoting lactating function of maternal mice,enhancing the quality of newborn mice,and improving the survival ratio of newborn mice by using the overload lactation model of mice.[Methods]Overload lactation model of maternal mice was established.Maternal mice were given different dosages of samples by gavage.The lactation volume,accumulative lactation volume,body weight change of newborn mice at lactation period were researched.The mammary gland index was detected; the changes of breast tissue morphology and physiology were observed.[Results] Compared with model group,11 and 16.5 g/kg dosage groups significantly improved the lactation volume of maternal mice(P0.05).Mammary gland index of 11 g/kg dosage group increased significantly.In 11 and 16.5 g/kg dosage groups,mammary gland acinus had dense structure; the acinus was arranged regularly with complete structure and significant increase in quantity,showing typical characters of secretory mammary gland.[Conclusions]Yuezhitang decoction promoted the lactation of maternal mice. 相似文献
7.
8.
《Medicinal Plant》2014,(2)
[Objective]To explore the anti-inflammatory and analgesic effects of 12 Guangdong Native Heat-clearing Herbs with identical dose( 16 g/kg) and to provide reliable experiment basis for the clinical development and application of anti-inflammatory drugs. [Methods]To explore the anti-inflammatory and analgesic effects of 12 Guangdong Native Heat-clearing Herbs by acetic acid writhing,hot plate method,ear swelling caused by xylene in mice and celiac capillary permeation in mice induced by acetic acid. [Results]After intragastric administration of drugs( 16 g / kg) in mice for 7 days,the inhibiting effects of Radix Helicteris,Thinleaf Adina Fruit,Nervilia fordii,Radix Ilicis Asprellae and Trikeraia hookeri on ear swelling caused by xylene in mice were significant and the inhibiting effects of which on the increase of capillary permeability in mice induced by acetic acid were also significant( P 0. 05). Radix Eupatorii Chinensis,Pronephrium triphyllum and Bidens biternata could inhibit ear swelling caused by xylene in mice significantly and Evodia lepta Merr,ovate leaf Holly Bark and Rubus parvifolius could inhibit the increase of capillary permeability in mice significantly( P 0. 05). The effects of 12 Guangdong Native Heat-clearing Herbs on thymus and spleen were not significant( P 0. 05); Trikeraia hookeri,Radix Ilicis Asprellae,ovate leaf Holly Bark,Radix Helicteris, Nervilia fordii and Herba Polygoni Chinensis could evidently reduce the times of writhing response in mice induced by acetic acid and increase the threshold of pain in mice induced by thermal stimulus; Evodia lepta Merr and Pronephrium triphyllum could evidently reduce the times of writhing response in mice induced by acetic acid,ovate leaf Holly Bark could significantly prolong the latent time of writhing response in mice induced by acetic acid( P 0. 05) and Bidens biternata could significantly increase the threshold of pain in mice induced by thermal stimulus. [Conclusions]Radix Helicteris,Thinleaf Adina Fruit,Nervilia fordii,Herba Polygoni Chinensis,Radix Ilicis Asprellae,Trikeraia hookeri, Radix Eupatorii Chinensis,Pronephrium triphyllum,Bidens biternata,Evodia lepta Merr,ovate leaf Holly Bark and Rubus parvifolius had anti-inflammatory action; Radix Helicteris,Nervilia fordii,Herba Polygoni Chinensis,Radix Ilicis Asprellae,Trikeraia hookeri,Pronephrium triphyllum,Bidens biternata,Evodia lepta Merr and ovate leaf Holly Bark,etc. had analgesic effect. 相似文献
9.
《Medicinal Plant》2014,(5)
[Objective] To research on the changes of total polysaccharides content and plant morphology in the 1- to 5-year-old stems of Panax quinquefolius L.,which were harvested from May to September in Canada. [Methods]Plant morphological characteristics(length,diameter,dry weight and fresh weight) of the stems of P. quinquefolius with different growth years in different collection months were detected;and the dry rate was calculated. Total polysaccharides content in the stems of P. quinquefolius was detected by UV spectrophotometry; and DPS2000 was used for data analysis. [Results]Plant morphological characteristics of the stems of P. quinquefolius showed a increasing trend as the growth years and harvest period prolonged. dry rates of P. quinquefolius stems with different growth years had significant differences(P=0.013 1 0.05),which were in the order of one-year-old stems(0.348) two-year-old stems(0.296) five-year-old stems(0.202) four-year-old stems(0. 174) three-year-old stems(0. 164). dry rates of P. quinquefolius stems in different harvest periods showed extremely significant differences(P = 0. 005 8 0. 01),which were in the order of July May June August September. Total polysaccharides contents of P. quinquefolius stems had extremely significant changes in different growth years(P = 0. 000 0 0. 01),which were in the order of two-year-old stems(30. 818 mg /g) one-year-old stems(28. 172 mg /g) three-year-old stems(26. 642 mg /g) four-year-old stems(24.89 mg/g) five-year-old stems(19.492 mg/g). Total polysaccharides contents of P. quinquefolius stems also had extremely significant changes in different harvest periods(P = 0. 000 0 0. 01),which were in the order of June July August May September. Content of total polysaccharides had little correlation with the dry rate. Therefore,the content of total polysaccharides could not be judged by the dry rate of the stems of P. quinquefolius. [Conclusions]The stem yield and polysaccharides content of P. quinquefolius were both at a relatively high level. Therefore,it was suggested that the stems of P. quinquefolius could be used as the extraction raw materials of total polysaccharides,considering from the angle of comprehensive utilization of P. quinquefolius. 相似文献
10.
加味玉屏风散对实验性免疫抑制黄鳝非特异性免疫功能的影响 总被引：1，自引：1，他引：0
【研究目的】研究了由黄芪、白术、防风、党参和甘草组成的加味玉屏风散对实验性免疫抑制黄鳝非特异性免疫功能的影响。【方法】阴性空白对照组只腹腔注射生理盐水,阳性空白对照组注射环磷酰胺,设低、中、高三个剂量阳性用药组注射环磷酰胺和加味玉屏风散,阳性用药对照组注射环磷酰胺和黄芪注射液,于第3d、第9d各注射一次,在第15d采样,分别测定脾脏体指数和抗氧化酶活性,并统计各组的死亡率。【结果】阳性空白对照组黄鳝与阴性空白对照组相比,死亡率显著升高（P<0.05）,脾脏体指数极显著降低（P<0.01）,抗氧化酶CAT、GSH-Px活性受抑制极显著（P<0.01）,SOD活性显著降低（P<0.05）。各用药组的死亡率均比阳性空白对照组的低,脾脏体指数和CAT、GSH-PX抗氧化酶活性均有回升,并接近或超过健康组;SOD活性则远超过健康组水平,其中尤以阳性用药低剂量组效果最为显著（P<0.01）。【结论】加味玉屏风散具有良好的增强黄鳝非特异性免疫功能的作用。 相似文献
11.
连翘酯苷对小鼠不同组织巨噬细胞功能的影响 总被引：1，自引：1，他引：0
目的 探讨连翘酯苷(FS)对小鼠不同组织巨噬细胞增殖和功能的影响。方法 取56只昆明系小鼠颈椎脱臼致死,无菌操作制备腹腔、骨髓和脾脏巨噬细胞,在体外细胞培养体系中分别加入不同浓度连翘酯苷（40、80、160mg.L-1）和脂多糖(LPS),通过MTT法检测细胞增殖,ELISA和Griess法分别检测细胞分泌TNF-α 和NO量,瑞氏-吉姆萨染色法测定腹腔巨噬细胞吞噬能力。结果 与LPS组比较,FS组腹腔巨噬细胞和LPS+FS组骨髓巨噬细胞吸光度A值极显著提高,但FS组脾脏和骨髓巨噬细胞以及LPS+FS组腹腔和脾脏巨噬细胞A值明显降低;此外,FS极显著提高环磷酰胺注射的小鼠脾脏和骨髓巨噬细胞增值但明显抑制腹腔巨噬细胞增殖。FS组不同组织巨噬细胞分泌TNF-α 量显著低于对照组和LPS组;FS明显增加LPS刺激的腹腔巨噬细胞NO分泌量,而脾脏巨噬细胞NO分泌量明显减少,且有显著剂量依赖性,骨髓巨噬细胞NO分泌量变化不明显;FS明显抑制环磷酰胺处理的小鼠脾脏和骨髓巨噬细胞分泌NO但不影响腹腔巨噬细胞分泌NO。FS提高了LPS刺激的腹腔巨噬细胞吞噬鸡红细胞能力。 结论 连翘酯苷对小鼠不同组织巨噬细胞增殖、TNF-α和NO分泌以及吞噬能力都有影响,这可能是连翘酯苷调节细胞免疫功能的机制之一。 相似文献
12.
复方黄连乳腺炎注射液的药理作用与安全性研究 总被引：2，自引：0，他引：2
为了探讨复方黄连乳腺炎注射液的药理作用及安全性,为兽医临床用药提供理论依据。采用小鼠耳廓肿胀、毛细血管通透性、和棉球诱发小鼠肉芽组织增生方法研究了复方黄连乳腺炎注射液的抗炎作用;采用小鼠腹腔巨噬细胞吞噬鸡红细胞、小鼠吞噬细胞碳粒廓清能力、以及胸腺指数、脾脏指数研究了该注射液的免疫作用;采用改进Karber法,以半数致死量(LD50)作为评价急性毒性强度的指标,研究了该注射液的急性毒性,并对该注射液的热源性、刺激性进行了检测。结果表明：复方黄连乳腺炎注射液高、中剂量组对小鼠耳廓的肿胀度分别为1.24、1.78 mg,与对照组(生理盐水)的肿胀度(2.94 mg)相比差异极显著(P＜0.01);对毛细血管通透性的OD值,高、中、低剂量组分别为0.05、0.14、0.14,与对照组（生理盐水）的OD值(0.21)相比差异极显著(P＜0.01);对小鼠肉芽组织增重,高、中、低剂量组分别为10.18、8.10、10.16 mg,与对照组肉芽组织增重(11.90 mg)相比差异极显著(P＜0.01);高、中、低剂量组对小鼠胸腺指数、脾指数的增加有极显著性差异(P<0.01);高、中剂量组对小鼠腹腔巨噬细胞吞噬红细胞能力与对照组比较具有极显著性差异(P<0.01);高剂量组对小鼠吞噬细胞碳粒廓清能力与对照组相比差异极显著(P<0.01),中剂量、低剂量与对照组相比差异不显著;急性毒性试验LD50为11222.77 mg/kg。数据表明复方黄连乳腺炎注射液对急性和慢性炎症有显著的抗炎作用,能增强机体的免疫功能,且安全可靠。 相似文献
13.
为研究葛根提取物葛根素对草鱼非特异性免疫指标和肝胰脏组织结构的影响,在基础饲料(对照组)中分别添加10、50、250、1250 mg/kg的葛根素,饲养平均体重(4.52±0.22)g的草鱼。经28天的饲养,结果表明,与对照组比较,10 mg/kg葛根素添加组碱性磷酸酶活性显著高于对照组(P0.05),10、50 mg/kg葛根素添加组超氧化物歧化酶显著高于对照组(P0.05),溶菌酶各组间无显著差异。肝胰脏指数各试验组与对照组无显著差异。对照组和各试验组之间肝胰脏组织结构差异也不显著。饲喂结束后,利用嗜水气单胞菌人工感染草鱼,各试验组的相对免疫保护率都提高,但10 mg/kg葛根素添加组对草鱼的保护率显著高于对照组(P0.05),免疫保护率达73.33%。试验表明,在饲料中添加一定量的葛根素(10 mg/kg)能提高草鱼的非特异性免疫机能,且不会造成肝胰脏组织结构的损伤。 相似文献
14.
旨在探究制备的牛、羊油脂对小鼠血液生理指标及脏器形态的影响及牛、羊油脂的部分免疫功能,为动物性脂肪产品的开发利用奠定基础。选择30 只体重28~30 g 的雄性昆明小鼠,分为生理盐水组（对照组）、羊油脂组以及牛油脂组,分别灌胃生理盐水、羊尾油脂及牛肾周油脂。30 天后眼球采血,测血液生理生化指标;采集心、肝、脾、胃、肾的组织样品称重,制作石蜡切片观察各脏器组织结构变化。羊油脂组的肝脏系数极显著高于生理盐水组(P＜0.01),胃脏器系数显著高于生理盐水组(P＜0.05),心、脾、肾脏器系数同生理盐水组无差异性(P＞0.05);牛油脂组心、肝器系数极显著高于生理盐水组(P＜0.01);脾、肾、胃脏器系数与生理盐水组无差异(P＞0.05)。2 种油脂均使小鼠血液白细胞显著增多,红细胞减少,羊油脂使血小板数目增加而牛油脂使血小板数目显著增加。在石蜡切片中观察到羊油脂组与牛油脂组心脏出现脂肪增加,少数心肌细胞发生脂肪变性,胃和肾周脂肪细胞增加,肝脏以及脾脏没有明显的变化。本试验结果表明牛、羊油脂具有一定的免疫功能。 相似文献
15.
《Medicinal Plant》2015,(Z1)
[Objective] To research on the changes of total polysaccharides content and plant morphology in the 1- to 5-year-old leaves of Panax quinquefolius L.,which were harvested from May to September in Canada.[Methods]Plant morphological characteristics( length,diameter,dry weight and fresh weight) of the leaves of P. quinquefolius with different growth years in different harvest periods were detected; and the drying rate was calculated. Total polysaccharides content in the leaves of P. quinquefolius was detected by UV spectrophotometry. [Results]The dry rates of P. quinquefolius stems with different growth years had no significant differences( P = 0. 278 8 0. 05) with two-year-old leaves( 0. 394) one-year-old leaves( 0. 372) five-year-old leaves( 0. 30) three-year-old leaves( 0. 27) four-year-old leaves( 0. 26).Drying rates of P. quinquefolius leaves in different harvest periods showed significant differences( P = 0. 028 9 0. 05). According to the mean values,it could be concluded that July( 0. 452) May( 0. 348) June( 0. 274) September( 0. 26) August( 0. 248). The total polysaccharides content of P. quinquefolius leaves had extremely significant changes in different growth years( P = 0. 000 0 0. 01) with two-yearold leaves( 16. 678 mg / g) three-year-old leaves( 15. 154 mg / g) four-year-old leaves( 14. 559 mg / g) one-year-old leaves( 13. 497 mg / g) five-year-old leaves( 11. 929 mg / g). Total polysaccharides contents of P. quinquefolius stems also had extremely significant changes in different harvest periods( P = 0. 000 0 0. 01) with June July August May September.[Conclusions]In the leaves of P. quinquefolius,content of total polysaccharides had little correlation with the drying rate. Therefore,the content of total polysaccharides could not be judged by the drying rate of the leaves of P. quinquefolius. Total polysaccharides contents in one-to five-year-old P. quinquefolius leaves firstly enhanced and then decreased from May to September,and were the relatively high in June. Two-year-old P. quinquefolius leaves had the maximum content of average total polysaccharides. According to the previous researches,the average contents of total polysaccharides in P. quinquefolius roots,stems and leaves were 8. 4%,2. 6% and 1. 5%,respectively. The sum of total polysaccharides contents in P. quinquefolius stems and leaves was 4. 1%,which was only 1 /2 of the total polysaccharides content in roots. Stems of P. quinquefolius were usually abandoned during the harvest of RADIX PANACIS QUINQUEFOLII in Ontario of Canada. Therefore,it was suggested that the stems( aboveground parts) of P. quinquefolius could be used as the raw materials for the extraction of total polysaccharides. 相似文献
16.
《Medicinal Plant》2014,(5)
[Objective] To extract and isolate the effective components from Sorbus tianschanica,and to research the hypoglycemic effects of n-Butanol part. [Methods]S. tianchanica was extracted by reflux extraction. After gradient elution,n-Butanol part was obtained. With diabetic mice induced by STZ as the model,blood glucose test was carried out. [Results]n-Butanol part in administration group had significant differences in hypoglycemic effects with that in model group(P 0. 05),showing that n-Butanol part had certain antidiabetic functions on diabetic mice induced by STZ. And the hypoglycemic effects showed a reducing trend as the administration dosage decreased,indicating that administration dosage had positive correlation with hypoglycemic effects. n-Butanol in different parts could reduce the blood glucose of diabetic mice in different degrees. And the blood glucose value in high-dosage group(8 g /kg) reduced greatly at 2 h after administration,having great differences with that in model group(P 0. 01). This showed that high dosage was helpful to the glucose tolerance of diseased mice,and could effectively protect against the rapid increase of blood glucose after meal. n-Butanol had no significant effects on the blood glucose of normal mice. However,the morality rates in high-and middle-dosage groups were both higher than that in low-dosage group; and the morality rate in administration group was lower than that in model group,showing that n-Butanol could promote the survival rate of diabetic mice. [Conclusions]S. tianchanica had certain effects of anti-diabetes. 相似文献
17.
《Medicinal Plant》2015,(Z3)
[Objective] To research the protective effects of Lycium ruthenicum Murr on irradiated mice. [Methods] Except normal control group,mice were radiated by X-Rays with the radiation dosage being 5 Gy. The RBC,WBC,PLT and HGB of mice were detected. The thymus and spleen indices were calculated. The antioxidase activity,DNA,caspase-3 and caspase-6 contents were detected. [Results] L. ruthenicum water extracts significantly enhanced the hemogram of irradiated mice,increased the SOD activity,improved DNA content,reduced the CAT,GSH-PX and T-AOC activities,and lowered the caspase-3 and caspase-6 contents. Viscera index showed no statistical significance.[Conclusions]L. ruthenicum water extracts had certain protective effects on irradiated mice. 相似文献
18.
《Medicinal Plant》2014,(8)
[Objective]To discuss the antioxidation of proanthocyanidins( OPCRR) in Rhodiola rosea L. [Methods]By establishing peroxide injury model of ICR mice induced by D-gal,intragastric administration of mice was carried out for continuous 49 d. Then,80,160 and 320( BW) mg/kg OPCRR were added into low-,middle- and high-dosage groups,respectively. The SOD,GSH,GSH-Px and MDA in serum,heart,liver and brain tissues and the MAO in liver and brain tissues were investigated. [Results] Compared with model control group,OPCRR at certain dosage could significantly enhance the SOD and GSH-Px activities of mice serum,heat,liver and brain tissues,and obviously reduced the MDA content. And high-dosage group was the most prominent. In high-dosage group,SOD activities of serum,heart,liver and brain tissues enhanced by 29. 5%,28. 1%,62. 7% and 90. 8%,respectively; GSH-Px activities enhanced by 67. 8%,58. 4%,32. 1% and50. 3%,respectively; MDA contents reduced by 19. 2%,30. 0%,33. 3% and 19. 2%. Besides,middle- and high-dosage groups showed extremely significant effects on reducing the brain MAO activity( P 0. 01),which decreased by 22. 3% and 28. 6%,respectively. High-dosage group significantly reduced the liver MAO activity( P 0. 05) by 36. 5%. [Conclusions] OPCRR protected the organism in different degrees,antagonized peroxidation injury induced by D-gal,and prevented from aging. 相似文献
19.
《Medicinal Plant》2015,(Z4)
[Objective]To research the pharmacodynamic effects of Aquilaria sinensis leaves,and to compare pharmacological actions between A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM. [Methods]Pharmacological experiments of analgesia,anti-inflammation,hypoglycemic action,relieving asthma and promoting intestine moving activity were carried out by whole animal tests. [Results] glucose values of diabetic mice induced by alloxan reduced significantly in LIGNUM AQUILARIAE RESINATUM group and high-dosage group of A. sinensis leaves( P 0. 05 or P 0. 01). Different dosage groups of A. sinensis leaves had extremely significant inhibitory effects on the auricle swelling of mice induced by xylene and the abdominal capillary permeability of mice induced by acetic acid( P 0. 01 or P 0. 05). Low- and middle-dosage groups of A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM group had significant inhibitory effects on pains induced by thermal stimulus and acetic acid( P 0. 05 or P 0. 01),and obviously prolonged the asthma latency time of guinea pigs( P 0. 05);and high-dosage group of A. sinensis leaves also obviously prolonged the asthma latency time of guinea pigs( P 0. 05). Water extracts of A. sinensis leaves showed significant differences in time to falling asleep and sleeping time of mice( P 0. 01 or P 0. 05). Different dosage groups of A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM group significantly enhanced the intestine moving distance and rate( P 0. 05,P 0. 01 or 0. 001). [Conclusions]Ethanol extracts from A. sinensis leaves and LIGNUM AQUILARIAE RESINATUM had certain functions ofanalgesia,anti-inflammation,hypoglycemic action,relieving asthma and promoting intestine moving activity. Effects of ethanol extracts from A. sinensis leaves were equal to the effects of LIGNUM AQUILARIAE RESINATUM; and the ethanol extracts from A. sinensis leaves was superior to LIGNUM AQUILARIAE RESINATUM in anti-asthma and promoting intestine moving activity. 相似文献
20.
复方杜仲对肉鸡免疫器官发育及ND-HI效价的影响 总被引：1，自引：0，他引：1
[目的]观察不同浓度复方杜仲对肉鸡免疫器官发育及新城疫血凝抑制（ND-HI）效价的影响。[方法]1日龄AA肉鸡400只随机均分4组。Ⅰ、Ⅱ、Ⅲ、Ⅳ组分别在饮水添加0 g/L、1.25 g/L、2.5 g/L和5 g/L的复方杜仲。每周末各组随机抽样8只称重、心脏采血、屠宰取胸腺、脾脏和法氏囊称重。[结果] 1至6周胸腺指数、法氏囊指数各组间无差异。14日龄脾指数Ⅱ组高于Ⅰ组(P<0.05);21日龄Ⅱ组高于其他组(P<0.05),其中Ⅱ、Ⅲ组间差异极显著(P﹤0.01);42日龄复方杜仲Ⅱ、Ⅲ组脾指数均低于Ⅰ组(P<0.05),Ⅳ组极显著低于Ⅰ组(P<0.01)。21日龄Ⅲ、Ⅳ组ND-HI抗体水平高于Ⅰ组(P<0.05);28日龄达到最高水平,Ⅱ、Ⅲ组高于Ⅰ组(P﹤0.05),Ⅳ组极显著高于Ⅰ组(P﹤0.01)。[结论] 复方杜仲水煎液对前3周肉鸡脾指数有一定的影响,且以低剂量组效果最佳。对ND-HI效价有增强作用,呈现量效递增关系。 相似文献