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茶多糖提纯、精制及其生理活性研究进展 总被引：1，自引：0，他引：1
综述了茶多糖的提纯精制方法、多糖组成及药理作用。目前多用水提法制茶多糖粗品;经除蛋白、脱色初步纯化;用沉淀法、超滤法或柱层析法等进一步纯化;多糖组成因原料及分离纯化方法不同有较大差别。茶多糖具有降血糖、降血脂、抗血栓、降血压及增强机体免疫力等功能,可用于糖尿病、心脑血管病的辅助治疗。 相似文献
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茶多糖对小鼠血糖、血脂和免疫功能的影响 总被引：36，自引：5，他引：36
研究了从粗老茶中提取的茶多糖对小鼠血糖、血脂和免疫功能的影响。结果表明：腹腔注射５０ｍｇ／ｋｇ·ｂｗ茶多糖有明显降低血糖的作用（Ｐ＜０．０１）；对血清胆固醇和血清甘油三酯影响不大，但有提高高密度脂蛋白胆固醇的效果；每天连续口服２５ｍｇ／ｋｇ·ｂｗ茶多糖，有增强免疫功能的作用。急性毒性试验表明，２４ｈ内腹腔注射总量１．０ｇ／ｋｇ·ｂｗ，未发现小鼠对茶多糖有中毒反应 相似文献
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茶多糖生物活性与结构的研究进展 总被引：22，自引：1，他引：22
糖类是自然界最多的有机化合物，也是重要的生物高分子化合物和重要的信息分子。多糖及糖复合物分布广泛，功能多种多样，它们参与了细胞各种生命活动的调节。有的多糖具有特殊生物活性，是一种免疫调节剂，且无毒副作用，而被作为临床用药或疫苗。茶多糖(TPS)能降血糖、防治糖尿病，还具有降血脂、抗动脉粥样硬化、降血压、抗凝…… 相似文献
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茶多糖的研究进展 总被引：8，自引：0，他引：8
糖类是自然界最多的有机化合物,多糖及糖复合物分布广泛,功能多种多样,它们参与了细胞各种生命活动的调节。茶多糖(TPS)能降血糖、防治糖尿病,还具有降血脂、抗动脉粥样硬化、降血压、抗凝血、抗血栓、防治心血管疾病等作用。在中国和日本民间有常饮用粗老茶治疗糖尿病的经验。一般随茶叶原料的老化,茶多糖含量增加,乌龙茶中茶多糖含量为2.63%±0.27%,约是红茶的31倍和绿茶的17倍。红茶一级的茶多糖含量为0.40%±0.10%,到了六级可达0.85%±0.10%。绿茶一级的茶多糖含量为0.81%±0.11%,六级达到1.41%±0.06%。本文对茶多糖的提取、分离提纯… 相似文献
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以糖苷酶溶液为工具酶,研究酶法修饰茶多糖对环磷酰胺抑制的免疫低下模型小鼠的免疫功能的影响。结果表明,原多糖TPS与改性后的茶多糖ETPS在免疫低下模型小鼠的细胞免疫功能、体液免疫功能、单核-巨噬细胞功能和NK细胞活性4个方面的实验中,结果均呈阳性,说明它们均具有明显的增强免疫功能的作用,酶法修饰改性能显著提高绿茶多糖的免疫活性。在同等剂量下,ETPS与TPS相比能提高脾指数、腹腔巨噬细胞吞噬率和吞噬指数,能显著提高DTH试验耳肿程度、血清HC50、NK细胞活性。绿茶多糖通过酶法修饰免疫活性得到增强。 相似文献
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茶多糖的组分及理化性质 总被引：65，自引：6，他引：65
粗老茶中含有较高能治疗糖尿病的茶多糖成分。用紫外、红外和气相色谱等方法对茶多糖分析结果表明，它是由糖类、蛋白质、果胶和灰分等物质组成；其多糖部分为阿拉伯糖、木糖、岩藻糖、葡萄糖和半乳糖等，各单糖的组成比例为５．５２：２．２１：６．０８：４４．２０：４１．９９。多糖的分子量约１０７０００。茶多糖的热稳定性较差，高温或过酸和偏碱均会使其中的多糖部分降解。它在沸水中溶解性能较好，但不溶于高浓度的有机溶剂。文中还对粗老茶中的降血糖成分、茶多糖组分和分子量上的差异原因，以及茶多糖中灰分含量高的原因进行了讨论。 相似文献
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分析不同种植海拔高度及采制时期对黄山"松谷"毛峰茶中茶多酚、游离氨基酸、咖啡碱、茶多糖和硒含量的影响;采用相关国家标准对黄山"松谷"毛峰茶中相应功能成分进行含量测定;从种植海拔高度看,茶样中茶多酚、游离氨基酸含量、酚氨比值及硒含量随种植海拔高度的增加而增加,对于咖啡碱,高海拔茶样中的含量显著高于平地地区茶样,而不同海拔高度的茶样中茶多糖含量差异不显著;从采制时期看,茶样中茶多酚含量为5月最高,4月次之,6月最低;游离氨基酸含量4月最高,5月次之,6月最低;茶样酚氨比值6月最高,5月次之,4月最低;咖啡碱含量4月和5月基本相同,均高于6月;氨碱比值4月最高,5月次之,6月最低;茶多糖含量6月最高,5月次之,4月最低;硒含量4月最高,5月和6月基本一致。此研究结果表明种植海拔高度及采制时期对黄山毛峰茶中茶多酚、游离氨基酸、咖啡碱、茶多糖和硒含量有交互性影响。 相似文献
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Sergey N. Fedorov Svetlana P. Ermakova Tatyana N. Zvyagintseva Valentin A. Stonik 《Marine drugs》2013,11(12):4876-4901
Many marine-derived polysaccharides and their analogues have been reported as showing anticancer and cancer preventive properties. These compounds demonstrate interesting activities and special modes of action, differing from each other in both structure and toxicity profile. Herein, literature data concerning anticancer and cancer preventive marine polysaccharides are reviewed. The structural diversity, the biological activities, and the molecular mechanisms of their action are discussed. 相似文献
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Paola Laurienzo 《Marine drugs》2010,8(9):2435-2465
The enormous variety of polysaccharides that can be extracted from marine plants and animal organisms or produced by marine bacteria means that the field of marine polysaccharides is constantly evolving. Recent advances in biological techniques allow high levels of polysaccharides of interest to be produced in vitro. Biotechnology is a powerful tool to obtain polysaccharides from a variety of micro-organisms, by controlling the growth conditions in a bioreactor while tailoring the production of biologically active compounds. Following an overview of the current knowledge on marine polysaccharides, with special attention to potential pharmaceutical applications and to more recent progress on the discovering of new polysaccharides with biological appealing characteristics, this review will focus on possible strategies for chemical or physical modification aimed to tailor the final properties of interest. 相似文献
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茶多糖和茶多酚的降血糖作用研究 总被引：17，自引：7，他引：17
目的:研究茶多糖、茶多酚对四氧嘧啶致糖尿病SD大鼠的降血糖作用和机制。方法:饲喂SD大鼠茶多糖、茶多酚3周后,观察大鼠血糖、葡萄糖耐量、血胰岛素以及小肠糖降解酶(淀粉酶、蔗糖酶、麦芽糖酶)变化。结果:茶多糖、茶多酚都有显著抑制糖尿病大鼠血糖升高的作用;与对照组比较,茶多糖组大鼠血胰岛素水平有显著提高(P<0.05),蔗糖酶和麦芽糖酶活性显著降低(P<0.05);茶多酚组的血胰岛素水平有升高趋势,小肠各降解酶活力也有下降趋势,但与对照组比较均未达到显著水平。结论:茶多糖对高血糖大鼠有显著的抑制血糖升高的作用,茶多糖的作用机制可能是抑制小肠糖降解酶活性。 相似文献
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In recent years, researchers across various fields have shown a keen interest in the exploitation of biocompatible natural polymer materials, especially the development and application of seaweed polysaccharides. Seaweed polysaccharides are a multi-component mixture composed of one or more monosaccharides, which have the functions of being anti-virus, anti-tumor, anti-mutation, anti-radiation and enhancing immunity. These biological activities allow them to be applied in various controllable and sustained anti-inflammatory and anticancer drug delivery systems, such as seaweed polysaccharide-based nanoparticles, microspheres and gels, etc. This review summarizes the advantages of alginic acid, carrageenan and other seaweed polysaccharides, and focuses on their application in gel drug delivery systems (such as nanogels, microgels and hydrogels). In addition, recent literature reports and applications of seaweed polysaccharides are also discussed. 相似文献
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研究和对比白茶多糖（White tea polysaccharide,WTP）、绿茶多糖（Green tea polysaccharide,GTP）和红茶多糖（Black tea polysaccharide,BTP）的成分、降血糖效果及机理。分别选取寿眉、龙井、白琳工夫作为白茶、绿茶和红茶的代表,测定分析茶多糖提取物的成分和分子量。以链脲佐菌素诱导小鼠糖尿病模型,二甲双胍作为阳性对照,研究茶多糖降血糖效果,qPCR测定小鼠肝脏中相关基因表达水平。结果表明,所选白茶、绿茶和红茶多糖的绝对重均分子量分别为18 180、19 470、8 745 Da。所选茶多糖提取物均具有降血糖功效,白茶、绿茶和红茶多糖干预组小鼠的血糖下降率分别为53.2%、52.8%及61.6%。茶多糖均可改善小鼠葡萄糖耐量,调节糖代谢相关基因表达,并且存在一定差异。 相似文献
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Saccharophagus degradans 2-40 is a γ-subgroup proteobacterium capable of using many of the complex polysaccharides found in the marine environment for growth. To utilize these complex polysaccharides, this bacterium produces a plethora of carbohydrases dedicated to the processing of a carbohydrate class. Aiding in the identification of the contributing genes and enzymes is the known genome sequence for this bacterium. This review catalogs the genes and enzymes of the S. degradans genome that are likely to function in the systems for the utilization of agar, alginate, α- and β-glucans, chitin, mannans, pectins, and xylans and discusses the cell biology and genetics of each system as it functions to transfer carbon back to the bacterium. 相似文献
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茶多酚具有抗氧化、抗肿瘤、抗辐射等多种生物活性,与环糊精、黑木耳多糖或壳聚糖等多种多糖作用后,功能活性增强,但相互作用的过程与机理尚不明确。因此,对茶多酚与多糖的结构及其相互作用的研究显得尤为重要。近几年,关于茶多酚与多糖之间相互作用的研究日益增多,本文介绍了茶多酚和多糖的分类及结构,概括了多糖与茶多酚之间的相互作用类型、影响因素及研究方法,针对二者之间的相互作用对茶多酚功能特性的影响进行了综述,为后续研究二者与其他活性物质相互作用以及功能特性变化等方面提供参考。 相似文献
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Jichen Chen Jianchao Yang Hong Du Muhmmad Aslam Wanna Wang Weizhou Chen Tangcheng Li Zhengyi Liu Xiaojuan Liu 《Marine drugs》2021,19(10)
During the processes of primary and secondary endosymbiosis, different microalgae evolved to synthesis different storage polysaccharides. In stramenopiles, the main storage polysaccharides are β-1,3-glucan, or laminarin, in vacuoles. Currently, laminarin is gaining considerable attention due to its application in the food, cosmetic and pharmaceuticals industries, and also its importance in global biogeochemical cycles (especially in the ocean carbon cycle). In this review, the structures, composition, contents, and bioactivity of laminarin were summarized in different algae. It was shown that the general features of laminarin are species-dependence. Furthermore, the proposed biosynthesis and catabolism pathways of laminarin, functions of key genes, and diel regulation of laminarin were also depicted and comprehensively discussed for the first time. However, the complete pathways, functions of genes, and diel regulatory mechanisms of laminarin require more biomolecular studies. This review provides more useful information and identifies the knowledge gap regarding the future studies of laminarin and its applications. 相似文献