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A potential BSE risk for milk and milk products has to be evaluated by means of risk analysis, especially risk assessment. The 3rd element of risk assessment--hazard exposition--is of decisive significance. In 1997, the Scientific Steering Committee of the European Commission has categorized risk materials in 4 classes. Colostrum, milk and tissues of the mammary gland have been classified in category 4, i.e. "infectivity not detected". A secondary contamination of the milk can be excluded (living animals). However, the term "not detected" refers also to the low sensitivity of the mouse test, which has to be taken into consideration. Therefore, in 2000 investigations started in Great Britain to test milk fractions, especially the fraction of somatic cells, for the possible occurrence of prions, using newly developed and highly sensitive methods. Results can not be expected before 2003 at the earliest. In case prions would be detected, their biological activity has to be demonstrated in order to develop an appropriate risk assessment for the consumer. Investigations in Great Britain in the early nineties of the last century with suckling cows under practical conditions have shown no indications of a BSE transfer via the milk to the calves. Therefore, the statement of national and international organizations is still valid, that milk can be regarded safe according to the present state of scientific knowledge.  相似文献   

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The study of allergies in creatures living together without being relatives can help us understand the impact of environmental influences. We tested the association of allergies in humans and their pets. A nested unmatched case-control study was performed in a random sample of 4261 inhabitants, aged 25-74 years, of the City of Augsburg, Germany and two adjacent counties. Using standardised computer-assisted face-to-face interviews, we determined and compared the prevalence of doctor-diagnosed atopic diseases (hay fever, asthma, atopic dermatitis) in the study subjects and veterinarian-diagnosed allergies in their pets. Pets were kept in 48.0% of the households (cats 26.1%, dogs 20.1%, rodents 9.7%) and a veterinarian had diagnosed an allergy in 3.9% (cats 3.3%, dogs 4.7%, rodents 1.2%). Atopic diseases were diagnosed in 20.2% of the study subjects (asthma 6.1%, hay fever 13.7%, atopic dermatitis 5.1%). After adjustment for age, sex, parental predisposition and social status a significant association between hay fever in the study subjects and allergies in their pets was observed [odds ratio (OR) 1.74, 95% confidence interval (CI) 1.01-2.97]. This association was more pronounced when investigating dogs only (OR 2.76, 95% CI 1.32-5.77) where in addition an association with the overall prevalence of atopic diseases in the study subjects reached significance (OR 2.31, 95% CI 1.16-4.58). We conclude that there is indication for a concomitant occurrence of allergies in humans and their pets. Shared environmental factors are the most likely explanation.  相似文献   

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The daily requirement for calcium and phosphorus by giraffes to sustain the growth and maintenance of their skeletons is large. The source of sufficient calcium is browse. The source of necessary phosphorus is obscure, but it could be osteophagia, a frequently observed behaviour in giraffes. We have assessed whether bone ingested as a result of osteophagia can be digested in the rumen. Bone samples from cancellous (cervical vertebrae) and dense bones (metacarpal shaft) were immersed in the rumens of five sheep, for a period of up to 30 days, and the effect compared to immersion in distilled water and in artificial saliva for 30 days. Distilled water had no effect on the bones. Dense bone samples were softened by exposure to the saliva and rumen fluid, but did not lose either calcium or phosphorus. In saliva and rumen fluid the cancellous bone samples also softened, and their mass and volume decreased as a result of exposure to saliva, but in neither fluid did they lose significant amounts of calcium and phosphorus. We conclude that although saliva and rumen fluid can soften ingested bones, there is an insignificant digestion of bones in the rumen.  相似文献   

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