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1.
We report 11 new cases of hereditary nasal parakeratosis in Labrador retrievers. The disease was first observed when the dogs were 6 months to 2 years of age, and affected dogs of either sex and all coat colours. Hyperkeratosis and depigmentation were confined to the nasal planum, and affected dogs were otherwise healthy. The principal histological findings in biopsy specimens were marked diffuse parakeratotic hyperkeratosis, multiple intracorneal serum lakes and superficial interstitial-to-interface lymphoplasmacytic dermatitis. Topical applications of propylene glycol in water or white petrolatum were often effective for treatment of the dermatosis. However, continued applications were required to maintain a beneficial response. A retrospective histological study of parakeratotic inflammatory diseases of canine haired skin and inflammatory diseases of the canine nasal planum was performed. The degree of parakeratotic hyperkeratosis and the number and size of intracorneal serum lakes were evaluated. The degree of parakeratotic hyperkeratosis was greater in hereditary nasal parakeratosis specimens than that seen in discoid lupus erythematosus and Malassezia dermatitis. There were more serum lakes in hereditary nasal parakeratosis specimens than in specimens from dogs with discoid lupus erythematosus, Malassezia dermatitis, primary seborrheic dermatitis or zinc-responsive dermatosis. Significant differences in sizes of serum lakes (if present) were not seen. 相似文献
2.
Scott D Fitzgerald Thomas M Cooley Melinda K Cosgrove 《Journal of zoo and wildlife medicine》2008,39(2):257-259
An adult female free-ranging American black bear (Ursus americanus) was presented in poor body condition, with advanced skin disease. Skin changes included hair loss, lichenification, crusting, and focal erosions. Skin scrapings and histopathology identified two distinct parasitic conditions that were contributing to this animal's dermatitis. Large numbers of larvae, nymphs, and adults of Sarcoptes scabiei were present in the superficial epidermis, and nematodes consistent with Pelodera strongyloides were abundant within the hair follicles. This appears to be the first reported case of Pelodera dermatitis in a bear species, adding a new differential agent to the list for dermatitis in bears. The sarcoptic mange and poor body condition of this bear may have been contributing factors to the development of the opportunistic Pelodera infestation. 相似文献
3.
A wild adult male swamp wallaby from Victoria was found to be infested with Sarcoptes scabiei. Hyperkeratotic skin lesions were confined predominantly to the head and shoulders. This is the first report of sarcoptic mange in a swamp wallaby. 相似文献
4.
The skin histology and the scanning electron microscope morphology of the hide defect light flecks and spots after tanning were studied in 11 steers infested with biting lice (Damalinia bovis). Nine steers from herds free of lice were used as controls. Skin biopsies from 6 of the animals in the lice infested group showed mild to moderate hyperkeratosis and moderate perivascular to diffuse dermatitis with infiltration of mainly mononuclear cells and some eosinophilic granulocytes. The steers were slaughtered at an age of 18 to 23 months. Light flecks and spots occurred on all examined hides from the infested group after tanning. No examined hides from the control group demonstrated similar damage. Both light microscopic examination of sections of tanned hide with light flecks and spots and scanning electron microscopy of the same defects showed superficial grain loss and craters with a irregular fibre base encircled by smooth and intact grain. The association between louse infestation at an early age and damage of hides following slaughter 6 to 15 months later, suggested that louse infestations lead to a prolonged or lifelong weakening in the dermis. This weakening may cause superficial grain loss during the tanning process. 相似文献
5.
Primary seborrhoea was diagnosed in 14 English springer spaniels over a 17-year period. Seven of the dogs developed clinical signs by two years of age. The dermatosis began as a generalised non-pmritic dry scaling which gradually worsened. Some dogs remained in this dry (seborrhoea sicca) stage, but in most cases the dermatosis became greasy and inflamed (seborrhoea oleosa and seborrhoeic dermatitis). Eight of the dogs suffered from recurrent episodes of superficial or deep bacterial pyoderma. Histological findings in skin biopsy specimens included marked orthokeratotic hyperkeratosis of surface and infundibular epithelium, papillomatosis, parakeratotic capping of the papillae, and superficial perivascular dermatitis in which lymphocytes and mast cells were prominent. The dogs with seborrhoea sicca responded more satisfactorily to therapy with topical emollient-humectant agents or oral omega-3/omega-6 fatty acid supplementation. Dogs with seborrhoea oleosa and seborrhoeic dermatitis did not respond satisfactorily to topical therapy. One dog, however, responded well to etretinate and omega-3/omega-6 fatty acid administration. No dog was cured. 相似文献
6.
María José G. M. Piedras Miguel Ángel García‐Cabezas Elena Sendagorta Marta Miró‐Murillo Carmen Cavada 《Veterinary dermatology》2011,22(2):209-214
A case of psoriasiform dermatitis in an adult male rhesus macaque is reported. Appearing spontaneously, the condition presented the clinical and histopathological features of human palmoplantar nonpustular psoriasis. The animal developed multiple scaly plaques on his palms and soles, as well as nail hyperkeratosis and widening of the nail root. Microscopically, the skin lesions showed epidermal hyperkeratosis with multifocal parakeratosis, neutrophil microabscesses in the stratum corneum, a loss of granule cell layer under the microabscesses, acanthosis, and elongation of the rete ridges; the superficial dermis showed a dense inflammatory infiltrate containing lymphocytes, macrophages and neutrophils, as well as dilated and tortuous blood vessels. The lesions improved for 15 days after intramuscular corticosteroid depot therapy and worsened slightly afterwards. Later, a spontaneous, progressive remission coincided with the beginning of spring and lasted until the end of summer; the skin lesions practically disappeared during this period, and the nails looked nearly normal. During the next autumn and winter only nail hyperkeratosis was present. Serum analyses showed hyperproteinaemia and hyperglobulinaemia during the outbreak phase and normal values during remission. The clinical and histopathological features of this case, as well as its evolution, are compared with the three other reported cases of psoriasiform skin lesions in nonhuman primates. To the authors’ knowledge, this is the first report of a definite palmoplantar nonpustular psoriasiform dermatitis in a rhesus macaque. 相似文献
7.
Chronic ulcers of the skin were observed in three Belgian Landrace sows. Lesions were located on ears, limbs, and in the mammary region and were resistant to treatment that included corticosteroid therapy. Major histologic changes were located at the dermo-epidermal junction. Ulcers were deep, and the adjacent epidermis had marked hyperkeratosis, acanthosis, and intracellular edema. Dermatitis was prominent, essentially located in the superficial dermis. By electron microscopy, basal lamina appeared disrupted. Dermo-epidermal separation occurred beneath the basal lamina. Collagen was morphologically normal. Desmosomes, hemidesmosomes, and anchorage fibers were present in areas adjacent to lesions. Ulcerative dermatitis of sows is morphologically similar to pemphigus, pemphigoid, systemic lupus erythematosus, epidermolysis bullosa simplex, erythema multiforme, toxic epidermal necrolysis, and drug eruption. However, significant differences exist between ulcerative dermatitis and these conditions. 相似文献
8.
P M Henricks 《Journal of the American Veterinary Medical Association》1987,191(2):237-238
A 9-year-old female dog with progressive pruritic dermatitis was examined 9 months after primidone treatment had been initiated. Alopecia, scaling, ulceration, pigmentation, and fissuring were evident over the dorsal trunk, head, perineum, caudal aspect of the thighs, hocks, elbows, and paws. Hydropic degeneration of epidermal basal cells, mononuclear lichenoid infiltrate in the superficial dermis, and marked parakeratotic hyperkeratosis were evident on biopsy. Antinuclear antibody in the serum was not detected and specific patterns of immunoglobulin deposition in the epidermis or basement membrane zone were lacking. Primidone-induced dermatitis was presumptively diagnosed. Successful treatment involved withdrawal of the primidone and administration of corticosteroids and antibiotics to relieve the pruritus and to eliminate the secondary pyoderma. 相似文献
9.
Hereditary nasal dermatitis is reported in 14 Labrador Retrievers and 4 Labrador Retriever crosses. This appears to be a newly described inherited disorder for which an autosomal recessive mode of inheritance is suspected. The lesions were first noted between 6 and 12 months of age. Histopathological analysis revealed parakeratotic hyperkeratosis, often with marked multifocal accumulation of proteinaceous fluid between keratinocytes within the stratum corneum and superficial stratum spinosum. There was also a sub-basal lymphoplasmacytic infiltration within the superficial dermis. Immunohistochemistry staining for IgG (n = 4), distemper and papillomaviruses (n = 4) were negative, as were serum antinuclear antibody serology (n = 4) and fungal culture (n = 7). Electron microscopy revealed an altered cornification process: retention of nuclear chromatin, absence of lamellar bodies and marked intercellular oedema. Dogs did not respond to oral administration of zinc methionin (n = 3), cephalexin (n = 4), vitamin A alcohol (n = 1) or topical tretinoin (n = 1). Improvement of the lesions was obtained with topical vitamin E (n = 2), petroleum jelly (n = 2), and propylene glycol (n = 5). 相似文献
10.
Chronic eosinophilic dermatitis: a manifestation of a multisystemic, eosinophilic, epitheliotropic disease in five horses 总被引：2，自引：0，他引：2
J S Nimmo Wilkie J A Yager P N Nation E G Clark H G Townsend J D Baird 《Veterinary pathology》1985,22(4):297-305
A generalized, chronic, progressive, exfoliative dermatitis in five horses is described. Histologically, the lesion is characterized by a superficial and deep perivascular dermatitis which is eosinophil-rich with a marked lymphocytic and plasmacytic component, accompanied by marked acanthosis and hyperkeratosis. More severe cases progress to a lichenoid pattern with the same cellular composition with focal eosinophilic spongiosis and eosinophilic subcorneal pustules. Clinically, the disease is associated with chronic, severe weight loss and is fulminating. The skin lesions are accompanied by lymphoplasmacytic and eosinophilic infiltrates and formation of eosinophilic granulomas in other epithelial organs, most noticeably the pancreas, in which a chronic, fibrosing pancreatitis develops. Other epithelial organs involved to various degrees are salivary glands, the gastrointestinal system, including the oral cavity and esophagus, biliary epithelium and bronchial epithelium. The etiology of this disease is unknown. 相似文献
11.
Extract A 6-year-old Thoroughbred-cross gelding was presented with ulcerative coronitis and sloughing of chestnuts and ergots. The horse was mildly lame and its faeces were soft and formless. Laboratory findings included a mild eosinophilia, mild hyperglobuli-naemia and a marked elevation of gamma glutamyl transferase and glutamate dehydrogenase. There was a general deterioration of the horse's condition over a 3-week period and the dermatitis became generalised and the diarrhoea severe. It was euthanised. At necropsy, the pancreas was pale, multinodular and firm. The liver had a lobular appearance and there was generalised thickening of the descending colon. Histologically, there was a marked, predominantly eosinophilic infiltrate of the pancreas, liver and colon. There was a superficial and deep perivascular dermatitis of the coronet, characterised by dense infiltrates of eosinophils in association with marked acanthosis and hyperkeratosis. The combination of clinical findings, haematology, serum biochemistry and gross changes in conjunction with the histology confirmed MEED. The aetiology of MEED has not been established. 相似文献
12.
A distinctive nodular dermatitis induced by Straelensia cynotis, a newly described trombidioid larval mite which resides in hair follicles, was identified in 12 dogs living in France. They all had scattered, small (1 to 3 mm in diameter), pale, firm skin nodules, variable in distribution but always affecting the dorsal regions of the head and trunk; they were distributed over the whole body of seven of the dogs. The animals were otherwise healthy except for three severely infested fox terriers which had a decreased appetite, were lethargic, and whose skin nodules were painful to the touch. The nodules did not induce pruritus. The lesions usually began as erythematous papules which developed into firm pale nodules. The dermatitis resolved within two to 12 months. Topical acaricides were ineffective but the skin nodules regressed after treatments with systemic avermectins. Histologically, each nodule was composed of a dilated follicular ostium containing a well-preserved larval mite, and showed a pseudoepitheliomatous follicular hyperplasia and an abundant perifollicular mucinosis. The larvae were identified as belonging to the genus Straelensia (Acari: Leeuwenhoekiidae). It was clearly established that the three fox terriers had become infested within a fox's den. The nymphs and adults of this species of mite are believed to live in foxes' dens; foxes are considered to be the natural host for the larval stage, and dogs a permissive but occasional host. 相似文献
13.
OBJECTIVE: To investigate the distribution of Echinococcus granulosus in wild dogs and foxes and hydatidosis in wildlife coexisting with foxes and wild dogs in and around Kosciuszko National Park. DESIGN: Prospective and ad hoc surveys by necropsy of definitive and intermediate hosts. PROCEDURE: Wild dogs and foxes were trapped at one location in the Kosciuszko National Park and at 7 locations around the periphery of the Park. Feral pigs, macropodid marsupials, wombats, and feral goats were collected at some of the same locations. The animals were humanely killed, their small intestines removed in the field, the contents collected, preserved and examined microscopically. All internal organs of intermediate hosts were examined for hydatid cysts. Unidentified lesions were examined histologically. RESULTS: Echinococcus granulosus tapeworms were found in wild dogs from all locations. Prevalence ranged up to 100% with worm burdens up to 300,000 worms. Prevalence in foxes ranged up to 50% in animals recovered from 5 locations. The worm burdens were usually less than 50 E. granulosus per fox. Hydatid cysts were found in all macropodid species. Prevalence (69%) and cyst fertility (100%) were highest in swamp wallabies (Wallabia bicolour). Prevalence of cysts in feral pigs ranged up to 49%. Less than 22% of the cysts were fertile. No cysts were found in any of the wombats or feral goats. CONCLUSION: Echinococcus granulosus occurs commonly in wildlife in and around the Kosciuszko National Park. High numbers of fertile cysts in swamp wallabies, a favoured dietary item for wild dogs in this region, suggests swamp wallabies are pivotal in maintaining transmission. Physical contact with wild dogs and foxes or accidental contact with wild canid faeces is a public health risk. 相似文献
14.
P C Stromberg W F Fisher F S Guillot J H Pruett R E Price R A Green 《American journal of veterinary research》1986,47(6):1326-1331
Nine Hereford calves were infested with Psoroptes ovis and were allowed to develop clinical mange during a 9-week period. Blood, serum, and urine samples were obtained before and after calves were infested and were compared with those from 3 noninfested control calves. All calves were euthanatized and necropsied 9 weeks after they were infested. Gross and microscopic anatomic changes occurred only in the skin. Calves developed typical exudative dermatitis, the extent of which was dependent on population density of mites. Severely infested calves (50% to 70% of skin with dermatitis) developed a mild anemia and lymphopenia with marked neutropenia and variable eosinophilia. There were also increases in fibrinogen, gamma-globulin, and in vitro lymphocyte response to mitogen stimulation and decreases in anion gap cortisol, albumin, albumin/globulin ratio, and fractional Na clearance values. The severity of many of the changes could be correlated with the extent of dermatitis. 相似文献
15.
16.
Marco I Lopez-Olvera JR Gibert P Abarca L Gauthier D Lavín S 《Zoonoses and public health》2007,54(6-7):278-280
Two free-ranging southern chamois (Rupicapra pyrenaica) - one 4-year-old male and one 3-year-old male - were diagnosed with clinical dermatophytosis in the French and Spanish Eastern Pyrenees respectively. Skin samples were collected for microbiological studies, Trichophyton mentagrophytes being isolated and identified in both animals. The first chamois was found dead at the base of a cliff, and presented with alopecia and scaling on the dorsum and left forelimb. The second chamois showed grey-yellow, rough to raised scaling and crusting skin lesions at the base of the horns, around the eyes, dorsum of the nose, sternum, tail and limbs. Histological examination was carried out only on the second animal. The main lesions were orthokeratotic hyperkeratosis with focal parakeratosis, irregular to papillary epidermal hyperplasia, intracorneal neutrophilic pustules, perivascular to diffuse dermatitis with neutrophilic folliculitis and furunculosis. In those follicles with folliculitis and/or furunculosis, fungal hyphae and arthrospores associated with the follicular keratin and hair shafts were seen. 相似文献
17.
Staphylococcus simulans, a coagulase-negative staphylococcal species, can cause several diseases in humans and animals. This report describes a case of dermatosis characterized by broad, well-circumscribed hyperkeratosis and alopecia on the back of a household pygmy hedgehog (Erinaceous albiventris). Quills and exudates were studied by microscopy. The microscopic examination of the exudates collected from the lesion revealed several leukocytes and numerous gram-positive cocci. An aerobic bacterial culture revealed overgrowth of the same gram-positive bacteria. The bacterium was identified as S. simulans by polymerase chain reaction amplification and direct sequencing targeted to the 16S ribosomal RNA gene. This report is the first to show that S. simulans could be related to the dermatitis of hedgehogs. 相似文献
18.
《Journal of Exotic Pet Medicine》2014,23(3):283-286
Actinic keratosis is well described in humans, dogs, and cats as a precancerous skin growth caused by ultraviolet light–induced DNA damage. This report describes a case of early actinic keratosis in a 6-year-old rabbit (Oryctolagus cuniculus). On dermatological examination, erythema and yellow adherent scales were observed on the external aspect of the pinnae. Mild pruritus was also present on the initial presentation. Histopathology revealed segmental epidermal hyperplasia with loss of polarity in the basal layer. Mild nuclear atypia and marked orthokeratotic hyperkeratosis were present. The superficial dermis had marked reticular fibrosis with thickening of collagen fibrils. Topical treatment with diclofenac resulted in clinical resolution of the disease. 相似文献
19.
Histopathology submissions from 28 goats with dermatological disease were identified in an archival search of pathology files. Microscopic sections of skin biopsy specimens were examined for the presence of Malassezia spp. organisms. Six cases with many Malassezia yeasts were identified histopathologically. Based on the extent of clinical disease, three cases were regarded as localized and three were generalized infections. Clinical findings included alopecia with dry seborrhoea (four cases), greasy seborrhoea (one case), and no clinical findings specific to localized Malassezia infection when concurrent bacterial infection was present (one case). Mild pruritus was reported in two cases of generalized infection. No breed predilection was apparent. Three cases were male and three were female. Malassezia dermatitis occurred in goats from 10 months to 13 years of age. Three of six cases had concurrent bacterial infection. Skin lesions resolved following topical antifungal therapy in the two goats that were treated. Histopathological findings in all cases were severe follicular and epidermal orthokeratotic hyperkeratosis with minimal epithelial change and mild superficial perivascular to interstitial nonsuppurative inflammation. Numerous budding yeasts were visible within the stratum corneum of all cases; however, Malassezia was not isolated in the three cases in which culture was attempted. Based upon these findings, the authors suggest that the diagnosis Malassezia dermatitis in goats is most likely to be made by cytological examination of skin impressions or by examination of skin biopsy samples. 相似文献
20.
KA Rose PD Kirkland RJ Davis D Blumstein LI Pritchard KM Newberry RA Lunt 《Australian veterinary journal》2012,90(12)
Epizootics of sudden death in tammar wallabies (Macropus eugenii) occurred at six research facilities and zoological gardens in New South Wales, Australia, in late 1998 and at one Queensland research facility in March 1999. There were 120 confirmed tammar wallaby deaths during this period; however, population censuses indicated that up to 230 tammar wallabies may have died. The majority of animals died without premonitory signs. A small proportion of wallabies exhibited increased respiratory rate, sat with a lowered head shortly before death or were discovered in lateral recumbency, moribund and with muscle fasciculations. Gross postmortem findings consistently included massive pulmonary congestion, mottled hepatic parenchyma and subcutaneous oedema throughout the hindlimbs and inguinal region. Approximately 30% of the animals examined also had extensive haemorrhage within the fascial planes and skeletal muscle of the hindlimb adductors, inguinal region, ventral thorax, dorsal cervical region and perirenal retroperitoneal area. The tissues of affected animals became autolytic within a short period after death. Bacteriological examination of tissues from 14 animals did not provide any significant findings. Toxicological examination of the gastric and colonic contents of four animals did not reveal evidence of brodifacoume or other rodenticides. Viruses from the Eubenangee serogroup of the Orbivirus genus were isolated from the cerebral cortex of nine, and the myocardium of two, tammar wallabies and the liver and intestine of another tammar wallaby. A similar orbivirus was also isolated from the cerebrospinal fluid of another tammar wallaby that died suddenly. The disease agent appears to be a previously unrecognised orbivirus in the Eubenangee serogroup. This is the first report of epizootics of sudden deaths in tammar wallabies apparently associated with an orbivirus infection. 相似文献