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1.
通过对两个年龄组共196例猪的鼻咽组织的研究,除见一般性病变外,检出了被覆上皮单纯性增生、被覆上皮异型性增生、被覆上皮单纯性鳞状化生、被覆上皮异型性鳞状化生、被覆上皮乳头状增生、外突型乳头状瘤、内翻型乳头状瘤、基底细胞内生性增生和癌变、乳头状瘤癌变和7例分化程度高低不一的鳞状细胞癌(包括原位癌与浸润癌)。研究证明:鼻咽上皮的增生性与化生性病变以年龄较大(2.5～12岁)的母猪多见。鼻咽的被覆上皮与陷窝上皮的鳞状化生以及基底细胞增生与癌变是形成猪鼻咽癌的病理组织学的基础;异型性鳞状化生是形成猪鼻咽鳞癌的必经阶段,它是这种恶性肿瘤的重要的癌前病变。 相似文献
2.
作者在29例肝内胆小管上皮有艾美耳(E.stiedae)球虫寄生的家兔中,除了发现由于球虫寄生致胆管上皮破坏外,并见上皮显著增生及乳头状腺瘤形成。上皮的增生率为100％(29/29),增生类型包括单纯性增生和乳头状增生。其中由增生发展形成的乳头状腺瘤计7例(7/29),肿瘤的发生率占所研究病例的24.13％。病理形态学研究结果提示:胆管上皮增生和乳头状腺瘤的形成与球虫寄生存在着相关关系,但球虫是否为此瘤的唯一病因,则需通过实验复制证实。 相似文献
3.
对犬的皮脂腺瘤、肛周腺腺瘤、肛周腺癌、毛基质瘤、间叶性软骨肉瘤、腺样型基底细胞上皮瘤、囊样型基底细胞上皮瘤、水母样型基底细胞上皮瘤、混合型基底细胞上皮瘤、基底鳞状细胞上皮瘤、甲状腺腺瘤、肥大细胞瘤、组织细胞瘤、乳腺良性混合瘤(软骨腺瘤)、乳腺良性混合瘤(肌上皮腺瘤)、恶性肌上皮细胞瘤、乳腺恶性混合瘤(癌肉瘤)、汗腺囊性增生、汗腺腺瘤、汗腺癌等20种24例肿瘤(良性肿瘤14种,恶性肿瘤6种)作了详细的病理组织学描述。 相似文献
4.
《畜牧与兽医》2016,(8):80-83
收集2008—2015年部分宠物医院的犬肛周肿物病例34例,采用组织病理学方法对犬肛周肿物进行组织学分类,并对病例中动物的年龄、性别等信息进行统计分析。结果显示:34例犬肛周肿物中,肿瘤性病变有29例,其中肛周腺腺瘤11例,肛周腺腺癌10例,鳞状上皮细胞癌4例,肛周腺上皮瘤、脂肪瘤、转移性性肿瘤和纤维瘤各1例;肛周腺增生2例;炎症性病变2例,化脓性炎症和直肠糜烂溃疡各1例;还有1例为硬皮病。肿瘤病占85.3%,增生性病变占5.9%,炎症占5.9%,其他占2.9%。结果表明:犬肛周肿物疾病中常见的病变以肿瘤为主,其次为增生性病变和炎症,发病年龄多为中老年犬。本研究可以为犬肛周肿物的流行病学及诊断提供帮助。 相似文献
5.
四川省一些长有蕨的山区发生牛地方性血尿症,通过27例的肉眼与组织学检查,发现主要损害在膀胱。除患慢性炎症的5例外,肿瘤占22例。病牛年龄在3岁以上,购自山区并有采食蕨的历史。肉眼上,膀胱壁增厚,肿瘤呈息肉状、乳头状、菜花状与岩块状,大小不等。显微镜检查,上皮性的肿瘤有乳头瘤,移行上皮癌Ⅰ-Ⅲ级、鳞癌和腺癌;非上皮性肿瘤有粘液瘤、横肌瘤、血管瘤、血管肉瘤及纤维肉瘤等。其中11例为复合瘤,有2～3种类型的肿瘤同在一膀胱上。 相似文献
6.
对流行于贵州省的牛膀胱肿瘤的调查表明:本病最显著的临床症状是长期间歇性血尿。在1570头屠宰牛中检出膀胱肿瘤257例(16.37%)。其中黄牛的检出率高达18.74%,水牛为0.57%。对328例牛膀胱肿瘤进行了病理形态学观察及组织学分类,并对其中3例作了电镜观察。各类型肿瘤出现的频率依次是:移行细胞癌126例,纤维瘤97例,血管瘤42例,平滑肌肉瘤42例,乳头状瘤30例,腺癌18例,横纹肌肉瘤16例,血管肉瘤12例,纤维肉瘤8例,鳞状细胞癌3例,粘液瘤2例,以及腺瘤、平滑肌瘤和未分化癌各1例。在64个病例中,每例同时存在上述的二或三种肿瘤成分。在28例中见肿瘤组织向淋巴结或/和其他器官转移。 相似文献
7.
研究多原发性癌瘤,在病因学、发生学、免疫学、诊断和防治等方面都有重要意义。国内外医学界对人类的多原发性癌瘤的研究日益重视。文献中有关家畜的多原发性癌瘤的资料则极为缺乏。本文报道在一个为数约800头、3～12岁的猪群中,经过历时五年(1975～1980)的追踪研究,经病理证实,先后检出了41个恶性肿瘤病例,检出率高达5.13％。此外还检出一些良性肿瘤、息肉与癌前病变。这些恶性肿瘤是副鼻窦癌(包括筛窦癌、蝶窦癌和上颌窦癌)、鼻咽癌、鼻腔癌、原发性肝癌和淋巴肉瘤。41个病例中含有的多原发癌瘤数目共54个。其中患一种恶性肿瘤者计30例(占73.17％);患二种者9例(21.9％);三种者两例(4.88％)。猪的这批肿瘤以群发性、多原发性出现,在公共卫生以及肿瘤的病因的探讨上,均有重要价值。本文重点介绍猪的这批多原发性癌瘤的诊断标准、检出的恶性肿瘤数目、发生率、肿瘤的组织学类别以及多原发癌瘤的好发部位等资料。最后并对这批病例的可能病因进行了讨论。 相似文献
8.
《畜牧与兽医》2017,(4):106-110
为了探讨腱糖蛋白C(TNC)表达与犬乳腺肿瘤生物学关系,对23例犬乳腺肿瘤临床病例进行病理学观察及分类,然后采用免疫组化SABC方法检测TNC蛋白在23例犬乳腺肿瘤和2例犬正常乳腺组织中的表达情况。结果显示:23例病例中,良性肿瘤有7例,占30.43%;恶性肿瘤有13例,占56.52%;增生病变有3例,占13.05%。在良性肿瘤中良性混合瘤最多,为3例,其余2例为导管内乳头状腺瘤,1例复杂腺瘤及1例纤维腺瘤。恶性肿瘤中,5例未分化癌,3例癌肉瘤,2例筛状癌,2例固体癌,1例纤维肉瘤,1例混合瘤引起的癌。TNC蛋白主要表达于细胞外基质。犬恶性乳腺肿瘤中,TNC蛋白阳性表达率为46.15%(6/13);良性乳腺肿瘤中,其阳性表达率为42.85%(3/7);乳腺增生病变和正常乳腺组织中,未见其表达。研究结果表明,TNC蛋白可以为犬乳腺肿瘤的鉴别诊断提供参考。 相似文献
9.
对比调查了湖北省钟祥县柴湖公社人食管癌高发的河南淅川县移民与低发的本地居民所养的鸡咽食管癌和口、咽、食管粘膜的非癌瘤性病变。发现:在饮水改善后,移民鸡咽食管癌的发病率(87.3/10万)仍显著高于本地居民鸡( P<0.05)。移民区与本地居民的鸡口、咽、食管粘膜上皮均有增生性病变、乳头状瘤、粘膜炎症、糜烂或溃疡、寄生虫的损害等病变。除寄生虫损害外,其余各种相应病变的发生率,移民区的鸡均显著高于本地居民鸡(P<0.05)。 本文将组织结构与超微结构结合起来,描述了鸡咽、食管癌及其口、咽、食管粘膜非癌瘤病变的病理学变化。在4例癌组织及9例增生的粘膜上皮中见有大小、形态类似于病毒的粒子。 相似文献
10.
为探讨犬常见肿瘤的发病规律,试验收集哈尔滨地区2016—2017年宠物医院部分犬肿瘤病例71例,采用组织病理学方法对犬肿瘤进行病理学诊断,并对患病动物的品种、性别、年龄、发生部位和饮食情况与肿瘤发生关系进行统计分析。结果显示,71例确诊肿瘤病例中,恶性肿瘤28例,包括鳞状上皮细胞癌3例,基底细胞癌5例,乳腺癌14例,淋巴瘤2例,肾母细胞瘤、精原细胞癌、生殖细胞癌、侵袭性血管黏液瘤各1例;良性肿瘤43例,包括良性乳腺肿瘤15例,纤维瘤10例,平滑肌瘤5例,乳头状瘤和精原细胞瘤各3例,造釉细胞瘤、耵聍腺瘤、脂肪瘤、结节样增生、性索间质细胞瘤、颗粒细胞瘤、肛周腺瘤各1例。上述病例中,乳腺和皮肤是犬肿瘤的高发部位,分别占全部患犬的40.8%和34.0%;患病犬年龄1~16岁不等,平均发病年龄为9.1岁,7岁以后是肿瘤的高发期,中老年犬仍为主要发病群体,但低龄犬发病数量上升;各品种犬均可发生肿瘤,其中杂种犬发病率最高,其次是贵宾犬和京巴犬,且主要为乳腺肿瘤;饮食习惯主要以剩饭剩菜类和肉拌饭类为主,分别占患犬总数的39%和30%;部分肿瘤类型与犬的性别、是否绝育有关,如乳腺肿瘤多发生于未绝育的老年母犬。本研究结果为犬肿瘤的流行病学及诊断提供了参考依据,对犬肿瘤的预防和诊断有一定的借鉴意义。 相似文献
11.
M J Murray 《Journal of the American Veterinary Medical Association》1989,195(8):1135-1141
Of 183 foals examined by use of gastroendoscopy during 1987 and 1988, 94 had gastric lesions. Sixty-eight of 120 foals in the 1- to 85-day-old age range had endoscopically confirmed gastric lesions, and 26 of 63 foals in the 90- to 310-day-old age range had gastric lesions. Lesions were observed most frequently in the stratified squamous mucosal epithelium, particularly adjacent to the margo plicatus. Lesions were observed in the gastric glandular mucosa in 26 of the 94 foals with gastric lesions, and with a greater frequency in foals with a clinical disorder than in foals with no disorder (27% vs 3%). In young foals, lesions were consistently observed in the stratified squamous mucosal epithelium adjacent to the margo plicatus along the greater curvature of the stomach at 2 specific sites. These lesions were frequently associated with desquamation of the stratified squamous mucosal epithelium, which was observed in 69 of the 82 foals less than or equal to 30 days old and in 13 of the 101 foals greater than 30 days old. Lesions in the stratified squamous mucosal epithelium adjacent to the margo plicatus were associated with concurrent clinical disorders in foals greater than 90 days old, but developed with identical frequency in foals less than 90 days old with or without a clinical disorder. Lesions in the stratified squamous mucosal epithelium along the lesser curvature of the stomach were observed only in foals with concurrent clinical disorder, and with a higher frequency in foals greater than 90 days old than in younger foals (24% vs 3%). 相似文献
12.
Gross and histologic lesions of paratuberculosis were studied in water buffaloes. Small intestines and associated mesenteric lymph nodes of 405 water buffaloes were examined. Of these, 20 animals having visible changes of intestinal thickening, mucosal corrugations, and enlargement of mesenteric lymph nodes exhibited histologic alteration characteristics of mild to moderate granulomatous inflammation. The histologic lesions observed in these animals were classified into 3 grades on the basis of type of cellular infiltration, granuloma formation, and presence of acid-fast bacilli. Grade-1 lesions observed in 8 animals were marked by the presence of scattered epithelioid macrophages amid large number of lymphocytes in the intestinal villi and in the paracortical regions of the associated mesenteric lymph nodes. Another 8 animals classified under grade-2 revealed microgranulomas, infiltration with a larger number of epithelioid macrophages besides lymphocytes in the intestinal villi, and granulomas in the mesenteric lymph nodes. Grade-3 lesions observed in 4 animals were characterized by the presence of epithelioid granulomas and giant cells in the intestines and the mesenteric lymph nodes. The Ziehl-Neelsen's stained tissue sections revealed acid-fast bacilli in grade-3 and -2 animals and acid-fast granular debris in grade-1 animals. Among these 20 buffaloes, 14 (70%) were positive in the IS900 specific polymerase chain reaction and 6 (30%) were positive in the bacterial culture. 相似文献
13.
Papillomavirus-associated cervical cancer is the second most common neoplasm in women but has rarely been reported in animals. This report describes cervical and vaginal intraepithelial neoplasms identified in routine histologic specimens obtained from 20 (5.2%) of 385 female cynomolgus macaques (Macaca fascicularis) being used in long-term studies. Lesion incidence was similar in both control and hormonally treated animals (4.7% and 5.5%, respectively). Neoplasms included benign vaginal papillomas, mild to severe intraepithelial dysplasias, and two invasive cervical carcinomas. Common morphologic features included koilocytosis, nuclear atypia, and expansion of the basal epithelium. Selective staining of lesions with at least one of three papillomavirus antibodies was observed in all cases (20 of 20). In contrast, immunostaining of lesions was negative for Epstein-Barr-related virus proteins (0 of 20). The unique similarities between the observed lesions and those seen in women suggest that macaques may provide a suitable animal model for study of papillomavirus oncogenesis. 相似文献
14.
Cryptosporidiosis in guinea pigs: a retrospective study 总被引：1，自引：0，他引：1
Cryptosporidiosis was diagnosed in 81 guinea pigs (Cavia porcellus) from 1979 through 1985 at a research animal diagnostic laboratory. Most of the guinea pigs were juveniles of Hartley stock and originated from 6 commercial laboratory animal suppliers or from one pet store supplier. Common clinical signs reported were failure to gain weight, weight loss, diarrhea, and death. At necropsy, macroscopic findings included emaciation, hyperemia of the small intestine, serosal edema of the cecal wall, and increased fluidity of ingesta throughout the intestines. Oval to round cryptosporidia (1 to 4 microns) were seen microscopically within or on the brush border of mucosal epithelial cells from the duodenum through the cecum. Acute histologic lesions consisted of necrosis and sloughing of enterocytes at the villus tips, inflammation, hyperemia and edema of the lamina propria, and hyperplasia of crypt epithelium. More chronic lesions consisted of marked villus bridging or villus fusion and blunting, metaplasia of the mucosal epithelium, and lymphocytic infiltration of the lamina propria. 相似文献
15.
Two groups of six 8-week-old pigs were challenged with 1x10(9) cfu Brachyspira (Serpulina) pilosicoli or Serpulina intermedia daily for 3 consecutive days to study the pathology of porcine colonic spirochetosis by scanning electron microscopy (SEM) and fluorescent in situ hybridization (FISH) with oligonucleotide probes targeting ribosomal RNA specific for B. pilosicoli and the genus Brachyspira/Serpulina. Six pigs served as noninoculated controls. The animals were euthanatized successively between postinoculation days 14 and 24. B. pilosicoli was reisolated in feces from all of the inoculated pigs; however, only two pigs developed transient watery diarrhea. S. intermedia was reisolated from four of the inoculated pigs, but clinical signs were not observed. Gross examination of the B. pilosicoli-infected pigs revealed dilated large intestines with a hyperemic mucosa, whereas the large intestines of the S. intermedia-inoculated pigs and the control pigs appeared normal. SEM examination of B. pilosicoli-infected pigs revealed degenerated epithelial cells and spirochetal colonization of the colonic mucosa in four pigs. By FISH, B. pilosicoli cells were found colonizing and invading the surface epithelium and the crypts in all the pigs. Spirochetal crypt colonization markedly exceeded the occurrence of spirochetes on the mucosal surface. SEM examination of S. intermedia-inoculated pigs revealed no abnormalities, and Serpulina cells were detected only sporadically in the otherwise normal-appearing mucosa of four pigs by FISH. The results provide further evidence that B. pilosicoli is associated with colitis in pigs, although the gross lesions are mild. The spirochete is capable of colonizing the large intestine, inducing mucosal damage, invasion of the crypt and surface epithelium, and focal infiltration of the lamina propria. In addition, the study shows the applicability of FISH for specific identification of B. pilosicoli in formalin-fixed tissue. 相似文献
16.
This paper is a retrospective morphologic study of 7 young Boxer dogs, showing end-stage kidney lesions compatible with chronic pyelonephritis with severe segmental cortical atrophy and fibrosis, associated with chronic tubulointerstitial inflammation of varying degree. Azotemia was observed in 6 of the 7 cases. The gross kidney lesions were as follows: bilateral small kidneys with numerous segmental cortical scars causing depression of the renal cortical surface. Histologic examination revealed salient atrophy of nephrons, including paucity of glomeruli, glomerulocystic lesions, colloid-filled tubular microcysts, and a conspicuously increased occurrence of arteries with narrowed lumina caused by intimal thickening. These segmental abnormalities were accompanied by pronounced interstitial fibrosis. All but 1 dog showed salient tubulointerstitial lympho-plasmacytic infiltration, which in 3 cases also included diffuse infiltration of polymorphonuclear neutrophilic leukocyte (PMN)-cells and occurrence of tubular PMN-casts. Morphologic signs of abnormal metanephric differentiation (renal dysplasia) were observed in all cases in the form of atypical tubules or asynchronous nephronic development (immature glomeruli) or both. However, other morphologic primary dysplastic features were absent. Based on the morphologic features, it is concluded that the end-stage kidney disease in these young Boxer dogs was the result of chronic atrophic nonobstructive pyelonephritis, most probably caused by vesico-ureteral reflux, compatible with reflux nephropathy causing segmental hypoplasia (Ask-Upmark kidney) in man. It is proposed that atypical tubular epithelium in the form of adenomatoid proliferation of collecting duct epithelial cells should be considered an acquired compensatory lesion, rather than the result of disorganized metanephric development. 相似文献
17.
18.
Forty-five cases of renal dysplasia in dogs are examined. Microscopic lesions of dysplasia include asynchronous differentiation of nephrons, persistent mesenchyme, persistent metanephric ducts, atypical tubular epithelium, and dysontogenic metaplasia. These may be distinguished from secondary lesions including compensatory hypertrophy and hyperplasia of the nephron and a variety of degenerative and inflammatory lesions. Although morphological features of renal dysplasia in dogs differ somewhat from those in man, microscopic criteria used in the diagnosis of human dysplasia may be useful when applied to the dog. 相似文献
19.
Fox KA Wootton SK Quackenbush SL Wolfe LL Levan IK Miller MW Spraker TR 《Veterinary pathology》2011,48(3):706-712
This article describes 10 cases of paranasal sinus masses in Rocky Mountain bighorn sheep (Ovis canadensis canadensis). Among 21 bighorns that were examined from 11 herds in Colorado, 10 individuals (48%) from 4 herds (36%) had masses arising from the paranasal sinuses. Affected animals included 9 of 17 females (53%) and 1 of 4 males (25%), ranging in age from approximately 2 years to greater than 10 years. Defining gross features of these masses included unilateral or bilateral diffuse thickening of the respiratory lining of the maxillary and/or frontal sinuses, with abundant seromucinous exudate in the affected sinus cavities. Defining histologic features of these masses included chronic inflammation and proliferation of mesenchymal and epithelial cells of the mucosa and submucosa. Epithelial changes included hyperplasia of mucosal epithelium, hyperplasia of submucosal glands and ducts, and neoplasia (adenocarcinoma). Mesenchymal changes included submucosal myxedema, submucosal fibroplasia/fibrosis, bone destruction, and neoplasia (myxomatous fibroma). Specific immunohistochemistry and polymerase chain reaction for Jaagsiekte sheep retrovirus and enzootic nasal tumor virus were performed with negative results. 相似文献
20.
Histological characteristics of induced acute peptic injury in equine gastric squamous epithelium. 总被引：1，自引：0，他引：1
The objective of the study reported here was to characterise the microscopic appearance of peptic-injured equine gastric squamous epithelium in relation to the duration of peptic injury. Erosions and ulcers were induced in equine gastric squamous epithelium using a feed deprivation protocol that results in prolonged increased gastric acidity. Specimens of normal gastric mucosa and mucosa with lesions created after 48 and 96 h of feed deprivation were compared for characteristics associated with angiogenesis and mucosal proliferation. Fifteen mature horses, 9 geldings and 6 mares, age 3-20 years, were divided into 3 groups. Group 1 (n = 5) had normal-appearing gastric squamous mucosal epithelium and had been killed due to problems unrelated to the gastrointestinal tract. Groups 2 (n = 5) and 3 (n = 5) had lesions induced in the gastric squamous epithelium by alternating 24 h periods of feed deprivation and ad libitum access to hay, for totals of 48 and 96 h feed deprivation, respectively. Following lethal injection of barbiturate, stomachs were removed and fixed by filling with 4-6 l 10% buffered formalin. Sections were made from lesions in the gastric squamous epithelium adjacent to the margo plicatus along the right side of the stomach/greater curvature and the lesser curvature. Measurements of total epithelial thickness, keratinised epithelium, nonkeratinised epithelium, epithelial projections, capillary extension into the epithelium and lamina propria thickness were made. The cross-sectional areas of arterial and venous vascular structures in the lamina propria at the lesions and their margins were measured using image analysis software. All horses, except one, in Group 2 developed erosions or ulcers in the gastric squamous epithelium after feed deprivation. There were several changes in the epithelium adjacent to erosions and ulcers, compared to normal epithelium, from horses in Groups 2 and 3: total epithelial thickness was significantly (P<0.05) greater, including both keratinised and nonkeratinised layers in most specimens; the length of epithelial projections and extent to which capillaries from the lamina propria extended toward the luminal surface, and the cross-sectional area of vascular structures (arterioles, capillaries, venules) in the lamina propria were significantly greater. Epithelial thickness of erosion beds was not significantly less than normal epithelium, although a greater proportion of the epithelium in erosions consisted of epithelial projections (Group 1, 23%; Group 2, 76%; Group 3, 72%). The cross-sectional area of vascular structures in the lamina propria beneath erosions was significantly greater than in normal mucosa only in Group 2 tissues, whereas in the lamina propria of ulcers it was significantly greater than in normal mucosa only in Group 3 tissues. The epithelial proliferation and increased vascular cross-sectional area in the lamina propria associated with peptic-induced gastric lesions are consistent with processes associated with the initiation of ulcer healing, and these changes temporally coincided with the initiation of peptic insult to the gastric squamous epithelium. These findings demonstrate that processes that promote ulcer healing begin soon after peptic injury and that they progress even with repeated peptic injury. Furthermore, our findings support observations that gastric ulcers often heal without medical intervention, and the theory that medications that reduce gastric acidity do not initiate healing, but rather facilitate ulcer healing by providing a microenvironment that is optimal for healing to proceed. 相似文献