共查询到20条相似文献，搜索用时 187 毫秒
1.
Slater JD Lunn DP Horohov DW Antczak DF Babiuk L Breathnach C Chang YW Davis-Poynter N Edington N Ellis S Foote C Goehring L Kohn CW Kydd J Matsumura T Minke J Morley P Mumford J Neubauer T O'Callaghan D Osterrieder K Reed S Smith K Townsend H van der Meulen K Whalley M Wilson WD 《Veterinary immunology and immunopathology》2006,111(1-2):3-13
Amongst the infectious diseases that threaten equine health, herpesviral infections remain a world wide cause of serious morbidity and mortality. Equine herpesvirus-1 infection is the most important pathogen, causing an array of disorders including epidemic respiratory disease abortion, neonatal foal death, myeloencephalopathy and chorioretinopathy. Despite intense scientific investigation, extensive use of vaccination, and established codes of practice for control of disease outbreaks, infection and disease remain common. While equine herpesvirus-1 infection remains a daunting challenge for immunoprophylaxis, many critical advances in equine immunology have resulted in studies of this virus, particularly related to MHC-restricted cytotoxicity in the horse. A workshop was convened in San Gimignano, Tuscany, Italy in June 2004, to bring together clinical and basic researchers in the field of equine herpesvirus-1 study to discuss the latest advances and future prospects for improving our understanding of these diseases, and equine immunity to herpesviral infection. This report highlights the new information that was the focus of this workshop, and is intended to summarize this material and identify the critical questions in the field. 相似文献
2.
Antczak DF 《Veterinary immunology and immunopathology》2012,148(1-2):6-11
In 2010 Doug Antczak was the recipient of the Distinguished Veterinary Immunologist Award of the Veterinary Immunology Committee of the International Union of Immunological Societies. Dr. Antczak is the Dorothy Havemeyer McConville Professor of Equine Medicine at the Baker Institute for Animal Health in the College of Veterinary Medicine at Cornell University. His research focuses on immunological and genetic aspects of the fetal-maternal relationship in the horse. This includes studies of major histocompatibility complex (MHC) genes and molecules, the regulation of their expression in the placenta, the composition and function of uterine lymphocytes, and alterations in maternal immune reactivity during pregnancy. For this research Dr. Antczak developed a herd of purpose-bred horses selected for homozygosity at the MHC. These horses are a unique genetic resource in equine immunology. During his career Dr. Antczak has mentored over 20 graduate students and post-doctoral fellows, many of whom have gone on to independent careers in immunology research. Dr. Antczak has made contributions to equine immunology, genetics, and reproduction, and collaborated widely with scientists in each of these disciplines. Through his relationship with the Havemeyer Foundation, Dr. Antczak has been a catalyst for cooperative research through a series of Havemeyer Foundation Workshops initiated over 25 years ago. Since 1995 he has been a principal participant in the international Horse Genome Project collaboration furthering his equine immunology research through genomic applications. In 2009 Dr. Antczak was inducted into the University of Kentucky's Equine Research Hall of Fame. 相似文献
3.
The metabolism of immunoglobulin classes has been closely examined in several animal species. Although the horse has received much attention in experimental and applied immunology there seems to be little information available on immunoglobulin kinetics in this species. The present report describes the metabolism of equine IgG in 4 healthy, normoimmunoglobulinaemic horses, in 1 horse with hyperimmunoglobulinaemia and in 1 horse with relatively low immunoglobulin levels. 相似文献
4.
鸡球虫病免疫学研究进展 总被引：1，自引：0，他引：1
鸡球虫病是严重危害养禽业的重要寄生虫病之一 ,长期以来对其防治主要依靠药物 ,并发挥了一定的积极效果。近年来因耐药虫株不断出现 ,尤其是药物残留对环境的污染及其对人类健康的威胁等一系列问题日益突出。因此 ,寻找防治球虫病的新方法是广大学者关注的焦点。在众多防治本病的措施中 ,免疫学方法因其安全、有效、无毒副作用等特点 ,倍受人们的青睐。但该方法目前仍然存在许多尚未阐明和有待解决的问题。文章对近年来鸡球虫病细胞免疫和体液免疫等方面的研究进展作了较全面系统的阐述 ,为兽医临床球虫病的有效防治提供科学的理论依据 相似文献
5.
The research was designed to analyze the rule of mRNA expression of IgG Fc receptor(FcR) in intestine from Yili horse aged at two-years-old by RT-PCR method, which aimed at providing data for researches on immunology mechanism and digestive physiology of equine, improving immunology function of horses, enhancing of nutrients absorbing, decreasing mortality.The results showed that the expression of IgG FcR gene in small gut was significantly higher than that of cecum (P< 0.05);it was also higher than that of large gut, its expression in large gut was higher than that of cecum(P> 0.05).The expression of IgG FcR had been identified in intestine of horses at two-year-old, it was different of immunology mechanism among horses, human and rat;Moreover, the expresson of IgG FcR in small gut was the highest among intestine, its expression rule was similar as other mammal animals (piggy and sheep).Above all, not only could be small gut thought as a digestive and absorption organ in nutrients, but also a important immunology organ in terms of its function, each plays special role in physiology of animal body. 相似文献
6.
Andrew N. McLean Paul D. McGreevy 《Journal of Veterinary Behavior: Clinical Applications and Research》2010,5(4):187-195
This review considers some contemporary training and restraining techniques that may lead to confusion or abuse in ridden and nonridden horses. As competitive equestrian sports boom, the welfare of the horse is under increasing scrutiny. The current focus on hyperflexion of the neck in dressage warm-up has exposed the problems with relying on subjective opinions when attempting to safeguard horse welfare. The discussion also highlights an opportunity for equestrian federations to evaluate practices within the various horse sports. Our review considers numerous examples of unorthodox practices that modify locomotion and posture. It offers a scientific framework for consideration of many contentious techniques in horse sports and emphasizes the role of Equitation Science in generating evidence-based enlightenment. 相似文献
7.
8.
马肠道微生物组成及影响因素的研究进展 《畜牧与饲料科学》2021,42(4):61-66
马肠道微生物群对其营养消化及维持机体健康具有重要作用,肠道不同部位的微生物具有不同功能,易受到各种因素的影响。马肠道正常微生物群结构遭到破坏,可导致肠道微生物失衡和机体功能紊乱,进而引起多种疾病。介绍了马肠道不同部位的微生物群结构组成特征,阐述了影响马肠道微生物群变化的各类因素,以期为改善马肠道营养健康、开发马健康监测和疾病预防工具提供科学依据,也为马肠道微生物研究提供新的视角。 相似文献
9.
The lung is a complex organ, and its physiology and immunology are regulated by various immune molecules and cells. Lung surfactant, a mixture of phospholipids and proteins produced by the bronchiolar and type II alveolar epithelial cells, is one such important player in lung physiology. Compared to knowledge about the biology of the surfactant in rodents and humans, only limited data are available on the surfactant in the horse. Although there are data linking levels of surfactant proteins with respiratory disease in the horse, there are no data on the cellular localization of surfactant protein A (SP-A) and surfactant protein D (SP-D). A member of the tetraspanin family of proteins, CD9 is a cell-signaling and adhesion protein and its expression has been detected in both normal and cancer cells, including those in the lung. Because there are no immunolocalization data on SP-A, SP-D, and CD9 in the normal lungs of the horse, our objective was to conduct a light and electron microscopic immunocytochemical study on normal lungs of the horse. The data showed SP-A and SP-D in bronchiolar epithelial and type II alveolar epithelial cells. These proteins were also localized in type I alveolar epithelial cells, pulmonary intravascular macrophages, and neutrophils, which is likely an outcome of endocytosis of the proteins by these cells. CD9 was present in the airway and vascular smooth muscle cells, endothelium, and blood cells, but not in the airway epithelium. These new data provide a baseline to further examine the expression and functions of SP-A, SP-D, and CD9 proteins in inflammation associated with respiratory diseases in the horse. 相似文献
10.
Lesley A. Hawson Andrew N. McLean Paul D. McGreevy 《Journal of Veterinary Behavior: Clinical Applications and Research》2010,5(6):324-338
Horse-related injuries to riders, handlers, and veterinarians can be both serious and long-term in their effects on the victim. This review of literature covering horse-related injuries to human beings sought to identify rider and handler injury incidence and the relationships between antecedents and demographics of incidents. Review and evaluation of previously recommended prevention strategies were also undertaken.There was evidence that recent technological advances in protective equipment may have mitigated some injuries but the frequency of the incident has not changed. Despite several authors acknowledging the important role the horse played in many of the incidents, there was little specific detail about this role recorded. The emerging field of equitation science will contribute important insights that make horse-use safer by reducing the “unpredictability” aspect of horse–human interactions. 相似文献
11.
Janne Rothmann Ole F. Christensen Eva Søndergaard Jan Ladewig 《Journal of Equine Veterinary Science》2014
Temperament traits in horses, especially reactivity, are an important trait in relation to human–horse accidents and the welfare of the horses. However, so far, temperament is often not included in many horse breeding programs. Most of the behavioral genetic studies in horses have been based on indirect indications of a sire effect and not on estimations of the heritability of temperament traits. Therefore, the aim of this study was to estimate the heritability of behavior reactions related to reactivity observed in a practical situation, that is, during the evaluation of the conformation of the horse at field tests. The study included 323 3-year-old Warmblood horses. Data were analyzed according to an animal model, and the estimation was based on restricted maximum likelihood. Results showed a low (0.17) heritability of reactivity. Probably because of the limited number of horses in the study, a high standard error was untainted. Nevertheless, results suggested a genetic variation of reactivity when assessed at field tests, but further research is needed before reactivity can be incorporated as a selection criteria into a breeding program. 相似文献
12.
Kirsten Tillotson Josie L Traub-Dargatz 《Veterinary Clinics of North America: Equine Practice》2003,19(3):599-615
The purpose of this article is to provide the reader with an overview of gastrointestinal cathartics and protectants and to point out possible applications for use in the horse with gastrointestinal disease. Most of the treatments described in this article have been used by the authors with apparent success; however, controlled studies with subsequent publication in the scientific literature with respect to these treatments in the horse are, for the most part, lacking. The authors view this emerging field of treatment as exciting and look forward to substantiating the efficacy of several of the treatments discussed. 相似文献
13.
鸡禽流感与新城疫免疫评价指标对科学指导家禽疫苗免疫工作意义重大,不仅关系到家禽免疫程序制定与免疫时机把握,更直接关系到家禽的健康生产与经济效益。本文根据近几年鸡禽流感与新城疫免疫抗体监测数据,结合当前禽病的流行情况、病原变异情况、免疫情况、饲养环境变化情况等,通过测定家禽免疫HI距离,研究建立了界差率（Q）指标,同现行的抗体合格率等免疫评价指标相比,通过本指标可以对家禽免疫水平和健康状态作出科学分析和评估,对适时掌握禽流感、新城疫免疫状态和免疫时机做好二者的免疫预防工作意义重大。 相似文献
14.
Differing viewpoints regarding wild (feral) horse management have resulted in majorcontroversy for public land management. While the livestock industry has not advocated the eradication of wild horses, much of the publicity on the issue has given this misleading impression. The livestock industry has advocated wild horse management. Wild horse herds have, in some cases, presented major management conflicts for ranchers when they have been allowed to multiply to uncontrolled numbers. In many areas, wild horse management has been secondary in priority to completion of environmental impact statements. During this interim period, wild horse herds have gone without management. Livestock numbers have been regulated by management agencies in accordance with forage production. Wild horses also must be managed within the carrying capacity of the rangeland. Management plans developed and implemented jointly by all interested factions present the best viable solution to the wild horse controversy. 相似文献
15.
An overview of recent developments in corneal immunobiology: potential relevance in the etiogenesis of corneal disease in the horse 总被引：1，自引：1，他引：0
A. G. Matthews 《Veterinary ophthalmology》2008,11(S1):66-76
This paper overviews some recent developments in mammalian corneal immunobiology, and discusses how these may act as pointers towards understanding the immunology underlying some common corneal diseases in the horse, including infectious ulceration and presumptively immune-mediated non-ulcerative disease. Specifically, three aspects of corneal immunobiology are examined: the role of Toll-like receptors in surface immunity and in the etiogenesis of microbial ulceration, the relationship between conjunctiva associated lymphoid tissue (CALT) and immunoprotection of the corneal surface, and the mechanisms determining corneal immune privilege (IP) and how down regulation of IP may be an important factor in the genesis of corneal immunoinflammatory disease. 相似文献
16.
Robin M Dabareiner G Kent Carter 《Veterinary Clinics of North America: Equine Practice》2003,19(2):417-441
In conclusion, horses with heel or navicular area pain vary, and no one treatment option is suitable for all horses. Each horse must be evaluated individually to determine which structure in the palmar aspect of the foot is injured, severity of disease, horse and hoof conformation, and horse use and level of performance expectation before a treatment plan can be developed. Overall, there are many treatment options to help these horses to perform their intended athletic event. 相似文献
17.
Katherine A. Robinson Stephen T. Manning 《The Canadian veterinary journal. La revue veterinaire canadienne》2015,56(12):1257-1260
Acupuncture is used without strong scientific evidence to treat many diseases of the horse, including palmar heel pain. Research is needed to provide evidence for the application of these treatments. Within the confines of our study, acupuncture did not reliably modulate palmar heel pain in horses. 相似文献
18.
This review presents a brief historical prospective of the genesis of regulated medication in the US racing industry of which the nonsteroidal anti-inflammatory drug (NSAID) phenylbutazone (PBZ) is the focus. It presents some historical guideposts in the development of the current rules on the use of PBZ by racing jurisdictions in the US. Based on its prevalent use, PBZ remains a focus of attention. The review examines the information presented in a number of different models used to determine the effects and duration of PBZ in the horse. They include naturally occurring lameness and reversible-induced lameness models that directly examine the effects and duration of the administration of various doses of PBZ. The review also examines indirect plasma and tissue models studying the suppression of the release of arachidonic acid-derived mediators of inflammation. The majority of studies suggest an effect of PBZ at 24 h at 4.4 mg/kg. This reflects and substantiates the opinion of many clinical veterinarians, many of whom will not perform a prepurchase lameness examination unless the horse is free of NSAID. This remains the opinion of many regulatory veterinarians responsible for the prerace examination of race horses that they wish to examine a horse without the possibility of an NSAID interfering with the examination and masking possible musculoskeletal conditions. Based on scientific studies, residual effects of PBZ remain at 24 h. The impact of sustained effect on the health and welfare of the horse and its contribution to injuries during competition remains problematic. 相似文献
19.
Heath TJ 《Australian veterinary journal》2004,82(8):474-478
OBJECTIVE: To give an account of the views held by Australian veterinarians who work with horses on the future of their professional field. METHOD: Questionnaires were mailed to 866 veterinarians who had been identified as working with horses, and 87% were completed and returned. Data were entered onto an Excel spreadsheet, and analysed using the SAS System for Windows. RESULTS: Their future prospects were believed to be very good or excellent by >60% of equine veterinarians but by only 30% of mixed practitioners seeing < 10% horses. The main factors believed likely to affect these prospects were the strength of the equine industries and the economic climate affecting horse owners, followed by the encroachment of cities into areas used for horses, competition from other veterinarians including specialist centres and from non-veterinary operators, and their ability to recruit and retain veterinarians with interest, experience and skill with horses. Urban encroachment, competition and recruitment were especially important for those seeing few horses. Concerns were also expressed about the competence and ethical behaviour of other veterinarians, the physical demands and dangers of horse work, the costs of providing equine veterinary services and of being paid for them, the regulatory restrictions imposed by governments and statutory bodies, the potential effects of litigation, and insurance issues. For many veterinarians in mixed practice these factors have reduced and are likely to reduce further the number of horses seen, to the extent that they have scant optimism about the future of horse work in their practices. CONCLUSION: Economic and local factors will result in an increasing proportion of equine veterinary work being done in specialised equine centres, and the future of horse work in many mixed practices is, at best, precarious. A key factor influencing future prospects will be the availability of competent veterinarians committed to working with horses. 相似文献
20.
Larsen LE 《Acta veterinaria Scandinavica》2000,41(1):1-24
Bovine respiratory syncytial virus (BRSV) infection is the major cause of respiratory disease in calves during the first year of life. The study of the virus has been difficult because of its lability and very poor growth in cell culture. However, during the last decade, the introduction of new immunological and biotechnological techniques has facilitated a more extensive study of BRSV as illustrated by the increasing number of papers published. Despite this growing focus, many aspects of the pathogenesis, epidemiology, immunology etc. remain obscure. The course and outcome of the infection is very complex and unpredictable which makes the diagnosis and subsequent therapy very difficult. BRSV is closely related to human respiratory syncytial virus (HRSV) which is an important cause of respiratory disease in young children. In contrast to BRSV, the recent knowledge of HRSV is regularly extensively reviewed in several books and journals. The present paper contains an updated review on BRSV covering most aspects of the structure, molecular biology, pathogenesis, pathology, clinical features, epidemiology, diagnosis and immunology based on approximately 140 references from international research journals. 相似文献