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1.
A salivary gland adenocarcinoma in a white Swiss mouse used in a titration of the scrapie agent is reported. The neoplasm originated from the serous cells of the parotid salivary gland. Retroviral particles were detected in the neoplastic salivary gland cells by electron microscopy. 相似文献
2.
Kazuya Kuzutani Toshiyuki Shibanushi Yumi Kangawa Tohru Kihara 《Journal of toxicologic pathology》2012,25(3):221-224
Spontaneous mammary adenocarcinoma was observed in a 12-week-old female SD rat. A
movable mass in the right cervical region was found at 11 weeks of age, and the rat was
sacrificed the following week. The mass was located in the vicinity of the right salivary
gland and measured 38 mm × 26 mm × 16 mm in gross size. It was a firm whitish mass, with a
cut surface that was also whitish in appearance. Histopathologically, neoplastic cells
formed glandular structures that contained secreted eosinophilic material.
Ultrastructurally, similar secreted material and lipid droplets were in the cytoplasm of
the neoplastic cells. Immunohistochemically, the neoplastic cells were positive for
cytokeratin 8, cytokeratin 18 and estrogen receptor α. Based on these findings, the tumor
was diagnosed as a mammary gland adenocarcinoma, and we therefore conclude that this tumor
type can occur spontaneously in female SD rats as young as 12 weeks of age. 相似文献
3.
E. J. McConnell M. G. Sanz U. C. M. Kafka N. M. Duncan 《Equine Veterinary Education》2014,26(11):610-615
This case report describes a geriatric gelding with a 2 month history of fast‐growing masses within the parotid and submandibular regions. The horse was dyspnoeic on presentation and upper airway endoscopy revealed partial airway obstruction at the level of the pharynx, secondary to a space‐occupying mass. Cytological evaluation of multiple fine‐needle aspirates obtained from the masses were suggestive of salivary gland neoplasia, therefore the horse was subjected to humane euthanasia. A computed tomographical scan was obtained post mortem and revealed a large multi‐lobulated mass involving both guttural pouches, resulting in 80% occlusion of the naso‐ and oropharynx. Histopathology confirmed a parotid salivary gland carcinoma (papillary‐cystic type). Salivary gland tumours are extremely rare in horses, with only a few cases reported in the literature. Treatment of these malignancies proves to be challenging, requiring complete parotidectomy or surgical debulkment, in combination with adjunctive therapy. 相似文献
4.
Diaa Massoud Mashael M. Bin-Meferij Attala F. El-Kott Mona M. Abd El-Maksoud Sally Negm 《Anatomia, histologia, embryologia》2023,52(2):254-261
This study aimed to investigate the major salivary glands in the southern white-breasted hedgehog (Erinaceus concolor) histologically and histochemically. Five adult males were included in this study. The results showed that anatomically the shape of the parotid, submandibular and sublingual glands of the Erinaceus concolor was respectively almost pear, elliptical to pyramidal and oval. Histologically, the parotid gland had serous acini and secretory cells showed negative reaction to alcian blue (AB) (pH = 2.5) and negative response to aldehyde fuchsin (AF), methylene blue (MB) and PAS stains. The submandibular gland was a mixed gland of mucous and serous acini. The mucous acini were strongly positive for PAS, AB, MB and AF. However, serous acini were week for PAS and negative against AB, MB and AF stains. The sublingual gland was purely composed of mucous acini. The mucous acini of the sublingual gland were strongly positives for PAS, AB and MB methods. While their reaction to the AF staining was negative. In conclusion, the histological and histochemical observations of the major salivary glands of the southern white-breasted hedgehog (E. concolor) indicated that these glands shown similarities and some special different histochemical features as compared to other mammalian species. 相似文献
5.
Mazzullo G Sfacteria A Ianelli N De Majo M Pennisi MG 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2005,34(1):61-64
A 9-year-old neutered male domestic shorthair cat was presented because of coughing, dysphagia, and prostration. Examination revealed firm bilateral anterocervical swellings extensively adhered to the surrounding tissues. Anisocoria with left-side miosis was also evident. X-ray and ultrasound examinations along with a fine-needle aspiration biopsy were performed. Slides were stained with May-Grünwald Giemsa, and a diagnosis of salivary gland carcinoma was made. At surgery, the tumor was found to involve both submandibular salivary glands as well as adjacent lymph nodes and surrounding tissues. The cat was euthanized and necropsy was performed. The majority of tissues and organs examined histologically, including mandibular and retropharyngeal lymph nodes, soft palate, laryngopharynx and lungs, contained neoplastic cells whose appearance was consistent with adenocarcinoma. Bilateral salivary adenocarcinoma has not previously been reported in cats, and extensive metastases are rare. 相似文献
6.
Marjorie Bercier David Sanchez-Migallon Guzman Jonathan Stockman Allison Zwingenberger Natalia Vapniarsky Linda Lowenstine Michelle G. Hawkins 《Journal of Exotic Pet Medicine》2013,22(2):218-224
A 2.4 kg, 7-year-old, female Rex rabbit was presented with a 4-month history of a left-sided head tilt, difficulty in mastication, lethargy, and chronic wasting. Diagnostic testing of the patient revealed a severe heterophilic leukocytosis and radiographic images of the skull radiographs indicated irregularity of the left tympanic bulla. A computed tomographic scan highlighted a heterogeneously contrast-enhancing mass, ventral and rostral to the left tympanic bulla, with contrast enhancement of the meninges on the left, consistent with an aggressive neoplasm. The patient was euthanized and the mass was identified as a salivary gland adenocarcinoma. The gland of origin is suspected to be the left parotid, owing to its location and close association with normal parotid tissue. To the authors' knowledge, this is the first report of a salivary gland adenocarcinoma in a domestic rabbit. A computed tomography (CT) scan and histopathology examination were useful modalities for identifying the neoplasm in this case. 相似文献
7.
Pérez-Martínez C García Fernández RA Reyes Avila LE Pérez-Pérez V González N García-Iglesias MJ 《Veterinary pathology》2000,37(4):350-353
A 12-year-old male Boxer dog presented with a 5 x 5 x 7-cm partially encapsulated mass in the right mandibular salivary gland. Histologically, the mass was composed of neoplastic epithelial and mesenchymal cells. The mesenchymal component consisted of two cell populations arranged in different patterns: coalescing nodules of neoplastic mononuclear cells with rare osteoid and numerous osteoclastlike giant cells; and sheets of neoplastic spindle cells intermingled with neoplastic epithelial cells and containing osteoid and well-formed bone trabeculae lined by osteoblasts and few osteoclastlike giant cells. On the basis of these histological features, two malignant salivary tumors were diagnosed: a malignant fibrous histiocytoma (giant cell type) and a malignant mixed tumor. Immunohistochemical studies demonstrated keratin 5 and 8 expression by the neoplastic epithelial cells, indicating a probable salivary ductal origin, and vimentin expression by all mesenchymal elements, suggesting a fibroblastic line of differentiation. 相似文献
8.
Ai Maeno Yoshimitsu Sakamoto Motoki Hojo Yukie Tada Jin Suzuki Akiko Inomata Takako Moriyasu Akihiko Hirose Noriko Kemuriyama Katsuhiro Miyajima Dai Nakae 《Journal of toxicologic pathology》2021,34(4):353
Zymbal’s gland neoplasms are induced in rats through the administration of various carcinogens, but spontaneous neoplasia is rare. This report describes a spontaneous Zymbal’s gland carcinoma with lung metastasis found in an aged male Fischer 344 rat. Macroscopically, the dome-like tumor nodule, approximately 30 mm in diameter with ulceration, was located near the ear canal of the rat. No healthy tissue or structure of Zymbal’s gland was identified on the corresponding side, while the normal salivary glands and a lacrimal gland were observed. Histologically, a large part of the tumor mass was occupied by poorly differentiated neoplastic cells, the shapes of which were oval to polygonal or fusiform. Additionally, clusters of sebaceous-like foamy cells and squamous metaplasia with prominent keratinization were observed. Tumor cells were found to metastasize to the lung; these cells displayed histological similarities, including a sebaceous gland-like pattern, to those in the primary site. The tumor cells were immunohistochemically positive for cytokeratin AE1/AE3 or vimentin but negative for CD68, S100, α-smooth muscle actin, von Willebrand factor, and desmin. Our results indicate that the tumor was a poorly differentiated Zymbal’s gland carcinoma with lung metastasis. 相似文献
9.
Wills TB Bohn AA Finch NP Harris SP Caplazi P 《Veterinary clinical pathology / American Society for Veterinary Clinical Pathology》2005,34(4):405-408
A 5-year-old male castrated ferret was presented to the Washington State University College of Veterinary Medicine for evaluation of progressive hair loss and a large, rapidly growing ventral neck mass. The patient had been diagnosed previously with an insulinoma, which was managed medically. Fine-needle aspirates of the neck mass were performed. The cytologic results were most consistent with epithelial neoplasia, likely a carcinoma; thyroid origin was considered likely based on tumor location and cell morphology. The tumor grew rapidly, and the owners elected euthanasia 1 week after examination. At necropsy, a circumscribed, ovoid mass disrupted the right cervical musculature next to the right lobe of the thyroid gland. Histopathologic evaluation revealed an infiltrative mass consisting of cuboidal cells arranged in solid sheets and irregular follicles enclosing colloid. The cells were large, with prominent nucleoli, and had a high mitotic rate. The histopathologic diagnosis was consistent with thyroid follicular adenocarcinoma. Immunochemical findings confirmed thyroglobulin production by neoplastic cells, but to a lesser extent than in normal ferret thyroid tissue. To our knowledge, this is the first case of thyroid follicular adenocarcinoma to be reported in a ferret, with only 1 other case of thyroid carcinoma, a C-cell carcinoma, described previously. 相似文献
10.
A cat was referred for investigation of a soft tissue mass caudal to the left mandible. Initial investigations suggested a malignant salivary gland tumour, and the mass was removed by extracapsular resection of the mandibular gland. Histopathology showed an oncocytoma within the salivary gland. An oncocytoma is a neoplastic transformation of oncocytes. Oncocytes are cells with a small nucleus and intense eosinophilic granular cytoplasm due to numerous mitochondria, which proliferate during ageing in exocrine and endocrine glandular tissues. Physiological proliferation occurs next to oncocytosis, oncocytoma, and oncocytic carcinoma. This is the first report of an oncocytoma in a feline mandibular salivary gland, and the first report of long-term survival after surgical removal. 相似文献
11.
Toyoda T Tsukamoto T Cho YM Onami S Takasu S Shi L Saito A Matsuo S Tatematsu M Nishikawa A Ogawa K 《Journal of toxicologic pathology》2011,24(3):173-177
A subcutaneous mass was found in the lower ventral neck region of a 55-week-old male Mongolian gerbil (Meriones unguiculatus). Histopathologically, the mass involved salivary glands and featured diffuse proliferation of pleomorphic neoplastic cells with large necrotic foci. The lesion was well demarcated from the surrounding tissue, although invasive growth to fibrous septa was occasionally observed. The neoplastic cells were mainly arranged in irregular sheets with severe cellular atypia, round to oval nuclei and varying amounts of eosinophilic cytoplasm. Mitotic figures and multinucleated giant cells were frequent. Immunohistochemical analysis revealed that the neoplastic cells were strongly positive for vimentin and S-100 and negative for NSE, cytokeratin, α-SMA, c-kit, factor VIII, CD34, α-1-antitrypsin, lysozyme and MSR-A. Based on the results, the mass was diagnosed as an undifferentiated sarcoma of the salivary gland. To the best of our knowledge, this is the first report of such a tumor in Mongolian gerbils. 相似文献
12.
A case of primary parotid salivary gland adenocarcinoma is described in a three-year-old entire female great dane. The presenting complaint was sudden onset blindness concomitant with the development of bilateral hyphaema and anterior uveitis. A soft-tissue swelling of the left subaural region and right forelimb lameness were also present. A definitive diagnosis of primary parotid salivary gland adenocarcinoma with bilateral ocular metastases was made on post mortem examination. Metastases were also present in the right proximal humerus, left and right prescapular lymph nodes, left axillary lymph node, left retropharyngeal lymph node, bronchial lymph nodes and all lung lobes. 相似文献
13.
Saulo Petinatti Pavarini Danilo Carloto Gomes Marcele Bettim Bandinelli Flademir Wouters Luciana Sonne David Driemeier Cláudio Estêv?o Farias da Cruz 《Acta veterinaria Scandinavica》2013,55(1):7
Chronic cardiac insufficiency was associated with a malignant peripheral nerve sheath tumor in a cow. An eight-year-old cow developed a progressive condition (over a period of three months) characterized by an enhanced abdominal volume, reluctance to move, a positive jugular pulse, watery diarrhea and death. At necropsy, moderate subcutaneous edema and an enhanced hepatic lobular pattern were observed. A 23x20x11 cm firm, grayish-white mass adhered to and infiltrated the right atrium. Multiple firm, yellowish-white nodules of 0.5 to 12 cm in diameter were diffusely scattered in the epicardium and parietal pericardium. Histologically, the tumor was poorly circumscribed with foci of infiltration of the myocardium. The neoplastic cells had two major histologic patterns, Antoni types A and B. Within occasional foci, pleomorphic cells with an epithelioid appearance were present in addition to multinucleated cells with periodic acid Schiff (PAS)-positive cytoplasmic globules. Foci of cartilaginous and granular differentiations were interspersed among the neoplastic cells. Multiple vessels presented wall hyalinization and tumoral embolus. Large necrotic foci with mineralization and cholesterol clefts were also observed. Immunohistochemically, the tumor was positive for S100 protein, vimentin and neuron-specific enolase labeling. 相似文献
14.
This report describes an invasive mammary carcinoma with a rare distinctive feature characterized by sebaceous differentiation of tumor cells. This tumor occurred in a 10-year-old female mixed breed dog. The patient had two masses in the left fifth mammary gland. Grossly, the masses were firm, whitish to light brown, and superficially ulcerated. On cut surface, they were multilobulated with foci of necrosis. Microscopically, the tumors were composed of two distinctive neoplastic components, intraductal papillary adenocarcinoma and sebaceous carcinoma. The regions of sebaceous tumor were clumped separately, contained well-developed sebaceous cells and keratinized epithelial cells, and were surrounded by few to several layers of basaloid cells. The cells with abundant foamy cytoplasm that resembled sebaceous cells were also found within the intraductal papillary-like nests of mammary carcinoma, providing evidence of sebaceous metaplasia. Sebaceous differentiation in a mammary gland tumor is possible, because skin appendages and ductal apparatus of the mammary gland share a common anlagen. This tumor had an aggressive behavior with lymphatic metastasis. Consequentially, the dog had a poor prognosis. 相似文献
15.
Noriyuki HORIUCHI Makoto KOMAGATA Keiichi SHITAMURA Shiori CHIBA Kotaro MATSUMOTO Hisashi INOKUMA Takane MATSUI Yoshiyasu KOBAYASHI 《The Journal of veterinary medical science / the Japanese Society of Veterinary Science》2015,77(6):729-732
An 11-year-old Holstein-Friesian cow exhibited anorexia and jaundice. A large mass was
found in the liver during necropsy. Macroscopically, the mass was composed of dark red
multilobular tissue and a centrally located abscess, which was connected to the hepatic
duct. Histologically, the mass consisted of proliferation of small neoplastic cells and
was demarcated from the hepatic parenchyma by a thick region of granulation tissue. The
neoplastic cells were predominantly arranged in solid sheets, but they also formed
blood-filled cancellous structures, and proliferating foci were seen around blood vessels.
Periodic acid-Schiff reaction demonstrated that a fine basement membrane-like structure
surrounded the neoplastic cells. Immunohistochemically, the neoplastic cells were positive
for vimentin and alpha smooth muscle actin and negative for cytokeratin, factor
VIII-related antigen, chromogranin and desmin. Based on its histopathological features,
the hepatic neoplasm was diagnosed as a primary glomus tumor. This is the first report
about a primary glomus tumor of the liver in a cow. 相似文献
16.
Smrkovski OA LeBlanc AK Smith SH LeBlanc CJ Adams WH Tobias KM 《Veterinary pathology》2006,43(3):374-377
A carcinoma ex pleomorphic adenoma was diagnosed in the left mandibular salivary gland of an 8-year-old female spayed dog. The animal presented with a large nonpainful swelling in the left submandibular region. A computed tomography scan detected an irregularly enhancing soft tissue mass that was closely associated with the left external ear canal and extended to the left wing of the atlas. On surgical exploration, the mass was intimately associated with the left mandibular salivary gland. Both the mass and the adjacent gland were removed, and the diagnosis was determined by histopathology. The tumor was comprised of basaloid and low columnar epithelial cells, many glandular units formed by well-differentiated sebocytes, and multifocal regions of necrosis, mineralization, and hemorrhage. Salivary gland tumors with sebaceous differentiation are very rare in animals, with one previously reported case in a cat. 相似文献
17.
Shin SK Kim TW Youm SY Kim G Na KJ Chang D Ahn B 《The Japanese journal of veterinary research》2011,59(4):173-179
Basosquamous carcinoma (BSCC) is a rare malignancy, primarily composed of basal cells with foci of squamous differentiation. It is considered to be histologically an intermediate type between basal cell carcinoma and squamous cell carcinoma, and is known to have aggressive behaviors. BSCC occurred in a 17-year-old female minipin with a history of surgical excision for a mammary tumor. The right upper hindlimb was severely enlarged to 8 x 5 cm. Cross-section showed a homogenous white to yellow-white mass compressing the surrounding muscular tissues. The tumor metastasized also to the lungs, heart, abdominal cavity, liver and salivary gland. Microscopically, basaloid cells were crowded into solid nests or lobules separated by well-developed fibrous tissues with occasional keratinizations. Since there was no skin lesions, the tumor is assumed to be originated from the formerly present tumor in mammary gland. To our literature review, this case is the first BSCC with systemic metastasis in a dog. 相似文献
18.
Hirayama K Honda Y Sako T Okamoto M Tsunoda N Tagami M Taniyama H 《Veterinary pathology》2003,40(1):86-91
A 21-year-old thoroughbred mare had a 35 x 14 x 10 cm mass involving the mammary gland. Metastases were found in the kidneys, lungs, skeletal muscles, and regional lymph nodes. Histopathologic examination of the tumor revealed a ductal solid carcinoma with extensive intraductal and intralobular involvement and focal infiltration of the adjacent stroma. The intralobular neoplasms were divided into irregularly shaped islands and sheets of polygonal and spindle-shaped epithelial cells by thick or thin fibrous connective tissue bundles. The neoplastic cells had a small or moderate amount of cytoplasm that stained faintly with eosin and round or oval hyperchromatic nuclei. Immunohistochemically, the neoplastic cells were strongly positive for Lu-5, weakly positive for AE1/AE3, vimentin, and glial fibrillary acidic protein, and negative for cytokeratin 8, cytokeratin 14, alpha-smooth muscle actin, calponin, and S100. The neoplasm was diagnosed as an invasive ductal carcinoma of the mammary gland with multiple metastases. 相似文献
19.
Objective To determine the outcome and effect of a partial ligation of the transposed parotid duct at the level of the parotid gland in four dogs with excessive salivation and ocular irritation. Methods Four dogs were previously diagnosed with absolute keratoconjunctivitis sicca. After a parotid duct transposition (PDT) surgery, these dogs experienced excessive saliva production and abundant salivary precipitates, which resulted in epiphora, moist dermatitis, blepharospasm, and keratitis. In an effort to decrease saliva production, a partial ligation of the transposed duct at the level of the parotid gland was performed. Two or three accessory branches to the primary parotid duct were ligated at the level of the salivary gland. Results The four cases were three Yorkshire terriers and a Chihuahua. The average age of the four patients was 2.5 years. Partial ligation of accessory branches of the parotid duct at the level of the parotid gland after a PDT in this study demonstrated improved ocular comfort, decreased salivary precipitates, and adequate Schirmer tear test results without marked epiphora in three of the four animals. The male Yorkshire had epiphora after the initial partial ligations of two accessory branches were placed at the level of the parotid gland. To correct the excessive salivary flow, two additional ligatures were placed at a later date, which resolved the epiphora. Conclusion Partial ligation of the parotid duct at the level of the parotid gland proved to be an effective technique in moderating the salivation in these four patients with excessive salivary secretions after PDT. 相似文献
20.
Militerno G Bazzo R Marcato PS 《Journal of veterinary medicine. A, Physiology, pathology, clinical medicine》2005,52(10):514-516
A case of mandibular salivary gland adenocarcinoma in a 9-year-old female dog is described. Material collected by fine needle aspiration underwent cytological examination and after the diagnosis of salivary carcinoma the mass was surgically excised and then was processed for histological examination. The aim of this work is to describe the cytopathological features of this carcinoma and to emphasize the usefulness of fine needle aspiration technique, which is an effective, inexpensive and minimally invasive method of diagnosis that can be performed before incisional biopsy or even before surgical excision. 相似文献