共查询到20条相似文献，搜索用时 31 毫秒
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Redox regulation of fos and jun DNA-binding activity in vitro 总被引：109，自引：0，他引：109
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Fos-associated protein p39 is the product of the jun proto-oncogene 总被引：109，自引：0，他引：109
F J Rauscher D R Cohen T Curran T J Bos P K Vogt D Bohmann R Tjian B R Franza 《Science (New York, N.Y.)》1988,240(4855):1010-1016
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A new member of the leucine zipper class of proteins that binds to the HLA DR alpha promoter 总被引：42，自引：0，他引：42
H C Liou M R Boothby P W Finn R Davidon N Nabavi N J Zeleznik-Le J P Ting L H Glimcher 《Science (New York, N.Y.)》1990,247(4950):1581-1584
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Human proto-oncogene c-jun encodes a DNA binding protein with structural and functional properties of transcription factor AP-1 总被引：231，自引：0，他引：231
D Bohmann T J Bos A Admon T Nishimura P K Vogt R Tjian 《Science (New York, N.Y.)》1987,238(4832):1386-1392
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DNA bending by Fos and Jun: the flexible hinge model 总被引：46，自引：0，他引：46
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Cyclic AMP-responsive DNA-binding protein: structure based on a cloned placental cDNA 总被引：117，自引：0，他引：117
J P Hoeffler T E Meyer Y Yun J L Jameson J F Habener 《Science (New York, N.Y.)》1988,242(4884):1430-1433
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K Muegge T M Williams J Kant M Karin R Chiu A Schmidt U Siebenlist H A Young S K Durum 《Science (New York, N.Y.)》1989,246(4927):249-251
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Scissors-grip model for DNA recognition by a family of leucine zipper proteins 总被引：152，自引：0，他引：152
C/EBP is a sequence-specific DNA binding protein that regulates gene expression in certain mammalian cells. The region of the C/EBP polypeptide required for specific recognition of DNA is related in amino acid sequence to other regulatory proteins, including the Fos and Jun transforming proteins. It has been proposed that these proteins bind DNA via a bipartite structural motif, consisting of a dimerization interface termed the "leucine zipper" and a DNA contact surface termed the "basic region." An evaluation of the properties of conserved amino acids within the basic region of 11 deduced protein sequences, coupled with the observation that they are located at an invariant distance from the leucine zipper, has led to the formulation of a "scissors-grip" model for DNA binding. The architectural features of this model are well suited for interaction with directly abutted, dyadsymmetric DNA sequences. Data supportive of the model were obtained with chemical probes of protein: DNA complexes. 相似文献
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Parallel association of Fos and Jun leucine zippers juxtaposes DNA binding domains 总被引：118，自引：0，他引：118
The protein products of the fos and jun proto-oncogenes form a heterodimeric complex that participates in a stable high affinity interaction with DNA elements containing AP-1 binding sites. The effects of deletions and point mutations in Fos and Jun on protein complex formation and DNA binding have been examined. The data suggest that Fos and Jun dimerize via a parallel interaction of helical domains containing a heptad repeat of leucine residues (the leucine zipper). Dimerization is required for DNA binding and results in the appropriate juxtaposition of basic amino acid regions from Fos and Jun, both of which are required for association with DNA. 相似文献
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Specific expression of nuclear proto-oncogenes before entry into meiotic prophase of spermatogenesis 总被引：15，自引：0，他引：15
The expression of proto-oncogenes representative of several functional categories has been investigated during development of mouse male germ cells. The c-raf proto-oncogene and three members of the c-ras gene family were expressed in mitotically active stem cells, throughout the prophase of meiosis and to varying extents in post-meiotic cell types. In contrast, the nuclear proto-oncogenes c-fos, c-jun, and c-myc were specifically expressed at high levels in type B spermatogonia. High levels of c-myc and c-jun RNAs were also detected in spermatocytes early in the prophase of meiosis. The type B spermatogonia represent the last mitotic cell division before entry into meiotic prophase; therefore, these nuclear proto-oncogenes may be involved in altering programs of gene expression at this developmental transition. 相似文献
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The leucine zipper: a hypothetical structure common to a new class of DNA binding proteins 总被引：563，自引：0，他引：563
A 30-amino-acid segment of C/EBP, a newly discovered enhancer binding protein, shares notable sequence similarity with a segment of the cellular Myc transforming protein. Display of these respective amino acid sequences on an idealized alpha helix revealed a periodic repetition of leucine residues at every seventh position over a distance covering eight helical turns. The periodic array of at least four leucines was also noted in the sequences of the Fos and Jun transforming proteins, as well as that of the yeast gene regulatory protein, GCN4. The polypeptide segments containing these periodic arrays of leucine residues are proposed to exist in an alpha-helical conformation, and the leucine side chains extending from one alpha helix interdigitate with those displayed from a similar alpha helix of a second polypeptide, facilitating dimerization. This hypothetical structure is referred to as the "leucine zipper," and it may represent a characteristic property of a new category of DNA binding proteins. 相似文献
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Light pulses that shift rhythms induce gene expression in the suprachiasmatic nucleus 总被引：22，自引：0，他引：22
Lighting cycles synchronize (entrain) mammalian circadian rhythms by altering activity of cells in the suprachiasmatic nucleus (SCN) of the hypothalamus, a circadian pacemaker. Exposure of hamsters and rats to light pulses at those phases of the circadian rhythm during which light can shift the rhythm caused increased immunoreactivity for the product of the immediate-early gene c-fos in cells in the region of the SCN that receives retinal fibers. Light pulses also increased messenger RNA for the Fos protein and for the immediate-early protein NGFI-A in the rat SCN. Similar increases in mRNA for NGFI-A were seen in the SCN of hamsters. Thus cells in this portion of the SCN undergo alterations in gene expression in response to retinal illumination, but only at times in the circadian cycle when light is capable of influencing entrainment. 相似文献
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The proto-oncogene c-fos is expressed in neurons in response to direct stimulation by growth factors and neurotransmitters. In order to determine whether the c-fos protein (Fos) and Fos-related proteins can be induced in response to polysynaptic activation, rat hindlimb motor/sensory cortex was stimulated electrically and Fos expression examined immunohistochemically. Three hours after the onset of stimulation, focal nuclear Fos staining was seen in motor and sensory thalamus, pontine nuclei, globus pallidus, and cerebellum. Moreover, 24-hour water deprivation resulted in Fos expression in paraventricular and supraoptic nuclei. Fos immunohistochemistry therefore provides a cellular method to label polysynaptically activated neurons and thereby map functional pathways. 相似文献
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光诱导c-fos基因在不同日龄母鸡中脑和间脑的表达 总被引：1，自引：0，他引：1
为了进一步探讨光照对母鸡生产性能的影响机制,用c-fos法研究了不同日龄母鸡脑部对光照刺激的反应。对14、60、120和180日龄母鸡右眼遮光7 d后,接受20 lx的光照刺激1.5 h,暗适应1.5 h后灌流固定,取脑制作石蜡切片,采用免疫组化方法检测c-fos基因在中脑和间脑的表达。结果显示,光照刺激后在母鸡视顶盖中央灰质层(SGC),圆核(ROT),外侧膝状腹侧核(Glv),峡核大细胞部(Imc),峡核小细胞部(Ipc),室旁核(PVN),弓状核(ARC)均见有Fos样免疫反应阳性神经元,阳性神经元主要出现在脑左侧。不同日龄母鸡中脑和间脑Fos样免疫反应的程度不同。在SGC,ROT,Glv,Imc,Ipc中,14,60日龄免疫反应阳性神经元的密度最大,120,180日龄保持较高水平,300日龄明显下降。在PVN,ARC,120,180日龄表达强度最大,14,60日龄次之,300日龄最低。其中在14和60日龄与其它3个日龄组之间差异显著。表明在中枢神经内,不同日龄母鸡对光照刺激的反应不同。 相似文献
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The Fos protein complex is associated with DNA in isolated nuclei and binds to DNA cellulose 总被引：18，自引：0，他引：18
The properties of the viral and cellular fos proteins (Fos) were investigated as a first step toward understanding the function of the fos gene. Treatment of nuclei with salt and nonionic detergents solubilized a complex that contained Fos together with several other cellular proteins. The majority of the Fos protein complex was released from isolated nuclei incubated in the presence of deoxyribonuclease I or micrococcal nuclease but not with ribonuclease A, suggesting that Fos is associated with chromatin. This hypothesis is supported by the finding that Fos protein from native or denatured nuclear extracts exhibited DNA-binding activity in vitro. These results suggest that Fos is involved in the regulation of gene expression. 相似文献