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The pathology of carcinoma of the small intestine in six adult cattle is described. The lesions were similar to those of carcinoma of the small intestine of sheep although a slightly less fibrous stroma and a greater tendency to metastasise was observed. Initial findings suggest the disease resembles small-intestinal carcinoma of sheep and cola-rectal carcinomas of man in having a higher prevalence in New Zealand than most other countries. This highlights the need to investigate common environmental factors which may be responsible for the induction and promotion of these tumours in both grazing ruminants and man. 相似文献
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Ester CB Araujo Bellisa F Barbosa Loyane B Coutinho Paulo VC Barenco Luciana A Sousa Cristiane M Milanezi Giuliano Bonfá Wander R Pavanelli Jo?o S Silva Eloisa AV Ferro Deise AO Silva Jair P Cunha-Junior Neide M Silva 《Veterinary research》2013,44(1):89
Heme oxygenase-1 (HO-1) is an enzyme that catabolizes free heme, which induces an intense inflammatory response. The expression of HO-1 is induced by different stimuli, triggering an anti-inflammatory response during biological stress. It was previously verified that HO-1 is able to induce indoleamine 2,3-dioxygenase (IDO), an enzyme that is induced by IFN-γ in Toxoplasma gondii infection. To verify the role of HO-1 during in vivo T. gondii infection, BALB/c and C57BL/6 mice were infected with the ME49 strain and treated with zinc protoporphyrin IX (ZnPPIX) or hemin, which inhibit or induce HO-1 activity, respectively. The results show that T. gondii infection induced high levels of HO-1 expression in the lung of BALB/c and C57BL6 mice. The animals treated with ZnPPIX presented higher parasitism in the lungs of both lineages of mice, whereas hemin treatment decreased the parasite replication in this organ and in the small intestine of infected C57BL/6 mice. Furthermore, C57BL/6 mice infected with T. gondii and treated with hemin showed higher levels of IDO expression in the lungs and small intestine than uninfected mice. In conclusion, our data suggest that HO-1 activity is involved in the control of T. gondii in the lungs of both mouse lineages, whereas the hemin, a HO-1 inducer, seems to be involved in the control of parasitism in the small intestine of C57BL/6 mice. 相似文献
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Halima SULTANA Ayumi KITANO Shaila WADUD Toshihiro TAKAHASHI Tetsuo MORITA Ryoji ONODERA 《Animal Science Journal》2003,74(4):283-287
Three segments of cattle small intestine (duodenum, upper jejuno‐ileum and lower jejuno‐ileum) were examined in an in vitro system for activity of ornithine carbamoyltransferase (OCT; EC 2.1.3.3) which is involved in the synthesis of citrulline (Cit) from ornithine (Orn). The mucosa of the three segments of small intestine was collected from Japanese black cattle, homogenized and then centrifuged. The supernatant fraction was used as the crude OCT enzyme solution. The OCT activity was assayed by the production of Cit from Orn determined directly by HPLC. The optimal pH and temperature for OCT activities in the duodenum, upper jejuno‐ileum and lower jejuno‐ileum of cattle small intestine were 7.47 and 39°C. Little difference was observed between the three segments. The OCT activity in cattle kidney was also examined for comparison, and almost no activity was found. The OCT activities in crude enzyme solutions of the three segments of small intestine were stable for up to one month of storage at ?20°C in Tris HCl buffer solution. Finally, the role of the small intestine in supplying Cit as a precursor for arginine synthesis in cattle kidney was discussed. 相似文献
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L. Vellengat J. M. V. M. Mouwen J. E. van Dijk H. J. Breukink 《The Veterinary quarterly》2013,33(4):322-332
Summary The literature on the biology and pathology of mammalian small intestinal permeability to macromolecules is reviewed. In mammals, macromolecules may penetrate the epithelial layer of the small intestinal mucosa, especially in the neonatal period. The neonatal uptake and transport of immunoglobulins is important in the acquisition of passive immunity in the newborn. In the mature small intestine the uptake of macromolecules almost ceases, except in M‐cells. Excessive uptake and transport of macromolecules has been demonstrated in several experimental and spontaneous gastrointestinal diseases, in which increased concentration of macromolecules in the small intestinal lumen and/or damage of one or more components of the small intestinal mucosal barrier is present. Finally, methods to study macromolecular permeation of the small intestine are discussed. 相似文献
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In the last five years, 3 carcinomas of the intestine were found in a total of 1961 necropsies of dogs. One proved to be a primary gastric carcinoma situated in the area of the Curvatura minor, another a primary carcinoma of the ileocaecal valve and the third one a signet-cell carcinoma in the end of the jejunum. The morphological characteristics of the carcinomas are discussed. 相似文献
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Sarah K Elefson Ning Lu Tyler Chevalier Shannon Dierking Ding Wang H James Monegue Jamie C Matthews Young Dal Jang Jun Chen Gregg K Rentfrow Sunday A Adedokun Merlin D Lindemann 《Journal of animal science》2021,99(9)
Visceral organs (VO) are essential for their role in the metabolism and distribution of consumed nutrients as well as other life functions in animals. Two experiments were conducted to assess the natural longitudinal changes that the VO undergo from birth through 150 kg body weight (BW). In Experiment 1, a total of 96 crossbred pigs were euthanized at birth (pre-suckle), d 1, 2, 3, 5, 7, 14, 21 (weaning), 22, 23, 24, 26, 28, 42, 49, and 63 of age. In Experiment 2, a total of 48 crossbred pigs were euthanized at 30, 50, 75, 100, 125, and 150 kg of BW. The absolute weight of VO, and the volume and length of the gastrointestinal tract (GIT) were measured. In both experiments, the absolute weight of VO, GIT length, and their volume increased (linear, quadratic, and/or cubic, P < 0.05) as BW and age increased. In Experiment 1, the relative weight of VO (liver, kidney, heart, and lung) decreased after initially increasing within the first week of life (linear, quadratic, and/or cubic, P < 0.05), whereas the relative weight of all VO decreased as BW increased in Experiment 2 (linear and/or quadratic, P < 0.05). The relative length of small intestine decreased and that of large intestine increased as age increased in Experiment 1 (linear and quadratic, P < 0.05), whereas the relative length of the small and large intestine in Experiment 2 were relatively constant at 80% and 20% of the total length of the intestine, respectively. As age and BW increased, the relative volume of the large intestine to the total volume of the GIT increased (linear and/or quadratic, P < 0.05), while the relative volume of the small intestine decreased (linear and/or quadratic, P < 0.05). In conclusion, results showed that both absolute and relative measurements (weight, volume, and length) of VO were dependent on the BW (age) of the pig. 相似文献
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J.A. Lawrence 《Veterinary parasitology》1977,3(4):305-315
Nineteen Friesian steers infested with between 5 000 and 45 000 cercariae of Schistosoma mattheei were slaughtered at intervals between 7 and 107 weeks post-infestation. The distribution of parasites was assessed directly after their recovery from blood vessels and indirectly from the distribution of their eggs. The predilection sites were the small intestine and proximal large intestine. During the period of acute clinical illness 8–9 weeks after infestation there appeared to be a relative shift of parasites to the distal large intestine. Commencing at about 18 weeks post-infestation there was a partial shift from the intestine to the stomachs and bladder. During the later stages of infestation there was a relative increase in egg deposition in the liver which was not associated with a shift of parasites. 相似文献
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Mitsuhiro IRIE Hirotaka TOMIYASU Hajime TSUJIMOTO Chiaki KITA Yumiko KAGAWA 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2021,83(9):1481
Few reports have investigated prognosis of canine gastrointestinal stromal tumor (GIST) cases treated by surgical resection alone. In the present study, we investigated the overall survival (OS) and prognostic factors for dogs with GIST treated by surgical complete resection alone. Fifty-three dogs were included, and the median OS was 18 months. Multivariate analysis showed that primary tumors in small intestine (P=0.04) is significantly associated with shorter OS, and median OS of the cases with cecum lesion and those with small intestine lesion was 22 and 6 months, respectively. The present study suggested primary tumor site was a novel prognostic factor for dogs with GIST treated by surgical complete resection alone. 相似文献
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The characteristics of Salmonella typhimurium infection in hatchlings and adult poultry given by the intravenous, oral and percloacal routes were compared. Based on LD50 determinations, 1-day-old birds were most susceptible to percloacal infection. It is claimed that this infection technique yields predictable results in terms of mortality and numbers of organisms in the liver, spleen and intestinal tissues. Though older birds do not die when given large doses of organisms by this route, small numbers are sufficient to establish transient infection or carriage in the intestine.Based on quantitative data, the course of the percloacal infection appeared similar to that given by the oral route in hatchlings; however, the number of organisms required to establish infection by the former route was significantly less. It is suggested that the percloacal infection route may be a useful model for studying Salmonella infection-immunity in birds, particularly if resistance mechanisms operating in the intestine are to be taken into account. The possibility that it may be an important infection route in natural circumstances must also be considered. 相似文献
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Metabolism of I131-albumin and I125-gamma globulin was examined simultaneously in 5 pigs (22-30 kg. bodyweight). Total daily catabolism of albumin and gamma globulin was 12-23 per cent/day and 10-13 per cent/day rsp.
The excretion of the two proteins into the small intestine was studied in Thiry-Vella type loops, situated at different levels of the small intestine. Considerable amounts of protein-bound radio-activity could be detected in succus entericus. Perfusions with isotonic magnesium sulphate solution, normal saline and 10 per cent magnesium sulphate solution were followed by increased excretion of both proteins. The increase was very considerable, even when isotonic fluids were used. The excretion of the two proteins was of the same order of magnitude.
Quantitative aspects are discussed with special reference to the difficulties derived from the fact that little is known on secretory variations along the intestine and on the role played by the passage of digesta in the excretion of proteins.
相似文献12.
Tatjana Pirman Vida Rezar Milka Vrecl Janez Salobir Alenka Levart 《The Journal of Poultry Science》2021,58(2):119
An experiment in broilers was conducted to investigate the effect of olive (Olea europea) leaves and marigold (Calendula officinalis) petal extract supplementation on oxidative stress, characteristics of intestinal contents, and on the morphology of the small intestine. Oxidative stress was induced by a n-3 polyunsaturated fatty acids rich diet. 1-day-old male broiler chickens, Ross 308, were housed in a deep litter system. After the first 21 days, animals were randomly divided into three groups of 16 animals in two replicates and fed, until slaughter on day 39, a diet that contained 7% linseed oil. Control diet (Cont) remained unsupplemented, while both experimental diets were supplemented with olive leaves (OliveEx) or marigold petal (MarigEx) extracts. Oxidative stress was evaluated in blood and liver by measuring markers of lipid peroxidation (malondialdehyde (MDA), isoprostanes), rate of DNA damage in lymphocytes and in blood (comet assay, 8-hydroxy-2′deoxyguanosine (8-OHdG)), and activity of antioxidant and liver enzymes in blood. In different parts of the intestine, levels of short chain fatty acids (SCFA), and viscosity of intestinal contents were measured, and the health of the gastrointestinal tract was assessed using histological measurements. OliveEx significantly (p<0.05) decreased the MDA and 8-OHdG concentration in plasma, and the level of ethanoic acid in small intestinal contents and total SCFA in caecum, indicating improved oxidative status and increased microbial activity in the intestine. MarigEx significantly (p<0.05) decreased the rate of lymphocyte DNA damage and the crypt depth in duodenum, indicating potentially beneficial effects on the immune system and the health of the small intestine. In conclusion, dietary OliveEx and MarigEx supplementation improved some markers of oxidative stress and intestinal health. However, positive effects could be more pronounced in more unfavorable environmental conditions or in cases of diseases, but further studies are needed. 相似文献
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本试验旨在研究野生林麝(Moschus berezovskii)瘤胃、小肠和大肠微生物组成和抗生素抗性基因。采集野生林麝消化道3个区段(瘤胃、小肠和大肠)的内容物进行宏基因组测序,并进行常规物种注释和抗生素抗性基因功能注释。结果表明:3个区段共有优势菌门为厚壁菌门(Firmicutes)和变形菌门(Proteobacteria);瘤胃中主要优势菌属为普雷沃氏菌属(Prevotella)、月形单胞菌属(Selenomonas),小肠中主要优势菌属为链球菌属(Streptococcus)、埃希氏菌属(Echerichia),大肠中主要优势菌属为梭菌属(Clostridium)、拟杆菌属(Bacteroides)。基因常规注释显示各个区段微生物基因在不饱和脂肪酸合成和抗生素抗性上差异较大。抗生素抗性基因注释显示macB、sav1866和bcrA绝对丰度最高,且都来自于大肠细菌;瘤胃中抗生素抗性基因绝对丰度最大的是Aminocoumarin_resistant_alaS,小肠中是adeG,大肠中是macB。通过对野生林麝消化道微生物组成分区段比对,发现瘤胃、小肠和大肠微生物组成和抗生素抗性基因分布存在较大差异,大肠和小肠中细菌与野生林麝的多重耐药性关系更密切。 相似文献
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The pathologic effects of Trichostrongylus colubriformis on the small intestine of 8-week-old calves were studied. Morphologic and enzymic alterations were confined to the proximal third of the small intestine, which was shown to be the principal habitat of the nematode. Changes in the mucosa varied according to the acuteness of the infection rather than the duration. Villous atrophy, infiltrations of the lamina propria with plasma cells and lymphocytes, infiltrations of glandular tissue with eosinophils, and necrosis and erosions of the surface epithelial cells were present. Enzymic changes were related to the extent of cellular injury. Alkaline phosphatase and leucine aminopeptidase were more severely reduced, while nonspecific esterase and succinic dehydrogenase were less affected. Enzymic activities in the distal areas were nor influenced by the lesions in the proximal region. 相似文献
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C.N. Zanuzzi C.G. Barbeito M.L. Ortíz P.A. Fontana E.J. Gimeno 《Research in veterinary science》2010,89(2):214-222
Vitamin D participates in mineral homeostasis, immunomodulation, cell growth and differentiation. The leaves of Solanum glaucophyllum contain high levels of 1,25-dihydroxyvitamin D3 as glycoside derivatives and their chronic ingestion generates a hypervitaminosis D-like state. We analyzed changes on carbohydrate expression as a cell differentiation indicator on samples of the small and large intestine of S. glaucophyllum-intoxicated rabbits, using conventional and lectin histochemistry. Male New Zealand white rabbits were intoxicated with S. glaucophyllum during two or four weeks and killed the day after. A group of animals (“possibly recovered group”) were intoxicated during 15 days and killed at day 45 of the beginning of the experiment. We found changes in the lectin binding pattern in the small and large intestine of the intoxicated rabbits. Some of these changes were reverted in the possibly recovered group. Vitamin D could be a new regulator factor of the intestinal glycosylation process. 相似文献
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P.H.G. Stockdale 《Veterinary parasitology》1976,1(4):367-376
Calves were infected with Eimeria zuernii given by stomach tube and also placed directly into surgically prepared pouches of small intestine. The calves were killed at 2 day intervals or less from the 2nd to the 21st day after injection. First generation schizogony occurred in the lamina propria of the lower ileum and the first generation schizont was a giant schizont. Second generation schizogony and gametogony took place in the epithelial cells of the caecum and proximal colon. Measurements of the various stages of the life cycle of E. zuernii are given. 相似文献
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Intestinal lymphangiectasia in a dog 总被引：2，自引：0，他引：2
D. Mattheeuws A. De Rick H. Thoonen J. Van Der Stock 《The Journal of small animal practice》1974,15(12):757-761
A case of intestinal lymphangiectasia in a 3-year-old female Dalmatian is described. The clinical examination, laboratory findings, histology of the small intestine and necropsy findings are discussed. 相似文献
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A dynamic mathematical model of the digestion of proteins in the small intestine of pigs was developed. The model integrates current knowledge on the transit of digesta along the small intestine, endogenous secretions, digestion of proteins, and absorption of amino acids into a mechanistic representation of digestion. The main characteristics of the model are the following: the small intestine is divided into several segments of variable length but with equal digesta retention time; the rate of transfer of digesta between segments is based on the progression of myoelectric migration complexes; pancreatic and biliary secretions are poured into the first segment, whereas intestinal secretions enter all intestinal segments; protein hydrolysis is described by first-order equations; and an intestinal absorption capacity is used to estimate absorption of hydrolyzed protein. Simulation results are consistent with observed data, although more information is needed to represent reality more closely. The sensitivity analysis shows that parameters for protein hydrolysis largely determine protein digestibility. The absorption capacity of the small intestine limits the absorption of amino acids at the beginning of a meal and modulates the appearance of amino nitrogen in the portal vein. It also shows that amino acid absorption can be limiting to protein digestibility when large amounts of protein are eaten in a single daily meal. The model is useful in evaluating the dynamics of protein digestion and absorption of feedstuffs. The model can be used in evaluating protein digestion of different feedstuffs and feeding strategies. 相似文献
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《Research in veterinary science》2012,92(3):e16-e24
The present work describes the distribution of S-100 protein in the intestinal tract of a Chinese soft-shelled turtle specimen (Pelodiscus sinensis). S-100 protein positive cells were located in the intestinal tract, from the proximal small to distal large intestine. S-100 protein positive dendritic cells had irregular shape and were positive in both cytoplasm and nucleus. Most of them were located both lamina propria and submucosa in the small intestine, while few were found in the large intestine. S-100 protein, C-kit positive ICCs and Silver staining glial cells were predominantly observed in three locations: (1) in the interspace between the submucosa and circular muscle layer; (2) in the circular muscle layer; and (3) between the circular and longitudinal muscle layers of the intestine. Fewer were found in the large intestinal lamina propria and submucosa. Three types of positive cells (S-100 protein positive cells, C-kit positive ICCs and Silver staining glial cells) with 1–2 long or 2–3 short processes were distributed as lace-like or surrounding blood vessels in the different locations mentioned above. In the lamina propria, all the positive cells with irregular processes were connected with each other and formed a network. In the submucosa, all the positive cells were found surrounding the blood vessels. 相似文献