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1.
Zanna G Fondevila D Bardagí M Docampo MJ Bassols A Ferrer L 《Veterinary dermatology》2008,19(5):314-318
Cutaneous mucinosis affects primarily shar-pei dogs. Hyaluronic acid (HA) is considered to be the main component of mucin and CD44 is the major cell surface receptor of HA, necessary for its uptake and catabolism. The aims of this study were to identify the composition of the mucin in cutaneous mucinosis of shar-pei dogs, investigate the correlation between the deposition of HA and the expression of CD44, and determine whether shar-pei dogs with cutaneous mucinosis presented with elevated levels of serum HA. In skin biopsies, the mucinous material was stained intensely with Alcian blue and bound strongly by the hyaluronan-binding protein. No correlation was found between the degree of HA deposition in the dermis and the expression of CD44 in the skin of shar-pei dogs affected or unaffected by cutaneous mucinosis. A clear positive correlation was found between the existence of clinical mucinosis and the serum HA concentration. In control dogs, serum HA ranged from 155.53 to 301.62 microg L(-1) in shar-pei dogs; without mucinosis it ranged from 106.72 to 1251.76 microg L(-1) and in shar-pei dogs with severe mucinosis it ranged between 843.51 to 2330.03 microg L(-1). Altogether, the results reported here suggest that mucinosis of shar-pei dogs is probably the consequence of a genetic defect in the metabolism of HA. 相似文献
2.
Docampo MJ Zanna G Fondevila D Cabrera J López-Iglesias C Carvalho A Cerrato S Ferrer L Bassols A 《Veterinary dermatology》2011,22(6):535-545
The Chinese shar-pei dog is known for its distinctive feature of wrinkled and thickened skin, defined as primary or hereditary cutaneous mucinosis. In a recent report, we identified the mucinous material deposited in the shar-pei skin as the polysaccharide hyaluronan (HA). In the present work, the molecular and cellular mechanisms underlying this phenotype have been identified in dermal fibroblasts isolated from shar-pei dogs. The production of HA, which appeared to be mainly associated with cell membrane protrusions and also intracellular, was higher in shar-pei fibroblasts than in control cells. The HA accumulation is related to a higher mRNA expression of the isoform HAS2 of the HA-synthesizing enzyme family, hyaluronan synthases (HAS). The higher expression of HAS2 in shar-pei fibroblasts was confirmed at the protein level. The other HAS isoenzymes, HAS1 and HAS3, and the HA-degrading enzymes, Hyal1 and Hyal2, were not differentially expressed in shar-pei fibroblasts compared with cells from control dogs. Fibroblasts from shar-pei dogs and from control dogs are morphologically different as observed by transmission electron microscopy. Scanning electron microscopy revealed a large number of cellular protrusions with associated globular deposits. Electron microscopy after labelling with biotinylated HA-binding protein confirmed an increased HA content in shar-pei fibroblasts, which could be localized in several subcellular structures. The authors propose the name hereditary cutaneous hyaluronosis (HCH) for affected dogs, because it better defines the cutaneous mucinosis of shar-pei dogs. 相似文献
3.
IgA deficiency in shar-pei dogs 总被引：1，自引：0，他引：1
S D Moroff A I Hurvitz M E Peterson L Saunders K E Noone 《Veterinary immunology and immunopathology》1986,13(3):181-188
Two shar-pei puppies examined because of signs of sinopulmonary disease, one of which also had skin disease, had deficient IgA concentrations. Deficient serum IgA concentrations also were confirmed in 30 of 39 (76.9%) clinically normal adult dogs in two colonies of shar-peis. Both courses of disease--sinopulmonary signs and chronic skin disease and a benign clinical course--have been reported in human patients with IgA deficiency. Thus, the shar-pei might be an appropriate model for studying the immunopathology of IgA deficiency in man. 相似文献
4.
J. M. Williams 《The Journal of small animal practice》1990,31(5):251-254
A combined axial and paraoesophageal hiatal hernia complicated by splenic involvement was diagnosed in a two-year-old Chinese shar-pei. A circumcostal gastropexy was performed following reduction of the hernia and fundoplication of the cardia The dog recovered well and is asymptomatic six months postoperatively. The literature concerning hiatal hernia in the dog is reviewed and the various surgical techniques described for its management are discussed. 相似文献
5.
J M Auger S M Riley 《The Canadian veterinary journal. La revue veterinaire canadienne》1997,38(10):640-642
This article presents an unusual combination of a type IV hiatal hernia and a pleuroperitoneal hernia in a young shar-pei. Pathogenesis, diagnosis, and treatment of both conditions are discussed. At surgery, close examination and palpation of the whole diaphragm are recommended to allow perioperative diagnosis of unexpected defects. 相似文献
6.
López A Spracklin D McConkey S Hanna P 《The Canadian veterinary journal. La revue veterinaire canadienne》1999,40(12):881-883
A 7-year-old shar-pei was presented because of a recurrent dermatologic condition. Skin biopsies revealed an idiopathic (primary) cutaneous mucinosis that initially responded to corticosteroids. The condition reappeared 2 years later and subsequent biopsies revealed a mast cell tumor in some of the skin sites previously diagnosed with mucinosis. 相似文献
7.
犬细小病毒免疫复合物解离试验的研究 总被引：3，自引：0，他引：3
以犬细小病毒（ＣＰＶ）做为示范性抗原,以抗犬细小病毒血清（Ａｎｔｉ－ＣＰＶ）做为示范性抗体,制成抗原抗体免疫复合物。探索测定了使犬细小病毒复合物中抗原抗体解离的物理振荡、电解质浓度、缓冲液ｐＨ值及作用温度的解离条件。 相似文献
8.
J A Ellis 《Veterinary Clinics of North America: Food Animal Practice》2001,17(3):535-50, vi-vii
The bovine respiratory disease complex continues to be an economically important syndrome in an era when immunologic control is likely to become increasingly important. Recent studies have yielded a better understanding of the interaction, at the molecular level, of various pathogens with the bovine immune system. Improved challenge models for important viral pathogens such as bovine viral diarrhea virus and bovine respiratory syncytial virus have provided evidence of the efficacy of immune responses stimulated by vaccination. This article highlights recent advances in understanding of the role of the immune response in the pathogenesis and prophylaxis of bovine respiratory disease complex. 相似文献
9.
Mario Delgado-Ortega Daniel Marc Joëlle Dupont Sascha Trapp Mustapha Berri François Meurens 《Veterinary immunology and immunopathology》2013,151(1-2):1-19
As for most biological processes, the immune response to microbial infections has to be tightly controlled to remain beneficial for the host. Inflammation is one of the major consequences of the host's immune response. For its orchestration, this process requires a fine-tuned interplay between interleukins, endothelial cells and various types of recruited immune cells. Suppressors of cytokine signalling (SOCS) proteins are crucially involved in the complex control of the inflammatory response through their actions on various signalling pathways including the JAK/STAT and NF-κB pathways. Due to their cytokine regulatory functions, they are frequent targets for exploitation by infectious agents trying to escape the host's immune response. This review article aims to summarize our current knowledge regarding SOCS family members in the different mammalian species studied so far, and to display their complex molecular interactions with microbial pathogens. 相似文献
10.
为探讨不同生理发育时期日本大耳白兔红细胞免疫功能的变化规律,应用红细胞C3b受体花环（E—C3bRR）和红细胞免疫复合物花环（E—ICRR）试验以及红细胞免疫粘附调节因子活性测定试验．对不同生理发育期日本大耳白兔红细胞免疫学进行了研究。结果显示：随着年龄的增长,日本大耳白兔的红细胞C3b受体花环（E—C3bRR）和红细胞免疫粘附促进因子（RFER）显著降低（P〈0．01）,而红细胞免疫复合物花环（E—ICRR）和红细胞免疫粘附抑制因子（RFIR）显著升高（P〈0．01）。日本大耳白兔红细胞E—C3bRR和RFER与年龄呈显著负相关,而E—ICRR和RFIR与年龄呈显著正相关。 相似文献
11.
用酸对鼠伤寒沙门氏菌进行处理,制成裸细菌,作为空肠弯曲菌共同抗原(CA)的载体.用这种裸细菌和CA的复合物免疫小鼠,以间接ELISA和琼脂糖凝胶扩散沉淀反应检测免疫反应的变化及血清效价.结果表明,用这种方法免疫的小鼠,其血清抗体的ELISA滴度与对照组(福氏完全佐剂+CA组,CA组)相差不显著,但能与可溶性CA形成沉淀线,并含有IgM和IgG两类抗体;而对照组则不与CA出现沉淀反应,且只含IgM一类抗体.这表明,酸处理的沙门氏菌作为异种细菌抗原的载体,在改变机体对某种抗原的免疫类型上具有一定的作用. 相似文献
12.
Srikumaran S Kelling CL Ambagala A 《Animal health research reviews / Conference of Research Workers in Animal Diseases》2007,8(2):215-229
Bovine respiratory tract disease is a multi-factorial disease complex involving several viruses and bacteria. Viruses that play prominent roles in causing the bovine respiratory disease complex include bovine herpesvirus-1, bovine respiratory syncytial virus, bovine viral diarrhea virus and parinfluenza-3 virus. Bacteria that play prominent roles in this disease complex are Mannheimia haemolytica and Mycoplasma bovis. Other bacteria that infect the bovine respiratory tract of cattle are Histophilus (Haemophilus) somni and Pasteurella multocida. Frequently, severe respiratory tract disease in cattle is associated with concurrent infections of these pathogens. Like other pathogens, the viral and bacterial pathogens of this disease complex have co-evolved with their hosts over millions of years. As much as the hosts have diversified and fine-tuned the components of their immune system, the pathogens have also evolved diverse and sophisticated strategies to evade the host immune responses. These pathogens have developed intricate mechanisms to thwart both the innate and adaptive arms of the immune responses of their hosts. This review presents an overview of the strategies by which the pathogens suppress host immune responses, as well as the strategies by which the pathogens modify themselves or their locations in the host to evade host immune responses. These immune evasion strategies likely contribute to the failure of currently-available vaccines to provide complete protection to cattle against these pathogens. 相似文献
13.
旋毛虫调节宿主免疫反应的机制 《畜牧与饲料科学》2016,37(12):105-105
旋毛虫释放的排泄分泌产物（excretory-secretory,ES）对于宿主免疫系统产生了一系列复杂的作用,发挥激活、活化以及抑制等功能影响机体的免疫反应,使其能够逃避宿主主动免疫,从而成功完成寄生过程。在此过程中,旋毛虫诱导的免疫调节机制还可以减轻免疫性疾病、过敏和癌症等疾病的症状。 相似文献
14.
Immune mechanisms in infections of poultry 总被引：1，自引：0，他引：1
P C Powell 《Veterinary immunology and immunopathology》1987,15(1-2):87-113
Resistance to infectious agents may depend upon innate mechanisms or acquired immune responses. Inflammation, phagocytosis, cell-mediated immunity and antibodies are components of a complex reaction which result either in resistance or in susceptibility. Most infectious organisms stimulate immune responses within every compartment of the immune system. In rather few infections of poultry, it is possible to pinpoint a limited number of immune reactions that are primarily responsible for resistance. In some situations, autoimmunity may contribute to the pathology associated with infections. 相似文献
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16.
Antibody, immune complexes, and complement activity fluctuations in kittens with experimentally induced feline infectious peritonitis 总被引：2，自引：0，他引：2
Humoral changes were studied in 6 specific-pathogen-free kittens during experimental infection with feline infectious peritonitis virus. Although the incubation period and the duration of the disease differed widely, a similar pattern of rectal temperatures, serum complement values, circulating immune complexes, and antibody titers was found for all kittens during the last 15 to 20 days of life. Antibody formation started 8 to 13 days before death and was accompanied by the appearance of circulating immune complexes with subsequent increased concentrations of complement followed by complement depletion. The data are discussed as evidence for an immune complex pathogenesis of feline infectious peritonitis. 相似文献
17.
S L Longhofer D D Frisbie H C Johnson C A Culham A J Cooley K T Schultz G F Grauer 《American journal of veterinary research》1991,52(3):480-487
To determine the role of thromboxane A2 in the pathogenesis of experimentally induced immune complex glomerulonephritis, 12 concanavalin A-immunized Beagles were infused with 1 mg of concanavalin A via each renal artery and treated twice daily for 8 days with either 30 mg of CGS 12970/kg, PO, a specific thromboxane synthetase inhibitor, or placebo. The effect of treatment was assessed by measuring endogenous creatinine clearance and urine protein and eicosanoid excretion, and by evaluating changes in glomerular morphometric characteristics. On postinfusion day 8, urine protein, thromboxane B2, and 11-dehydro-thromboxane B2 excretion, glomerular epithelial crescent formation, and glomerular cell proliferation in the CGS 12970-treated dogs were significantly decreased when compared with values in the placebo-treated group. Differences were not observed in endogenous creatinine clearance, urine prostaglandin E2 and 6-keto-prostaglandin F1 alpha excretion, or glomerular polymorphonuclear leukocyte infiltration between groups in this study. These findings suggest thromboxane A2 has a role in the development of immune complex glomerulonephritis and that thromboxane synthetase inhibition may be beneficial in attenuating some of the functional and histological changes associated with immune complex glomerulonephritis. 相似文献
18.
动物肠道共生着数量庞大、结构复杂的菌群,而肠壁内存在着为数众多、功能强大的黏膜淋巴细胞。肠道菌群具有促进肠黏膜免疫系统生长与发育和调控肠黏膜屏障与免疫功能的双重作用。本文主要从动物肠道菌群的定植与特性、肠黏膜免疫细胞的功能以及肠道菌群对肠黏膜屏障与免疫功能的调控作用进行综述。 相似文献
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20.
Breed and swine lymphocyte antigen haplotype differences in agglutination titers following vaccination with B. bronchiseptica 总被引：1，自引：0，他引：1
M F Rothschild H L Chen L L Christian W R Lie L Venier M Cooper C Briggs C M Warner 《Journal of animal science》1984,59(3):643-649
Genetic differences in immune response to B. bronchiseptica after vaccination with a commercial B. bronchiseptica bacterin were investigated in 1,069 8-wk-old pigs. These pigs were from 65 litters born in the spring and 66 litters born in the fall of 1982 and were purebreds from the Chester White (n = 128), Duroc (n = 281), Hampshire (n = 143), Landrace (n = 309) and Yorkshire (n = 208) breeds. Each litter was raised separately. Individual pigs were vaccinated im at 4 and 6 wk of age with 2 ml of B. bronchiseptica bacterin. At 8 wk of age, 8 ml of blood were collected from each animal and serum prepared to determine agglutinating antibody titers against B. bronchiseptica bacterin by a bacterial agglutination method. In addition, lymphocytes were separated from 1 ml of heparinized blood and used to determine Swine Lymphocyte Antigen (SLA) haplotypes by using cytotoxic antibodies against the SLA complex. Antisera for 3 SLA haplotypes were made available by the National Institutes of Health. Results indicated that breed of pig (P less than .01) and dam of pig (P less than .01) affected the immune response of the pig after B. bronchiseptica vaccination. Higher immune response was also associated (P less than .05) with one of the SLA haplotypes tested. Heritability estimates for immune response following vaccination were .10 +/- .12 (half-sib) and .42 +/- .19 (full-sib). Results suggest that the relationship of the SLA complex to immune response in the pig and nonadditive genetic and maternal effects on immune response should be further investigated. 相似文献