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1.
Crumlish PT Sweeney T Jones B Angles JM 《Veterinary journal (London, England : 1997)》2006,171(2):308-313
Hypertrophic osteodystrophy (HOD) is a canine bone disease that affects mainly large breed dogs, including the Weimaraner, and studies have shown a link between recent vaccination with a modified live virus and the onset of HOD in this breed. In humans, it has been suggested that human leukocyte antigen (HLA) alleles can influence antibody response to vaccination. The aim of this study was to investigate whether there is an association between the development of HOD in Weimaraners and MHC alleles at the DLA-DQA1 locus in a group of 33 unrelated dogs. The DQA1 allele and genotype frequencies were determined by sequence-based typing. Although clinical signs developed within six weeks of vaccination in all 12 dogs for which information was available, no association was found between DQA1 alleles and HOD in this population of Weimaraner dogs. A role for other immune-response genes in the pathogenesis of HOD should not however be ruled out. Whereas recent vaccination may be a trigger for the disease, it was concluded that there is no specific vaccine that is most responsible for the expression of the disease. 相似文献
2.
María J. Snchez‐Guerrero Sara Negro‐Rama Sebastin Demyda‐Peyras Marina Sol‐Berga Pedro J. Azor‐Ortiz Mercedes Valera‐Crdoba 《Animal Science Journal》2019,90(1):14-22
Gene mutations influencing melanocytes also impact on physiological and behavioural functions. In this study, we investigated their association with four different coat colours in the Pura Raza Español (PRE) horse using morphological traits and molecular datasets. Four different subpopulations were identified according to individual coat colour: grey, bay, chestnut and black. Coat colour significantly associated with morphological measurements. Observed and expected heterozygosity values were low in grey compared with the other three subpopulations, suggesting the presence of unique ancestral alleles probably arisen by genetic drift and selection mechanism effects. Nei's distance demonstrated a clear division among subpopulations, the grey being the most divergent group. Gene flow estimates were similar, showing the lowest values in grey. Divergence times among subpopulations assessed with the average square distance suggested that grey was the original PRE population which diverged from bay, chestnut and black. Our results also demonstrated a clear morphological differentiation according to coat colour. The close genetic structure of bay and chestnut PRE subpopulations and the clear differences in most morphological traits of grey and chestnut PRE mares would suggest the pleiotropic effect of genomic regions determining coat colour in horses. However, further analysis including genomic information would be necessary to elucidate the mechanisms involved. 相似文献
3.
本研究旨在了解酪氨酸酶相关蛋白1（tyrosinase related protein 1，TYRP1）基因在中国地方绵羊群体内的遗传变异，以及TYRP1基因突变与不同毛色表型绵羊群体的相关性。通过直接测序法和PCR-RFLP技术对10个中国地方绵羊群体进行单核苷酸多态性（SNP）检测，利用Beagle、PLINK和POPGENE等软件对突变位点数据进行单倍型构建、连锁不平衡分析和遗传变异研究。突变位点检测结果表明，在绵羊TYRP1基因内识别了13个SNPs，其中位于TYRP1基因外显子上的10个SNPs位点，除个别位点在大尾寒羊、中国美利奴羊和岷县黑裘皮羊中没有发生突变外，其他突变位点在所有绵羊品种中均出现不同程度变异，说明中国地方绵羊群体具有较高的遗传多样性。单倍型分析结果表明，所有样本中共有42个单倍型，优势单倍型0000000000（245/918）、0100000001（91/918）在所有绵羊群体中均存在，除单倍型0101100000（93/918）在中国美利奴羊中没有出现，单倍型0001000001（69/918）在岷县黑裘皮羊、哈萨克羊群体中没有出现外，在其他群体中均存在。连锁分析结果表明，10个SNPs在所有样本中均存在2个连锁模块。群体遗传变异分析表明，中国地方绵羊群体具有较高水平的群体内遗传变异，各绵羊品种间存在明显的遗传分化模式，且各品种遗传关系与其品种传统分类结果基本一致。本研究为进一步研究TYRP1基因对绵羊毛色遗传性状的影响提供了参考依据。 相似文献
4.
Performance in racehorses of various colours 总被引：1，自引：0，他引：1
A relationship between the coat colour and the horse's performance, which has been suggested since centuries, is possible from the genetic point of view. It may result from a linkage of genes affecting these characters and from pleiotropy of certain genes. The objective of the study has been to examine if there is a relationship between the basic and grey colours and the racing results. Indices (number of starts, log of earnings, log of earnings per start, general handicap) of 14,504 starts from 1103 Thoroughbreds and 796 Purebred Arabians were analyzed. In the analysis of variance, the phenotypes have been considered according to the brightness of the colour (grey/chestnut/light bay and bay/dark bay/seal brown/black), with regard to the alleles in G locus (grey/non-grey) and the alleles in MC1R locus (phaeomelanic/eumelanic). The results indicate that the examined coat colours are not considerably related to the racing performance. A tendency of such relationship may be due to the physiological properties connected with the brightness of the hair and the activity of alleles from MC1R (Extension) locus. No difference found between the results of grey and non-grey horses indicates that possible QTLs affecting the racing performance are not linked with the Grey locus. 相似文献
5.
Background – The melanocortin 1 receptor (MC1R) gene plays a key role in determining coat colour in mammals by controlling the proportion of eumelanin and pheomelanin granules. Wild raccoon dogs have a mixed coat colour, with black to brown and grey hairs. Hypothesis/Objectives – The study was performed to identify the cause of the variant yellow coat colour in a wild raccoon dog. Animals – A wild raccoon dog that showed coat colour change to yellow and four wild‐type raccoon dogs that showed normal coat colour were included. Methods – To identify the cause of the variant yellow coat colour, we examined the sequence of the MC1R gene and its expression at the mRNA and protein levels. Results – The coding region of the MC1R gene of this raccoon dog comprised 954 bp, the same as for wild‐type raccoon dogs and domestic dogs. By comparing the gene with that in the wild‐type raccoon dog, a 2 bp deletion was detected in the 5′‐untranslated region, positioned 152 bp upstream of the start codon. However, there was no significant difference in the mRNA expression level. The yellow raccoon dog revealed a significantly decreased MC1R protein level compared with the wild‐type raccoon dogs, indicating an increase in pheomelanin synthesis. Conclusions and clinical importance – These results suggest that the variant coat colour in the yellow raccoon dog was associated with decreased MC1R function. 相似文献
6.
Safra N Pedersen NC Wolf Z Johnson EG Liu HW Hughes AM Young A Bannasch DL 《Veterinary journal (London, England : 1997)》2011,189(2):220-226
The dog leukocyte antigen (DLA) system contains many of the functional genes of the immune system, thereby making it a candidate region for involvement in immune-mediated disorders. A number of studies have identified associations between specific DLA class II haplotypes and canine immune hemolytic anemia, thyroiditis, immune polyarthritis, type I diabetes mellitus, hypoadrenocorticism, systemic lupus erythematosus-related disease complex, necrotizing meningoencephalitis (NME) and anal furunculosis. These studies have relied on sequencing approximately 300 bases of exon 2 of each of the DLA class II genes: DLA-DRB1, DLA-DQA1 and DLA-DQB1. In the present study, an association (odds ratio=4.29) was identified by this method between Weimaraner dogs with hypertrophic osteodystrophy (HOD) and DLA-DRB1?01501. To fine map the association with HOD, a genotyping assay of 126 coding single nucleotide polymorphisms (SNPs) from across the entire DLA, spanning a region of 2.5 Mb (3,320,000-5,830,000) on CFA12, was developed and tested on Weimaraners with HOD, as well as two additional breeds with diseases associated with DLA class II: Nova Scotia duck tolling retrievers with hypoadrenocorticism and Pug dogs with NME. No significant associations were found between Weimaraners with HOD or Nova Scotia duck tolling retrievers with hypoadrenocorticism and SNPs spanning the DLA region. In contrast, significant associations were found with NME in Pug dogs, although the associated region extended beyond the class II genes. By including a larger number of genes from a larger genomic region, a SNP genotyping assay was generated that provides coverage of the extended DLA region and may be useful in identifying and fine mapping DLA associations in dogs. 相似文献
7.
L J Kennedy S D Carter A Barnes S Bell D Bennett B Ollier W Thomson 《Veterinary immunology and immunopathology》1999,69(2-4):101-111
Although 36 DLA-DRB1 and 10 DLA-DQA1 allele sequences have been published to date, no data on individual allele frequencies exists, either for specific breeds or cross breeds, and the full extent of the polymorphism at each of these loci is still not known. We have used sequence-specific oligonucleotide probing (SSOP) to characterise a series of 367 dogs for their DRB1 and DQA1 alleles. These included individual animals from over 60 different breeds, with numbers per breed ranging from 1 to 39. DLA types were generated from 218 dogs for DRB1 and from 330 dogs for DQA1, while 181 dogs were characterised for both these loci. The frequency of individual DRB1 and DQA1 alleles showed considerable interbreed variation, e.g. 83% of West Highland White Terriers were DRB1*01 as opposed to 9% of Collies. No breed had >9 of the 22 DRB1 types defined in this study; several breeds had only two DRB1 types. DLA-DQA1 showed less variation in allele numbers per breed, but also showed considerable interbreed frequency variation. Haplotype analysis revealed over 44 different DRB1/DQA1 combinations. Of these, 25 were in a number of animals, and also in an animal that was homozygous for one or both of these loci. Some DRB1 alleles could be found in combination with several different DQA1 alleles, while others were only present in one haplotypic combination. DLA allele frequency data in normal dogs will be critical for disease association studies. It may also be possible to use haplotype data to establish the genetic relationships between different dog breeds. 相似文献
8.
Coat colour inheritance in horses 总被引：1，自引：0，他引：1
The colours of the horses have long been a subject of interest to owners and breeders of horses as well as to scientists. Though, the colour of horses has little to do with its performance, it is a primary means of identification and also the first indicator of questionable parentage. Probably the ancestral colour of the horse was a black-based pattern that provided camouflage protection against predators. Horse colours are mostly controlled by genes at 12 different loci. The three basic colours of horses are black, bay and chestnut. The genetic control of the basic colours of horses resides at two genetic loci, namely Extension (E) and Agouti (A) loci. Among the basic colours bay is dominant to black and both are epistatic to chestnut. Dilution of basic colours of horses as a result of four colour dilution genes such as cream dilution, dun, silver dapple and champagne resulted in extensive array of possible colours of horses. The most widespread and familiar of the horse colour dilution gene is the one that produces the golden body colour and are called as palomino or buckskin based on the colour of the points. The grey coat colour is due to the presence of dominant gene (G) at the grey locus. Grey is epistatic to all coat colour genes except white and a grey horse must have at least one grey parent. Roan is due to a dominant gene (Rn) at roan locus and this combines with any base colour to produce the various shades of roan pattern. White coat is due to a single dominant gene (W) and it is epistatic to the genes controlling all other colours. White marking in the face and legs are due to genetic and non-genetic factors. Several genes are involved in producing white markings. During recent years, comparative genomics and whole genome scanning have been used to develop DNA tests for different variety of horse colours. Molecular genetic studies on coat colour in horses helped in identification of the genes and mutation responsible for coat colour variants. In future, this will be applied to breeding programmes to reduce the incidence of diseases and to increase the efficiency of race horse population. 相似文献
9.
H. Klungland H. G. Olsen M. S. Hassanane K. Mahrous D. I. Våge 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2000,117(4):217-224
In this paper we describe the use of polymorphic genes affecting coat colour as a tool in diversity studies of domestic animals. Although phenotypic data has been the main criteria for establishing different breeds, calculation of genetic distances between breeds is normally performed using noncoding microsatellite markers. As anticipated, MC1‐R (melanocyte stimulating hormone receptor) allele frequencies vary greatly between cattle breeds expressing different coat colours. In multicoloured breeds, like Icelandic cattle, a high frequency of the E+ allele appears to be essential for colour variation. Whereas black breeds have a high frequency of the dominant acting allele ED, entirely red breeds have no ED. Animals being homozygous for the defective allele e occurred frequently in some cattle breeds, indicating that the MC1‐R does not have crucial impact on animal physiology other than coat colour. The E+ and e alleles were observed in the closely related river buffalo as well. None of the breeds included in this study express the roan phenotype. Consequently, they were monomorphic at the MGF locus. As for the MC1‐R locus, a correlation to colour pattern was observed for two c‐kit alleles as well, confirming that selection of specific phenotypes strongly affect the allelic variation of underlying loci. Information on genes affecting the phenotype is therefore well suited for describing different breeds of livestock and, consequently, a practical tool in breed conservation. 相似文献
10.
Oguro-Okano M Honda M Yamazaki K Okano K 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2011,73(7):853-858
To identify factors that control coat color in Akita-inu dogs, we sequenced all the exons of the melanocortin 1 receptor (MC1R), β-defensin103 (CBD103) and agouti signaling protein (ASIP) genes of dogs with four distinct coat colors, namely, brindle, sesame, red and white. Then we examined correlations among specific alleles and coat color. In the case of the MC1R gene, all white dogs were homozygous for a nonsense mutation, R306ter, while brindle, sesame, and red dogs had at least one R306 allele. In the case of the CBD103 gene, all brindle dogs were heterozygous for the G23del mutation (deletion of codon 23, encoding glycine), while all sesame and red dogs were homozygous for G23. In the case of the ASIP gene, all dogs, regardless of coat color, had at least one S82 H83 allele. A missense mutation in the ASIP gene, P87L, was identified for the first time in some Akita-inu dogs but was not associated with any specific coloration. Our results indicate that the 2 key mutations, R306ter in the MC1R gene and G23del in the CBD103 gene, are associated with the phenotypic discriminations among brindle, red/sesame, and white coats, while no mutation that might potentially be associated with the discrimination of a sesame coat from a red coat is present in the coding sequences of these three genes. 相似文献
11.
Kropatsch R Streitberger K Schulte-Middelmann T Dekomien G Epplen JT 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2011,128(1):64-72
Paternally inherited Y chromosomal markers and maternally inherited mitochondrial (mt) DNA sequences were investigated in 27 dog breeds (Canis familiaris), of which the Weimaraner hunting dog was studied in greater detail. Altogether, nine potentially polymorphic markers of the Y chromosome were examined as well as parts of the canine mt genome (1947 base pairs) in 111 male dogs and four wolves for comparison. Twenty Y chromosomal and fifty-nine mitochondrial DNA (mtDNA) haplotypes were identified in the canine breeds and wolves. In 34 Weimaraners, four distinct Y chromosomal haplotypes were observed as well as three mtDNA types thus reflecting at least four male and three female ancestors for the current population in Germany. Tracing patri- and matrilineages, several entries in the Weimaraner stud book cannot be reconciled with the male-only, Y chromosomal neither the female-only, mt inheritance patterns, respectively. The investigated breeds represent 9 of 10 groups defined by the Fédération Cynologique Internationale (FCI). The level of Y chromosomal and especially mtDNA diversity was immense considering the relatively small number of individuals investigated per breed. Unique haplotypes were found only in a few breeds and the wolf. Other haplotypes were shared among several breeds, also across different FCI groups, suggesting that these canine breeds had common male and female ancestors. 相似文献
12.
Ito H Nara H Inoue-Murayama M Shimada MK Koshimura A Ueda Y Kitagawa H Takeuchi Y Mori Y Murayama Y Morita M Iwasaki T Ota K Tanabe Y Ito S 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2004,66(7):815-820
Various canine breeds are remarkably different from each other not only in their sizes and shapes but also in behavioral traits, suggesting that some of them are under genetic control. Although dopaminergic neurotransmission system is considered to affect animal behavior, little is known about related genes in canine. Relations between specific alleles in polymorphic regions of the dopamine receptor D4 gene (DRD4) and personality or psychiatric disorders have been reported in humans, and we first found polymorphism in exon III region of the gene in 4 canine breeds. In this study we surveyed allele frequency distribution in 23 breeds including a total of 1,535 unrelated individuals. In exon III, 8 alleles including a novel allele were identified. A group of breeds in which the alleles 447b, 498 and 549 were frequent tended toward high scores in aggression-related behavioral traits than that with frequent alleles 435 and 447a. Moreover, a polymorphism based on 24 bp insertion/deletion was found in exon I region for the first time in dogs. This information may be of use for candidate gene studies of behavioral variation in dogs. 相似文献
13.
Juraschko K Meyer-Lindenberg A Nolte I Distl O 《Veterinary journal (London, England : 1997)》2003,166(2):164-169
We have analysed the systematic influences, phenotypic colour markers and the additive genetic variation for congenital sensorineural deafness (CSD) in German Dalmatian dogs in order to help elucidate the importance of phenotypic breed characteristics for genetic differences of CSD. Linear animal models using restricted maximum likelihood methods were employed to estimate variance components. Data were obtained from all three German Dalmatian kennel clubs associated with the German Association for Dog Breeding and Husbandry (VDH). CSD was recorded by standardized protocols for brainstem auditory-evoked response (BAER). The material included 1899 German Dalmatian dogs from 354 litters in 169 different kennels. BAER testing results were from the years 1986 to 1999. Pedigree information was available for up to seven generations. The animal model regarded the fixed effects of sex, coat colour, eye colour, presence of patches, litter size, percentage of examined puppies per litter, kennel club, and inbreeding coefficient. The common environment of the litter and kennel as well as the additive genetic effect of the animal were taken into account as randomly distributed effects. The fixed effects of eye colour, percentage of puppies examined per litter and kennel club were significant in the mixed model analysis. A significant proportion of additive genetic variation could be shown despite corrections for phenotypic colour variants. The heritability estimate for CSD in German Dalmatian dogs was h(2)=0.27+/-0.07. The additive genetic correlation of CSD with presence of blue eyes was r(g)=0.53+/-0.41 and with presence of patches r(g)=-0.36+/-0.24. We concluded that additional genes other than those associated with phenotypic colour markers in German Dalmatian dogs significantly contribute to the occurrence of CSD. 相似文献
14.
S. Rieder C. Stricker H. Joerg R. Dummer G. Stranzinger 《Zeitschrift für Tierzüchtung und Züchtungsbiologie》2000,117(2):73-82
Ageing grey horses are particularly susceptible to melanoma. Using segregation analysis, six genetic and nongenetic (environmental) models in two grey horse family groups (n = 71) were compared. The polygenic model still fits the data significantly better than an environmental model, indicating a strong genetic impact on the phenomenon. Pmel17/gp100 and TYRP1/gp75 , two genes which are specific for melanocytes, and Cdkn2 a/p16 a gene coding for an inhibitor of a cell cycle regulator were partially cloned, sequenced and mapped. Using Northern blotting analysis a striking difference in mRNA expression of Pmel17/gp100 and TYRP1/gp75 was found comparing skin samples of solid-coloured (normal level) and grey horses (low level) as well as horse melanoma tumour samples (high). Staining of skin samples with antibodies recognizing the product of Pmel17/gp100 , confirmed the results of the corresponding Northern blotting analysis. It seems that Pmel17/gp100 and TYRP1/gp75 are involved in progressive greying of horses. No mutation was found in a partial sequence of equine Cdkn2a/p16 analysed so far. Thus, the relation between equine melanoma susceptibility and Cdkn2a/p16 is subject to further investigation. 相似文献
15.
[目的]验证TYRP1基因的错义突变(g.1300C>T)与中国黄牛毛色性状是否存在相关性。[方法]采用PCR测序及生物信息学的方法,对991头中国黄牛、48头安格斯牛、104头婆罗门牛的TYRP1基因进行多态性分析。[结果]通过对中国黄牛的等位基因频率和基因型频率的分析,发现此变异与中国黄牛棕色毛色性状不相关。[结论]TYRP1基因的错义突变(g.1300C>T)与中国黄牛棕色表型不相关。该位点可能在一些品种中受到了选择,中国黄牛的棕色表型可能受其他基因调控。 相似文献
16.
乌骨绵羊MC1R基因多态性研究 总被引：1，自引：2，他引：1
酪氨酸酶(TYR)、酪氨酸酶相关蛋白1(TYRP1)和酪氨酸酶相关蛋白2(TYRP2)是动物黑色素生物合成过程的重要酶,黑素皮质素1受体(MC1R)一旦与配体α-促黑素细胞激素(α-MSH)结合,对TYR、TYRP1和TYRP2酶活性的表达水平均有重要影响,因此认为MC1R是黑素合成模式的控制点。本研究以MC1R基因为候选基因,对乌骨绵羊MC1R基因多态性进行了研究,希望揭示MC1R基因与乌骨绵羊乌质性状之间的关系。结果表明,乌骨绵羊MC1R基因存在2个多态位点,分别为A12G和G144C。翻译表明这2处突变都为同义突变,对应的氨基酸分别是丝氨酸(Ser)和亮氨酸(Leu)。PCR-RFLP分析发现绵羊MC1R存在2个等位基因,即MC1R*1和MC1R*2,对应11型、22型和12型3种基因型。乌骨绵羊和兰坪本地绵羊MC1R等位基因的频率差异不显著,而与罗姆尼羊差异显著,推测MC1R基因可能不是控制乌骨绵羊乌质性状的主效基因。 相似文献
17.
The objective of the study has been to verify the hypothesis that the coat colour is regarded in the selection of Polish Thoroughbred horse population. Formally, the colour is not a selection criterion in this breed selected mainly for speed. The material consisted of twelve groups of foals registered in successive volumes of the Stud Book (11,688 foals, in total) and their parents selected to the breeding stud. The frequency of alleles in ASIP, MC1R and GREY loci controlling the coat colours was estimated from the recessive phenotype frequency square in the groups of foals. The inflow of foreign genes was limited and the population great, hence the migration effect was very low. The drift and Wahlund effect hardly influenced the genetic structure in the groups which enabled to analyze the population not divided. The total offspring frequency of recessive a, e and g alleles amounted to 0.1552, 0.4877 and 0.9773, respectively. Accuracy of the assessment of the a and e frequency was confirmed on the basis of test matings. The a, e and g alleles were more frequent in dams than in sires and the a alleles occurred more often in fillies than in colts. The frequency of a and e alleles was higher in the offspring than in the parents. The genotype distribution in the offspring differed from the expected one, assessed from the gamete frequency in sires and in dams. Fewer bay foals were born than anticipated. All the results show that the coat colour is not entirely disregarded in the breeding of Thoroughbred horses. The dominant A and E alleles producing the colour are preferred in the selection, particularly in the sires. This leads to some alterations in the phenotypic structure of the population. On the other hand, the horses are mated randomly, irrespective of the coat colour. 相似文献
18.
B. A. Valentine M. B. Calderwood Mays H. S. Cheramie 《Equine Veterinary Education》2014,26(3):156-158
Information regarding signalment, clinical findings, treatment and outcome of 5 previously reported cases of anaplastic malignant melanoma of the tail in non‐grey horses and of 5 additional cases are summarised. Age was recorded for 9 horses and mean age was 16 years, range 8–23 years. Gender was recorded for 8 horses and 6 of these 8 horses were male horses over 14 years of age. The most common coat colour was bay (6 horses). Other coat colours were palomino (one horse), chestnut (one horse) and black (one horse); coat colour of one non‐grey horse was not specified. Follow‐up information was available for 9 horses and only one horse, a palomino, survived more than 10 months following diagnosis and tail amputation. Surgical excision, including tail amputation and medical therapy with oral cimetidine, was not effective in non‐grey, non‐palomino horses. Tumour recurred on tail tissue remaining after amputation in 2 horses, widespread metastases were documented in 4 cases and metastasis was suspected at the time of death or euthanasia in 3 cases, including one case with amputation site regrowth. No subjective histopathological differences were detected in the palomino horse that survived as compared to horses of other coat colours. Findings suggest that anaplastic malignant melanoma of the tail in non‐grey horses is most often a very aggressive neoplasm, but that there are rare exceptions. 相似文献
19.
为研究小鼠Oct-1基因的生物学特性,试验扩增小鼠黑色素细胞中Oct-1基因CDS区序列,并运用生物信息学软件分析小鼠Oct-1基因序列的特性、编码蛋白理化性质、亚细胞定位、靶基因及保守性结构域等,从而预测其是否调控黑色素的生成。结果表明,小鼠Oct-1基因大小为2 313 bp,编码蛋白质的分子式C3425H5606N976O1163S15,是一个不稳定可溶性蛋白质,二级结构以无规卷曲和α-螺旋为主,亚细胞定位主要分布在细胞核,推测其可能在能量代谢和辅因子的生物合成过程中发挥信号转导和转录因子调控的作用;Oct-1基因在小鼠黑色素细胞中表达,其编码的蛋白含有一个保守的POU结构域和一个保守的同源域,参与调控13个黑色素形成相关基因转录表达,在黑色素生成关键基因MITF、TYR、TYRP1、TYRP2的启动子上存在Oct-1转录因子的作用位点,Oct-1蛋白质还可能与Brf2、Pou2af1、Tbp等蛋白相互作用调控毛色基因表达,故可以推测转录因子Oct-1在黑素细胞的黑色素生成中发挥着重要的作用,为研究毛色形成机制提理论依据。 相似文献
20.
Variation in hair coat and skin texture in blue dogs 总被引：1，自引：0，他引：1
R Langebaek 《Nordisk veterinaermedicin》1986,38(6):383-387
A clinical examination of 6 dogs with blue coat color (genotype dd) has been carried out. The results show that the majority of blue dogs have an abnormally textured hair coat and skin. These changes, however, are not observed in all blue dogs. 相似文献