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吡喹酮治疗耕牛血吸虫病疗效观察 总被引：5，自引：0，他引：5
吡喹酮治疗耕牛血吸虫病疗效观察刘杏海湖北省荆州地区太湖港农场畜禽服务公司，江陵４３４１１５）１９８８～１９９３年，我们采用毗喹酮肌肉注射、口服以及重瓣胃注射等不同给药途径、剂量、剂型治疗耕牛血吸虫病的效果满意。报告如下。一、对象与方法（一）病样选择：... 相似文献
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1958年6月浙江省农业厅和卫生厅派来家畜血吸虫病调查队,在本县17个乡范围内进行了一次耕牛血吸虫病普查。经过一个多月的调查,共检查了耕牛7,359头,检出病牛1,471头;其中黄牛921头,占受检数的33.4%,水牛550头,占受检数的11.9%,平均感染率20%。这证明本县的耕牛血吸虫病十分严重,不但影响了耕牛健康,同时成为人血吸虫病的传染病源。如果不消灭家畜血吸虫病,就不能彻底消灭血吸虫病的流行。因此县委很重视,在9月5日全面开展防治工作,苦战一 相似文献
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“粪便孵化诊断法”是诊断耕牛日本血吸虫病的主要方法。这一方法已经沿用了二十多年,在普查耕牛血吸虫病工作中起了很大作用。由于连续多年的普查普治,耕牛血吸虫病的感染率和感染强度显著下降,这就相应地增加了查病工作的难度。因此要求进一步改进粪孵诊断方法,提高阳性检出率,以适应新的形势要求。为此,自七十年代初期以来,血吸虫病流行区的各省、市科研单位、高等院校和农业部门开展了血防科研大协作,对耕牛血吸虫病 相似文献
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一、安吉县血吸虫病耕牛粪孵诊断结果1983年6月28日—7月5日,中国农业科学院上海家畜血吸虫病研究所病原诊断组在安吉县血吸虫病流行区进行毛蚴孵集器考核试验,用四种工具,各经一粪四检,从10个公社,17个大队,计86头牛次粪便的诊断结果,未能查出一头病牛。为此进行了深入调查与分析;探明安吉县原是血吸虫病耕牛阳性很高的流行区,解放后,曾用锑剂治疗,因副作用大,没 相似文献
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环卵沉淀反应血纸法诊断耕牛日本血吸虫病的试验 总被引：1，自引：0，他引：1
环卵沉淀反应(简称环沉)诊断耕牛日本血吸虫病是一种快速、简便、检出率高的方法。鉴于用全血(干燥血纸)进行间接血凝诊断耕牛伊氏锥虫病效果好,我们进行了本试验,并在1986年底用本法对我市血吸虫病疫区的耕牛进行了普查,结果满意,介绍如下。材料和方法(一)试剂:1.标准抗原:已铺有热处理超声干卵抗原的薄膜,由上海血吸虫病防治研究所提供。2.PBS:pH6.8—7.2的生理盐水磷酸缓冲液。 相似文献
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我省是血吸虫病严重疫区，疫区存栏耕牛棚余万头，大量牛粪污染湖洲，传播病源。随着防治对策的调整，化疗耕牛、打击病源体，已成为防治工作中的主要环节。因此，快速诊断病牛具有重要意义。为较全面地掌握我省耕牛血吸虫病感染情况，探讨快速简便、敏感特异的免疫学诊断方法，1991年6月，我们采用间接血凝试验，在21个县、市、农场进行耕牛日本血吸虫病调查，结果报告如下：一、材料来源和方法1．血清标本：2103例，来自疫区ZI个县、市、农场。其中基消区石门县、益阳市、宁乡县、望城县332例，17个流行县、市、农场1771例。2．标准试剂… 相似文献
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选择湖北省江陵县5个行政村的水牛和黄牛，用血清学诊断法、饱和盐水漂浮虫卵法、顶管毛蚴孵化法检测日本血吸虫感染情况，并采用抽样法对调查村所属的湖滩钉螺分布情况进行了检查。结果，牛日本血吸虫病血清抗体检查阳性率为17．92％，饱和盐水漂浮虫卵法检查阳性率为19．46%，粪便毛蚴孵化法检查阳性率为16．04%，5个村湖滩钉螺的平均密度为0．445只／m^2。结果显示，该县日本血吸虫病流行严重。 相似文献
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目的了解石首市糜鹿血吸虫病流行情况。方法选择湖北省石首市天鹅洲的3个地区的麋鹿为研究对象,用直接毛蚴孵化法、顶管毛蚴孵化法、饱和食盐水虫卵漂浮法检测验麋鹿的感染情况,并对石首天鹅洲故道旁钉螺进行调查。结果直接毛蚴孵化法检查阳性率为16.0%,顶管毛蚴孵化法检查阳性率为12.0%,饱和食盐水虫卵漂浮法阳性率为12.0%,石首天鹅洲钉螺阳性率平均为4.8%。结论结果显示,该市天鹅洲麋鹿血吸虫感染为主。 相似文献
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IgM-ELISA法用于日本血吸虫病早期诊断初探 总被引：2，自引：0，他引：2
目的 验证血清特异性IgM抗体检测对急性日本血吸虫病的早期诊断价值。方法 采用IgM-ELISA方法检测感染血吸虫的小鼠和急性血吸虫病人血清中的特异性IgM抗体水平，与IgG—ELISA相比较，并与急性血吸虫病人的流行病学调查资料相比对。结果 感染4周时小鼠血清中特异性IgM抗体水平显著升高，5周时阳性检出率达100％，比IgG-ELISA提早2-3周。检测急性血吸虫病人血清阳性率达100％，IgG—ELISA为91．4％。急血病人接触疫水后5周，特异性IgM抗体水平明显高于IgG。7周时两者水平相近，8周时IgG抗体水平超过IgM。结论 IgM—ELISA具有早期诊断急性血吸虫病的价值. 相似文献
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用血清学诊断法、顶管毛蚴孵化法、饱和食盐水漂浮虫卵法等检测湖北荆州部分地区羊血吸虫感染情况。结果显示,血清学检查阳性率为16.88%,饱和食盐水漂浮虫卵法检查阳性率为17.46%,粪便毛蚴孵化法检查阳性率为13.57%。提示在血吸虫病的老疫区,羊血吸虫病以中、轻度感染居多。 相似文献
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Development and validation of a questionnaire for measuring behavior and temperament traits in pet dogs 总被引：7，自引：0，他引：7
OBJECTIVE: To develop and validate a questionnaire to assess behavior and temperament traits of pet dogs. DESIGN: Cross-sectional survey of dog owners. Animals-1,851 dogs belonging to clients of a veterinary teaching hospital or members of national breed clubs and 203 dogs examined by canine behavior practitioners because of behavior problems. PROCEDURE: Owners were asked to complete a questionnaire consisting of 152 items eliciting information on how dogs responded to specific events and situations in their usual environment. Data from completed questionnaires were subjected to factor analysis, and the resulting factors were tested for reliability and validity. RESULTS: Factor analysis yielded 11 factors from 68 of the original questionnaire items that together accounted for 57% of the common variance in questionnaire item scores. Reliability was acceptable for all but 1 of these factors. Behavior problems in 200 of the 203 dogs with behavior problems could be assigned to 7 diagnostic categories that matched 7 of the factors identified during factor analysis of questionnaire responses. Dogs assigned to particular diagnostic categories had significantly higher scores for corresponding questionnaire factors than did those assigned to unrelated diagnostic categories, indicating that the factors were valid. Validity of the remaining 4 factors could not be examined because of a lack of information on dogs with behavior problems related to these factors. CONCLUSIONS AND CLINICAL RELEVANCE: Findings suggest that the resulting 68-item questionnaire is a reliable and valid method of assessing behavior and temperament traits in dogs. The questionnaire may be useful in screening dogs for behavior problems and in evaluating the clinical effects of various treatments for behavior problems. 相似文献
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Hanzlicek AS Harkin KR Dryden MW Chun R Payne PA Nietfeld JC Debey BM 《Journal of the American Animal Hospital Association》2011,47(6):e95-e102
This is a retrospective case series consisting of five dogs diagnosed with schistosomiasis. The purpose of this article is to report the presence of naturally occurring canine schistosomiasis in Kansas and to provide clinical details regarding schistosomiasis. Medical records of dogs diagnosed with schistosomiasis from 2000 to 2009 were reviewed, and information extracted included signalment, history, clinical signs, diagnostic test results, treatment, and outcome. Affected dogs were primarily medium to large breed and young to middle aged. All dogs were considered outdoor dogs, with three having known access to surface water. Common clinical signs included gastrointestinal disease and signs associated with hypercalcemia. Fecal flotation was negative in all dogs in contrast to fecal saline sedimentation and fecal polymerase chain reaction, which were both positive in all dogs in which it was performed. All dogs treated specifically for schistosomiasis fully recovered. This article describes the first reported cases of canine schistosomiasis in the Midwest and the first reported case of intestinal intussusception secondary to schistosomiasis. Recognizing that canine schistosomiasis is present in Kansas and possibly other Midwestern states should prompt veterinarians to perform appropriate diagnostic investigation in suspect animals as the diagnosis is straight forward and relatively inexpensive. 相似文献
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"封洲禁牧"控制我国大湖区血吸虫病的意义和实践 总被引：4，自引：0，他引：4
目的 采取"封洲禁牧"措施,切断病原,净化草洲,保护人、畜免受新感染和重复感染,达到控制大湖区血吸虫病的流行。方法 每年3月1日～10月31日实施封洲禁牧,并在每年10月15日以前对人、畜进行血吸虫病的查治。结果 两个试点经过"封洲禁牧"后,均达到了国家基本控制血吸虫病的标准。结论 认为"封洲禁牧"是目前用于控制大湖区血吸虫病流行中科学性强,方法简便,速度快,效果好的措施。 相似文献
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为研究湖滩型日本血吸虫病中重度流行区化疗后牛群血吸虫感染、再感染及其危险因素,采用在观察试区,以34例感染牛经吡喹酮治疗后虫卵转为阴性的30头牛为"再感染"研究对象,98例粪检阴性牛群作为"感染"研究对象,追踪观察2组牛群在一个感染季节后的再感染情况,并调查其接触疫水情况以及当地螺情和疫水变化情况等因素,再对其进行单因素分析和多因素非条件Logistic回归分析。结果显示,基线感染率为20.26%,经过一个感染季节后,标准化感染率为10.01%,标准化再感染率高达20.62%,再感染率已恢复到化疗前牛群感染水平,其中黄牛再感染率(26.66%)高于水牛感染率(13.33%)。接触疫水处水体尾蚴密度、年龄、6～9月疫水接触指数、牧地距阳性螺点距离是再感染发生的主要危险因素。接触疫水处水体尾蚴密度、牛采食和6～9月疫水接触指数是血吸虫病感染的主要危险因素。本研究表明,在日本血吸虫病重度流行区存在较快感染和再感染趋势,初步揭示了感染和再感染的主要危险因素。 相似文献
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To observe the clinical therapeutic effect of 30% praziquantel injection on buffalo schistosomiasis, the sick buffalos naturally infected with Schistosoma japonicum were selected by miracidium hatching method. In experimental clinical trials, sick buffalos were randomly divided into five groups, high-dose (20 mg/kg), middle-dose (10 mg/kg) and low-dose (5 mg/kg) praziquantel injection groups, praziquantel tablet group (30 mg/kg) and positive control group. After the treatment of 30 d, the negative conversion rate of miracidium were 100.0%, 100.0%, 77.8% and 85.7%, respectively, in praziquantel injection groups with the high, middle and low dose and oral medication group. In expanded clinical trials, the sick buffalos were randomly divided into two groups, praziquantel injection group (10 mg/kg, i.m.) and praziquantel tablet group (30 mg/kg). The results showed that, the negative conversion rate of miracidium were all 100% in the former 52 patients and the latter 6 patients after 30 d. The research confirmed that praziquantel injection was significantly effective in the treatment of buffalo schistosomiasis and convenient for administration. It was concluded that 30% praziquantel injection could replace the traditional oral praziquantel tablet for the treatment of buffalo schistosomiasis, and the recommended dose was 10 mg/kg. 相似文献
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采用粪便毛蚴孵化法筛选自然感染血吸虫病水牛,考察30%吡喹酮注射液对水牛血吸虫病的临床治疗效果。在实验性临床试验中,将自然感染血吸虫病水牛随机分为5组,分别为吡喹酮注射液高（20 mg/kg）、中（10 mg/kg）、低（5 mg/kg）剂量组,吡喹酮片组（30 mg/kg）和阳性对照组（不用药组）。给药30 d后,吡喹酮注射液高、中、低剂量组及吡喹酮片组的粪便毛蚴孵化转阴率分别为100.0%、100.0%、77.8%和85.7%。在扩大临床试验中,将自然感染血吸虫病水牛随机分为2组,分别为吡喹酮注射液推荐剂量组（10 mg/kg）和吡喹酮片组（30 mg/kg）,给药30 d后,吡喹酮注射液组的52头患牛的粪便毛蚴孵化转阴率为100%,吡喹酮片组的6头患牛的粪便毛蚴孵化转阴率为100%。研究结果表明,30%吡喹酮注射液对水牛血吸虫病具有良好的治疗效果,给药方便,可以替代传统内服片剂,临床推荐剂量为10 mg/kg。 相似文献