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1.
为了证实灭虫丁地甘南藏系绵羊体外寄生虫和体内线虫的驱杀效果，灭虫丁片剂按每千克体重０．２ｍｇ剂量对碌曲县尕海乡加仓三队和郎木寺乡贡巴四队的两群１３７０只藏系绵羊进行了驱治试验和防治示范应用。试验前检查两群试验羊体外寄生虫的感染率均为１００％；加仓和贡巴两村羊群消化道线虫感染率分别为８４．２％和８０．１％，肺线虫幼虫阳性率分别为７３．７％和５４．１％。灌服灭虫丁后羊体表寄生虫的杀灭率为１００％，消化 相似文献
2.
应用两种药物驱除山羊自然感染肝片吸虫、莫尼茨绦虫和捻转血柔线虫的试验,结果表明：硫双二氯酚和左旋咪唑联合用药对肝片吸虫和捻转血矛线虫的粗计驱虫率和驱净率均为１００％,对肝片吸虫分别为８１．０％和６０．０％,对莫尼茨绦虫无效;吡喹酮和左旋咪唑联合用药对捻转血矛线虫的粗计驱虫率和驱净率均为１００％,对莫尼茨绦虫分别为９４．１％和８０．０％,对肝片吸虫无效,建议在山羊生产中采用硫酸二氯酚和左旋咪唑联合用 相似文献
3.
用我们研制的复合杀虫剂－杀虫净片在阿坝州进行牦牛和绵羊驱杀内外寄生虫试验。结果是剂量和高剂量一次口服,对肝片形吸虫,莫尼茨绦虫,消化道线虫,牛皮蝇蚴,牛毛虱的驱杀率可达１００％,牦牛用３倍中剂量,绵羊用４倍中剂量均无任何副反应。 相似文献
4.
本次对广州地区某羊场山羊的体内外寄生虫进行了调查,通过体表、粪便检查以及尸体剖检发现;体外寄生虫有山羊蚧螨和山羊毛虱;体内寄生虫有寄生于第四胃和小肠物毛圆科线虫,包括血矛线虫属、毛圆属、奥斯特属、马歇尔属、古柏属多种线虫。采用害获灭和螨净对以上寄生虫进行治疗试验。发现害获灭对山羊螨、虱及胃肠道线虫都有较好的驱杀作用。其中对胃肠道线虫的驱净率达１００％,某此螨病较为严重的山羊采用害获灭肌注,同时配合 相似文献
5.
用公莎能奶山羊与槐山羊杂交一代外貌特征趋于莎能山羊；初生重提高１５．２％，４月龄体重提高３９．５％，８月龄体重提高３４％，８月龄胴体重，净肉重分别提高３９．８％和４０．４％；板皮面积增大０．１４平方米，板皮质量无不下降趋势，级别明显提高；８月龄只均比槐山羊增值３１．７１元。中区验证试验，结果与小区试验基本相同，有很大推广应用价值。 相似文献
6.
国产伊维菌素口服液对绵羊寄生虫的驱除试验 总被引：5，自引：1，他引：4
本文利用中国农业大学生产的伊维菌素（Ｉｖｅｒｍｅｃｔｉｎ）口服液，选择１．５～２．０岁严重感染消化道线虫和某些外寄生虫的绵羊１００只，分别口服０．１５ｍｇ／ｋｇ、０．２５ｍｇ／ｋｇ和０．３０ｍｇ／ｋｇ体重的剂量，同时用进口害获灭（Ｉｖｏｍｅｃ）以０．２ｍｇ／ｋｇ体重皮下注射作对照。结果表明：①０．２５ｍｇ／ｋｇ和０．３０ｍｇ／ｋｇ口服液对消化道线虫的虫卵转阴率、虫卵减少率和驱虫率均为１００％，对羊狂蝇蛆、痒螨病和羊虱能全部杀死；②０．１５ｍｇ／ｋｇ口服液对奥斯特线虫的虫卵减少率仅为９２．３％。对奥斯特线虫、毛圆线虫、毛首线虫的驱除率分别为９８．５％、９９．２％、９３．３％。对其余线虫的驱虫率均为１００％。其驱虫效果略次于０．２５ｍｇ／ｋｇ、０．３０ｍｇ／ｋｇ两剂量组；③对照药物害获灭对奥斯特线虫的虫卵减少率和驱虫率分别为９７．６％和９５．５％，对其余线虫的驱虫率也为１００％。总之，从成本考虑，国产伊维菌素０．１５ｍｇ／ｋｇ口服液口服经济、实惠、高效、安全 相似文献
7.
对自然感染寄生线虫和痒螨的绵羊用爱普瑞克制剂进行驱杀疗效观察.通过虫卵和瘁螨检查确定阳性羊,设爱普瑞克0.05、0.1、0.2 mg/kg体重3个剂量组,同时设阿维菌素0.2 mg/kg体重和空白对照组,经羊皮下注射药物.结果表明,爱普瑞克按0.2 mg/kg体重和阿维菌素0.2 mg/kg体重驱杀绵羊瘁螨杀净率均达100%,寄生线虫虫卵转阴率、卵减率都达100%.而爱普瑞克0.05 mg/kg体重,0.1 mg/kg体重驱治效果差,螨虫杀净率为53%～80%,且用药后第20天瘁螨病复发;寄生线虫虫卵转阴率、卵减率只有30%～80%.0.2 mg/kg体重为爱普瑞克驱杀绵羊寄生线虫和痒螨最低有效剂量. 相似文献
8.
灭虫清驱杀山羊寄生虫试验报告 总被引：1，自引：0，他引：1
灭虫清是一种复方广谱抗寄生虫药。以20mg/kg体重的剂量一次灌服对山羊的肝片形吸虫、莫尼茨绦虫、捻转血矛线虫、食道口线虫、奥斯特线虫、细颈线虫、马歇尔线虫和山羊螨类有良好的驱杀作用。本药具有抗虫广谱、疗效高、剂量小、使用简便、对山羊安全,无副作用等特点。 相似文献
9.
对140头猪的驱(杀)虫试验显示含15% levamisole的`内虫净'擦剂以0．15mL／kg体重剂量涂擦于皮肤，对猪蛔虫、结节虫虫卵有100%的驱(杀)虫效果，0．1mL／kg体重剂量对蛔虫、结节虫虫卵有77．8%、50%驱虫效果，含8%NC－129的`外虫净'擦剂，以0．15mL／kg体重剂量对猪疥螨具有100%杀螨率，0．1mL／kg体重剂量杀螨率也达88%，结果证明：levamisole和NC－129是良好的驱虫和杀螨药物，并可以经透皮吸收形式给药。 相似文献
10.
11.
The plasma levels, disposition kinetics and a dosage regimen for pralidoxime (2-PAM) were investigated in male buffalo calves following single intramuscular administration (15 or 30 mg/kg). The effects of 2-PAM on various blood enzymes were also determined. The absorption half-life, elimination half-life, apparent volume of distribution and total body clearance of 2-PAM were 1.08±0.19 h, 3.14–3.19 h, 0.83–1.01 L/kg and 184.9–252.1 ml/(kg h), respectively. At doses of 15 and 30 mg/kg body weight, a plasma concentration 4 g/ml was maintained for up to 4 and 6 h, respectively. Pralidoxime significantly lowered the serum level of transferases, phosphatases and lactate dehydrogenase but did not influence the acetylcholinesterase and carboxylesterase enzymes. The most appropriate dosage regimen for 2-PAM in the treatment of organophosphate toxicity in buffaloes would be 25 mg/kg followed by 22 mg/kg at 8 h intervals. 相似文献
12.
Serum and tissue fluid norfloxacin concentrations after oral administration of the drug to healthy dogs 总被引：1，自引：0，他引：1
R D Walker G E Stein S C Budsberg E J Rosser K H MacDonald 《American journal of veterinary research》1989,50(1):154-157
Norfloxacin, a 4-quinolone antibiotic, was administered orally to 4 healthy dogs at dosages of 11 and 22 mg/kg of body weight, every 12 hours for 4 days, with a 4-week interval between dosing regimens. Serum and tissue cage fluid (TCF) norfloxacin concentrations were measured at 0, 0.5, 1, 1.5, 2, 3, 4, 5, 6, 8, 10, and 12 hours after the first and seventh dose of each dosing regimen. When administered at a dosage of 11 mg/kg, the mean peak serum concentration (Cmax) was 1.0 microgram/ml at 1 hour, the time of mean peak concentration (Tmax) after the first dose. After the seventh dose, the Cmax was 1.4 micrograms/ml at Tmax of 1.5 hours. The Tmax for the TCF concentration was 5 hours, with Cmax of 0.3 microgram/ml and 0.7 microgram/ml after the first and seventh dose, respectively. When administered at a dosage of 22 mg/kg, the serum Tmax was 2 hours after the first dose, with Cmax of 2.8 micrograms/ml. After the seventh dose, the serum Tmax was 1.5 hours, with Cmax of 2.8 micrograms/ml. The Tmax for the TCF concentration was 5 hours after the first and seventh doses, with Cmax of 1.2 micrograms/ml and 1.6 micrograms/ml, respectively. After the seventh dose, the serum elimination half-life was 6.3 hours for a dosage of 11 mg/kg and was 6.7 hours for a dosage of 22 mg/kg. For serum concentration, the area under the curve from 0 to 12 hours (AUC0----12) was 8.77 micrograms.h/ml and 18.27 micrograms.h/ml for dosages of 11 mg/kg and 22 mg/kg, respectively.(ABSTRACT TRUNCATED AT 250 WORDS) 相似文献
13.
Jacobs C Grebe S Kietzmann M Mischke R 《DTW. Deutsche tier?rztliche Wochenschrift》1999,106(11):478-481
In this study pharmacokinetic data for the unfractionated heparin Liquemin were obtained after intravenous and subcutaneous application. Each dosage was examined in 5 healthy, adult Beagle dogs. After intravenous application of 25, 50 and 100 I.U./kg body weight heparin plasma activity of 0.65 +/- 0.15 I.U./ml (mean +/- s), 0.91 +/- 0.10 I.U./ml and 1.94 +/- 0.22 I.U./ml was measured. Subcutaneous applications of 250, 500 or 750 I.U./kg revealed maximum plasma heparin activities of 0.25 +/- 0.10, 0.60 +/- 0.15 and 1.29 +/- 0.24 I.U./ml. The maximum heparin activity in the plasma was observed after 3.8 +/- 1.1 (250 und 500 I.E./kg) or 4.0 +/- 1.0 hours (750 I.E./kg), respectively. Intravenously applicated heparin has a short terminal half-life time (t50) between 22 and 44 minutes. The t50 after subcutaneous application of heparin was distinctly longer. After 250, 500 or 750 I.U./kg the t50 was 3.7 +/- 2.4, 3.5 +/- 1.2 or 5.3 +/- 2.4 hours. Corresponding to this result a lower total clearance (Cltot) was found with increasing doses. Especially the Cltot after subcutaneous injection decreased from 2.08 +/- 0.73 ml/min/kg (250 I.E./kg) to 0.83 +/- 0.27 ml/min/kg (750 I.E./kg). The volume of distribution of heparin corresponded approximately to the plasma volume. The total bioavailability of subcutaneously administered UFH was 53-100% depending on the dosage. 相似文献
14.
Pharmacokinetics of cefotaxime in the domestic cat 总被引：1，自引：0，他引：1
Cefotaxime was administered as single IV or IM dose for the purpose of examining its pharmacokinetics in healthy cats. The mean predicted plasma concentration of cefotaxime in 6 cats at 0 time after a single IV dosage of 10 mg/kg of body weight was 88.9 micrograms/ml. The mean plasma concentrations decreased to 10.8 micrograms/ml at 2 hours, 3.7 micrograms/ml at 3 hours, and 0.5 microgram/ml at 6 hours. The half-life was 0.98 +/- 0.25 hour (mean +/- SD), and the total body clearance was determined to be 2.76 +/- 1.25 ml/min/kg. After a single IM injection of 10 mg/kg of body weight, the mean maximum observed plasma concentration was 36.2 micrograms/ml at 0.75 hour. The mean absorption half-life was 0.24 hour. In 2 animals, the bioavailability of an IM injection was 98.2% and 93.0%. 相似文献
15.
The oral absorption and bioavailability of flumequine was studied in 1-, 5- and 18-week-old calves following intravenous and oral administration of different formulations of flumequine (Flumix, Flumix C and pure flumequine). Increasing age had a negative influence on the Cmax after the administration of Flumix, based on a larger VD in the older calves. The Cmax decreased from 5.02 +/- 1.46 micrograms/ml in the first week to 3.28 +/- 0.42 micrograms/ml in the 18th week. Adding colistin sulfate to the flumequine formulation and administring pure flumequine mixed with milk replacer had a negative effect on the Cmax of flumequine after oral administration of 5 and 10 mg/kg body weight. The bioavailability of the orally administered flumequine formulations was 100% in all cases except after the administration of Flumix C, for which it was 75.9 +/- 18.2%. The urinary recovery of flumequine after intravenous injection of a 10% solution varied from 35.2 +/- 2.3% for Group B, to 41.2 +/- 6.3% for Group C. The dosage of 5 mg/kg body weight Flumix twice daily in 1-week-old veal calves is sufficient to reach therapeutic plasma concentrations, based on a MIC value of 0.8 micrograms/ml of the target bacteria. In older calves it is advisable to increase the dosage 7.5 or 10 mg/kg body weight every 12 hours. In combination with colistin sulfate it is also advisable to increase the dosage slightly because of the negative effect of the colistin sulfate on the Cmax of flumequine. 相似文献
16.
Aspirin dosages calculated from published pharmacokinetic data were tested in 3 male and 3 female Basset Hounds. Emesis occurred frequently after dosing at the rate of 50 mg/kg of body weight, a dosage that would be required for a convenient 12-hour dosing interval. A dosage of 25 mg/kg every 12 hours avoided emesis but did not maintain serum salicylate concentrations within the desired range of 10 to 30 mg/100 ml. A dosage of 25 mg/kg every 8 hours resulted in serum salicylate concentrations varying from 12.5 to 17.8 mg/100 ml. It was concluded that a maintenance dosage of 25 to 35 mg/kg every 8 hours in optimal for the dog, based on extrapolation of data obtained in man. 相似文献
17.
Pharmacokinetics of gentamicin in laboratory rabbits 总被引：2，自引：0，他引：2
The pharmacokinetics of gentamicin was studied in 5 healthy adult laboratory rabbits of both sexes. Gentamicin sulfate (5% aqueous solution) was administered rapidly (IV) at a dosage of 3 mg/kg of body weight. Venous blood samples were taken at 0 (baseline), 5, 10, 15, and 30 minutes, and 1, 1.5, 2, 2.5, 3, 4, 5, and 6 hours after gentamicin administration. Serum gentamicin concentration was measured by radioimmunoassay. With the aid of a nonlinear least-squares program, the gentamicin concentration data were found to be best described by a 2-compartment model, with r2 = 0.989. Half-life, as determined from the terminal phase, was 56.6 +/- 2.4 (mean +/- SD) minutes. Calculation of total body clearance provided a mean of 1.69 +/- 0.07 ml/min/kg of body weight. Volume of distribution, calculated from the area under the curve for each animal, was 0.138 +/- 0.005 L/kg. 相似文献
18.
B E Stromberg J C Schlotthauer B P Seibert G A Conboy K M Newcomb 《American journal of veterinary research》1985,46(12):2527-2529
The efficacy of closantel against experimentally induced Fascioloides magna infection in sheep was studied. In each of 3 experiments, closantel was administered 8 weeks after the sheep were given (oral inoculation) 100 metacercariae of F magna. In the 1st experiment, closantel was given orally to 5 groups of 6 sheep each at dosages of 0 (nontreated control), 5, 7.5, 10, and 15 mg/kg of body weight. In the 2nd and 3rd experiments, groups of 10 or 12 sheep were treated to confirm the efficacy of the previously determined optimal dosage of 15 mg/kg. An additional group of sheep (n = 10) was used in the 3rd experiment to evaluate the efficacy of closantel given IM at a dosage of 7.5 mg/kg. Closantel given orally at a dosage level of 15 mg/kg was highly effective (94.6% to 97.7%) in reducing F magna burdens. Also, pathologic scores associated with the F magna infection were reduced by 81.3% to 92.6% in sheep given this dosage of closantel. Efficacy of the IM administered dosage of 7.5 mg of drug/kg was equivalent to that of the 15 mg/kg oral dosage. Other than mild, transient lameness of the limbs which were injected with the drug (group 10), side effects were not observed. 相似文献
19.
为了研究抗脂肪细胞膜蛋白抗体对猪内脏器官重量及红细胞比容的影响,试验首先制备了兔抗猪脂肪细胞膜蛋白抗体,然后进行动物饲养试验。选择健康、胎次相近、体重为13￣15kg的6周龄云南长撒二元杂交仔猪20头,公母各半,随机分为4组,每组5头。Ⅰ、Ⅱ、Ⅲ组为试验组,腹腔内分别注射抗脂肪细胞膜蛋白抗体10、20和30ml;Ⅳ为对照组,注射20ml非免疫血清。研究结果表明:抗脂肪细胞膜蛋白抗体免疫对心脏和肾脏重量有一定影响,而且随剂量的增加而增大;对红细胞比容有一定的影响,但一般2周后恢复正常。 相似文献
20.
Pharmacokinetics of probenecid and the effect of oral probenecid administration on the pharmacokinetics of cefazolin in mares 总被引：1，自引：0，他引：1
The pharmacokinetics and bioavailability of probenecid given IV and orally at the dosage level of 10 mg/kg of body weight to mares were investigated. Probenecid given IV was characterized by a rapid disposition phase with a mean half-life of 14.0 minutes and a subsequent slower elimination phase with a mean half-life of 87.8 minutes in 5 of 6 mares. In the remaining mare, a rapid disposition phase was not observed, and the half-life of the elimination phase was slower (172 minutes). The mean residence time of probenecid averaged 116 minutes for all 6 mares and 89.2 minutes for the 5 mares with biphasic disposition. The total plasma clearance of probenecid averaged 1.18 +/- 0.49 ml/min/kg, whereas renal clearance accounted for 42.6 +/- 9.3% of the total clearance. The steady-state volume of distribution of probenecid averaged 116 +/- 28.2 ml/kg. Plasma protein binding of probenecid was extensive, with 99.9% of the drug bound at plasma probenecid concentrations of 10 micrograms/ml. The maximum plasma probenecid concentration after 10 mg/kg orally averaged nearly 30 micrograms/ml. The half-life of probenecid after oral administration was approximately 120 minutes. Oral bioavailability was good with greater than 90% of the dose absorbed. The effect of probenecid on tubular secretion of organic anions was evaluated by determining the pharmacokinetics of IV cefazolin (11 mg/kg) administered alone and 15 minutes after probenecid (10 mg/kg orally). Treatment with probenecid did not affect pharmacokinetic values of cefazolin. This failure of probenecid to alter the pharmacokinetics of cefazolin may be caused by insufficient plasma probenecid concentrations after the oral dose. 相似文献