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The role of the c-mos gene in the 8;21 translocation in human acute myeloblastic leukemia 总被引：2，自引：0，他引：2
M O Diaz M M Le Beau J D Rowley H A Drabkin D Patterson 《Science (New York, N.Y.)》1985,229(4715):767-769
The human c-mos proto-oncogene is located on chromosome 8 at band q22, close to the breakpoint in the t(8;21) (q22;q22) chromosome rearrangement. This translocation is associated with acute myeloblastic leukemia, subgroup M2. The c-myc gene, another proto-oncogene, has been mapped to 8q24. The breakpoint at 8q22 separates these genes, as determined by in situ hybridization of c-mos and c-myc probes. The c-mos gene remains on the 8q-chromosome and the c-myc gene is translocated to the 21q+ chromosome. Southern blot analysis of DNA from bone marrow cells of four patients with this translocation showed no rearrangement of c-mos. 相似文献
3.
Locus of the alpha-chain of the T-cell receptor is split by chromosome translocation in T-cell leukemias 总被引：23，自引：0，他引：23
J Erikson D L Williams J Finan P C Nowell C M Croce 《Science (New York, N.Y.)》1985,229(4715):784-786
Mouse lymphoma cells were hybridized with two human acute T-cell leukemias with a t(11;14) (p13;q11) translocation and the segregated hybrids were examined for the presence of the DNA segments coding for the constant (C) and the variable (V) regions of the alpha chain (C alpha and V alpha) of the T-cell receptor. The C alpha segment was translocated to the involved chromosome 11 (11p+) while the V alpha segment remained on the involved chromosome 14 (14q-). The data indicate that the locus for the alpha chain of the T-cell receptor is split by the chromosomal breakpoint between the V alpha and the C alpha gene segments, and that the V alpha segments are proximal to the C alpha segment within chromosome band 14q11.2. 相似文献
4.
The t(14;18) chromosome translocations involved in B-cell neoplasms result from mistakes in VDJ joining 总被引：97，自引：0，他引：97
In this study, the joining sequences between chromosomes 14 and 18 on the 14q+ chromosomes of a patient with pre-B-cell leukemia and four patients with follicular lymphoma carrying a t(14;18) chromosome translocation were analyzed. In each case, the involved segment of chromosome 18 has recombined with the immunoglobulin heavy-chain joining segment (JH) on chromosome 14. The sites of the recombination on chromosome 14 are located close to the 5' end of the involved JH segment, where the diversity (D) regions are rearranged with the JH segments in the production of active heavy-chain genes. As extraneous nucleotides (N regions) were observed at joining sites and specific signal-like sequences were detected on chromosome 18 in close proximity to the breakpoints, it is concluded that the t(14;18) chromosome translocation is the result of a mistake during the process of VDJ joining at the pre-B-cell stage of differentiation. The putative recombinase joins separated DNA segments on two different chromosomes instead of joining separated segments on the same chromosome, causing a t(14;18) chromosome translocation in the involved B cells. 相似文献
5.
Common region on chromosome 14 in T-cell leukemia and lymphoma 总被引：28，自引：0，他引：28
Chromosome 14 breakpoints in malignant human lymphocytes cluster on the long (q) arm near bands q11 and q32. An inversion of chromosome 14 due to breaks in q11.2 and q32.3 has now been found in a newly established childhood T-cell lymphoma cell line and confirmed in T-cell chronic lymphocytic leukemia. A translocation was also found between chromosomes 10 and 14 with a breakpoint at 14q11.2 in another T-cell lymphoma cell line. It is proposed that a proximal region on chromosome 14 in or near sub-band q11.2 is related to T-cell function. Rearrangements in this region may affect the growth of T lymphocytes and be involved in the development of T-cell malignancies. 相似文献
6.
Translocation and rearrangements of the c-myc oncogene locus in human undifferentiated B-cell lymphomas 总被引：61，自引：0，他引：61
R Dalla-Favera S Martinotti R C Gallo J Erikson C M Croce 《Science (New York, N.Y.)》1983,219(4587):963-967
The locus for the cellular myc (c-myc) oncogene in humans is located on the region of chromosome 8 that is translocated to chromosome 14 in cells from most undifferentiated B-cell lymphomas. It is shown in this study that the c-myc locus is rearranged in 5 out of 15 cell lines from patients with undifferentiated B-cell lymphomas, and that the rearrangement involves a region at the 5' side of an apparently intact c-myc gene. In at least three patients, this rearranged region appears to contain immunoglobulin heavy chain mu sequences that are located on chromosome 14. The data indicate that this region contains the crossover point between chromosomes 8 and 14. The break point can occur at different positions on both chromosomes among individual cell lines. 相似文献
7.
Molecular analysis of the t(2;14) translocation of childhood chronic lymphocytic leukemia 总被引：3，自引：0，他引：3
Two rare cases of chronic lymphocytic leukemia (CLL) in children have been studied; both are associated with a previously undescribed chromosomal translocation [t(2;14) (p13;q32)]. In one patient the translocation was reciprocal and the breakpoint on chromosome 14 occurred just 5' of the C gamma 2 region on the productive immunoglobulin heavy-chain allele. The breakpoint on chromosome 2 does not involve the K locus but lies within an uncharacterized region that coincides with the position of a constitutive fragile site that occurs within normal lymphocytes. Data on the second patient are consistent with these findings and suggest that these cases represent a rare but distinct subgroup of CLL's with a specific cytogenetic change. 相似文献
8.
Physical mapping of a translocation breakpoint in neurofibromatosis 总被引：13，自引：0，他引：13
J W Fountain M R Wallace M A Bruce B R Seizinger A G Menon J F Gusella V V Michels M A Schmidt G W Dewald F S Collins 《Science (New York, N.Y.)》1989,244(4908):1085-1087
The gene for von Recklinghausen neurofibromatosis (NF1), one of the most common autosomal-dominant disorders of humans, was recently mapped to chromosome 17 by linkage analysis. The identification of two NF1 patients with balanced translocations that involved chromosome 17q11.2 suggests that the disease can arise by gross rearrangement of the NF1 locus, and that the NF1 gene might be identified by cloning the region around these translocation breakpoints. To further define the region of these translocations, a series of chromosome 17 Not I-linking clones has been mapped to proximal 17q and studied by pulsed-field gel electrophoresis. One clone, 17L1 (D17S133), clearly identifies the breakpoint in an NF1 patient with a t(1;17) translocation. A 2.3-megabase pulsed-field map of this region was constructed and indicates that the NF1 breakpoint is only 10 to 240 kilobases away from 17L1. This finding prepares the way for the cloning of NF1. 相似文献
9.
elk, tissue-specific ets-related genes on chromosomes X and 14 near translocation breakpoints 总被引：39，自引：0，他引：39
V N Rao K Huebner M Isobe A ar-Rushdi C M Croce E S Reddy 《Science (New York, N.Y.)》1989,244(4900):66-70
10.
Common mechanism of chromosome inversion in B- and T-cell tumors: relevance to lymphoid development 总被引：12，自引：0，他引：12
C T Denny G F Hollis F Hecht R Morgan M P Link S D Smith I R Kirsch 《Science (New York, N.Y.)》1986,234(4773):197-200
An inversion of chromosome 14 present in the tumor cells of a patient with childhood acute lymphoblastic leukemia of B-cell lineage was shown to be the result of a site-specific recombination event between an immunoglobulin heavy-chain variable gene and the joining segment of a T-cell receptor alpha chain. This rearrangement resulted in the formation of a hybrid gene, part immunoglobulin and part T-cell receptor. Furthermore, this hybrid gene was transcribed into messenger RNA with a completely open reading frame. Thus, two loci felt to be normally activated at distinct and disparate points in lymphocyte development were unified and expressed in this tumor. 相似文献
11.
Translocation and rearrangement of myeloperoxidase gene in acute promyelocytic leukemia 总被引：3，自引：0，他引：3
S C Weil G L Rosner M S Reid R L Chisholm R S Lemons M S Swanson J J Carrino M O Diaz M M Le Beau 《Science (New York, N.Y.)》1988,240(4853):790-792
Acute promyelocytic leukemia (subtype M3) is characterized by malignant promyelocytes exhibiting an abundance of abnormally large or aberrant primary granules. Myeloperoxidase (MPO) activity of these azurophilic granules, as assessed by cytochemical staining, is unusually intense. In addition, M3 is universally associated with a chromosomal translocation, t(15;17)(q22;q11.2). In this report, the MPO gene was localized to human chromosome 17 (q12-q21), the region of the breakpoint on chromosome 17 in the t(15;17), by somatic cell hybrid analysis and in situ chromosomal hybridization. By means of MPO complementary DNA clones for in situ hybridization and Southern blot analysis, the effect of this specific translocation on the MPO gene was examined. In all cases of M3 examined, MPO is translocated to chromosome 15. Genomic blot analyses indicate rearrangement of MPO in leukemia cells of two of four cases examined. These findings suggest that MPO may be pivotal in the pathogenesis of acute promyelocytic leukemia. 相似文献
12.
A novel mechanism of somatic rearrangement predicted by a human T-cell antigen receptor beta-chain complementary DNA 总被引：10，自引：0，他引：10
The T-cell antigen receptor is a cell surface molecule vital in mediating the cellular immune response. The arrangement and rearrangement of the gene segments encoding the beta-chain polypeptide of the receptor are similar to those of immunoglobulin gene segments. The two constant region genes of the human T-cell antigen receptor are 8 kilobases apart with a cluster of joining segments located 5' of each constant region gene. Although most beta-chain gene rearrangements involve the variable, diversity, and joining segments, analysis of a beta-chain complementary DNA clone suggests the occasional occurrence of another type of rearrangement. 相似文献
13.
Location of gene for beta subunit of human T-cell receptor at band 7q35, a region prone to rearrangements in T cells 总被引：15，自引：0，他引：15
The T-cell receptor is formed by two chains, alpha and beta, for which specific clones were recently obtained. In this report the gene for the beta chain of the human T-cell receptor was located on the long arm of chromosome 7, band q35, by means of in situ hybridization. This chromosome region in T cells is unusually prone to develop breaks in vivo, perhaps reflecting instability generated by somatic rearrangement of T-cell receptor genes during normal differentiation in this cell lineage. 相似文献
14.
Interferon and c-ets-1 genes in the translocation (9;11)(p22;q23) in human acute monocytic leukemia 总被引：13，自引：0，他引：13
Gene probes for interferons alpha and beta 1 and v-ets were hybridized to metaphase chromosomes from three patients with acute monocytic leukemia who had a chromosomal translocation, t(9;11)(p22;q23). The break in the short arm of chromosome 9 split the interferon genes, and the interferon-beta 1 gene was translocated to chromosome 11. The c-ets-1 gene was translocated from chromosome 11 to the short arm of chromosome 9 adjacent to the interferon genes. No DNA rearrangement was observed when these probes were hybridized to genomic DNA from leukemic cells of two of the patients. The results suggest that the juxtaposition of the interferon and c-ets-1 genes may be involved in the pathogenesis of human monocytic leukemia. 相似文献
15.
Fragile sites at 16q22 are not at the breakpoint of the chromosomal rearrangement in AMMoL 总被引：5，自引：0，他引：5
There is much speculation about fragile sites on human chromosomes predisposing to specific chromosome rearrangements seen in cancer. Acute myelomonocytic leukemia is characterized by neoplastic chromosome rearrangements involving band 16q22 in patients who carry the rare fragile site at 16q22. This specific leukemic breakpoint is within the metallothionein gene cluster, which is here shown to be proximal to the rare fragile site (FRA16B) and to a common fragile site (FRA16C) in this region. Hence neither of these fragile sites are at the breakpoint in this leukemic chromosomal rearrangement. 相似文献
16.
Repression of rearranged mu gene and translocated c-myc in mouse 3T3 cells X Burkitt lymphoma cell hybrids 总被引：18，自引：0，他引：18
K Nishikura A ar-Rushdi J Erikson E DeJesus D Dugan C M Croce 《Science (New York, N.Y.)》1984,224(4647):399-402
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Involvement of the bcl-2 gene in human follicular lymphoma 总被引：69，自引：0，他引：69
18.
Sequence-specific binding of human Ets-1 to the T cell receptor alpha gene enhancer 总被引：48，自引：0，他引：48
I C Ho N K Bhat L R Gottschalk T Lindsten C B Thompson T S Papas J M Leiden 《Science (New York, N.Y.)》1990,250(4982):814-818
19.
Gene for alpha-chain of human T-cell receptor: location on chromosome 14 region involved in T-cell neoplasms 总被引：39，自引：0，他引：39
C M Croce M Isobe A Palumbo J Puck J Ming D Tweardy J Erikson M Davis G Rovera 《Science (New York, N.Y.)》1985,227(4690):1044-1047
A human complementary DNA clone specific for the alpha-chain of the T-cell receptor and a panel of rodent X human somatic cell hybrids were used to map the alpha-chain gene to human chromosome 14 in a region proximal to the immunoglobulin heavy chain locus. Analysis by means of in situ hybridization of human metaphase chromosomes served to further localize the alpha-chain gene to region 14q11q12, which is consistently involved in translocations and inversions detectable in human T-cell leukemias and lymphomas. Thus, the locus for the alpha-chain T-cell receptor may participate in oncogene activation in T-cell tumors. 相似文献